Bioconductor Affymetrix Probe Listing

Probe Symbol Description Chromosome Chromosome Location GenBank Gene PubMed Gene Ontology Pathway
TC1100003401.mm.2 Ccl3 chemokine (C-C motif) ligand 3 11 -83647842 NM_011337, BC111443 NM_011337, BC111443 260

monocyte chemotaxis

cytokine activity

protein binding

extracellular region

extracellular space

extracellular space

chemotaxis

inflammatory response

immune response

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

chemokine activity

chemokine activity

chemokine activity

regulation of cell shape

neutrophil chemotaxis

neutrophil chemotaxis

leukocyte chemotaxis

positive regulation of interleukin-1 beta production

positive regulation of tumor necrosis factor production

positive regulation of neuron apoptotic process

positive regulation of GTPase activity

astrocyte cell migration

positive regulation of osteoclast differentiation

positive regulation of transcription by RNA polymerase II

CCR chemokine receptor binding

macrophage chemotaxis

lymphocyte chemotaxis

positive regulation of inflammatory response

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

04060

04062

04620

05142

05323

TC1200000203.mm.2 Rrm2 ribonucleotide reductase M2 12 24708253 NM_009104, BC085136 NM_009104, BC085136 72

blastocyst development

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

protein binding

nuclear envelope

cytoplasm

cytosol

cytosol

cytosol

ribonucleoside-diphosphate reductase complex

ribonucleoside-diphosphate reductase complex

DNA replication

ferric iron binding

deoxyribonucleotide metabolic process

deoxyribonucleotide biosynthetic process

deoxyribonucleotide biosynthetic process

oxidoreductase activity

identical protein binding

protein homodimerization activity

metal ion binding

protein heterotetramerization

00230

00240

00480

01100

04115

TC0600001606.mm.2 Emp1 epithelial membrane protein 1 6 135362930, 135367492 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 29

plasma membrane

plasma membrane

cell death

membrane

integral component of membrane

cell growth

bleb assembly

 
TC0800001737.mm.2 Gas6 growth arrest specific 6 8 -13465373 NM_019521, BC005444 NM_019521, BC005444 109

neuron migration

phosphatidylserine binding

positive regulation of protein phosphorylation

positive regulation of cytokine-mediated signaling pathway

positive regulation of glomerular filtration

signaling receptor binding

calcium ion binding

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

protein phosphorylation

phagocytosis

signal transduction

enzyme linked receptor protein signaling pathway

blood coagulation

cellular response to starvation

positive regulation of gene expression

negative regulation of tumor necrosis factor-mediated signaling pathway

macrophage cytokine production

peptidyl-serine phosphorylation

fusion of virus membrane with host plasma membrane

viral genome replication

protein tyrosine kinase activator activity

protein-macromolecule adaptor activity

receptor tyrosine kinase binding

cell-substrate adhesion

positive regulation of TOR signaling

activation of protein kinase B activity

negative regulation of interferon-gamma production

negative regulation of interleukin-1 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

positive regulation of natural killer cell differentiation

positive regulation of peptidyl-serine phosphorylation

cellular response to interferon-alpha

cellular response to drug

B cell chemotaxis

regulation of growth

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

apoptotic cell clearance

apoptotic cell clearance

negative regulation of DNA-binding transcription factor activity

protein kinase B signaling

protein kinase B signaling

protein kinase B signaling

protein kinase B signaling

positive regulation of protein kinase activity

negative regulation of transcription, DNA-templated

viral entry into host cell

receptor-mediated virion attachment to host cell

positive regulation of protein export from nucleus

metal ion binding

receptor ligand activity

receptor ligand activity

receptor ligand activity

positive regulation of fibroblast proliferation

positive regulation of phagocytosis

positive regulation of protein kinase B signaling

positive regulation of protein tyrosine kinase activity

negative regulation of biomineral tissue development

positive regulation of ERK1 and ERK2 cascade

calcium ion transmembrane transport

cellular response to vitamin K

cellular response to glucose stimulus

cellular response to growth factor stimulus

cellular response to growth factor stimulus

protein localization to plasma membrane

hematopoietic stem cell migration to bone marrow

negative regulation of oligodendrocyte apoptotic process

negative regulation of fibroblast apoptotic process

negative regulation of endothelial cell apoptotic process

positive regulation of dendritic cell chemotaxis

negative regulation of dendritic cell apoptotic process

 
TC0400001856.mm.2 Dhrs3 dehydrogenase/reductase (SDR family) member 3 4 144893136, 144892826, 144893076 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 30

retinoid metabolic process

retinoid metabolic process

outflow tract morphogenesis

retinol dehydrogenase activity

retinol dehydrogenase activity

lipid droplet

membrane

integral component of membrane

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

regulation of ossification

retinol metabolic process

regulation of retinoic acid receptor signaling pathway

negative regulation of retinoic acid receptor signaling pathway

NADP-retinol dehydrogenase activity

roof of mouth development

bone morphogenesis

cardiac septum morphogenesis

00830

01100

TC1000000372.mm.2 Sesn1 sestrin 1 10 41810573, 41887438 NM_001013370, NM_001162908, BC055753, BC100403 NM_001013370, NM_001162908, BC055753, BC100403 NM_001013370, NM_001162908, BC055753, BC100403 NM_001013370, NM_001162908, BC055753, BC100403 33

fibrillar center

protein binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

positive regulation of macroautophagy

oxidoreductase activity

oxidoreductase activity, acting on peroxide as acceptor

negative regulation of cell growth

TORC2 complex

cellular response to amino acid starvation

cellular response to glucose starvation

regulation of protein kinase B signaling

GATOR2 complex

GATOR2 complex

leucine binding

leucine binding

cellular response to amino acid stimulus

cellular response to leucine

reactive oxygen species metabolic process

cellular oxidant detoxification

regulation of response to reactive oxygen species

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

cellular response to leucine starvation

04115

TC0100000298.mm.2 Il1rl1 interleukin 1 receptor-like 1 1 40439628, 40439628, 40429569 NM_001025602, NM_010743, BC051445 NM_001025602, NM_010743, BC051445 NM_001025602, NM_010743, BC051445 293

interleukin-33 binding

interleukin-33 binding

interleukin-33 receptor activity

interleukin-33 receptor activity

negative regulation of T-helper 1 type immune response

interleukin-1 receptor activity

protein binding

extracellular region

extracellular space

cytosol

plasma membrane

focal adhesion

signal transduction

negative regulation of cell population proliferation

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

integral component of membrane

hydrolase activity

extracellular matrix

negative regulation of interferon-gamma production

positive regulation of chemokine production

positive regulation of interleukin-5 production

positive regulation of macrophage activation

negative regulation of I-kappaB kinase/NF-kappaB signaling

NAD(P)+ nucleosidase activity

positive regulation of inflammatory response

NAD+ nucleotidase, cyclic ADP-ribose generating

 
TC0400001639.mm.2 Stmn1 stathmin 1 4 134468319 NM_019641, BC010581, BC031831, BC054396 NM_019641, BC010581, BC031831, BC054396 NM_019641, BC010581, BC031831, BC054396 NM_019641, BC010581, BC031831, BC054396 112

mitotic cytokinesis

mitotic cytokinesis

protein binding

cytoplasm

cytoplasm

cytosol

cytoskeleton

microtubule

microtubule depolymerization

microtubule depolymerization

mitotic spindle organization

multicellular organism development

nervous system development

axonogenesis

tubulin binding

tubulin binding

membrane

cell differentiation

regulation of microtubule polymerization or depolymerization

regulation of microtubule polymerization or depolymerization

negative regulation of microtubule polymerization

negative regulation of microtubule polymerization

neuron projection development

negative regulation of Rho protein signal transduction

neuron projection

hepatocyte growth factor receptor signaling pathway

positive regulation of cellular component movement

negative regulation of stress fiber assembly

establishment of skin barrier

negative regulation of thrombin-activated receptor signaling pathway

negative regulation of guanyl-nucleotide exchange factor activity

04010

TC0500003472.mm.2         NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024  

nucleotide binding

double-strand break repair via break-induced replication

in utero embryonic development

negative regulation of B cell apoptotic process

DNA binding

DNA helicase activity

DNA helicase activity

DNA replication origin binding

single-stranded DNA binding

single-stranded DNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

cytosol

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

DNA unwinding involved in DNA replication

DNA replication initiation

DNA strand elongation involved in DNA replication

cellular response to DNA damage stimulus

cell cycle

cell aging

sensory perception of sound

cell population proliferation

Wnt signaling pathway

hydrolase activity

regulation of phosphorylation

MCM complex

MCM complex

negative regulation of apoptotic process

regulation of viral genome replication

regulation of viral genome replication

long-term synaptic potentiation

SMAD protein signal transduction

cellular response to inorganic substance

cellular response to xenobiotic stimulus

cellular response to forskolin

single-stranded 3'-5' DNA helicase activity

 
TC0400001934.mm.2 Srm spermidine synthase 4 148591512 NM_009272, BC005566 NM_009272, BC005566 24

catalytic activity

spermidine synthase activity

spermidine synthase activity

polyamine metabolic process

polyamine biosynthetic process

spermidine biosynthetic process

spermidine biosynthetic process

transferase activity

identical protein binding

protein homodimerization activity

cellular response to leukemia inhibitory factor

00270

00330

00410

00480

01100

TC1400000176.mm.2 Plau plasminogen activator, urokinase 14 20836661 NM_008873, BC120709, BC120713 NM_008873, BC120709, BC120713 NM_008873, BC120709, BC120713 311

angiogenesis

response to hypoxia

serine-type endopeptidase activity

protein binding

extracellular region

extracellular space

extracellular space

proteolysis

peptidase activity

serine-type peptidase activity

positive regulation of cell population proliferation

cell surface

regulation of signaling receptor activity

smooth muscle cell migration

regulation of smooth muscle cell migration

positive regulation of smooth muscle cell migration

membrane

hydrolase activity

positive regulation of cell migration

plasminogen activation

plasminogen activation

regulation of cell adhesion mediated by integrin

regulation of cell adhesion mediated by integrin

wound healing

regulation of cell population proliferation

fibrinolysis

fibrinolysis

skeletal muscle tissue regeneration

positive regulation of ovulation

neuron death

regulation of smooth muscle cell-matrix adhesion

regulation of hepatocyte proliferation

positive regulation of reactive oxygen species metabolic process

04610

TC1400002746.mm.2 Gpr183 G protein-coupled receptor 183 14 -121952330 NM_183031, BC052868 NM_183031, BC052868 50

adaptive immune response

B cell activation involved in immune response

mature B cell differentiation involved in immune response

immune system process

dendritic cell chemotaxis

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

humoral immune response

signal transduction

G protein-coupled receptor signaling pathway

oxysterol binding

oxysterol binding

T cell chemotaxis

membrane

integral component of membrane

osteoclast differentiation

leukocyte chemotaxis

leukocyte chemotaxis

positive regulation of B cell proliferation

positive regulation of B cell proliferation

dendritic cell homeostasis

cell chemotaxis

T follicular helper cell differentiation

positive regulation of ERK1 and ERK2 cascade

regulation of astrocyte chemotaxis

 
TSUnmapped00000029.mm.2 Psd3 pleckstrin and Sec7 domain containing 3 8 -67689081, -67689081, -67689081 NM_177698 22

guanyl-nucleotide exchange factor activity

plasma membrane

membrane

cell junction

ARF protein signal transduction

regulation of ARF protein signal transduction

ruffle membrane

ruffle membrane

cell projection

synapse

04144

TC0600002233.mm.2 Tmem176b transmembrane protein 176B 6 -48833810, -48833811, -48833811 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 NM_001164207, NM_001164208, NM_001164209, NM_001286651, NM_001286652, NM_023056, NR_104575, BC019539, BC022166 34

protein binding

nucleus

membrane

integral component of membrane

cell differentiation

negative regulation of dendritic cell differentiation

negative regulation of dendritic cell differentiation

 
TC1100001220.mm.2 Ccl7 chemokine (C-C motif) ligand 7 11 82045711 NM_013654, BC061126 NM_013654, BC061126 80

monocyte chemotaxis

cytokine activity

extracellular region

extracellular space

extracellular space

chemotaxis

inflammatory response

immune response

G protein-coupled receptor signaling pathway

chemokine activity

heparin binding

neutrophil chemotaxis

CCR2 chemokine receptor binding

positive regulation of GTPase activity

CCR chemokine receptor binding

eosinophil chemotaxis

lymphocyte chemotaxis

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to ethanol

04060

04062

TC0900001182.mm.2 Slc9a9 solute carrier family 9 (sodium/hydrogen exchanger), member 9 9 94669891 NM_177909, BC099942, BC153825 NM_177909, BC099942, BC153825 NM_177909, BC099942, BC153825 22

endosome

plasma membrane

ion transport

cation transport

sodium ion transport

regulation of pH

antiporter activity

solute:proton antiporter activity

sodium:proton antiporter activity

potassium:proton antiporter activity

membrane

integral component of membrane

regulation of intracellular pH

recycling endosome

recycling endosome

transmembrane transport

potassium ion transmembrane transport

sodium ion import across plasma membrane

 
TC1100000168.mm.2 Cnrip1 cannabinoid receptor interacting protein 1 11 17051858 NM_029861, BC087946 NM_029861, BC087946 27

cytoplasm

plasma membrane

plasma membrane

protein C-terminus binding

regulation of signaling receptor activity

type 1 cannabinoid receptor binding

type 1 cannabinoid receptor binding

myelin sheath

negative regulation of signaling receptor activity

negative regulation of signaling receptor activity

 
TC0200002532.mm.2 Ube2c ubiquitin-conjugating enzyme E2C 2 164769928 NM_026785, BC147032, BC147033 NM_026785, BC147032, BC147033 NM_026785, BC147032, BC147033 25

ubiquitin ligase complex

nucleotide binding

protein polyubiquitination

ubiquitin-protein transferase activity

ATP binding

nucleus

anaphase-promoting complex

cytosol

plasma membrane

ubiquitin-dependent protein catabolic process

cell cycle

exit from mitosis

free ubiquitin chain polymerization

protein ubiquitination

transferase activity

regulation of mitotic metaphase/anaphase transition

anaphase-promoting complex-dependent catabolic process

anaphase-promoting complex-dependent catabolic process

positive regulation of exit from mitosis

ubiquitin-like protein ligase binding

cell division

ubiquitin conjugating enzyme activity

ubiquitin conjugating enzyme activity

protein K48-linked ubiquitination

protein K11-linked ubiquitination

04120

TC0200001045.mm.2 Itga6 integrin alpha 6 2 71786938 NM_001277970, NM_008397, BC058095 NM_001277970, NM_008397, BC058095 NM_001277970, NM_008397, BC058095 274

integrin binding

protein binding

basement membrane

plasma membrane

plasma membrane

adherens junction

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

integrin complex

external side of plasma membrane

basal plasma membrane

cell surface

cell surface

positive regulation of cell-substrate adhesion

positive regulation of neuron projection development

membrane

integral component of membrane

basolateral plasma membrane

positive regulation of cell-cell adhesion

hemidesmosome

filopodium

positive regulation of cell migration

cell-substrate adhesion

cellular response to extracellular stimulus

insulin-like growth factor I binding

cell adhesion mediated by integrin

integrin alpha6-beta4 complex

nail development

neuregulin binding

positive regulation of phosphorylation

odontogenesis of dentin-containing tooth

positive regulation of apoptotic process

laminin binding

positive regulation of GTPase activity

skin morphogenesis

protein-containing complex binding

basal part of cell

positive regulation of transcription by RNA polymerase II

filopodium assembly

metal ion binding

brown fat cell differentiation

leukocyte migration

leukocyte migration

cell-cell adhesion

negative regulation of extrinsic apoptotic signaling pathway

04510

04512

04514

04640

04810

05145

05200

05222

05410

05412

05414

TC1900000216.mm.2         XM_986941      
TC0300001639.mm.2 Fabp4 fatty acid binding protein 4, adipocyte 3 -10204342 NM_024406, BC002148, BC054426 NM_024406, BC002148, BC054426 NM_024406, BC002148, BC054426 198

cytokine production

long-chain fatty acid transporter activity

fatty acid binding

nucleus

nucleoplasm

cytoplasm

cytosol

negative regulation of protein kinase activity

fatty acid metabolic process

positive regulation of cell population proliferation

lipid binding

response to bacterium

long-chain fatty acid transport

long-chain fatty acid binding

cholesterol homeostasis

negative regulation of transcription, DNA-templated

regulation of inflammatory response

positive regulation of inflammatory response

white fat cell differentiation

brown fat cell differentiation

hormone receptor binding

cellular response to lithium ion

cellular response to tumor necrosis factor

positive regulation of cold-induced thermogenesis

03320

TC1500000031.mm.2 Dab2 disabled 2, mitogen-responsive phosphoprotein 15 6386747, 6299788 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 118

negative regulation of transcription by RNA polymerase II

cell morphogenesis involved in differentiation

fibrillar center

in utero embryonic development

positive regulation of receptor recycling

positive regulation of protein phosphorylation

positive regulation of receptor internalization

integrin binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

nucleus

cytoplasm

cytoplasm

plasma membrane

plasma membrane

plasma membrane

clathrin-coated pit

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

pinocytosis

apoptotic process

activation of JUN kinase activity

multicellular organism development

endoderm development

excretion

protein C-terminus binding

positive regulation of epithelial to mesenchymal transition

positive regulation of epithelial to mesenchymal transition

positive regulation of pathway-restricted SMAD protein phosphorylation

positive regulation of pathway-restricted SMAD protein phosphorylation

negative regulation of neuron projection development

protein transport

membrane

Wnt signaling pathway

apical plasma membrane

myeloid cell differentiation

clathrin coat of coated pit

clathrin-coated vesicle

cell differentiation

clathrin binding

negative regulation of cell growth

positive regulation of cell migration

positive regulation of cell migration

positive regulation of transforming growth factor beta receptor signaling pathway

clathrin-coated vesicle membrane

cytoplasmic vesicle

negative regulation of protein binding

positive regulation of aldosterone biosynthetic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of transcription elongation from RNA polymerase II promoter

leading edge cell differentiation

phosphatidylinositol binding

AP-2 adaptor complex binding

clathrin adaptor activity

clathrin adaptor activity

cargo receptor activity

cargo receptor activity

negative regulation of apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

positive regulation of cell adhesion

positive regulation of cell adhesion

positive regulation of endocytosis

positive regulation of endocytosis

positive regulation of transcription by RNA polymerase II

SMAD binding

clathrin coat assembly

clathrin coat assembly

perinuclear region of cytoplasm

response to steroid hormone

negative regulation of epithelial cell proliferation

low-density lipoprotein particle receptor binding

positive regulation of SMAD protein signal transduction

negative regulation of androgen receptor signaling pathway

negative regulation of ERK1 and ERK2 cascade

cellular response to epidermal growth factor stimulus

hematopoietic stem cell proliferation

cellular response to transforming growth factor beta stimulus

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to plasma membrane

positive regulation of Wnt signaling pathway, planar cell polarity pathway

regulation of Rho-dependent protein serine/threonine kinase activity

positive regulation of clathrin-dependent endocytosis

positive regulation of clathrin-dependent endocytosis

positive regulation of early endosome to late endosome transport

positive regulation of aldosterone secretion

positive regulation of integrin-mediated signaling pathway

negative regulation of extrinsic apoptotic signaling pathway

04144

TC0100003026.mm.2 Mcm6 minichromosome maintenance complex component 6 1 -128331574 NM_008567, BC050886, BC057584 NM_008567, BC050886, BC057584 NM_008567, BC050886, BC057584 58

nucleotide binding

double-strand break repair via break-induced replication

DNA binding

DNA helicase activity

DNA helicase activity

DNA replication origin binding

single-stranded DNA binding

single-stranded DNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

DNA unwinding involved in DNA replication

DNA replication initiation

cell cycle

hydrolase activity

MCM complex

MCM complex

identical protein binding

mitotic DNA replication

single-stranded 3'-5' DNA helicase activity

03030

04110

TC1000000937.mm.2 Chst11 carbohydrate sulfotransferase 11 10 82985496 NM_021439, BC137629, BC144793 NM_021439, BC137629, BC144793 NM_021439, BC137629, BC144793 35

N-acetylgalactosamine 4-O-sulfotransferase activity

in utero embryonic development

chondrocyte development

Golgi apparatus

carbohydrate metabolic process

respiratory gaseous exchange by respiratory system

sulfotransferase activity

sulfotransferase activity

post-embryonic development

membrane

integral component of membrane

carbohydrate biosynthetic process

transferase activity

proteoglycan biosynthetic process

chondroitin sulfate metabolic process

chondroitin sulfate biosynthetic process

chondroitin sulfate biosynthetic process

chondroitin sulfate biosynthetic process

embryonic limb morphogenesis

negative regulation of transforming growth factor beta receptor signaling pathway

polysaccharide localization

post-anal tail morphogenesis

regulation of cell population proliferation

embryonic digit morphogenesis

negative regulation of apoptotic process

chondroitin 4-sulfotransferase activity

developmental growth

embryonic viscerocranium morphogenesis

embryonic skeletal system morphogenesis

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

cartilage development

00532

00920

TC1500000453.mm.2 Myc myelocytomatosis oncogene 15 61985340 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 1226

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

MAPK cascade

re-entry into mitotic cell cycle

chromatin

euchromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

core promoter sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

branching involved in ureteric bud morphogenesis

B cell apoptotic process

positive regulation of mesenchymal cell proliferation

regulation of oxidative phosphorylation

positive regulation of B cell apoptotic process

DNA binding

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

spindle

glucose metabolic process

chromatin remodeling

transcription, DNA-templated

DNA-templated transcription, initiation

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

pyruvate transport

amino acid transport

cellular iron ion homeostasis

activation of cysteine-type endopeptidase activity involved in apoptotic process

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

inner mitochondrial membrane organization

cell cycle arrest

regulation of mitotic cell cycle

transcription factor binding

cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

response to radiation

response to radiation

response to gamma radiation

regulation of gene expression

regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of mitochondrial membrane potential

positive regulation of smooth muscle cell migration

Wnt signaling pathway

protein processing

nuclear body

transformation of host cell by virus

axon

ubiquitin protein ligase binding

negative regulation of protein binding

regulation of telomere maintenance

protein-DNA complex disassembly

protein-containing complex

activating transcription factor binding

cellular response to interferon-alpha

cellular response to drug

cellular response to drug

skeletal muscle cell differentiation

middle ear morphogenesis

regulation of apoptotic process

regulation of apoptotic process

positive regulation of catalytic activity

response to alkaloid

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of DNA binding

pigmentation

sequence-specific DNA binding

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

canonical Wnt signaling pathway involved in positive regulation of apoptotic process

protein-containing complex binding

negative regulation of monocyte differentiation

positive regulation of cell cycle

positive regulation of glycolytic process

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of glucose import

lactic acid secretion

protein dimerization activity

positive regulation of fibroblast proliferation

negative regulation of fibroblast proliferation

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

skeletal system morphogenesis

positive regulation of epithelial cell proliferation

detection of mechanical stimulus involved in sensory perception of sound

chromosome organization

negative regulation of cell division

positive regulation of telomerase activity

positive regulation of glial cell proliferation

positive regulation of transcription initiation from RNA polymerase II promoter

negative regulation of cell death

ERK1 and ERK2 cascade

repressing transcription factor binding

E-box binding

cellular response to hypoxia

positive regulation of metanephric cap mesenchymal cell proliferation

positive regulation of cellular respiration

positive regulation of oxidative phosphorylation

regulation of somatic stem cell population maintenance

positive regulation of DNA methylation

positive regulation of DNA biosynthetic process

positive regulation of response to DNA damage stimulus

positive regulation of ATP biosynthetic process

positive regulation of apoptotic signaling pathway

positive regulation of apoptotic signaling pathway

04010

04012

04110

04310

04350

04630

05200

05210

05213

05216

05219

05220

05221

05222

TC0500001734.mm.2 Daglb diacylglycerol lipase, beta 5 143464492 NM_144915, BC016105 NM_144915, BC016105 29

prostaglandin biosynthetic process

triglyceride lipase activity

nucleoplasm

plasma membrane

lipid metabolic process

icosanoid metabolic process

G protein-coupled glutamate receptor signaling pathway

neuroblast proliferation

positive regulation of triglyceride catabolic process

membrane

integral component of membrane

lipid catabolic process

lipase activity

lipase activity

hydrolase activity

arachidonic acid metabolic process

arachidonic acid metabolic process

arachidonic acid metabolic process

neurogenesis

neurogenesis

neurotransmitter biosynthetic process

neurotransmitter biosynthetic process

postsynaptic membrane

metal ion binding

regulation of inflammatory response

endocannabinoid signaling pathway

retrograde trans-synaptic signaling by endocannabinoid

 
TC0600002491.mm.2 Mat2a methionine adenosyltransferase II, alpha 6 -72432795 NM_145569, BC003451, BC058360 NM_145569, BC003451, BC058360 NM_145569, BC003451, BC058360 42

nucleotide binding

methionine adenosyltransferase activity

methionine adenosyltransferase activity

methionine adenosyltransferase activity

ATP binding

cytosol

cytosol

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

one-carbon metabolic process

circadian rhythm

response to hormone

amino acid binding

transferase activity

protein hexamerization

response to drug

identical protein binding

metal ion binding

methionine adenosyltransferase complex

methionine adenosyltransferase complex

protein heterooligomerization

response to cAMP

cellular response to leukemia inhibitory factor

00270

01100

TC1200001605.mm.2 Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 12 -32173396, -32173396 NM_001146200, NM_001146201, NM_020272, BC051246 NM_001146200, NM_001146201, NM_020272, BC051246 NM_001146200, NM_001146201, NM_020272, BC051246 NM_001146200, NM_001146201, NM_020272, BC051246 302

nucleotide binding

angiogenesis

regulation of protein phosphorylation

immune system process

positive regulation of acute inflammatory response

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

phosphatidylinositol 3-kinase complex

phosphatidylinositol 3-kinase complex

phosphatidylinositol 3-kinase complex, class IA

phosphatidylinositol 3-kinase complex, class IB

phosphatidylinositol 3-kinase complex, class IB

protein phosphorylation

endocytosis

chemotaxis

inflammatory response

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of endothelial cell migration

positive regulation of endothelial cell migration

negative regulation of triglyceride catabolic process

phosphatidylinositol 3-kinase signaling

phosphatidylinositol 3-kinase signaling

phosphatidylinositol 3-kinase signaling

membrane

membrane

kinase activity

1-phosphatidylinositol-3-kinase activity

1-phosphatidylinositol-3-kinase activity

1-phosphatidylinositol-3-kinase activity

phosphorylation

cell migration

transferase activity

secretory granule localization

1-phosphatidylinositol-4-phosphate 3-kinase activity

1-phosphatidylinositol-4-phosphate 3-kinase activity

positive regulation of Rac protein signal transduction

positive regulation of Rac protein signal transduction

phosphatidylinositol-3-phosphate biosynthetic process

identical protein binding

positive regulation of catalytic activity

positive regulation of MAP kinase activity

phosphatidylinositol phosphorylation

phosphatidylinositol phosphorylation

ephrin receptor binding

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

phosphatidylinositol-mediated signaling

positive regulation of protein kinase B signaling

phosphatidylinositol kinase activity

cellular response to cAMP

hepatocyte apoptotic process

regulation of calcium ion transmembrane transport

negative regulation of fibroblast apoptotic process

00562

04012

04062

04070

04150

04210

04370

04380

04510

04620

04630

04650

04660

04662

04664

04666

04670

04722

04810

04910

04914

04930

04960

04973

05100

05142

05145

05146

05160

05200

05210

05211

05212

05213

05214

05215

05218

05220

05221

05222

05223

TC0100000476.mm.2 Cd28 CD28 antigen 1 60746387 NM_007642, BC064058, CD28 NM_007642, BC064058, CD28 NM_007642, BC064058, CD28 502

immunological synapse

protease binding

positive regulation of inflammatory response to antigenic stimulus

plasma membrane

immune response

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

positive regulation of gene expression

negative regulation of gene expression

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

integral component of membrane

protein kinase binding

T cell costimulation

T cell costimulation

T cell costimulation

T cell costimulation

T cell costimulation

positive regulation of interleukin-10 production

positive regulation of interleukin-2 production

positive regulation of interleukin-2 production

positive regulation of interleukin-4 production

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

T cell activation

T cell activation

regulation of T cell proliferation

identical protein binding

negative thymic T cell selection

regulatory T cell differentiation

membrane raft

regulation of regulatory T cell differentiation

positive regulation of mitotic nuclear division

positive regulation of transcription by RNA polymerase II

positive regulation of alpha-beta T cell proliferation

positive regulation of alpha-beta T cell proliferation

positive regulation of isotype switching to IgG isotypes

T cell receptor signaling pathway

T cell receptor signaling pathway

positive regulation of protein kinase B signaling

apoptotic signaling pathway

protein complex involved in cell adhesion

04514

04660

04672

04940

05320

05322

05323

05330

05332

05416

TC0800002992.mm.2 Maf avian musculoaponeurotic fibrosarcoma oncogene homolog 8 -115703252 NM_001025577 182

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

cytokine production

lens development in camera-type eye

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

positive regulation of gene expression

regulation of chondrocyte differentiation

identical protein binding

sequence-specific DNA binding

protein-containing complex binding

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

cell development

inner ear development

lens fiber cell differentiation

lens fiber cell differentiation

sequence-specific double-stranded DNA binding

 
TC0300000627.mm.2 Gask1b golgi associated kinase 1B 3 79885929 NM_133187, BC056975 NM_133187, BC056975 14

molecular_function

Golgi apparatus

biological_process

membrane

integral component of membrane

 
TC0600001433.mm.2 Cdca3 cell division cycle associated 3 6 124830175 NM_013538, BC002006 NM_013538, BC002006 23

molecular_function

cytoplasm

adherens junction

cell cycle

cell division

 
TC1100004051.mm.2 Cd300lb CD300 molecule like family member B 11 -114922778 NM_199221, CD300, BC160263 NM_199221, CD300, BC160263 NM_199221, CD300, BC160263 21

immune system process

neutrophil mediated immunity

transmembrane signaling receptor activity

protein binding

plasma membrane

membrane

integral component of membrane

positive regulation of mast cell activation

cellular response to lipopolysaccharide

 
TC1100003561.mm.2 Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 11 -94343294 NM_029600, BC150788 NM_029600, BC150788 46

nucleotide binding

ATP binding

plasma membrane

integral component of plasma membrane

drug transmembrane transport

ABC-type xenobiotic transporter activity

glucuronoside transmembrane transporter activity

ABC-type glutathione S-conjugate transporter activity

ABC-type bile acid transporter activity

bile acid and bile salt transport

canalicular bile acid transport

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

ATPase activity

transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

xenobiotic transport

xenobiotic transmembrane transporter activity

transmembrane transport

transmembrane transport

icosanoid transmembrane transporter activity

leukotriene transport

anion transmembrane transport

02010

04976

TC1400001676.mm.2 Sh3bp5 SH3-domain binding protein 5 (BTK-associated) 14 -31372613, -31372613 NM_011894, BC018237, BC053741 NM_011894, BC018237, BC053741 NM_011894, BC018237, BC053741 27

protein kinase inhibitor activity

protein kinase inhibitor activity

guanyl-nucleotide exchange factor activity

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

negative regulation of protein kinase activity

membrane

nuclear body

SH3 domain binding

cytoplasmic vesicle membrane

cytoplasmic vesicle

intracellular signal transduction

intracellular signal transduction

negative regulation of protein tyrosine kinase activity

 
TC0600002404.mm.2 Hpgds hematopoietic prostaglandin D synthase 6 -65117292 NM_019455, BC116735, BC116737 NM_019455, BC116735, BC116737 NM_019455, BC116735, BC116737 47

magnesium ion binding

prostaglandin biosynthetic process

glutathione transferase activity

glutathione transferase activity

prostaglandin-D synthase activity

prostaglandin-D synthase activity

calcium ion binding

nucleoplasm

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

prostaglandin metabolic process

prostaglandin metabolic process

glutathione metabolic process

transferase activity

isomerase activity

protein homodimerization activity

intracellular membrane-bounded organelle

negative regulation of male germ cell proliferation

00590

01100

TC0700004624.mm.2 Plk1 polo like kinase 1 7 122159434 NM_011121, BC006880 NM_011121, BC006880 147

mitotic sister chromatid segregation

G2/M transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

establishment of mitotic spindle orientation

nucleotide binding

mitotic cell cycle

mitotic cell cycle

mitotic cytokinesis

magnesium ion binding

chromosome, centromeric region

kinetochore

kinetochore

condensed chromosome, centromeric region

chromatin

synaptonemal complex

spindle pole

spindle pole

condensed nuclear chromosome outer kinetochore

microtubule bundle formation

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

chromosome

cytoplasm

cytoplasm

centrosome

centrosome

centriole

spindle

cytoskeleton

spindle microtubule

protein phosphorylation

protein phosphorylation

cell cycle

mitotic spindle assembly checkpoint

centrosome cycle

regulation of mitotic cell cycle

microtubule binding

positive regulation of peptidyl-threonine phosphorylation

anaphase-promoting complex binding

microtubule cytoskeleton

kinase activity

phosphorylation

female meiosis chromosome segregation

protein ubiquitination

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

protein kinase binding

regulation of mitotic metaphase/anaphase transition

midbody

protein destabilization

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cytokinesis

regulation of cytokinesis

protein localization to organelle

centriolar satellite

polar body extrusion after meiotic divisions

identical protein binding

negative regulation of apoptotic process

regulation of protein binding

regulation of protein binding

homologous chromosome segregation

establishment of protein localization

negative regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of proteolysis

nuclear envelope disassembly

spindle midzone

cell division

positive regulation of ubiquitin-protein transferase activity

synaptonemal complex disassembly

protein localization to chromatin

signal transduction involved in G2 DNA damage checkpoint

protein localization to nuclear envelope

mitotic spindle pole

regulation of mitotic spindle assembly

positive regulation of ubiquitin protein ligase activity

regulation of protein localization to cell cortex

04110

04114

04914

TC0400003366.mm.2 Kif2c kinesin family member 2C 4 -117159632, -117159635 NM_134471, BC006841 NM_134471, BC006841 32

nucleotide binding

chromosome, centromeric region

chromosome, centromeric region

kinetochore

microtubule motor activity

ATP binding

nucleus

chromosome

cytoplasm

centrosome

spindle

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

microtubule depolymerization

cell cycle

chromosome segregation

mitotic metaphase plate congression

microtubule binding

microtubule cytoskeleton

ATPase activity

establishment or maintenance of microtubule cytoskeleton polarity

microtubule plus-end

microtubule plus-end binding

cell division

metaphase plate congression

attachment of mitotic spindle microtubules to kinetochore

regulation of chromosome segregation

 
TC1100001219.mm.2 Ccl2 chemokine (C-C motif) ligand 2 11 82035576 NM_011333, BC145867, BC145869 NM_011333, BC145867, BC145869 NM_011333, BC145867, BC145869 908

angiogenesis

G protein-coupled receptor binding

positive regulation of leukocyte mediated cytotoxicity

positive regulation of endothelial cell proliferation

leukocyte migration involved in inflammatory response

monocyte chemotaxis

positive regulation of leukocyte migration

positive regulation of cellular extravasation

cytokine activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

extracellular space

cytoplasm

rough endoplasmic reticulum

cellular calcium ion homeostasis

chemotaxis

inflammatory response

immune response

cytoskeleton organization

transforming growth factor beta receptor signaling pathway

G protein-coupled receptor signaling pathway

chemokine activity

chemokine activity

heparin binding

glial cell migration

regulation of cell shape

response to heat

response to wounding

response to bacterium

regulation of vascular endothelial growth factor production

positive regulation of gene expression

positive regulation of macrophage chemotaxis

positive regulation of macrophage chemotaxis

negative regulation of angiogenesis

cytokine-mediated signaling pathway

sensory perception of pain

positive regulation of cell-cell adhesion

endocytic vesicle

dendrite

neutrophil chemotaxis

neutrophil chemotaxis

killing of cells of other organism

CCR2 chemokine receptor binding

positive regulation of tumor necrosis factor production

positive regulation of collagen biosynthetic process

helper T cell extravasation

monocyte homeostasis

neuronal cell body

perikaryon

positive regulation of GTPase activity

axon terminus

C-fiber

synapse

positive regulation of cell adhesion

vascular endothelial growth factor receptor signaling pathway

CCR chemokine receptor binding

eosinophil chemotaxis

eosinophil chemotaxis

macrophage chemotaxis

lymphocyte chemotaxis

lymphocyte chemotaxis

perinuclear region of cytoplasm

positive regulation of synaptic transmission

positive regulation of T cell activation

positive regulation of nitric-oxide synthase biosynthetic process

positive regulation of synaptic transmission, glutamatergic

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to lipopolysaccharide

cellular response to interferon-gamma

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to tumor necrosis factor

positive regulation of monocyte chemotaxis

positive regulation of monocyte chemotaxis

positive regulation of immune complex clearance by monocytes and macrophages

positive regulation of wound healing

positive regulation of protein targeting to membrane

positive regulation of NMDA glutamate receptor activity

positive regulation of apoptotic cell clearance

04062

TC1300001814.mm.2 F13a1 coagulation factor XIII, A1 subunit 13 -36867177, -36867177 NM_001166391, NM_028784, BC040274 NM_001166391, NM_028784, BC040274 NM_001166391, NM_028784, BC040274 69

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

extracellular region

cytoplasm

blood coagulation

blood coagulation

hemostasis

transferase activity

transferase activity, transferring acyl groups

peptide cross-linking

peptide cross-linking

peptide cross-linking

metal ion binding

collagen-containing extracellular matrix

blood coagulation, fibrin clot formation

blood coagulation, fibrin clot formation

blood coagulation, fibrin clot formation

04610

TC1100004053.mm.2 Cd300ld CD300 molecule like family member d 11 -114982445 NM_145437, BC019814, CD300-like NM_145437, BC019814, CD300-like NM_145437, BC019814, CD300-like 16

virus receptor activity

immune system process

transmembrane signaling receptor activity

protein binding

plasma membrane

plasma membrane

membrane

integral component of membrane

regulation of interleukin-6 production

regulation of tumor necrosis factor production

 
TC1900001095.mm.2 Fads2 fatty acid desaturase 2 19 -10062764 NM_019699, BC057189 NM_019699, BC057189 39

stearoyl-CoA 9-desaturase activity

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

membrane

integral component of membrane

linoleoyl-CoA desaturase activity

oxidoreductase activity

00592

01040

03320

TC1500001963.mm.2 Nfam1 Nfat activating molecule with ITAM motif 1 15 -82996735, -82996735, -82996735 NM_001271411, NM_001271412, NM_001271413, NM_001271414, NM_028728, BC150488 NM_001271411, NM_001271412, NM_001271413, NM_001271414, NM_028728, BC150488 NM_001271411, NM_001271412, NM_001271413, NM_001271414, NM_028728, BC150488 NM_001271411, NM_001271412, NM_001271413, NM_001271414, NM_028728, BC150488 NM_001271411, NM_001271412, NM_001271413, NM_001271414, NM_028728, BC150488 NM_001271411, NM_001271412, NM_001271413, NM_001271414, NM_028728, BC150488 14

positive regulation of cytokine production

transmembrane signaling receptor activity

transmembrane signaling receptor activity

transmembrane signaling receptor activity

plasma membrane

signal transduction

signal transduction

cell surface

membrane

integral component of membrane

integral component of membrane

integral component of membrane

B cell differentiation

intracellular signal transduction

intracellular signal transduction

membrane raft

membrane raft

regulation of B cell differentiation

B cell receptor signaling pathway

B cell receptor signaling pathway

positive regulation of B cell receptor signaling pathway

positive regulation of DNA-binding transcription factor activity

positive regulation of DNA-binding transcription factor activity

 
TC1800000291.mm.2 Kif20a kinesin family member 20A 18 34624935, 34624623, 34625032 NM_001166406, NM_001166407, NM_009004, BC060608 NM_001166406, NM_001166407, NM_009004, BC060608 NM_001166406, NM_001166407, NM_009004, BC060608 NM_001166406, NM_001166407, NM_009004, BC060608 33

nucleotide binding

mitotic cytokinesis

microtubule bundle formation

microtubule motor activity

ATP binding

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

spindle

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

microtubule binding

protein transport

ATPase activity

protein kinase binding

midbody

cleavage furrow

regulation of cytokinesis

intercellular bridge

midbody abscission

 
TC0800000937.mm.2 Asf1b anti-silencing function 1B histone chaperone 8 83955693 NM_024184, BC003428 NM_024184, BC003428 23

chromatin

chromatin

blastocyst hatching

nucleus

nucleoplasm

chromatin organization

chromatin assembly or disassembly

nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

DNA replication-independent nucleosome assembly

protein-containing complex

histone binding

histone binding

 
TC1400000322.mm.2 Nt5dc2 5'-nucleotidase domain containing 2 14 31134735, 31131088 NM_027289, BC011230 NM_027289, BC011230 17

cellular_component

5'-nucleotidase activity

 
TC0100002285.mm.2 Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 1 -45908069 NM_016917, BC003438 NM_016917, BC003438 138

lymphocyte homeostasis

endothelium development

iron ion transmembrane transporter activity

iron ion transmembrane transporter activity

iron ion transmembrane transporter activity

protein binding

nucleoplasm

cytosol

plasma membrane

plasma membrane

ion transport

iron ion transport

cellular iron ion homeostasis

synaptic vesicle

ferrous iron transmembrane transporter activity

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

basolateral plasma membrane

peptide hormone binding

peptide hormone binding

peptide hormone binding

regulation of transcription from RNA polymerase II promoter in response to iron

iron ion transmembrane transport

iron ion transmembrane transport

iron ion transmembrane transport

identical protein binding

negative regulation of apoptotic process

positive regulation of transcription by RNA polymerase II

spleen development

iron ion homeostasis

iron ion homeostasis

spleen trabecula formation

multicellular organismal iron ion homeostasis

iron ion export across plasma membrane

 
TC1100004229.mm.2 Cbr2 carbonyl reductase 2 11 -120729484 NM_007621, BC010758 NM_007621, BC010758 25

carbonyl reductase (NADPH) activity

carbonyl reductase (NADPH) activity

carbonyl reductase (NADPH) activity

protein binding

mitochondrion

xylulose metabolic process

glucose metabolic process

NADH oxidation

oxidoreductase activity

identical protein binding

protein self-association

L-xylulose reductase (NADP+) activity

00590

01100

TC0800000096.mm.2 Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 8 11758364, 11728057, 11779283, 11728057, 11758364 NM_001113517, NM_001113518, NM_017402, BC044838 NM_001113517, NM_001113518, NM_017402, BC044838 NM_001113517, NM_001113518, NM_017402, BC044838 NM_001113517, NM_001113518, NM_017402, BC044838 81

storage vacuole

hematopoietic progenitor cell differentiation

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

cytosol

plasma membrane

focal adhesion

Golgi organization

small GTPase mediated signal transduction

nervous system development

protein kinase binding

protein kinase binding

lamellipodium

lamellipodium assembly

cell junction

growth cone

small GTPase binding

positive regulation of protein binding

protein-containing complex

regulation of Rho protein signal transduction

intracellular signal transduction

cell projection

neuron projection

neuronal cell body

positive regulation of apoptotic process

positive regulation of GTPase activity

positive regulation of GTPase activity

positive regulation of GTPase activity

astrocyte cell migration

positive regulation of growth hormone secretion

postsynaptic actin cytoskeleton organization

GABA-ergic synapse

presynaptic actin cytoskeleton organization

regulation of GTP binding

04810

TC0100003029.mm.2 Cxcr4 chemokine (C-X-C motif) receptor 4 1 -128588198 NM_009911, BC031665, BC098322 NM_009911, BC031665, BC098322 NM_009911, BC031665, BC098322 580

branching involved in blood vessel morphogenesis

ameboidal-type cell migration

neuron migration

neuron migration

kidney development

positive regulation of protein phosphorylation

epithelial cell development

ventricular septum development

actin binding

G protein-coupled receptor activity

chemokine receptor activity

protein binding

nucleus

cytoplasm

lysosome

endosome

early endosome

late endosome

plasma membrane

plasma membrane

cell-cell junction

chemotaxis

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

germ cell development

nervous system development

brain development

brain development

motor neuron axon guidance

germ cell migration

animal organ morphogenesis

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

cell migration

C-C chemokine receptor activity

calcium-mediated signaling

calcium-mediated signaling

cytokine binding

C-C chemokine binding

C-C chemokine binding

neurogenesis

neurogenesis

telencephalon cell migration

cell junction

regulation of cell adhesion

regulation of cell migration

regulation of cell migration

positive regulation of cell migration

growth cone

cell leading edge

cytoplasmic vesicle

ubiquitin protein ligase binding

myosin light chain binding

protein-containing complex

positive regulation of vascular wound healing

hematopoietic stem cell migration

aorta development

C-X-C motif chemokine 12 receptor activity

CXCL12-activated CXCR4 signaling pathway

T cell proliferation

identical protein binding

regulation of programmed cell death

ubiquitin binding

myelin maintenance

endothelial cell differentiation

generation of neurons

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis

regulation of viral process

regulation of chemotaxis

positive regulation of chemotaxis

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception of pain

regulation of calcium ion transport

cardiac muscle contraction

cell chemotaxis

endothelial tube morphogenesis

neural precursor cell proliferation

positive regulation of ERK1 and ERK2 cascade

cellular response to cytokine stimulus

cellular response to cytokine stimulus

positive regulation of calcium ion import

positive regulation of cold-induced thermogenesis

positive regulation of dendrite extension

positive regulation of mesenchymal stem cell migration

positive regulation of macrophage migration inhibitory factor signaling pathway

04060

04062

04144

04360

04670

04672

TC0800001247.mm.2 Prmt7 protein arginine N-methyltransferase 7 8 106211053 NM_145404, BC006705, BC057177 NM_145404, BC006705, BC057177 NM_145404, BC006705, BC057177 42

spliceosomal snRNP assembly

fibrillar center

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

chromatin organization

regulation of gene expression by genetic imprinting

protein methylation

methyltransferase activity

histone-arginine N-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

[myelin basic protein]-arginine N-methyltransferase activity

histone methylation

transferase activity

peptidyl-arginine methylation

cell differentiation

methylation

histone arginine methylation

protein-arginine omega-N monomethyltransferase activity

protein-arginine omega-N monomethyltransferase activity

protein-arginine omega-N symmetric methyltransferase activity

protein-arginine omega-N symmetric methyltransferase activity

ribonucleoprotein complex binding

DNA methylation involved in gamete generation

histone methyltransferase activity (H4-R3 specific)

 
TC1500000175.mm.2         NM_020332, NR_106065, BC054379 NM_020332, NR_106065, BC054379 NM_020332, NR_106065, BC054379  

inorganic phosphate transmembrane transporter activity

inorganic phosphate transmembrane transporter activity

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

phosphate ion transport

phosphate ion transmembrane transporter activity

membrane

integral component of membrane

integral component of membrane

regulation of bone mineralization

inorganic diphosphate transmembrane transporter activity

inorganic diphosphate transmembrane transporter activity

inorganic diphosphate transmembrane transporter activity

phosphate ion transmembrane transport

 
TC0900000051.mm.2 Mmp27 matrix metallopeptidase 27 9 7571395 NM_001030289 12

metalloendopeptidase activity

extracellular matrix organization

collagen catabolic process

extrinsic component of endoplasmic reticulum membrane

 
TC0100003210.mm.2 Rgs18 regulator of G-protein signaling 18 1 -144752682 NM_022881, BC099387, BC132544, BC132546 NM_022881, BC099387, BC132544, BC132546 NM_022881, BC099387, BC132544, BC132546 NM_022881, BC099387, BC132544, BC132546 21

GTPase activator activity

cytoplasm

G protein-coupled receptor signaling pathway

regulation of G protein-coupled receptor signaling pathway

negative regulation of signal transduction

 
TC0200000603.mm.2 Angptl2 angiopoietin-like 2 2 33215960 NM_011923, BC138609, BC138610 NM_011923, BC138609, BC138610 NM_011923, BC138609, BC138610 53

angiogenesis

signaling receptor binding

extracellular region

extracellular space

extracellular space

collagen-containing extracellular matrix

 
TC0900001173.mm.2 Plscr4 phospholipid scramblase 4 9 92457377 NM_178711, BC052067 NM_178711, BC052067 14

plasma membrane

plasma membrane

membrane

integral component of membrane

plasma membrane phospholipid scrambling

phospholipid scramblase activity

enzyme binding

CD4 receptor binding

cellular response to lipopolysaccharide

 
TC1100004057.mm.2         NM_001101656, NM_001101657, BC119352 NM_001101656, NM_001101657, BC119352 NM_001101656, NM_001101657, BC119352  

immune system process

molecular_function

transmembrane signaling receptor activity

protein binding

cellular_component

lysosome

endosome

plasma membrane

biological_process

membrane

integral component of membrane

positive regulation of protein ubiquitination

positive regulation of toll-like receptor 9 signaling pathway

positive regulation of toll-like receptor 9 signaling pathway

 
TC0300001378.mm.2 Slc39a8 solute carrier family 39 (metal ion transporter), member 8 3 135825789, 135825656, 135825278 NM_001135149, NM_001135150, NM_026228, BC006731 NM_001135149, NM_001135150, NM_026228, BC006731 NM_001135149, NM_001135150, NM_026228, BC006731 NM_001135149, NM_001135150, NM_026228, BC006731 51

iron ion transmembrane transporter activity

manganese ion transmembrane transporter activity

manganese ion transmembrane transporter activity

manganese ion transmembrane transporter activity

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

lysosome

lysosomal membrane

plasma membrane

plasma membrane

integral component of plasma membrane

transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

protein N-linked glycosylation

arginine metabolic process

ion transport

cobalt ion transport

zinc ion transport

cellular cadmium ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

cadmium ion transmembrane transporter activity

cadmium ion transmembrane transporter activity

cadmium ion transmembrane transporter activity

cobalt ion transmembrane transporter activity

bicarbonate transmembrane transporter activity

anion:cation symporter activity

bicarbonate transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

metal ion transport

cellular manganese ion homeostasis

extracellular matrix organization

extracellular matrix organization

organelle membrane

regulation of membrane potential

metal ion transmembrane transporter activity

transmembrane transport

leukocyte adhesion to arterial endothelial cell

cadmium ion transmembrane transport

cadmium ion transmembrane transport

cadmium ion transmembrane transport

manganese ion transmembrane transport

manganese ion transmembrane transport

manganese ion transmembrane transport

zinc ion transmembrane transport

zinc ion transmembrane transport

zinc ion import across plasma membrane

zinc ion import across plasma membrane

zinc ion import across plasma membrane

zinc ion import across plasma membrane

selenite:proton symporter activity

plasma membrane selenite transport

plasma membrane selenite transport

iron ion import across plasma membrane

iron ion import across plasma membrane

zinc:bicarbonate symporter activity

cartilage homeostasis

mitochondrial manganese ion transmembrane transport

 
TC0800000846.mm.2 Mcm5 minichromosome maintenance complex component 5 8 75109508 NM_008566, BC094416 NM_008566, BC094416 41

nucleotide binding

double-strand break repair via break-induced replication

DNA binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA replication initiation

cell cycle

hydrolase activity

single-stranded DNA helicase activity

MCM complex

MCM complex

3'-5' DNA helicase activity

03030

04110

TC0900001673.mm.2 Ccr3 chemokine (C-C motif) receptor 3 9 124021970 NM_009914, BC108967, BC108968 NM_009914, BC108967, BC108968 NM_009914, BC108967, BC108968 76

positive regulation of endothelial cell proliferation

mast cell chemotaxis

G protein-coupled receptor activity

chemokine receptor activity

protein binding

extracellular space

cytoplasm

endosome

plasma membrane

chemotaxis

inflammatory response

immune response

signal transduction

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

membrane

integral component of membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

C-C chemokine binding

C-C chemokine binding

angioblast cell migration

positive regulation of angiogenesis

positive regulation of angiogenesis

eosinophil chemotaxis

cell chemotaxis

ERK1 and ERK2 cascade

04060

04062

TC0600002690.mm.2 Mcm2 minichromosome maintenance complex component 2 6 -88883473 NM_008564, BC055318 NM_008564, BC055318 82

nucleotide binding

double-strand break repair via break-induced replication

chromatin

DNA binding

DNA replication origin binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nuclear origin of replication recognition complex

chromosome

cytoplasm

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

DNA unwinding involved in DNA replication

DNA replication initiation

DNA replication initiation

nucleosome assembly

apoptotic process

cell cycle

hydrolase activity

single-stranded DNA helicase activity

enzyme binding

histone binding

MCM complex

MCM complex

3'-5' DNA helicase activity

metal ion binding

cellular response to interleukin-4

cochlea development

mitotic DNA replication initiation

negative regulation of DNA helicase activity

03030

04110

TC1600000650.mm.2 Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 16 44139808, 44139790 NM_028108, BC046283, BC055846, BC057117 NM_028108, BC046283, BC055846, BC057117 NM_028108, BC046283, BC055846, BC057117 NM_028108, BC046283, BC055846, BC057117 26

peptide alpha-N-acetyltransferase activity

protein binding

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

N-terminal protein amino acid acetylation

N-terminal protein amino acid acetylation

mitotic sister chromatid cohesion

N-acetyltransferase activity

H4 histone acetyltransferase activity

histone acetylation

transferase activity

transferase activity, transferring acyl groups

NatA complex

NatA complex

establishment of mitotic sister chromatid cohesion

peptidyl-lysine acetyltransferase activity

mitotic sister chromatid cohesion, centromeric

 
TC1100001256.mm.2 Ccl4 chemokine (C-C motif) ligand 4 11 83662583 NM_013652, BC119257, BC119259 NM_013652, BC119257, BC119259 NM_013652, BC119257, BC119259 86

monocyte chemotaxis

cytokine activity

protein binding

extracellular region

extracellular space

extracellular space

chemotaxis

inflammatory response

inflammatory response

immune response

G protein-coupled receptor signaling pathway

chemokine activity

chemokine activity

response to toxic substance

neutrophil chemotaxis

leukocyte chemotaxis

CCR1 chemokine receptor binding

CCR5 chemokine receptor binding

positive regulation of tumor necrosis factor production

cellular response to drug

identical protein binding

positive regulation of vascular permeability

positive regulation of GTPase activity

negative regulation by host of viral transcription

CCR chemokine receptor binding

eosinophil chemotaxis

lymphocyte chemotaxis

positive regulation of calcium-mediated signaling

positive regulation of calcium ion transport

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

positive regulation of natural killer cell chemotaxis

04060

04062

04620

04623

TC1000001207.mm.2 Dusp6 dual specificity phosphatase 6 10 99263230 NM_026268, BC003869 NM_026268, BC003869 165

inactivation of MAPK activity

inactivation of MAPK activity

negative regulation of protein phosphorylation

phosphoprotein phosphatase activity

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein binding

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

protein dephosphorylation

protein dephosphorylation

protein dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

protein tyrosine/threonine phosphatase activity

positive regulation of cell death

dephosphorylation

hydrolase activity

phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-threonine dephosphorylation

positive regulation of apoptotic process

positive regulation of apoptotic process

mitogen-activated protein kinase binding

regulation of heart growth

regulation of heart growth

negative regulation of ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

04010

TC1300001558.mm.2 H2ac15 H2A clustered histone 15 13 -21753376 NM_178183, BC119335 NM_178183, BC119335 7

nucleosome

DNA binding

nucleus

chromosome

chromatin silencing

protein heterodimerization activity

05322

TC1600001011.mm.2 Itsn1 intersectin 1 (SH3 domain protein 1A) 16 91729370, 91729370, 91729370 NM_001110275, NM_001110276, NM_010587, BC172688 NM_001110275, NM_001110276, NM_010587, BC172688 NM_001110275, NM_001110276, NM_010587, BC172688 NM_001110275, NM_001110276, NM_010587, BC172688 71

guanyl-nucleotide exchange factor activity

calcium ion binding

protein binding

nucleus

nuclear envelope

cytoplasm

cytoplasm

endosome

cytosol

plasma membrane

plasma membrane

clathrin-coated pit

clathrin-coated pit

clathrin-coated pit

exocytosis

endocytosis

small GTPase mediated signal transduction

protein transport

membrane

endosomal transport

kinase activator activity

lamellipodium

cell junction

endocytic vesicle

cytoplasmic vesicle

cellular protein localization

regulation of Rho protein signal transduction

intracellular signal transduction

presynaptic membrane

cell projection

neuron projection

neuronal cell body

dendritic spine

negative regulation of neuron apoptotic process

calyx of Held

synapse

metal ion binding

synaptic vesicle endocytosis

synaptic vesicle endocytosis

positive regulation of protein kinase B signaling

molecular adaptor activity

molecular adaptor activity

positive regulation of growth hormone secretion

positive regulation of dendritic spine development

proline-rich region binding

apical dendrite

intracellular vesicle

intracellular vesicle

presynaptic endocytic zone

postsynaptic actin cytoskeleton

glutamatergic synapse

clathrin-dependent synaptic vesicle endocytosis

regulation of modification of postsynaptic actin cytoskeleton

positive regulation of caveolin-mediated endocytosis

 
TC1100002224.mm.2 Fignl1 fidgetin-like 1 11 -11800287 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 23

nucleotide binding

nuclear chromosome

osteoblast differentiation

ATP binding

nucleus

nucleus

cytoplasm

male meiotic nuclear division

microtubule-severing ATPase activity

regulation of double-strand break repair via homologous recombination

hydrolase activity

ATPase activity

cytoplasmic microtubule organization

osteoblast proliferation

negative regulation of apoptotic process

metal ion binding

perinuclear region of cytoplasm

regulation of cell cycle

cellular response to ionizing radiation

negative regulation of intrinsic apoptotic signaling pathway

 
TC0800000126.mm.2 Tfdp1 transcription factor Dp 1 8 13338803, 13338750 NM_009361, BC132567, BC132569, BC145344 NM_009361, BC132567, BC132569, BC145344 NM_009361, BC132567, BC132569, BC145344 NM_009361, BC132567, BC132569, BC145344 62

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

cytoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

cell cycle

transcription factor binding

epidermis development

protein domain specific binding

anoikis

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-binding transcription factor activity

regulation of cell cycle

negative regulation of fat cell proliferation

RNA polymerase II transcription regulator complex

positive regulation of G1/S transition of mitotic cell cycle

regulation of DNA biosynthetic process

04110

04350

TC1500001940.mm.2 Cenpm centromere protein M 15 -82233775, -82233775 NM_001080158, NM_025639, NM_178269, BC009160 NM_001080158, NM_025639, NM_178269, BC009160 NM_001080158, NM_025639, NM_178269, BC009160 NM_001080158, NM_025639, NM_178269, BC009160 19

chromosome, centromeric region

kinetochore

molecular_function

nucleus

chromosome

cytoplasm

cytosol

biological_process

 
TC0500000052.mm.2 Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B 5 8798146 NM_011075, BC141363, BC150811 NM_011075, BC141363, BC150811 NM_011075, BC141363, BC150811 256

Golgi membrane

nucleotide binding

ATP binding

mitochondrion

plasma membrane

establishment of endothelial blood-brain barrier

membrane

integral component of membrane

apical plasma membrane

ATPase activity

response to drug

ATPase-coupled transmembrane transporter activity

xenobiotic transmembrane transporter activity

phospholipid translocation

intercellular canaliculus

transmembrane transport

Sertoli cell barrier remodeling

phosphatidylcholine floppase activity

phosphatidylethanolamine flippase activity

external side of apical plasma membrane

ceramide floppase activity

ceramide translocation

02010

04976

TC1300000246.mm.2 H3c8 H3 clustered histone 8 13 23535417 NM_145073, BC125355, BC125357 NM_145073, BC125355, BC125357 NM_145073, BC125355, BC125357 28

nuclear chromosome

nucleosome

nucleus

nucleoplasm

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC1000003119.mm.2 Lrp1 low density lipoprotein receptor-related protein 1 10 -127538157 NM_008512 324

protease binding

astrocyte activation involved in immune response

cardiac septum development

calcium ion binding

protein binding

nucleus

cytoplasm

endosome

early endosome

Golgi apparatus

cytoskeleton

plasma membrane

integral component of plasma membrane

clathrin-coated pit

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

phagocytosis

lysosomal transport

positive regulation of cytosolic calcium ion concentration

protein kinase C-activating G protein-coupled receptor signaling pathway

multicellular organism development

cholesterol metabolic process

cell population proliferation

external side of plasma membrane

negative regulation of cell-substrate adhesion

positive regulation of cholesterol efflux

positive regulation of cell death

positive regulation of neuron projection development

negative regulation of neuron projection development

negative regulation of smooth muscle cell migration

coreceptor activity

membrane

integral component of membrane

basolateral plasma membrane

alpha-2 macroglobulin receptor activity

cell junction

clathrin-coated vesicle

negative regulation of Wnt signaling pathway

dendrite

clathrin heavy chain binding

positive regulation of protein binding

positive regulation of lipid transport

regulation of cholesterol transport

regulation of phospholipase A2 activity

insulin-responsive compartment

regulation of actin cytoskeleton organization

apolipoprotein binding

positive regulation of insulin secretion involved in cellular response to glucose stimulus

aorta morphogenesis

cargo receptor activity

cargo receptor activity

neuronal cell body

negative regulation of apoptotic process

receptor complex

apoptotic cell clearance

negative regulation of neuron apoptotic process

cellular lipid catabolic process

axonal growth cone

protein-containing complex binding

apical part of cell

synapse

positive regulation of axon extension

positive regulation of endocytosis

metal ion binding

perinuclear region of cytoplasm

positive regulation of axon extension involved in regeneration

positive regulation of collateral sprouting of injured axon

positive regulation of phagocytosis

positive regulation of protein transport

negative regulation of cytosolic calcium ion concentration

negative regulation of focal adhesion assembly

negative regulation of cell death

coronary vasculature development

chemoattraction of axon

positive regulation of ERK1 and ERK2 cascade

amyloid-beta clearance

amyloid-beta clearance by transcytosis

amyloid-beta clearance by transcytosis

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

transport across blood-brain barrier

positive regulation of Schwann cell migration

positive regulation of amyloid-beta clearance

positive regulation of protein localization to plasma membrane

positive regulation of cholesterol import

positive regulation of transcytosis

cellular response to amyloid-beta

positive regulation of vascular associated smooth muscle cell migration

positive regulation of lysosomal protein catabolic process

positive regulation of chemokine (C-X-C motif) ligand 2 production

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

05010

05144

TC0200001748.mm.2 Knstrn kinetochore-localized astrin/SPAG5 binding 2 118814002 NM_026412, BC031709 NM_026412, BC031709 22

mitotic sister chromatid segregation

mitotic sister chromatid segregation

microtubule cytoskeleton organization

chromosome, centromeric region

kinetochore

kinetochore

ruffle

protein binding

nucleus

chromosome

cytoplasm

cytoskeleton

microtubule

plasma membrane

cell cycle

spindle organization

spindle organization

chromosome segregation

cell migration

centriolar satellite

centriolar satellite

microtubule plus-end

microtubule plus-end

protein homodimerization activity

microtubule plus-end binding

cell division

regulation of attachment of spindle microtubules to kinetochore

regulation of attachment of spindle microtubules to kinetochore

cellular response to epidermal growth factor stimulus

mitotic spindle

mitotic spindle

 
TC0600001443.mm.2 Lpar5 lysophosphatidic acid receptor 5 6 125067919, 125071334 NM_001163268, NM_001163269, BC116702, BC117528 NM_001163268, NM_001163269, BC116702, BC117528 NM_001163268, NM_001163269, BC116702, BC117528 NM_001163268, NM_001163269, BC116702, BC117528 39

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

positive regulation of CREB transcription factor activity

positive regulation of CREB transcription factor activity

behavioral response to pain

behavioral response to pain

 
TC0300000934.mm.2 H3c13 H3 clustered histone 13 3 96268653 NM_178215, BC139251, BC139252, BC156965 NM_178215, BC139251, BC139252, BC156965 NM_178215, BC139251, BC139252, BC156965 NM_178215, BC139251, BC139252, BC156965 5

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC0200000245.mm.2 Mrc1 mannose receptor, C type 1 2 14229413 NM_008625, BC141338 NM_008625, BC141338 108

transmembrane signaling receptor activity

protein binding

mannose binding

endosome

plasma membrane

plasma membrane

plasma membrane

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

cell surface

endosome membrane

membrane

integral component of membrane

carbohydrate binding

signaling receptor activity

cargo receptor activity

cellular response to lipopolysaccharide

cellular response to interferon-gamma

cellular response to interleukin-4

04145

TC0900002593.mm.2 Ccnb2 cyclin B2 9 -70407688 NM_007630, BC008247 NM_007630, BC008247 54

regulation of cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase holoenzyme complex

in utero embryonic development

protein binding

nucleus

cytoplasm

cytoplasm

centrosome

centrosome

cytosol

cell cycle

spindle assembly involved in female meiosis I

spindle assembly involved in female meiosis I

G2/MI transition of meiotic cell cycle

G2/MI transition of meiotic cell cycle

microtubule cytoskeleton

membrane

cyclin-dependent protein serine/threonine kinase regulator activity

regulation of growth

T cell homeostasis

mitotic cell cycle phase transition

thymus development

cell division

04110

04114

04115

04914

TC0700002422.mm.2 C5ar1 complement component 5a receptor 1 7 -16246742, -16246744 NM_001173550, NM_007577, BC125641, BC125643 NM_001173550, NM_007577, BC125641, BC125643 NM_001173550, NM_007577, BC125641, BC125643 NM_001173550, NM_007577, BC125641, BC125643 256

microglial cell activation

complement component C5a binding

complement receptor mediated signaling pathway

complement receptor activity

complement component C5a receptor activity

complement component C5a receptor activity

complement component C5a receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

apoptotic process

chemotaxis

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of macrophage chemotaxis

membrane

integral component of membrane

basolateral plasma membrane

cell proliferation in hindbrain

neutrophil chemotaxis

cytoplasmic vesicle

response to peptidoglycan

complement component C5a signaling pathway

mRNA transcription by RNA polymerase II

negative regulation of neuron apoptotic process

apical part of cell

positive regulation of angiogenesis

astrocyte activation

positive regulation of epithelial cell proliferation

defense response to Gram-positive bacterium

cognition

positive regulation of ERK1 and ERK2 cascade

positive regulation of neutrophil chemotaxis

amyloid-beta clearance

presynapse organization

regulation of tau-protein kinase activity

04080

04610

05150

TC1300000262.mm.2 H1f1 H1.1 linker histone, cluster member 13 23763667 NM_030609, BC116820, BC116850 NM_030609, BC116820, BC116850 NM_030609, BC116820, BC116850 42

nucleosome

DNA binding

double-stranded DNA binding

protein binding

nucleus

nucleus

chromosome

nucleosome assembly

spermatogenesis

spermatogenesis

heparin binding

cell surface

nucleosome positioning

chromosome condensation

nucleosomal DNA binding

negative regulation of chromatin silencing

vesicle

negative regulation of DNA recombination

positive regulation of receptor-mediated endocytosis

 
TC1300002037.mm.2 Cltb clathrin, light polypeptide (Lcb) 13 -54592385 NM_028870, BC070404 NM_028870, BC070404 32

structural molecule activity

trans-Golgi network

cytosol

plasma membrane

plasma membrane

plasma membrane

clathrin-coated pit

intracellular protein transport

membrane

vesicle-mediated transport

clathrin coat

clathrin vesicle coat

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

synaptic vesicle membrane

synaptic vesicle membrane

cytoplasmic vesicle

clathrin heavy chain binding

peptide binding

intracellular membrane-bounded organelle

clathrin coat assembly

ciliary membrane

clathrin-dependent endocytosis

presynaptic endocytic zone membrane

postsynaptic endocytic zone cytoplasmic component

04142

04144

05016

05100

TC1000001066.mm.2 Igf1 insulin-like growth factor 1 10 87861110, 87859051, 87858264 NM_001111274, NM_001111275, NM_001111276, NM_010512, BC012409, NM_184052 NM_001111274, NM_001111275, NM_001111276, NM_010512, BC012409, NM_184052 NM_001111274, NM_001111275, NM_001111276, NM_010512, BC012409, NM_184052 NM_001111274, NM_001111275, NM_001111276, NM_010512, BC012409, NM_184052 NM_001111274, NM_001111275, NM_001111276, NM_010512, BC012409, NM_184052 NM_001111274, NM_001111275, NM_001111276, NM_010512, BC012409, NM_184052 992

activation of MAPK activity

osteoblast differentiation

cell activation

regulation of protein phosphorylation

blood vessel remodeling

blood vessel remodeling

negative regulation of immune system process

insulin receptor binding

insulin receptor binding

insulin-like growth factor receptor binding

insulin-like growth factor receptor binding

integrin binding

hormone activity

steroid binding

protein binding

extracellular region

interstitial matrix

extracellular space

extracellular space

extracellular space

cytoplasm

plasma membrane

regulation of translation

nervous system development

sensory perception of smell

memory

circadian rhythm

growth factor activity

cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

response to heat

glial cell differentiation

regulation of gene expression

positive regulation of glycoprotein biosynthetic process

positive regulation of cardiac muscle hypertrophy

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

negative regulation of muscle cell apoptotic process

phosphatidylinositol 3-kinase signaling

positive regulation of phosphatidylinositol 3-kinase signaling

positive regulation of phosphatidylinositol 3-kinase signaling

skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration

muscle hypertrophy

myotube cell development

positive regulation of smooth muscle cell migration

positive regulation of cerebellar granule cell precursor proliferation

water homeostasis

proteoglycan biosynthetic process

positive regulation of cell growth

lung development

positive regulation of cell migration

mammary gland development

exocrine pancreas development

platelet alpha granule

positive regulation of myelination

activation of protein kinase B activity

negative regulation of interleukin-1 beta production

negative regulation of tumor necrosis factor production

regulation of establishment or maintenance of cell polarity

regulation of intracellular steroid hormone receptor signaling pathway

negative regulation of smooth muscle cell apoptotic process

multicellular organism growth

bone mineralization involved in bone maturation

alphav-beta3 integrin-IGF-1-IGF1R complex

wound healing

positive regulation of activated T cell proliferation

regulation of cell population proliferation

positive regulation of tyrosine phosphorylation of STAT protein

insulin-like growth factor ternary complex

insulin-like growth factor ternary complex

neuronal cell body

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of DNA binding

positive regulation of MAPK cascade

protein kinase B signaling

positive regulation of blood vessel endothelial cell migration

protein serine/threonine kinase activator activity

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of nitric oxide biosynthetic process

myoblast differentiation

response to ethanol

positive regulation of fat cell differentiation

positive regulation of osteoblast differentiation

positive regulation of glycogen biosynthetic process

positive regulation of glycolytic process

positive regulation of mitotic nuclear division

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of glucose import

positive regulation of Ras protein signal transduction

insulin-like growth factor receptor signaling pathway

insulin-like growth factor receptor signaling pathway

phosphatidylinositol-mediated signaling

positive regulation of fibroblast proliferation

lung alveolus development

lung alveolus development

cell development

positive regulation of smooth muscle cell proliferation

branching morphogenesis of an epithelial tube

inner ear development

chondroitin sulfate proteoglycan biosynthetic process

positive regulation of epithelial cell proliferation

positive regulation of protein secretion

positive regulation of peptidyl-tyrosine phosphorylation

negative regulation of peptidyl-tyrosine phosphorylation

protein stabilization

detection of mechanical stimulus involved in sensory perception

regulation of protein metabolic process

myoblast proliferation

positive regulation of protein kinase B signaling

regulation of calcium ion transport

positive regulation of glial cell proliferation

negative regulation of oocyte development

lung vasculature development

lung vasculature development

lung lobe morphogenesis

lung lobe morphogenesis

type I pneumocyte differentiation

type II pneumocyte differentiation

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

prostate gland growth

prostate gland growth

prostate gland epithelium morphogenesis

prostate gland stromal morphogenesis

negative regulation of androgen receptor signaling pathway

positive regulation of cell growth involved in cardiac muscle cell development

ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

exocytic vesicle

positive regulation of calcineurin-NFAT signaling cascade

cellular response to glucose stimulus

positive regulation of protein serine/threonine kinase activity

positive regulation of steroid hormone biosynthetic process

negative regulation of release of cytochrome c from mitochondria

extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of neuroinflammatory response

negative regulation of oligodendrocyte apoptotic process

negative regulation of neuron death

negative regulation of amyloid-beta formation

positive regulation of trophectodermal cell proliferation

negative regulation of cholangiocyte apoptotic process

cellular response to amyloid-beta

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of vascular endothelial cell proliferation

cellular response to insulin-like growth factor stimulus

positive regulation of myoblast proliferation

positive regulation of transcription regulatory region DNA binding

negative regulation of extrinsic apoptotic signaling pathway

04114

04115

04150

04510

04730

04914

04960

05200

05214

05215

05218

05410

05414

TC0100001985.mm.2 Eya1 EYA transcriptional coactivator and phosphatase 1 1 -14168957 NM_001252192, NM_010164, BC060260, BC066860 NM_001252192, NM_010164, BC060260, BC066860 NM_001252192, NM_010164, BC060260, BC066860 NM_001252192, NM_010164, BC060260, BC066860 151

establishment of mitotic spindle orientation

establishment of mitotic spindle orientation

metanephros development

ureteric bud development

branching involved in ureteric bud morphogenesis

outflow tract morphogenesis

RNA binding

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

DNA repair

double-strand break repair

chromatin organization

protein dephosphorylation

cellular response to DNA damage stimulus

multicellular organism development

pattern specification process

pattern specification process

mesodermal cell fate specification

animal organ morphogenesis

response to ionizing radiation

striated muscle tissue development

histone dephosphorylation

histone dephosphorylation

nuclear body

hydrolase activity

protein sumoylation

cell differentiation

protein-containing complex

protein-DNA complex

cellular protein localization

establishment or maintenance of apical/basal cell polarity

peptidyl-tyrosine dephosphorylation

aorta morphogenesis

ear morphogenesis

inner ear morphogenesis

inner ear morphogenesis

outer ear morphogenesis

middle ear morphogenesis

cell fate commitment

regulation of neuron differentiation

regulation of neuron differentiation

positive regulation of DNA repair

positive regulation of DNA repair

positive regulation of Notch signaling pathway

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

metal ion binding

neuron fate specification

embryonic skeletal system morphogenesis

semicircular canal morphogenesis

anatomical structure development

anatomical structure development

positive regulation of epithelial cell proliferation

pharyngeal system development

lung epithelial cell differentiation

otic vesicle development

otic vesicle morphogenesis

positive regulation of secondary heart field cardioblast proliferation

cochlea morphogenesis

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

 
TC0X00003241.mm.2 Ptchd1 patched domain containing 1 X -155569735 NM_001093750, BC116312, BC116313 NM_001093750, BC116312, BC116313 NM_001093750, BC116312, BC116313 18

protein binding

plasma membrane

plasma membrane

smoothened signaling pathway

chemical synaptic transmission

short-term memory

long-term memory

membrane

integral component of membrane

thalamus development

social behavior

synapse

synapse

cognition

cognition

cognition

excitatory chemical synaptic transmission

inhibitory chemical synaptic transmission

 
TC0100001550.mm.2 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 1 167349990 NM_019993, BC003297 NM_019993, BC003297 27

aldehyde dehydrogenase (NAD+) activity

aldehyde dehydrogenase (NAD+) activity

cytoplasm

mitochondrion

cytosol

cytosol

cellular aldehyde metabolic process

carnitine metabolic process

oxidoreductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

aminobutyraldehyde dehydrogenase activity

aminobutyraldehyde dehydrogenase activity

neurotransmitter biosynthetic process

identical protein binding

amine binding

4-trimethylammoniobutyraldehyde dehydrogenase activity

4-trimethylammoniobutyraldehyde dehydrogenase activity

NAD binding

protein homotetramerization

00010

00053

00071

00280

00310

00330

00340

00380

00410

00561

00620

00640

01100

TC0900000046.mm.2 Mmp12 matrix metallopeptidase 12 9 7347373, 7344396 NM_008605, BC019135 NM_008605, BC019135 159

negative regulation of transcription by RNA polymerase II

core promoter sequence-specific DNA binding

metalloendopeptidase activity

metalloendopeptidase activity

calcium ion binding

collagen binding

extracellular region

extracellular region

extracellular space

extracellular space

extracellular space

nucleus

nucleus

cytoplasm

proteolysis

protein import into nucleus

protein import into nucleus

peptidase activity

metallopeptidase activity

zinc ion binding

positive regulation of gene expression

hydrolase activity

extracellular matrix organization

collagen catabolic process

extracellular matrix

positive regulation of interferon-alpha production

wound healing, spreading of epidermal cells

wound healing

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

metal ion binding

lung alveolus development

regulation of defense response to virus by host

positive regulation of epithelial cell proliferation involved in wound healing

elastin catabolic process

negative regulation of type I interferon-mediated signaling pathway

positive regulation of type I interferon-mediated signaling pathway

bronchiole development

bronchiole development

cellular response to virus

regulation of trophoblast cell migration

negative regulation of endothelial cell-matrix adhesion via fibronectin

 
TC0300001137.mm.2 Sort1 sortilin 1 3 108284063 NM_001271599, NM_019972, BC056343 NM_001271599, NM_019972, BC056343 NM_001271599, NM_019972, BC056343 120

ossification

protein binding

nucleus

lysosome

endosome

early endosome

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cytosol

plasma membrane

plasma membrane

clathrin-coated pit

protein targeting to lysosome

post-Golgi vesicle-mediated transport

Golgi to endosome transport

Golgi to endosome transport

endocytosis

endocytosis

endocytosis

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

multicellular organism development

endosome to lysosome transport

extrinsic apoptotic signaling pathway via death domain receptors

cell surface

endosome membrane

nerve growth factor receptor activity

regulation of gene expression

myotube differentiation

myotube differentiation

membrane

integral component of membrane

integral component of membrane

vesicle organization

vesicle organization

vesicle organization

enzyme binding

clathrin-coated vesicle

trans-Golgi network transport vesicle

cell differentiation

neurotensin receptor activity, non-G protein-coupled

dendrite

cytoplasmic vesicle membrane

cytoplasmic vesicle

endosome transport via multivesicular body sorting pathway

response to insulin

response to insulin

neuronal cell body

intracellular membrane-bounded organelle

negative regulation of fat cell differentiation

glucose import

glucose import

neurotrophin TRK receptor signaling pathway

plasma membrane to endosome transport

nerve growth factor binding

perinuclear region of cytoplasm

negative regulation of lipoprotein lipase activity

Golgi to lysosome transport

positive regulation of epithelial cell apoptotic process

retromer complex binding

04142

04722

TC0100003069.mm.2 Cdk18 cyclin-dependent kinase 18 1 -132113546 NM_008795, BC119617 NM_008795, BC119617 20

regulation of transcription involved in G1/S transition of mitotic cell cycle

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

protein phosphorylation

kinase activity

phosphorylation

transferase activity

 
TC1100004058.mm.2         NM_199201, BC120623, NM_001101656, NM_001101657, CD300(Cd300lh),, BC119352, CD300 NM_199201, BC120623, NM_001101656, NM_001101657, CD300(Cd300lh),, BC119352, CD300 NM_199201, BC120623, NM_001101656, NM_001101657, CD300(Cd300lh),, BC119352, CD300 NM_199201, BC120623, NM_001101656, NM_001101657, CD300(Cd300lh),, BC119352, CD300 NM_199201, BC120623, NM_001101656, NM_001101657, CD300(Cd300lh),, BC119352, CD300 NM_199201, BC120623, NM_001101656, NM_001101657, CD300(Cd300lh),, BC119352, CD300 NM_199201, BC120623, NM_001101656, NM_001101657, CD300(Cd300lh),, BC119352, CD300  

immune system process

molecular_function

transmembrane signaling receptor activity

protein binding

cellular_component

lysosome

endosome

plasma membrane

biological_process

membrane

integral component of membrane

positive regulation of protein ubiquitination

positive regulation of toll-like receptor 9 signaling pathway

positive regulation of toll-like receptor 9 signaling pathway

 
TC0300001856.mm.2 Ccna2 cyclin A2 3 -36564864 NM_009828, BC052730 NM_009828, BC052730 199

regulation of cyclin-dependent protein serine/threonine kinase activity

G2/M transition of mitotic cell cycle

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase holoenzyme complex

female pronucleus

male pronucleus

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

regulation of DNA replication

cell cycle

cyclin-dependent protein serine/threonine kinase regulator activity

cyclin-dependent protein serine/threonine kinase regulator activity

histone phosphorylation

protein kinase binding

protein kinase binding

protein domain specific binding

mitotic cell cycle phase transition

cell cycle G1/S phase transition

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of fibroblast proliferation

cell division

cyclin A2-CDK2 complex

cyclin A2-CDK2 complex

cyclin A2-CDK2 complex

04110

04914

TC1300001837.mm.2 Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 13 -38645690 NM_025380, BC048466 NM_025380, BC048466 27

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

translation

negative regulation of cell population proliferation

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

positive regulation of apoptotic process

positive regulation of DNA damage response, signal transduction by p53 class mediator

cellular response to leukemia inhibitory factor

positive regulation of cellular senescence

positive regulation of apoptotic signaling pathway

 
TC0300002313.mm.2 Lmna lamin A 3 -88481147, -88483204, -88483204 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 327

protein binding

nucleus

nucleus

nuclear envelope

nuclear envelope

nuclear envelope

lamin filament

nucleoplasm

nucleoplasm

cytosol

intermediate filament

protein import into nucleus

nucleus organization

nucleus organization

nuclear envelope organization

nuclear envelope organization

muscle organ development

protein phosphatase 1 binding

negative regulation of cell population proliferation

positive regulation of gene expression

nuclear matrix

nuclear body

nuclear speck

establishment of cell polarity

regulation of cell migration

establishment or maintenance of microtubule cytoskeleton polarity

regulation of protein stability

nuclear membrane

regulation of telomere maintenance

protein localization to nucleus

cellular protein localization

site of double-strand break

identical protein binding

positive regulation of osteoblast differentiation

perinuclear region of cytoplasm

ventricular cardiac muscle cell development

negative regulation of mesenchymal cell proliferation

negative regulation of release of cytochrome c from mitochondria

positive regulation of cell aging

positive regulation of histone H3-K9 trimethylation

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of adipose tissue development

DNA double-strand break attachment to nuclear envelope

negative regulation of extrinsic apoptotic signaling pathway

05410

05412

05414

TC1200000664.mm.2 Rhoj ras homolog family member J 12 75308312 NM_023275, BC043719 NM_023275, BC043719 34

nucleotide binding

angiogenesis

GTPase activity

GTPase activity

GTPase activity

protein binding

GTP binding

GTP binding

intracellular anatomical structure

plasma membrane

endocytosis

small GTPase mediated signal transduction

Rho protein signal transduction

regulation of cell shape

regulation of endothelial cell migration

membrane

cell migration

cell projection assembly

actin cytoskeleton organization

actin cytoskeleton organization

Cdc42 protein signal transduction

retina vasculature morphogenesis in camera-type eye

positive regulation of cell migration involved in sprouting angiogenesis

regulation of sprouting angiogenesis

 
TC1100001592.mm.2 Igfbp4 insulin-like growth factor binding protein 4 11 99041243 NM_010517, BC019836 NM_010517, BC019836 101

regulation of cell growth

protein binding

insulin-like growth factor binding

extracellular region

extracellular space

extracellular space

extracellular space

regulation of glucose metabolic process

growth factor binding

insulin-like growth factor I binding

insulin-like growth factor II binding

regulation of growth

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

type B pancreatic cell proliferation

 
TC0300000656.mm.2 Tmem154 transmembrane protein 154 3 84666191 NM_177260, BC096432, BC113174, BC113175 NM_177260, BC096432, BC113174, BC113175 NM_177260, BC096432, BC113174, BC113175 NM_177260, BC096432, BC113174, BC113175 11

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC1900001498.mm.2 Blnk B cell linker 19 -40928926 NM_008528, BC059785 NM_008528, BC059785 107

protein binding

cytoplasm

cytoplasm

cytosol

plasma membrane

transmembrane receptor protein tyrosine kinase signaling pathway

positive regulation of gene expression

membrane

enzyme binding

intracellular signal transduction

intracellular signal transduction

signaling adaptor activity

cytoplasmic ribonucleoprotein granule

B cell activation

SH2 domain binding

B cell receptor signaling pathway

protein tyrosine kinase binding

04380

04662

05340

TC1300001633.mm.2 H3c6 H3 clustered histone 6 13 -23561474 NM_178205, BC156786 NM_178205, BC156786 11

nuclear chromosome

chromatin

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC1300001561.mm.2 H3c11 H3 clustered histone 11 13 -21782914 NM_178207, BC116383 NM_178207, BC116383 10

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC1000002453.mm.2 Pdxk pyridoxal (pyridoxine, vitamin B6) kinase 10 -78436746 NM_172134, BC027745 NM_172134, BC027745 31

nucleotide binding

magnesium ion binding

ATP binding

nucleoplasm

cytoplasm

cytosol

zinc ion binding

pyridoxal kinase activity

pyridoxal kinase activity

pyridoxal 5'-phosphate salvage

pyridoxal 5'-phosphate salvage

kinase activity

phosphorylation

transferase activity

pyridoxal phosphate binding

potassium ion binding

sodium ion binding

lithium ion binding

small molecule binding

protein homodimerization activity

pyridoxal phosphate biosynthetic process

negative regulation of apoptotic process

metal ion binding

pyridoxal binding

00750

01100

TC1200001324.mm.2 Cdca7l cell division cycle associated 7 like 12 117843860 NM_146040, BC006933 NM_146040, BC006933 19

fibrillar center

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

regulation of transcription, DNA-templated

positive regulation of cell population proliferation

 
TC0800000955.mm.2 Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 8 84415363 NM_001252059, NM_001252060, NM_001252061, NM_007578 NM_001252059, NM_001252060, NM_001252061, NM_007578 NM_001252059, NM_001252060, NM_001252061, NM_007578 NM_001252059, NM_001252060, NM_001252061, NM_007578 343

regulation of neurotransmitter levels

ion channel activity

voltage-gated ion channel activity

voltage-gated calcium channel activity

voltage-gated calcium channel activity

voltage-gated calcium channel activity

voltage-gated calcium channel activity

calcium channel activity

protein binding

calmodulin binding

nucleus

cytoplasm

plasma membrane

voltage-gated calcium channel complex

voltage-gated calcium channel complex

ion transport

calcium ion transport

calcium ion transport

calcium ion transport

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

gamma-aminobutyric acid signaling pathway

chemical synaptic transmission

chemical synaptic transmission

chemical synaptic transmission

neuron-neuron synaptic transmission

neuromuscular synaptic transmission

synapse assembly

adult walking behavior

adult walking behavior

cell death

high voltage-gated calcium channel activity

high voltage-gated calcium channel activity

high voltage-gated calcium channel activity

regulation of hormone levels

gamma-aminobutyric acid secretion

regulation of acetylcholine secretion, neurotransmission

membrane

integral component of membrane

calcium-ion regulated exocytosis

regulation of calcium ion-dependent exocytosis

transmission of nerve impulse

sensory perception of pain

syntaxin binding

spinal cord motor neuron differentiation

cerebellum maturation

cerebellar molecular layer development

cerebellar Purkinje cell layer development

cerebellar Purkinje cell differentiation

vestibular nucleus development

central nervous system neuron differentiation

dendrite

cellular chloride ion homeostasis

regulation of sulfur amino acid metabolic process

negative regulation of hormone biosynthetic process

protein-containing complex

regulation of ion transmembrane transport

synaptic transmission, glutamatergic

regulation of membrane potential

glucose homeostasis

cell projection

neuronal cell body

neuronal cell body

receptor clustering

perikaryon

negative regulation of neuron apoptotic process

metal ion binding

response to pain

behavioral response to pain

calcium ion-regulated exocytosis of neurotransmitter

dendrite morphogenesis

regulation of axonogenesis

modulation of chemical synaptic transmission

nervous system process

musculoskeletal movement, spinal reflex action

neuromuscular process controlling balance

neuromuscular process

neuromuscular process

membrane depolarization

transmembrane transport

rhythmic synaptic transmission

calcium ion import

calcium ion import

calcium ion transmembrane transport

glutamatergic synapse

glutamatergic synapse

integral component of presynaptic active zone membrane

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

regulation of voltage-gated calcium channel activity

response to amyloid-beta

cellular response to amyloid-beta

04010

04020

04730

04742

04930

TC1900000152.mm.2 Wdr74 WD repeat domain 74 19 8735838 NM_134139, BC019968, BC024478 NM_134139, BC019968, BC024478 NM_134139, BC019968, BC024478 21

nuclear exosome (RNase complex)

blastocyst formation

molecular_function

nucleus

nucleus

nucleoplasm

nucleolus

nucleolus

rRNA processing

RNA metabolic process

preribosome, large subunit precursor

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

 
TC1000002650.mm.2 Utp20 UTP20 small subunit processome component 10 -88746606 NM_175158 20

nucleus

nucleolus

nucleolus

plasma membrane

rRNA processing

90S preribosome

small-subunit processome

 
TC1200001990.mm.2 Actn1 actinin, alpha 1 12 -80167541 NM_134156, BC054830 NM_134156, BC054830 100

stress fiber

stress fiber

stress fiber

ruffle

ruffle

double-stranded RNA binding

actin binding

integrin binding

integrin binding

calcium ion binding

protein binding

cytoskeletal regulatory protein binding

nucleus

cytoplasm

cytoskeleton

actin filament

plasma membrane

brush border

cell-cell junction

fascia adherens

focal adhesion

focal adhesion

actin filament organization

membrane

vinculin binding

vinculin binding

protein domain specific binding

sarcomere

Z disc

Z disc

cell junction

secretory granule

platelet formation

nuclear receptor coactivator activity

cortical cytoskeleton

cortical actin cytoskeleton

cortical cytoskeleton organization

dense core granule membrane

platelet morphogenesis

protein homodimerization activity

protein homodimerization activity

cell projection

dendritic spine

ion channel binding

metal ion binding

focal adhesion assembly

synapse organization

actin filament binding

actin filament binding

actin filament bundle assembly

negative regulation of cellular component movement

actin filament network formation

actin crosslink formation

glutamatergic synapse

postsynapse organization

structural constituent of postsynapse

04510

04520

04530

04670

04810

05146

05322

05412

TC1900001266.mm.2 Mamdc2 MAM domain containing 2 19 -23302608 NM_174857, BC042773 NM_174857, BC042773 14

glycosaminoglycan binding

extracellular region

interstitial matrix

endoplasmic reticulum

membrane

peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan

extracellular matrix

 
TC1900000491.mm.2 Lipn lipase, family member N 19 34067357 NM_027340 12

extracellular region

lipid metabolic process

lipid catabolic process

hydrolase activity

hydrolase activity, acting on ester bonds

intracellular membrane-bounded organelle

 
TC0600000324.mm.2 Akr1b8 aldo-keto reductase family 1, member B8 6 34354145 NM_008012, BC005789 NM_008012, BC005789 23

retinoid metabolic process

retinal dehydrogenase activity

alditol:NADP+ 1-oxidoreductase activity

cytoplasm

mitochondrion

cytosol

alcohol dehydrogenase (NADP+) activity

farnesol catabolic process

oxidoreductase activity

daunorubicin metabolic process

doxorubicin metabolic process

geranylgeranyl reductase activity

indanol dehydrogenase activity

NADP-retinol dehydrogenase activity

cellular detoxification of aldehyde

00040

00051

00052

00561

00620

01100

TC0100003522.mm.2 Fcgr2b Fc receptor, IgG, low affinity IIb 1 -170960558 NM_001077189, NM_010187, BC038070 NM_001077189, NM_010187, BC038070 NM_001077189, NM_010187, BC038070 472

amyloid-beta binding

negative regulation of type I hypersensitivity

immune complex clearance

negative regulation of immunoglobulin production

negative regulation of inflammatory response to antigenic stimulus

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of humoral immune response mediated by circulating immunoglobulin

transmembrane signaling receptor activity

protein binding

extracellular region

cytoplasm

cytoskeleton

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

integral component of plasma membrane

receptor-mediated endocytosis

phagocytosis, engulfment

defense response

cell surface receptor signaling pathway

cell surface receptor signaling pathway

response to bacterium

external side of plasma membrane

cell surface

membrane

integral component of membrane

immunoglobulin mediated immune response

dendrite development

low-affinity IgG receptor activity

IgG binding

IgG binding

immunoglobulin binding

antigen processing and presentation of exogenous peptide antigen via MHC class II

cerebellum development

negative regulation of B cell proliferation

endocytic recycling

negative regulation of interleukin-10 production

negative regulation of neutrophil apoptotic process

Fc-gamma receptor signaling pathway involved in phagocytosis

dendritic spine

cell body

protein-containing complex binding

membrane raft

positive regulation of JNK cascade

regulation of long-term neuronal synaptic plasticity

negative regulation of phagocytosis

positive regulation of phagocytosis

regulation of immune response

negative regulation of immune response

negative regulation of B cell receptor signaling pathway

positive regulation of DNA-binding transcription factor activity

recycling endosome

cellular response to molecule of bacterial origin

positive regulation of neuron death

positive regulation of neuron death

regulation of dendritic spine maintenance

regulation of dendritic spine maintenance

cellular response to amyloid-beta

cellular response to amyloid-beta

positive regulation of response to endoplasmic reticulum stress

positive regulation of response to endoplasmic reticulum stress

04145

04380

04662

04666

05150

05322

TC1000003117.mm.2 Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 10 -127517122 NM_001252316, NM_028230, BC004825, BC051396 NM_001252316, NM_028230, BC004825, BC051396 NM_001252316, NM_028230, BC004825, BC051396 NM_001252316, NM_028230, BC004825, BC051396 33

translation repressor activity, mRNA regulatory element binding

regulation of oxidative phosphorylation

regulation of oxidative phosphorylation

regulation of oxidative phosphorylation

chromatin binding

catalytic activity

glycine hydroxymethyltransferase activity

glycine hydroxymethyltransferase activity

nucleus

nucleus

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial intermembrane space

mitochondrial matrix

mitochondrial matrix

cytosol

glycine metabolic process

glycine biosynthetic process

L-serine metabolic process

L-serine biosynthetic process

L-serine catabolic process

one-carbon metabolic process

one-carbon metabolic process

zinc ion binding

positive regulation of cell population proliferation

L-allo-threonine aldolase activity

purine nucleobase biosynthetic process

microtubule cytoskeleton

membrane

amino acid binding

transferase activity

glycine biosynthetic process from serine

glycine biosynthetic process from serine

pyridoxal phosphate binding

pyridoxal phosphate binding

response to type I interferon

response to type I interferon

tetrahydrofolate interconversion

mitochondrial nucleoid

identical protein binding

protein homodimerization activity

tetrahydrofolate metabolic process

tetrahydrofolate metabolic process

folic acid metabolic process

mRNA 5'-UTR binding

cobalt ion binding

protein tetramerization

protein homotetramerization

protein homotetramerization

regulation of mitochondrial translation

regulation of mitochondrial translation

protein K63-linked deubiquitination

BRISC complex

BRISC complex

serine binding

regulation of aerobic respiration

regulation of aerobic respiration

00260

00460

00670

01100

TC1400000940.mm.2 Pbk PDZ binding kinase 14 65805910 NM_023209, BC020099 NM_023209, BC020099 33

nucleotide binding

mitotic cell cycle

negative regulation of protein phosphorylation

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

protein phosphorylation

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of stress-activated MAPK cascade

cellular response to UV

negative regulation of inflammatory response

 
TC0100002033.mm.2 Mcm3 minichromosome maintenance complex component 3 1 -20802967 NM_008563, BC031700 NM_008563, BC031700 65

nucleotide binding

double-strand break repair via break-induced replication

DNA binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA replication initiation

DNA strand elongation involved in DNA replication

cell cycle

hydrolase activity

MCM complex

MCM complex

perinuclear region of cytoplasm

mitotic DNA replication initiation

03030

04110

TC0300002284.mm.2 Fcrls Fc receptor-like S, scavenger receptor 3 -87250964 NM_030707, BC016551 NM_030707, BC016551 22

transmembrane signaling receptor activity

integral component of plasma membrane

cell surface receptor signaling pathway

 
TC1700001622.mm.2         NM_007634, NR_039596, BC037662 NM_007634, NR_039596, BC037662 NM_007634, NR_039596, BC037662  

regulation of cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase holoenzyme complex

re-entry into mitotic cell cycle

placenta development

nucleus

nucleus

cytoplasm

centrosome

centrosome

centriole

cytoskeleton

cell cycle

negative regulation of centrosome duplication

negative regulation of centrosome duplication

cyclin-dependent protein serine/threonine kinase regulator activity

protein ubiquitination

SCF ubiquitin ligase complex

cell junction

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

mitotic cell cycle phase transition

cell division

regulation of cell cycle

 
TC1300000181.mm.2         NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162  

nucleosome

DNA binding

nucleus

nucleus

chromosome

chromatin silencing

negative regulation of cell population proliferation

protein heterodimerization activity

 
TC1300001565.mm.2         NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162  

nucleosome

DNA binding

nucleus

nucleus

chromosome

chromatin silencing

negative regulation of cell population proliferation

protein heterodimerization activity

 
TC0800000564.mm.2 Dctd dCMP deaminase 8 48109957, 48110012, 48099091 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 16

catalytic activity

dCMP deaminase activity

pyrimidine nucleotide metabolic process

dUMP biosynthetic process

dTMP biosynthetic process

metabolic process

zinc ion binding

nucleotide biosynthetic process

hydrolase activity

identical protein binding

metal ion binding

00240

01100

TC0100002576.mm.2 Tns1 tensin 1 1 -73910231 NM_001289895, NM_027884 NM_001289895, NM_027884 27

actin binding

focal adhesion

focal adhesion

cell-substrate junction assembly

fibroblast migration

cell-substrate junction

 
TC0100001387.mm.2         NM_008131, NR_106194, BC015086 NM_008131, NR_106194, BC015086 NM_008131, NR_106194, BC015086  

nucleotide binding

magnesium ion binding

angiogenesis

catalytic activity

glutamate-ammonia ligase activity

glutamate-ammonia ligase activity

protein binding

ATP binding

cytoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

endoplasmic reticulum

rough endoplasmic reticulum

cytosol

plasma membrane

glutamate metabolic process

glutamine biosynthetic process

glutamine biosynthetic process

nitrogen compound metabolic process

cell population proliferation

cellular response to starvation

response to glucose

regulation of endothelial cell migration

regulation of endothelial cell migration

membrane

glutamate binding

transferase activity

ligase activity

protein palmitoylation

ammonia assimilation cycle

protein-cysteine S-palmitoyltransferase activity

manganese ion binding

positive regulation of insulin secretion

protein-containing complex

ribosome biogenesis

identical protein binding

cell projection

neuron projection

perikaryon

myelin sheath

myelin sheath

intracellular membrane-bounded organelle

axon terminus

cell body

dynein light chain binding

metal ion binding

positive regulation of epithelial cell proliferation

positive regulation of synaptic transmission, glutamatergic

glial cell projection

regulation of sprouting angiogenesis

regulation of sprouting angiogenesis

regulation of protein localization to nucleolus

 
TC0100003697.mm.2 Lbr lamin B receptor 1 -181815314 NM_133815, BC021516, BC042522 NM_133815, BC021516, BC042522 NM_133815, BC021516, BC042522 67

DNA binding

protein binding

nucleus

nuclear envelope

nuclear envelope

nuclear inner membrane

nuclear inner membrane

nuclear pore

nuclear lamina

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

nuclear localization sequence binding

steroid metabolic process

cholesterol metabolic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

neutrophil differentiation

nuclear membrane

nuclear membrane

delta14-sterol reductase activity

delta14-sterol reductase activity

chaperone binding

chromo shadow domain binding

NADPH binding

 
TC0500003632.mm.2 Slc46a3 solute carrier family 46, member 3 5 -147875897 NM_027872, BC006902 NM_027872, BC006902 18

membrane

integral component of membrane

transmembrane transporter activity

vacuolar transmembrane transport

transmembrane transport

integral component of lysosomal membrane

 
TC1700000937.mm.2 Trem2 triggering receptor expressed on myeloid cells 2 17 48346400 NM_001272078, NM_031254, BC032959, BC033485, BC052784 NM_001272078, NM_031254, BC032959, BC033485, BC052784 NM_001272078, NM_031254, BC032959, BC033485, BC052784 NM_001272078, NM_031254, BC032959, BC033485, BC052784 NM_001272078, NM_031254, BC032959, BC033485, BC052784 169

lipopolysaccharide binding

amyloid-beta binding

microglial cell activation

microglial cell activation

positive regulation of protein phosphorylation

microglial cell activation involved in immune response

positive regulation of antigen processing and presentation of peptide antigen via MHC class II

response to ischemia

transmembrane signaling receptor activity

transmembrane signaling receptor activity

protein binding

phospholipid binding

extracellular region

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

phagocytosis, engulfment

phagocytosis, engulfment

high-density lipoprotein particle binding

lipid binding

regulation of gene expression

regulation of gene expression

negative regulation of autophagy

negative regulation of autophagy

positive regulation of gene expression

positive regulation of mitochondrion organization

membrane

integral component of membrane

low-density lipoprotein particle binding

osteoclast differentiation

intrinsic component of plasma membrane

lipopolysaccharide-mediated signaling pathway

regulation of TOR signaling

positive regulation of TOR signaling

detection of lipopolysaccharide

detection of peptidoglycan

regulation of interleukin-6 production

negative regulation of interleukin-1 beta production

negative regulation of tumor necrosis factor production

positive regulation of interleukin-10 production

apolipoprotein binding

apolipoprotein A-I binding

very-low-density lipoprotein particle binding

positive regulation of macrophage fusion

signaling receptor activity

defense response to bacterium

peptidoglycan binding

negative regulation of apoptotic process

apoptotic cell clearance

plasma membrane raft

protein-containing complex binding

innate immune response

regulation of innate immune response

positive regulation of osteoclast differentiation

astrocyte activation

positive regulation of protein secretion

regulation of peptidyl-tyrosine phosphorylation

regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of calcium-mediated signaling

positive regulation of calcium-mediated signaling

positive regulation of chemotaxis

regulation of resting membrane potential

positive regulation of phagocytosis, engulfment

positive regulation of phagocytosis, engulfment

positive regulation of phagocytosis, engulfment

microglial cell proliferation

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

detection of lipoteichoic acid

lipoteichoic acid binding

cellular response to lipoteichoic acid

cellular response to peptidoglycan

regulation of macrophage inflammatory protein 1 alpha production

lipoprotein particle binding

dendritic cell differentiation

scaffold protein binding

amyloid-beta clearance

import into cell

regulation of plasma membrane bounded cell projection organization

regulation of plasma membrane bounded cell projection organization

regulation of plasma membrane bounded cell projection organization

complement-mediated synapse pruning

neuroinflammatory response

positive regulation of neuroinflammatory response

positive regulation of amyloid-beta clearance

positive regulation of engulfment of apoptotic cell

positive regulation of NIK/NF-kappaB signaling

positive regulation of proteasomal protein catabolic process

positive regulation of inward rectifier potassium channel activity

regulation of intracellular signal transduction

positive regulation of protein localization to plasma membrane

positive regulation of C-C chemokine receptor CCR7 signaling pathway

positive regulation of microglial cell activation

positive regulation of microglial cell activation

positive regulation of microglial cell activation

negative regulation of autophagic cell death

positive regulation of microglial cell migration

positive regulation of microglial cell migration

cellular response to amyloid-beta

positive regulation of CAMKK-AMPK signaling cascade

protein tyrosine kinase binding

positive regulation of CD40 signaling pathway

positive regulation of ATP biosynthetic process

04380

TC1000001894.mm.2 Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 10 -24637913 NM_008813, BC160371 NM_008813, BC160371 131

nucleic acid binding

catalytic activity

exonuclease activity

phosphodiesterase I activity

phosphodiesterase I activity

phosphodiesterase I activity

nucleotide diphosphatase activity

nucleotide diphosphatase activity

nucleotide diphosphatase activity

scavenger receptor activity

insulin receptor binding

calcium ion binding

ATP binding

extracellular region

extracellular space

extracellular space

plasma membrane

integral component of plasma membrane

generation of precursor metabolites and energy

phosphate-containing compound metabolic process

immune response

zinc ion binding

nucleoside triphosphate catabolic process

nucleoside triphosphate catabolic process

cell surface

cell surface

cell surface

membrane

integral component of membrane

hydrolase activity

polysaccharide binding

negative regulation of ossification

negative regulation of cell growth

melanocyte differentiation

regulation of bone mineralization

negative regulation of bone mineralization

inorganic diphosphate transport

inorganic diphosphate transport

cellular phosphate ion homeostasis

sequestering of triglyceride

biomineral tissue development

negative regulation of protein autophosphorylation

cellular response to insulin stimulus

NADH pyrophosphatase activity

identical protein binding

protein homodimerization activity

cell projection

neuron projection

neuronal cell body

cell body

synapse

negative regulation of fat cell differentiation

negative regulation of fat cell differentiation

negative regulation of fat cell differentiation

negative regulation of glycogen biosynthetic process

ATP metabolic process

ATP metabolic process

negative regulation of glucose import

negative regulation of insulin receptor signaling pathway

bone remodeling

metal ion binding

nucleoside-triphosphate diphosphatase activity

nucleoside-triphosphate diphosphatase activity

3'-phosphoadenosine 5'-phosphosulfate metabolic process

nucleic acid phosphodiester bond hydrolysis

apical dendrite

basal dendrite

cyclic-GMP-AMP hydrolase activity

cyclic-GMP-AMP hydrolase activity

cyclic-GMP-AMP hydrolase activity

negative regulation of hh target transcription factor activity

00230

00500

00740

00760

00770

01100

TC1900000508.mm.2 Kif20b kinesin family member 20B 19 34922357 NM_183046, BC151061, BC172148 NM_183046, BC151061, BC172148 NM_183046, BC151061, BC172148 35

nucleotide binding

neural tube closure

microtubule motor activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

centrosome

cytosol

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

cell cycle

regulation of mitotic nuclear division

microtubule binding

microtubule binding

positive regulation of cell population proliferation

positive regulation of cell population proliferation

ATP-dependent microtubule motor activity, plus-end-directed

microtubule cytoskeleton

ATPase activity

ATPase activity

midbody

midbody

positive regulation of cytokinesis

protein localization to microtubule

protein homodimerization activity

cell projection

intercellular bridge

perinuclear region of cytoplasm

neuron projection morphogenesis

WW domain binding

spindle midzone

cell division

regulation of establishment of protein localization

contractile ring

positive regulation of intracellular protein transport

mitotic spindle pole

positive regulation of mitotic cytokinetic process

mitotic spindle midzone

regulation of establishment of cell polarity

regulation of establishment of cell polarity

regulation of neuron migration

positive regulation of neuron migration

 
TC1700001173.mm.2 Rasgrp3 RAS, guanyl releasing protein 3 17 75435904, 75465537 NM_001166493, NM_207246, BC066069, BC066127 NM_001166493, NM_207246, BC066069, BC066127 NM_001166493, NM_207246, BC066069, BC066127 NM_001166493, NM_207246, BC066069, BC066127 21

guanyl-nucleotide exchange factor activity

GTPase activator activity

cytoplasm

Ras protein signal transduction

kinase binding

small GTPase binding

small GTPase binding

guanyl-nucleotide exchange factor complex

regulation of GTPase activity

perinuclear region of cytoplasm

04010

04662

TC1100002001.mm.2 Slc26a11 solute carrier family 26, member 11 11 119355556 NM_178743, BC132493, BC137897 NM_178743, BC132493, BC137897 NM_178743, BC132493, BC137897 17

nucleoplasm

lysosome

lysosomal membrane

endoplasmic reticulum

Golgi apparatus

plasma membrane

integral component of plasma membrane

ion transport

secondary active sulfate transmembrane transporter activity

sulfate transport

anion transmembrane transporter activity

sulfate transmembrane transporter activity

anion:anion antiporter activity

membrane

integral component of membrane

intracellular membrane-bounded organelle

transmembrane transport

 
TC0400002010.mm.2 Nol9 nucleolar protein 9 4 152039320, 152039320, 152039337 NM_001159599, NM_028727, BC125432, BC132099 NM_001159599, NM_028727, BC125432, BC132099 NM_001159599, NM_028727, BC125432, BC132099 NM_001159599, NM_028727, BC125432, BC132099 19

nucleotide binding

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA

RNA binding

ATP binding

nucleus

nucleolus

rRNA processing

RNA processing

kinase activity

transferase activity

intermediate filament cytoskeleton

polynucleotide 5'-hydroxyl-kinase activity

polynucleotide 5'-hydroxyl-kinase activity

 
TC0100002965.mm.2 Steap3 STEAP family member 3 1 -120226413, -120226413, -120226413, -120226413 NM_001085409, NM_133186, BC037435 NM_001085409, NM_133186, BC037435 NM_001085409, NM_133186, BC037435 33

ferric-chelate reductase activity

ferric-chelate reductase activity

protein binding

cytoplasm

endosome

endosome

multivesicular body

plasma membrane

plasma membrane

ion transport

iron ion transport

apoptotic process

cell cycle

cupric reductase activity

cupric reductase activity

protein secretion

protein secretion

copper ion import

copper ion import

copper ion import

membrane

integral component of membrane

oxidoreductase activity

iron import into cell

identical protein binding

positive regulation of apoptotic process

metal ion binding

ferric-chelate reductase (NADPH) activity

ferric-chelate reductase (NADPH) activity

ferric-chelate reductase (NADPH) activity

iron ion homeostasis

iron ion import across cell outer membrane

iron ion import across cell outer membrane

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

exosomal secretion

04115

TC0300002500.mm.2 H3c15 H3 clustered histone 15 3 96246699, -96238478 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 5

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC0300003216.mm.2         NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965  

negative regulation of transcription by RNA polymerase II

nuclear chromosome

nucleosome

chromatin binding

nucleus

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

 
TC0200002990.mm.2 Hacd1 3-hydroxyacyl-CoA dehydratase 1 2 -14026830 NM_001012396, NM_013935, BC138116, BC141017 NM_001012396, NM_013935, BC138116, BC141017 NM_001012396, NM_013935, BC138116, BC141017 NM_001012396, NM_013935, BC138116, BC141017 14

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

multicellular organism development

regulation of G2/M transition of mitotic cell cycle

positive regulation of cell-substrate adhesion

myotube differentiation

membrane

integral component of membrane

lyase activity

3-hydroxyacyl-CoA dehydratase activity

3-hydroxyacyl-CoA dehydratase activity

enzyme binding

sphingolipid biosynthetic process

sphingolipid biosynthetic process

integral component of endoplasmic reticulum membrane

fatty acid elongation

fatty acid elongation

cellular protein-containing complex assembly

very long-chain fatty acid biosynthetic process

very long-chain fatty acid biosynthetic process

hydroxyapatite binding

cementum mineralization

3-hydroxy-arachidoyl-CoA dehydratase activity

3-hydroxy-behenoyl-CoA dehydratase activity

3-hydroxy-lignoceroyl-CoA dehydratase activity

regulation of G1/S transition of mitotic cell cycle

 
TC0700000236.mm.2 Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 7 16781345 NM_009201, BC029873, BC037462 NM_009201, BC029873, BC037462 NM_009201, BC029873, BC037462 33

plasma membrane

plasma membrane

amino acid transport

glutamine transport

basal plasma membrane

glutamine secretion

neutral amino acid transmembrane transporter activity

L-aspartate transmembrane transporter activity

L-aspartate transmembrane transporter activity

L-glutamine transmembrane transporter activity

L-serine transmembrane transporter activity

symporter activity

L-serine transport

membrane

integral component of membrane

metal ion binding

protein homotrimerization

L-aspartate import across plasma membrane

L-aspartate import across plasma membrane

transport across blood-brain barrier

L-glutamine import across plasma membrane

04974

TC1300000972.mm.2 Mef2c myocyte enhancer factor 2C 13 83504033, 83573606, 83524742, 83523655 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 401

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

MAPK cascade

MAPK cascade

MAPK cascade

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

blood vessel development

osteoblast differentiation

osteoblast differentiation

neuron migration

B cell homeostasis

heart looping

endochondral ossification

endochondral ossification

blood vessel remodeling

chondrocyte differentiation

germinal center formation

regulation of germinal center formation

primary heart field specification

secondary heart field specification

outflow tract morphogenesis

sinoatrial valve morphogenesis

cardiac ventricle formation

cardiac ventricle formation

DNA binding

DNA binding

minor groove of adenine-thymine-rich DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

apoptotic process

humoral immune response

multicellular organism development

nervous system development

heart development

heart development

skeletal muscle tissue development

muscle cell fate determination

learning or memory

positive regulation of cardiac muscle hypertrophy

positive regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of alkaline phosphatase activity

neural crest cell differentiation

cardiac muscle hypertrophy in response to stress

nuclear speck

sarcomere

cell differentiation

neuron differentiation

platelet formation

monocyte differentiation

negative regulation of ossification

melanocyte differentiation

positive regulation of bone mineralization

positive regulation of B cell proliferation

protein-containing complex

activating transcription factor binding

cellular response to drug

skeletal muscle cell differentiation

skeletal muscle cell differentiation

cellular response to trichostatin A

B cell proliferation

histone deacetylase binding

histone deacetylase binding

intracellular membrane-bounded organelle

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

cell fate commitment

regulation of megakaryocyte differentiation

positive regulation of myoblast differentiation

positive regulation of neuron differentiation

positive regulation of osteoblast differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of neurotransmitter secretion

protein heterodimerization activity

protein dimerization activity

regulation of synaptic plasticity

positive regulation of skeletal muscle tissue development

neuron development

cell morphogenesis involved in neuron differentiation

embryonic viscerocranium morphogenesis

embryonic skeletal system morphogenesis

negative regulation of epithelial cell proliferation

B cell receptor signaling pathway

smooth muscle cell differentiation

regulation of synapse assembly

regulation of synaptic transmission, glutamatergic

cardiac muscle cell differentiation

cardiac muscle cell differentiation

ventricular cardiac muscle cell differentiation

roof of mouth development

regulation of synaptic activity

positive regulation of cardiac muscle cell proliferation

excitatory postsynaptic potential

transdifferentiation

regulation of sarcomere organization

cartilage morphogenesis

regulation of dendritic spine development

renal tubule morphogenesis

cellular response to lipopolysaccharide

cellular response to calcium ion

cellular response to retinoic acid

cellular response to growth factor stimulus

cellular response to parathyroid hormone stimulus

cellular response to fluid shear stress

cellular response to transforming growth factor beta stimulus

HMG box domain binding

positive regulation of cell proliferation in bone marrow

glomerulus morphogenesis

nephron tubule epithelial cell differentiation

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of vascular associated smooth muscle cell migration

negative regulation of vascular endothelial cell proliferation

sequence-specific double-stranded DNA binding

positive regulation of macrophage apoptotic process

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiac muscle cell differentiation

positive regulation of behavioral fear response

epithelial cell proliferation involved in renal tubule morphogenesis

positive regulation of skeletal muscle cell differentiation

04010

TC1100003470.mm.2 Prr11 proline rich 11 11 -87089155 NM_175563, BC023918 NM_175563, BC023918 14

molecular_function

nucleus

nucleus

cytoplasm

cytoplasm

cell cycle arrest

regulation of cell cycle

 
TC0200002474.mm.2 Srsf6 serine and arginine-rich splicing factor 6 2 162931507 NM_026499, BC012039 NM_026499, BC012039 30

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

RNA binding

mRNA binding

protein binding

nucleus

mRNA splice site selection

mRNA splice site selection

mRNA processing

RNA splicing

negative regulation of gene expression

regulation of keratinocyte proliferation

nuclear speck

nuclear speck

pre-mRNA binding

negative regulation of keratinocyte differentiation

negative regulation of mRNA splicing, via spliceosome

positive regulation of epithelial cell proliferation involved in lung morphogenesis

negative regulation of cell death

regulation of wound healing

negative regulation of type B pancreatic cell apoptotic process

03040

TC0400003390.mm.2 Cdc20 cell division cycle 20 4 -118432900 NM_023223, BC003215 NM_023223, BC003215 81

mitotic metaphase

protein binding

nucleoplasm

anaphase-promoting complex

anaphase-promoting complex

cytoplasm

centrosome

cytosol

cytoskeleton

cell cycle

mitotic sister chromatid cohesion

nervous system development

protein C-terminus binding

positive regulation of cell population proliferation

anaphase-promoting complex binding

enzyme binding

cell differentiation

anaphase-promoting complex-dependent catabolic process

anaphase-promoting complex-dependent catabolic process

positive regulation of synaptic plasticity

protein-containing complex

regulation of meiotic nuclear division

histone deacetylase binding

perinuclear region of cytoplasm

regulation of dendrite development

cell division

positive regulation of synapse maturation

mitotic spindle assembly

ubiquitin-protein transferase activator activity

positive regulation of ubiquitin protein ligase activity

positive regulation of anaphase-promoting complex-dependent catabolic process

ubiquitin ligase activator activity

04110

04114

04120

TC1300000174.mm.2 H3c10 H3 clustered histone 10 13 21717627 NM_178206 3

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC0600001279.mm.2 Pparg peroxisome proliferator activated receptor gamma 6 115422065, 115360950, 115362348, 115361143 NM_001127330, NM_011146, BC021798 NM_001127330, NM_011146, BC021798 NM_001127330, NM_011146, BC021798 1453

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II repressing transcription factor binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

negative regulation of cytokine production

placenta development

response to dietary excess

diet induced thermogenesis

negative regulation of acute inflammatory response

DNA binding

DNA binding

chromatin binding

double-stranded DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

steroid hormone receptor activity

nuclear receptor activity

nuclear receptor activity

nuclear receptor activity

nuclear receptor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

fatty acid metabolic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

inflammatory response

signal transduction

protein C-terminus binding

transcription factor binding

regulation of blood pressure

zinc ion binding

negative regulation of cell population proliferation

negative regulation of cell population proliferation

response to light stimulus

hormone-mediated signaling pathway

regulation of gene expression

macrophage derived foam cell differentiation

negative regulation of macrophage derived foam cell differentiation

negative regulation of cholesterol storage

negative regulation of cholesterol storage

negative regulation of sequestering of triglyceride

long-chain fatty acid transport

negative regulation of angiogenesis

regulation of lipid metabolic process

regulation of lipid metabolic process

fatty acid oxidation

enzyme binding

protein phosphatase binding

cell differentiation

monocyte differentiation

negative regulation of cell growth

estrogen receptor binding

nuclear receptor coactivator activity

negative regulation of BMP signaling pathway

epithelial cell differentiation

response to food

cellular response to insulin stimulus

cellular response to insulin stimulus

negative regulation of collagen biosynthetic process

activating transcription factor binding

response to lipid

response to lipid

peroxisome proliferator activated receptor signaling pathway

peroxisome proliferator activated receptor signaling pathway

peptide binding

glucose homeostasis

regulation of circadian rhythm

identical protein binding

lipoprotein transport

positive regulation of apoptotic process

intracellular membrane-bounded organelle

receptor complex

positive regulation of DNA binding

negative regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

protein self-association

cell fate commitment

cell fate commitment

fat cell differentiation

fat cell differentiation

fat cell differentiation

fat cell differentiation

regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of fatty acid metabolic process

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of fatty acid oxidation

metal ion binding

retinoid X receptor binding

retinoic acid receptor signaling pathway

retinoic acid receptor signaling pathway

cell maturation

perinuclear region of cytoplasm

rhythmic process

negative regulation of smooth muscle cell proliferation

positive regulation of oligodendrocyte differentiation

arachidonic acid binding

DNA binding domain binding

LBD domain binding

WW domain binding

negative regulation of inflammatory response

white fat cell differentiation

white fat cell differentiation

brown fat cell differentiation

positive regulation of DNA-binding transcription factor activity

alpha-actinin binding

negative regulation of telomerase activity

positive regulation of phagocytosis, engulfment

negative regulation of interferon-gamma-mediated signaling pathway

negative regulation of gene silencing by miRNA

E-box binding

cellular response to lithium ion

cellular response to low-density lipoprotein particle stimulus

cellular response to organic cyclic compound

negative regulation of peptide hormone secretion

RNA polymerase II transcription regulator complex

negative regulation of neuroinflammatory response

negative regulation of cellular response to insulin stimulus

positive regulation of pri-miRNA transcription by RNA polymerase II

negative regulation of microglial cell activation

negative regulation of vascular associated smooth muscle cell proliferation

positive regulation of vascular associated smooth muscle cell apoptotic process

negative regulation of vascular endothelial cell proliferation

positive regulation of low-density lipoprotein receptor activity

promoter-specific chromatin binding

negative regulation of pancreatic stellate cell proliferation

negative regulation of signaling receptor activity

03320

04380

05016

05200

05216

TC0200005164.mm.2 Sulf2 sulfatase 2 2 -166073898, -166073898 NM_001252578, NM_001252579, NM_028072, BC141086 NM_001252578, NM_001252579, NM_028072, BC141086 NM_001252578, NM_001252579, NM_028072, BC141086 NM_001252578, NM_001252579, NM_028072, BC141086 66

kidney development

chondrocyte development

glomerular filtration

catalytic activity

arylsulfatase activity

calcium ion binding

glycosaminoglycan binding

extracellular space

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

sulfur compound metabolic process

N-acetylglucosamine-6-sulfatase activity

N-acetylglucosamine-6-sulfatase activity

N-acetylglucosamine-6-sulfatase activity

sulfuric ester hydrolase activity

response to wounding

cell surface

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of vascular endothelial growth factor production

esophagus smooth muscle contraction

hydrolase activity

positive regulation of Wnt signaling pathway

positive regulation of Wnt signaling pathway

heparan sulfate proteoglycan metabolic process

heparan sulfate proteoglycan metabolic process

heparan sulfate proteoglycan metabolic process

glomerular basement membrane development

glomerular basement membrane development

glial cell-derived neurotrophic factor receptor signaling pathway

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of fibroblast growth factor receptor signaling pathway

metal ion binding

embryonic skeletal system development

cartilage development

bone development

innervation

positive regulation of canonical Wnt signaling pathway

liver regeneration

regulation of hepatocyte proliferation

 
TC1900000184.mm.2 Rab3il1 RAB3A interacting protein (rabin3)-like 1 19 10018193, 10001668, 10018193, 10018193, 10018250, 10001724, 10015046, 10018250 NM_144538, BC020147 NM_144538, BC020147 19

guanyl-nucleotide exchange factor activity

exocytosis

protein transport

kinase binding

identical protein binding

Golgi to plasma membrane transport vesicle

 
TC1600000447.mm.2 Tfrc transferrin receptor 16 32608895, 32609121 NM_011638, BC054522 NM_011638, BC054522 174

positive regulation of protein phosphorylation

double-stranded RNA binding

transferrin receptor activity

transferrin receptor activity

iron ion transmembrane transporter activity

protein binding

extracellular region

extracellular space

nucleus

cytoplasm

mitochondrion

endosome

endosome

early endosome

plasma membrane

plasma membrane

integral component of plasma membrane

clathrin-coated pit

clathrin-coated pit

iron ion transport

iron ion transport

cellular iron ion homeostasis

cellular iron ion homeostasis

endocytosis

receptor-mediated endocytosis

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

endosome membrane

positive regulation of gene expression

negative regulation of mitochondrial fusion

membrane

membrane

integral component of membrane

basolateral plasma membrane

protein kinase binding

osteoclast differentiation

Hsp70 protein binding

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of protein-containing complex assembly

cytoplasmic vesicle

receptor internalization

cellular response to extracellular stimulus

positive regulation of peptidyl-serine phosphorylation

transferrin transport

intracellular signal transduction

cellular response to drug

positive regulation of T cell proliferation

positive regulation of T cell proliferation

identical protein binding

protein homodimerization activity

negative regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

intracellular membrane-bounded organelle

protein-containing complex binding

positive regulation of bone resorption

positive regulation of isotype switching

perinuclear region of cytoplasm

perinuclear region of cytoplasm

chaperone binding

positive regulation of NF-kappaB transcription factor activity

recycling endosome

recycling endosome

recycling endosome membrane

extracellular exosome

extracellular exosome

cellular response to iron ion

positive regulation of protein localization to nucleus

HFE-transferrin receptor complex

HFE-transferrin receptor complex

cellular response to leukemia inhibitory factor

04144

04145

04640

TC0400001107.mm.2 Dhcr24 24-dehydrocholesterol reductase 4 106561037 NM_053272, BC019797 NM_053272, BC019797 47

delta24(24-1) sterol reductase activity

delta24(24-1) sterol reductase activity

nucleus

cytoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

cytoskeleton

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

Ras protein signal transduction

protein localization

steroid metabolic process

steroid metabolic process

cholesterol metabolic process

negative regulation of cell population proliferation

tissue development

tissue development

membrane

membrane

integral component of membrane

sterol metabolic process

sterol biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

enzyme binding

male genitalia development

plasminogen activation

peptide antigen binding

amyloid precursor protein catabolic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

skin development

delta24-sterol reductase activity

flavin adenine dinucleotide binding

membrane organization

FAD binding

00100

01100

TC1400000975.mm.2 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 14 69337150, 69555400 BC043134, NM_026174 BC043134, NM_026174 23

Golgi membrane

autophagosome membrane

guanosine-diphosphatase activity

guanosine-diphosphatase activity

Golgi apparatus

UDP catabolic process

nucleoside diphosphate catabolic process

membrane

nucleoside-diphosphatase activity

nucleoside-diphosphatase activity

nucleoside-triphosphatase activity

integral component of Golgi membrane

cytidine-diphosphatase activity

CTPase activity

uridine-diphosphatase activity

uridine-diphosphatase activity

integral component of autophagosome membrane

00230

00240

04142

TC0200003195.mm.2 Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) 2 -26593056 NM_026212, BC125530, BC137840 NM_026212, BC125530, BC137840 NM_026212, BC125530, BC137840 31

positive regulation of cytokine production

1-acylglycerol-3-phosphate O-acyltransferase activity

1-acylglycerol-3-phosphate O-acyltransferase activity

1-acylglycerol-3-phosphate O-acyltransferase activity

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

lipid metabolic process

phosphatidic acid biosynthetic process

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

00561

00564

01100

04975

TC1300000543.mm.2 Rnf144b ring finger protein 144B 13 47194002, 47122719 NM_001170643, NM_146042, BC025007 NM_001170643, NM_146042, BC025007 NM_001170643, NM_146042, BC025007 20

ubiquitin ligase complex

protein polyubiquitination

ubiquitin-protein transferase activity

cytoplasm

cytoplasm

mitochondrion

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

apoptotic process

membrane

integral component of membrane

protein ubiquitination

transferase activity

ubiquitin conjugating enzyme binding

mitochondrial membrane

mitochondrial membrane

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of apoptotic process

metal ion binding

ubiquitin protein ligase activity

 
TC0300002334.mm.2 Fdps farnesyl diphosphate synthetase 3 -89093587 NM_001253751, NM_134469, BC048497, BC087886 NM_001253751, NM_134469, BC048497, BC087886 NM_001253751, NM_134469, BC048497, BC087886 NM_001253751, NM_134469, BC048497, BC087886 37

dimethylallyltranstransferase activity

geranyltranstransferase activity

geranyltranstransferase activity

nucleoplasm

cytoplasm

mitochondrion

mitochondrial matrix

peroxisome

cytosol

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

isoprenoid biosynthetic process

sterol biosynthetic process

transferase activity

farnesyl diphosphate biosynthetic process

farnesyl diphosphate biosynthetic process

positive regulation of cholesterol biosynthetic process

metal ion binding

positive regulation of cell growth involved in cardiac muscle cell development

00900

01100

TC0100002866.mm.2 Pam peptidylglycine alpha-amidating monooxygenase 1 -97821093, -97821093 NM_013626, BC166013 NM_013626, BC166013 51

peptide amidation

long-chain fatty acid metabolic process

catalytic activity

monooxygenase activity

peptidylglycine monooxygenase activity

peptidylglycine monooxygenase activity

peptidylglycine monooxygenase activity

peptidylamidoglycolate lyase activity

copper ion binding

calcium ion binding

extracellular region

extracellular space

trans-Golgi network

cytosol

plasma membrane

integral component of plasma membrane

regulation of transcription by RNA polymerase II

peptide metabolic process

peptide metabolic process

metabolic process

zinc ion binding

response to pH

toxin metabolic process

cell surface

response to zinc ion

membrane

integral component of membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

lyase activity

protein amidation

protein metabolic process

protein kinase binding

secretory granule

secretory granule membrane

cytoplasmic vesicle

L-ascorbic acid binding

regulation of actin cytoskeleton organization

response to drug

identical protein binding

neuron projection

neuronal cell body

perikaryon

metal ion binding

perinuclear region of cytoplasm

regulation of protein secretion

fatty acid primary amide biosynthetic process

 
TC1500001656.mm.2 Sla src-like adaptor 15 -66780818 NM_001029841, NM_009192, BC032922 NM_001029841, NM_009192, BC032922 NM_001029841, NM_009192, BC032922 49

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

signaling receptor binding

protein binding

cytoplasm

endosome

focal adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

regulation of signal transduction

cell differentiation

extrinsic component of cytoplasmic side of plasma membrane

dendritic spine

innate immune response

 
TC0900002369.mm.2 Scamp5 secretory carrier membrane protein 5 9 -57441326 NM_020270, BC018613 NM_020270, BC018613 22

Golgi membrane

positive regulation of cytokine production

endosome

Golgi apparatus

plasma membrane

exocytosis

synaptic vesicle

synaptic vesicle

protein transport

membrane

integral component of membrane

cell junction

integral component of synaptic vesicle membrane

cytoplasmic vesicle

trans-Golgi network membrane

trans-Golgi network membrane

response to endoplasmic reticulum stress

protein-containing complex binding

synapse

negative regulation of endocytosis

positive regulation of calcium ion-dependent exocytosis

recycling endosome membrane

recycling endosome membrane

regulation of synaptic vesicle endocytosis

 
TC0200004811.mm.2 Cd93 CD93 antigen 2 -148436650 NM_010740, BC156937, CD93 NM_010740, BC156937, CD93 NM_010740, BC156937, CD93 42

complement component C1q complex binding

calcium ion binding

plasma membrane

plasma membrane

cell adhesion

cell surface

membrane

integral component of membrane

carbohydrate binding

cytoplasmic vesicle

cell-cell adhesion

cell-cell adhesion

 
TC1300001576.mm.2         NM_178186, BC065803, BC116373 NM_178186, BC065803, BC116373 NM_178186, BC065803, BC116373  

DNA binding

nucleus

chromatin silencing

negative regulation of cell population proliferation

 
TC1800000528.mm.2 Sncaip synuclein, alpha interacting protein (synphilin) 18 52768092, 52767810, 52768143 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 40

nucleoplasm

cytoplasm

cell death

ubiquitin protein ligase binding

cytoplasmic ribonucleoprotein granule

dopamine metabolic process

identical protein binding

regulation of neurotransmitter secretion

regulation of inclusion body assembly

05012

TC1400000075.mm.2 Rpp14 ribonuclease P 14 subunit 14 8080312 NM_025938, BC026988, BC046803 NM_025938, BC026988, BC046803 NM_025938, BC026988, BC046803 20

tRNA 5'-leader removal

ribonuclease P activity

nucleolus

multimeric ribonuclease P complex

ribonuclease P RNA binding

03013

TC0800002235.mm.2 Neil3 nei like 3 (E. coli) 8 -53586866 NM_146208, BC024921, BC034753 NM_146208, BC024921, BC034753 NM_146208, BC024921, BC034753 34

bubble DNA binding

nucleic acid binding

DNA binding

damaged DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

catalytic activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

nucleus

nucleus

nucleoplasm

chromosome

DNA repair

base-excision repair

base-excision repair

base-excision repair

nucleotide-excision repair

cellular response to DNA damage stimulus

metabolic process

zinc ion binding

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds

lyase activity

DNA N-glycosylase activity

DNA N-glycosylase activity

DNA N-glycosylase activity

metal ion binding

03410

TC0500000054.mm.2 Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 5 8893720 NM_008830, BC150687 NM_008830, BC150687 156

Golgi membrane

nucleotide binding

ATP binding

nucleoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

plasma membrane

plasma membrane

focal adhesion

lipid transport

actin cytoskeleton

membrane

integral component of membrane

apical plasma membrane

ATPase activity

cytoplasmic vesicle

positive regulation of cholesterol transport

bile acid secretion

ATPase-coupled transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

xenobiotic transmembrane transporter activity

phospholipid translocation

phospholipid translocation

intercellular canaliculus

transmembrane transport

lipid homeostasis

positive regulation of phospholipid translocation

phosphatidylcholine floppase activity

phosphatidylcholine floppase activity

phosphatidylethanolamine flippase activity

ceramide floppase activity

response to fenofibrate

cellular response to bile acid

positive regulation of phospholipid transport

02010

04976

TC1700000775.mm.2 Olfr110 olfactory receptor 110 17 37492467 NM_146328, BC132347 NM_146328, BC132347 7

olfactory receptor activity

G protein-coupled receptor signaling pathway

sensory perception of smell

integral component of membrane

04740

TC0400003000.mm.2 Hacd4 3-hydroxyacyl-CoA dehydratase 4 4 -88413955, -88410341 NM_025760, BC020155 NM_025760, BC020155 13

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

membrane

integral component of membrane

lyase activity

3-hydroxyacyl-CoA dehydratase activity

3-hydroxyacyl-CoA dehydratase activity

enzyme binding

sphingolipid biosynthetic process

integral component of endoplasmic reticulum membrane

fatty acid elongation

fatty acid elongation

very long-chain fatty acid biosynthetic process

very long-chain fatty acid biosynthetic process

3-hydroxy-arachidoyl-CoA dehydratase activity

3-hydroxy-behenoyl-CoA dehydratase activity

3-hydroxy-lignoceroyl-CoA dehydratase activity

 
TC1200002396.mm.2 Cinp cyclin-dependent kinase 2 interacting protein 12 -110872609 NM_026048, NM_027223, BC011066, BC021867 NM_026048, NM_027223, BC011066, BC021867 NM_026048, NM_027223, BC011066, BC021867 NM_026048, NM_027223, BC011066, BC021867 17

molecular_function

cellular_component

nucleus

DNA replication

DNA repair

cellular response to DNA damage stimulus

cell cycle

biological_process

cell division

 
TC0700000652.mm.2 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 7 35119292, 35119292 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 476

urea cycle

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

RNA polymerase I transcription regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

liver development

embryonic placenta development

DNA binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

transcription regulator complex

nucleolus

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase I

mitochondrion organization

Notch signaling pathway

multicellular organism development

transcription factor binding

transcription factor binding

cholesterol metabolic process

negative regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

positive regulation of gene expression

nuclear matrix

cytokine-mediated signaling pathway

kinase binding

kinase binding

protein domain specific binding

myeloid cell differentiation

myeloid cell differentiation

macrophage differentiation

lung development

granulocyte differentiation

granulocyte differentiation

protein-containing complex

Rb-E2F complex

CHOP-C/EBP complex

regulation of cell population proliferation

glucose homeostasis

identical protein binding

protein homodimerization activity

histone deacetylase binding

positive regulation of macrophage activation

intracellular membrane-bounded organelle

sequence-specific DNA binding

sequence-specific DNA binding

protein-containing complex binding

fat cell differentiation

fat cell differentiation

fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of osteoblast differentiation

negative regulation of cell cycle

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase III

protein heterodimerization activity

cell maturation

inner ear development

positive regulation of inflammatory response

white fat cell differentiation

brown fat cell differentiation

lipid homeostasis

interleukin-6-mediated signaling pathway

cellular response to lithium ion

cellular response to tumor necrosis factor

cellular response to organic cyclic compound

HMG box domain binding

RNA polymerase II transcription regulator complex

positive regulation of DNA-templated transcription, initiation

05200

05221

TC1500002012.mm.2 Cerk ceramide kinase 15 -86139100 NM_145475, BC094253 NM_145475, BC094253 42

nucleotide binding

magnesium ion binding

lipid kinase activity

ceramide kinase activity

ceramide kinase activity

ceramide kinase activity

ceramide kinase activity

NAD+ kinase activity

ATP binding

cytoplasm

mitochondrion

plasma membrane

sphingolipid metabolic process

ceramide metabolic process

ceramide metabolic process

membrane

integral component of membrane

kinase activity

phosphorylation

transferase activity

00600

TC1900000727.mm.2 Gsto1 glutathione S-transferase omega 1 19 47854972 NM_010362, BC085165 NM_010362, BC085165 36

glutathione transferase activity

basement membrane

nucleoplasm

cytoplasm

cytosol

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

oxidoreductase activity

transferase activity

L-ascorbic acid metabolic process

L-ascorbic acid biosynthetic process

axon

nuclear membrane

xenobiotic catabolic process

myelin sheath

cell body

glutathione dehydrogenase (ascorbate) activity

glutathione dehydrogenase (ascorbate) activity

methylarsonate reductase activity

negative regulation of ryanodine-sensitive calcium-release channel activity

positive regulation of ryanodine-sensitive calcium-release channel activity

cellular response to arsenic-containing substance

00480

00980

00982

TC0400002980.mm.2 Plin2 perilipin 2 4 -86656564 NM_007408, BC054766 NM_007408, BC054766 135

protein binding

nucleus

cytoplasm

lipid droplet

lipid droplet

lipid droplet

cytosol

cytosol

plasma membrane

positive regulation of sequestering of triglyceride

long-chain fatty acid transport

membrane

lipid storage

lipid storage

 
TC0200001760.mm.2 Rad51 RAD51 recombinase 2 119112813 NM_011234, BC027384 NM_011234, BC027384 173

recombinase activity

nucleotide binding

nuclear chromosome

telomere maintenance via recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

DNA recombinase assembly

DNA recombinase assembly

chromosome, telomeric region

chromosome, telomeric region

chromatin

condensed chromosome

condensed nuclear chromosome

condensed nuclear chromosome

synaptonemal complex

lateral element

lateral element

regulation of protein phosphorylation

DNA binding

chromatin binding

chromatin binding

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

cytoplasm

mitochondrion

cytoskeleton

DNA metabolic process

DNA unwinding involved in DNA replication

DNA repair

DNA recombination

mitotic recombination

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

reciprocal meiotic recombination

reciprocal meiotic recombination

protein C-terminus binding

DNA-dependent ATPase activity

regulation of double-strand break repair via homologous recombination

telomere maintenance via telomere lengthening

PML body

single-stranded DNA helicase activity

enzyme binding

replication fork processing

replication fork processing

telomere organization

protein-containing complex

site of double-strand break

interstrand cross-link repair

strand invasion

identical protein binding

perinuclear region of cytoplasm

positive regulation of DNA ligation

meiotic cell cycle

DNA polymerase binding

chromosome organization involved in meiotic cell cycle

chromosome organization involved in meiotic cell cycle

cellular response to alkaloid

cellular response to ionizing radiation

cellular response to hydroxyurea

cellular response to camptothecin

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination-dependent replication fork processing

03440

05200

05212

TC1600001373.mm.2 Tmem41a transmembrane protein 41a 16 -21934326 NM_025693, NR_037773, BC019770 NM_025693, NR_037773, BC019770 NM_025693, NR_037773, BC019770 13

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC0500002152.mm.2 Tyms thymidylate synthase 5 -30058199 NM_021288, NR_033402, BC020139 NM_021288, NR_033402, BC020139 NM_021288, NR_033402, BC020139 38

translation repressor activity, mRNA regulatory element binding

mRNA binding

thymidylate synthase activity

thymidylate synthase activity

folic acid binding

nucleus

nucleolus

cytoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

cytosol

dTMP biosynthetic process

dTMP biosynthetic process

regulation of translation

methyltransferase activity

nucleotide biosynthetic process

membrane

transferase activity

negative regulation of translation

methylation

tetrahydrofolate interconversion

protein homodimerization activity

heterocyclic compound binding

sequence-specific mRNA binding

00240

00670

01100

TC0600001400.mm.2 Clec4b1 C-type lectin domain family 4, member b1 6 123049961 NM_001190310, NM_027218, BC146521 NM_001190310, NM_027218, BC146521 NM_001190310, NM_027218, BC146521 15

positive regulation of release of sequestered calcium ion into cytosol

 
TC1600001143.mm.2 Ubald1 UBA-like domain containing 1 16 -4874778 NM_145359, BC013706, BC064081 NM_145359, BC013706, BC064081 NM_145359, BC013706, BC064081 15

molecular_function

cellular_component

biological_process

 
TC1700001003.mm.2 Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 17 56303336, 56304312 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 107

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

chromatin

euchromatin

heterochromatin

heterochromatin

cis-regulatory region sequence-specific DNA binding

DNA binding

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

replication fork

plasma membrane

DNA repair

chromatin organization

ubiquitin-dependent protein catabolic process

cellular response to DNA damage stimulus

cell cycle

zinc ion binding

methyl-CpG binding

maintenance of DNA methylation

maintenance of DNA methylation

maintenance of DNA methylation

histone monoubiquitination

histone monoubiquitination

nuclear matrix

protein ubiquitination

histone ubiquitination

transferase activity

cytoplasmic vesicle

nucleosomal histone binding

positive regulation of cellular protein metabolic process

methylated histone binding

methylated histone binding

histone binding

identical protein binding

hemi-methylated DNA-binding

hemi-methylated DNA-binding

metal ion binding

regulation of epithelial cell proliferation

protein autoubiquitination

protein autoubiquitination

ubiquitin protein ligase activity

ubiquitin protein ligase activity

 
TC0200002542.mm.2 Mmp9 matrix metallopeptidase 9 2 164948218 NM_013599, BC046991 NM_013599, BC046991 1041

skeletal system development

skeletal system development

positive regulation of protein phosphorylation

fibronectin binding

positive regulation of leukocyte migration

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

serine-type endopeptidase activity

extracellular region

extracellular space

proteolysis

response to oxidative stress

heart development

embryo implantation

aging

peptidase activity

peptidase activity

metallopeptidase activity

zinc ion binding

hydrolase activity

transformation of host cell by virus

extracellular matrix organization

extracellular matrix organization

extracellular matrix organization

positive regulation of cell migration

collagen catabolic process

collagen catabolic process

collagen catabolic process

extracellular matrix

positive regulation of synaptic plasticity

protein-containing complex

cellular response to reactive oxygen species

response to drug

identical protein binding

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of DNA binding

protein-containing complex binding

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of angiogenesis

metal ion binding

negative regulation of fibroblast proliferation

tissue remodeling

positive regulation of keratinocyte migration

collagen-containing extracellular matrix

cellular response to cadmium ion

cellular response to cell-matrix adhesion

cellular response to UV-A

positive regulation of release of cytochrome c from mitochondria

positive regulation of receptor binding

response to amyloid-beta

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of epithelial cell differentiation involved in kidney development

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cation channel activity

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

04670

05200

05219

TC1100004183.mm.2 Sgsh N-sulfoglucosamine sulfohydrolase (sulfamidase) 11 -119343488 NM_018822, BC130268 NM_018822, BC130268 46

protein binding

glycosaminoglycan binding

lysosome

lysosome

glycosaminoglycan catabolic process

glycosaminoglycan catabolic process

N-acetylglucosamine-6-sulfatase activity

sulfuric ester hydrolase activity

sulfuric ester hydrolase activity

N-sulfoglucosamine sulfohydrolase activity

N-sulfoglucosamine sulfohydrolase activity

heparan sulfate proteoglycan catabolic process

heparan sulfate proteoglycan catabolic process

heparan sulfate proteoglycan metabolic process

00531

01100

04142

TC1600001262.mm.2 Fgd4 FYVE, RhoGEF and PH domain containing 4 16 -16416914, -16416914, -16416914 NM_139232, BC129902, BC129903, NM_139233, NM_139234 NM_139232, BC129902, BC129903, NM_139233, NM_139234 NM_139232, BC129902, BC129903, NM_139233, NM_139234 NM_139232, BC129902, BC129903, NM_139233, NM_139234 NM_139232, BC129902, BC129903, NM_139233, NM_139234 30

actin binding

guanyl-nucleotide exchange factor activity

cytoplasm

cytoskeleton

cytoskeleton organization

activation of JUN kinase activity

regulation of cell shape

lamellipodium

lamellipodium assembly

microspike assembly

filopodium

regulation of Rho protein signal transduction

cell projection

filopodium assembly

metal ion binding

actin filament binding

 
TC0700002617.mm.2 Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 7 -24978168, -24978168 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 83

nucleotide binding

amyloid-beta binding

photoreceptor inner segment

P-type sodium:potassium-exchanging ATPase activity

P-type sodium:potassium-exchanging ATPase activity

ATP binding

nucleus

cytoplasm

endoplasmic reticulum

Golgi apparatus

sodium:potassium-exchanging ATPase complex

sodium:potassium-exchanging ATPase complex

ion transport

potassium ion transport

sodium ion transport

cellular sodium ion homeostasis

cellular sodium ion homeostasis

cellular sodium ion homeostasis

memory

adult locomotory behavior

visual learning

potassium transmembrane transporter activity, phosphorylative mechanism

membrane

integral component of membrane

cellular potassium ion homeostasis

cellular potassium ion homeostasis

axon

organelle membrane

D1 dopamine receptor binding

ionotropic glutamate receptor signaling pathway

sodium ion export across plasma membrane

sodium ion export across plasma membrane

sodium ion export across plasma membrane

sarcolemma

response to drug

neuronal cell body

myelin sheath

myelin sheath

heparan sulfate proteoglycan binding

calyx of Held

dendritic spine neck

dendritic spine head

synapse

metal ion binding

chaperone binding

cardiac muscle contraction

regulation of cardiac muscle cell membrane potential

sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential

postsynapse

neuron to neuron synapse

integral component of presynaptic membrane

ion antiporter activity involved in regulation of presynaptic membrane potential

proton transmembrane transport

cellular response to amyloid-beta

neuron projection maintenance

potassium ion import across plasma membrane

potassium ion import across plasma membrane

04260

04960

04964

04970

04971

04972

04973

04974

04976

TC0300000491.mm.2 P2ry1 purinergic receptor P2Y, G-protein coupled 1 3 61002784 NM_001282016, NM_008772, BC138634, BC138635 NM_001282016, NM_008772, BC138634, BC138635 NM_001282016, NM_008772, BC138634, BC138635 NM_001282016, NM_008772, BC138634, BC138635 114

nucleotide binding

G protein-coupled ADP receptor activity

positive regulation of protein phosphorylation

G protein-coupled adenosine receptor signaling pathway

G protein-coupled receptor activity

ATP binding

mitochondrion

plasma membrane

plasma membrane

integral component of plasma membrane

cilium

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

glial cell migration

regulation of cell shape

response to mechanical stimulus

regulation of signaling receptor activity

negative regulation of norepinephrine secretion

postsynaptic density

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

sensory perception of pain

signal transduction involved in regulation of gene expression

platelet activation

dendrite

A1 adenosine receptor binding

positive regulation of inositol trisphosphate biosynthetic process

G protein-coupled purinergic nucleotide receptor signaling pathway

eating behavior

positive regulation of ion transport

positive regulation of ion transport

ADP binding

cell body

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled ATP receptor activity

postsynaptic membrane

positive regulation of transcription by RNA polymerase II

positive regulation of hormone secretion

protein heterodimerization activity

negative regulation of binding

positive regulation of penile erection

positive regulation of ERK1 and ERK2 cascade

cellular response to organic cyclic compound

cellular response to purine-containing compound

protein localization to plasma membrane

relaxation of muscle

scaffold protein binding

blood vessel diameter maintenance

glutamatergic synapse

integral component of presynaptic active zone membrane

regulation of presynaptic cytosolic calcium ion concentration

regulation of synaptic vesicle exocytosis

04080

TC1300000245.mm.2 H2ac10 H2A clustered histone 10 13 23533874 NM_175661, BC125011 NM_175661, BC125011 10

nucleosome

DNA binding

nucleus

chromosome

chromatin silencing

protein heterodimerization activity

05322

TC1000002341.mm.2 Cdk1 cyclin-dependent kinase 1 10 -69335145 NM_007659, BC024396 NM_007659, BC024396 223

G2/M transition of mitotic cell cycle

nucleotide binding

cyclin-dependent protein kinase holoenzyme complex

chromatin binding

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

mitochondrion

mitochondrial matrix

mitochondrial matrix

centrosome

cytosol

cytoskeleton

spindle microtubule

protein phosphorylation

protein phosphorylation

protein phosphorylation

apoptotic process

cell cycle

mitotic G2 DNA damage checkpoint

mitotic G2 DNA damage checkpoint

cell aging

cell population proliferation

RNA polymerase II CTD heptapeptide repeat kinase activity

RNA polymerase II CTD heptapeptide repeat kinase activity

response to organonitrogen compound

positive regulation of gene expression

negative regulation of gene expression

positive regulation of G2/M transition of mitotic cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

chromosome condensation

cyclin binding

midbody

Hsp70 protein binding

animal organ regeneration

protein localization to kinetochore

histone kinase activity

positive regulation of protein import into nucleus

regulation of circadian rhythm

negative regulation of apoptotic process

mitotic cell cycle phase transition

response to ethanol

positive regulation of DNA replication

positive regulation of mitotic cell cycle

rhythmic process

cell division

positive regulation of cardiac muscle cell proliferation

protein-containing complex assembly

mitotic spindle

Golgi disassembly

cyclin B1-CDK1 complex

cyclin-dependent protein kinase activity

positive regulation of protein localization to nucleus

positive regulation of mitochondrial ATP synthesis coupled electron transport

04110

04114

04115

04540

04914

TC0500001663.mm.2 Fam20c FAM20C, golgi associated secretory pathway kinase 5 138755080 NM_030565 44

nucleotide binding

skeletal system development

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

calcium ion binding

ATP binding

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

cytoplasm

Golgi apparatus

Golgi apparatus

protein phosphorylation

protein phosphorylation

protein phosphorylation

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, alcohol group as acceptor

manganese ion binding

positive regulation of bone mineralization

biomineral tissue development

osteoclast maturation

regulation of fibroblast growth factor receptor signaling pathway

positive regulation of osteoblast differentiation

ATP metabolic process

metal ion binding

regulation of phosphorus metabolic process

enamel mineralization

enamel mineralization

odontoblast differentiation

dentinogenesis

 
TC1500000432.mm.2 Sqle squalene epoxidase 15 59315091 NM_009270, BC042781, BC056361 NM_009270, BC042781, BC056361 NM_009270, BC042781, BC056361 31

squalene monooxygenase activity

squalene monooxygenase activity

endoplasmic reticulum

cellular aromatic compound metabolic process

cholesterol metabolic process

cholesterol metabolic process

response to organic substance

membrane

integral component of membrane

sterol biosynthetic process

sterol biosynthetic process

oxidoreductase activity

regulation of cell population proliferation

intracellular membrane-bounded organelle

flavin adenine dinucleotide binding

FAD binding

lipid droplet formation

00100

01100

TC1600001191.mm.2 Emp2 epithelial membrane protein 2 16 -10281748 NM_007929, BC041670 NM_007929, BC041670 31

membrane raft assembly

T cell mediated cytotoxicity

regulation of cell-matrix adhesion

regulation of cell-matrix adhesion

positive regulation of cell-matrix adhesion

regulation of glomerular filtration

integrin binding

integrin binding

nucleus

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

plasma membrane

plasma membrane

actin filament organization

cell adhesion

cell adhesion

cell-matrix adhesion

embryo implantation

embryo implantation

cell death

positive regulation of cell population proliferation

cell surface

regulation of endothelial cell migration

membrane

integral component of membrane

apical plasma membrane

cell migration

kinase binding

protein kinase binding

protein kinase binding

cytoplasmic vesicle

bleb assembly

activation of protein kinase activity

protein localization to cell surface

blood vessel endothelial cell migration

regulation of kinase activity

early endosome to late endosome transport

membrane raft

membrane raft

apical part of cell

regulation of angiogenesis

actin-mediated cell contraction

protein localization to plasma membrane

positive regulation of integrin-mediated signaling pathway

positive regulation of integrin-mediated signaling pathway

positive regulation of integrin-mediated signaling pathway

regulation of vasculogenesis

 
TC0900002503.mm.2 Hacd3 3-hydroxyacyl-CoA dehydratase 3 9 -64986982 NM_021345, BC031755, BC057023 NM_021345, BC031755, BC057023 NM_021345, BC031755, BC057023 26

protein binding

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

I-kappaB kinase/NF-kappaB signaling

JNK cascade

Rho protein signal transduction

membrane

integral component of membrane

lyase activity

3-hydroxyacyl-CoA dehydratase activity

3-hydroxyacyl-CoA dehydratase activity

enzyme binding

sphingolipid biosynthetic process

integral component of endoplasmic reticulum membrane

fatty acid elongation

fatty acid elongation

nuclear membrane

very long-chain fatty acid biosynthetic process

very long-chain fatty acid biosynthetic process

positive regulation of viral genome replication

positive regulation by virus of viral protein levels in host cell

3-hydroxy-arachidoyl-CoA dehydratase activity

3-hydroxy-behenoyl-CoA dehydratase activity

3-hydroxy-lignoceroyl-CoA dehydratase activity

 
TC1300000572.mm.2 Iars isoleucine-tRNA synthetase 13 49682129 NM_172015, BC067029 NM_172015, BC067029 26

tRNA binding

nucleotide binding

aminoacyl-tRNA editing activity

aminoacyl-tRNA ligase activity

isoleucine-tRNA ligase activity

isoleucine-tRNA ligase activity

isoleucine-tRNA ligase activity

ATP binding

nucleoplasm

cytoplasm

cytosol

translation

tRNA aminoacylation for protein translation

isoleucyl-tRNA aminoacylation

isoleucyl-tRNA aminoacylation

isoleucyl-tRNA aminoacylation

ligase activity

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

GTPase binding

00290

00970

TC1000002264.mm.2 Ddx21 DExD box helicase 21 10 -62580246 NM_019553, BC043655, BC059237 NM_019553, BC043655, BC059237 NM_019553, BC043655, BC059237 47

nucleotide binding

immune system process

positive regulation of myeloid dendritic cell cytokine production

nucleic acid binding

RNA binding

RNA binding

RNA helicase activity

RNA helicase activity

RNA helicase activity

double-stranded RNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

nucleolus

cytoplasm

mitochondrion

cytosol

rRNA processing

transcription by RNA polymerase II

response to virus

hydrolase activity

rRNA binding

snoRNA binding

miRNA binding

identical protein binding

positive regulation of I-kappaB kinase/NF-kappaB signaling

response to exogenous dsRNA

innate immune response

defense response to virus

R-loop disassembly

7SK snRNA binding

 
TC0800000959.mm.2 Lyl1 lymphoblastomic leukemia 1 8 84701456 NM_008535, BC005736 NM_008535, BC005736 45

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

blood vessel maturation

DNA binding

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

B cell differentiation

positive regulation of transcription, DNA-templated

protein dimerization activity

definitive hemopoiesis

 
TC1700000036.mm.2 Zdhhc14 zinc finger, DHHC domain containing 14 17 5492599 NM_146073, BC059814 NM_146073, BC059814 19

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

protein targeting to membrane

membrane

integral component of membrane

palmitoyltransferase activity

transferase activity

transferase activity, transferring acyl groups

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein-cysteine S-palmitoyltransferase activity

 
TC0200004410.mm.2 Gpr176 G protein-coupled receptor 176 2 -118277097 NM_201367, BC052037 NM_201367, BC052037 18

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

membrane

integral component of membrane

rhythmic process

circadian behavior

 
TC1100000582.mm.2 Cdkn2aipnl CDKN2A interacting protein N-terminal like 11 51967630 NM_029976, BC116362, BC116363 NM_029976, BC116362, BC116363 NM_029976, BC116362, BC116363 20

molecular_function

nucleoplasm

nucleolus

 
TC1800001048.mm.2 B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 18 -20684598 NM_019737, BC011149 NM_019737, BC011149 28

lactosylceramide biosynthetic process

cellular_component

Golgi apparatus

Golgi apparatus

carbohydrate metabolic process

lipid metabolic process

sphingolipid metabolic process

glycosphingolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosyltransferase activity

galactosyltransferase activity

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

ganglioside biosynthetic process via lactosylceramide

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

central nervous system neuron axonogenesis

central nervous system myelination

sphingolipid biosynthetic process

neuron maturation

metal ion binding

glycosylation

00600

01100

TC1100000983.mm.2 Pimreg PICALM interacting mitotic regulator 11 72042501 NM_144526, BC020115, BC029115 NM_144526, BC020115, BC029115 NM_144526, BC020115, BC029115 18

molecular_function

nucleus

nucleoplasm

nucleolus

cell cycle

cell division

 
TC1600000480.mm.2 Itgb5 integrin beta 5 16 33829664 NM_001145884, NM_010580, BC046280, BC058246 NM_001145884, NM_010580, BC046280, BC058246 NM_001145884, NM_010580, BC046280, BC058246 NM_001145884, NM_010580, BC046280, BC058246 91

signaling receptor binding

integrin binding

integrin binding

protein binding

plasma membrane

focal adhesion

focal adhesion

cell adhesion

cell-matrix adhesion

cell-matrix adhesion

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin complex

cell surface

cell surface

membrane

integral component of membrane

cell migration

cell leading edge

cell adhesion mediated by integrin

integrin alphav-beta5 complex

integrin alphav-beta5 complex

signaling receptor activity

stress fiber assembly

stress fiber assembly

receptor complex

epithelial cell-cell adhesion

glutamatergic synapse

integral component of synaptic membrane

04145

04510

04512

04810

05410

05412

05414

TC1800001404.mm.2 Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 18 -60684493, -60684493, -60684493, -60701433, -60684493, -60684493 NM_008306, BC066098, BC079561 NM_008306, BC066098, BC079561 NM_008306, BC066098, BC079561 88

polysaccharide biosynthetic process

cardiac septum development

catalytic activity

protein binding

Golgi apparatus

protein deacetylation

protein sulfation

protein sulfation

inflammatory response

heart development

respiratory gaseous exchange by respiratory system

sulfotransferase activity

metabolic process

cell population proliferation

fibroblast growth factor receptor signaling pathway

embryo development

animal organ morphogenesis

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

[heparan sulfate]-glucosamine N-sulfotransferase activity

[heparan sulfate]-glucosamine N-sulfotransferase activity

[heparan sulfate]-glucosamine N-sulfotransferase activity

membrane

integral component of membrane

transferase activity

hydrolase activity

deacetylase activity

deacetylase activity

glycosaminoglycan metabolic process

forebrain development

forebrain development

midbrain development

aorta development

positive regulation of MAPK cascade

positive regulation of smoothened signaling pathway

embryonic neurocranium morphogenesis

embryonic viscerocranium morphogenesis

coronary vasculature development

heparan sulfate N-deacetylase activity

00534

01100

TC0200001776.mm.2 Nusap1 nucleolar and spindle associated protein 1 2 119618297 NM_001042652, NM_133851, BC004787, BC100392 NM_001042652, NM_133851, BC004787, BC100392 NM_001042652, NM_133851, BC004787, BC100392 NM_001042652, NM_133851, BC004787, BC100392 31

mitotic sister chromatid segregation

microtubule cytoskeleton organization

mitotic cytokinesis

mitotic cytokinesis

DNA binding

nucleus

chromosome

nucleolus

nucleolus

cytoplasm

spindle

cytoskeleton

microtubule

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

microtubule binding

microtubule binding

establishment of mitotic spindle localization

establishment of mitotic spindle localization

positive regulation of mitotic nuclear division

cell division

mitotic spindle

 
TC0400001217.mm.2 Pdzk1ip1 PDZK1 interacting protein 1 4 115088707 NM_001164557, NM_001164558, NM_026018, BC013542 NM_001164557, NM_001164558, NM_026018, BC013542 NM_001164557, NM_001164558, NM_026018, BC013542 NM_001164557, NM_001164558, NM_026018, BC013542 24

molecular_function

biological_process

membrane

integral component of membrane

 
TC1100001155.mm.2 Spag5 sperm associated antigen 5 11 78301590 NM_017407, BC052672 NM_017407, BC052672 31

mitotic sister chromatid segregation

chromosome, centromeric region

kinetochore

chromosome

cytoplasm

spindle

cytosol

cytoskeleton

microtubule

cell cycle

spindle organization

chromosome segregation

microtubule binding

nuclear body

positive regulation of intracellular transport

centriolar satellite

microtubule plus-end

establishment of spindle orientation

cell division

regulation of attachment of spindle microtubules to kinetochore

protein localization to centrosome

mitotic spindle

mitotic spindle

regulation of metaphase plate congression

mitotic spindle pole

positive regulation of spindle assembly

 
TC0200001144.mm.2 Gm14461 predicted gene 14461 2 78237546 NM_177843 10    
TC0700001756.mm.2 Prkcb protein kinase C, beta 7 122289124 NM_008855, BC127083 NM_008855, BC127083 222

nucleotide binding

response to hypoxia

adaptive immune response

immune system process

chromatin binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein kinase C activity

protein kinase C activity

protein kinase C binding

calcium channel regulator activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

centrosome

cytosol

plasma membrane

chromatin organization

regulation of transcription by RNA polymerase II

protein phosphorylation

calcium ion transport

cellular calcium ion homeostasis

apoptotic process

spectrin

zinc ion binding

regulation of glucose transmembrane transport

negative regulation of glucose transmembrane transport

regulation of dopamine secretion

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

nuclear receptor coactivator activity

positive regulation of vascular endothelial growth factor receptor signaling pathway

brush border membrane

histone kinase activity (H3-T6 specific)

histone H3-T6 phosphorylation

intracellular signal transduction

regulation of growth

B cell activation

histone binding

response to drug

positive regulation of I-kappaB kinase/NF-kappaB signaling

calyx of Held

calyx of Held

positive regulation of angiogenesis

negative regulation of insulin receptor signaling pathway

metal ion binding

androgen receptor binding

B cell receptor signaling pathway

positive regulation of B cell receptor signaling pathway

positive regulation of NF-kappaB transcription factor activity

cellular response to carbohydrate stimulus

presynaptic modulation of chemical synaptic transmission

presynaptic modulation of chemical synaptic transmission

presynaptic cytosol

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle exocytosis

04010

04012

04020

04062

04070

04270

04310

04370

04510

04530

04540

04650

04662

04664

04666

04670

04720

04730

04912

04916

04960

04970

04971

04972

04973

05140

05143

05146

05200

05214

05223

TC0X00003021.mm.2 Tceal8 transcription elongation factor A (SII)-like 8 X -136168983 NM_001168578, NM_025703, BC027269 NM_001168578, NM_025703, BC027269 NM_001168578, NM_025703, BC027269 18

nucleus

WW domain binding

 
TC0100002736.mm.2 Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 1 -86099036 NM_008311, BC023690 NM_008311, BC023690 104

Gq/11-coupled serotonin receptor activity

neural crest cell migration

positive regulation of cytokine production

positive regulation of cytokine production

positive regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

G-protein alpha-subunit binding

G protein-coupled receptor internalization

heart morphogenesis

cardiac muscle hypertrophy

G protein-coupled receptor activity

G protein-coupled serotonin receptor activity

G protein-coupled serotonin receptor activity

G protein-coupled serotonin receptor activity

G protein-coupled serotonin receptor activity

GTPase activator activity

nucleoplasm

cytoplasm

cytoplasm

plasma membrane

plasma membrane

integral component of plasma membrane

cellular calcium ion homeostasis

smooth muscle contraction

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

phospholipase C-activating G protein-coupled receptor signaling pathway

activation of phospholipase C activity

protein kinase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

phospholipase C-activating serotonin receptor signaling pathway

chemical synaptic transmission

heart development

behavior

positive regulation of cell population proliferation

negative regulation of autophagy

positive regulation of phosphatidylinositol biosynthetic process

neural crest cell differentiation

phosphatidylinositol 3-kinase signaling

intestine smooth muscle contraction

membrane

integral component of membrane

phosphorylation

calcium-mediated signaling

cGMP-mediated signaling

cell junction

dendrite

dendrite

neurotransmitter receptor activity

ion transmembrane transport

vasoconstriction

response to drug

response to drug

neuron projection

neuronal cell body

negative regulation of apoptotic process

positive regulation of MAP kinase activity

synapse

embryonic morphogenesis

regulation of behavior

regulation of behavior

positive regulation of nitric-oxide synthase activity

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol

serotonin binding

serotonin binding

positive regulation of cell division

negative regulation of cell death

ERK1 and ERK2 cascade

ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

protein kinase C signaling

cellular response to amine stimulus

cellular response to temperature stimulus

G protein-coupled serotonin receptor signaling pathway

G protein-coupled serotonin receptor complex

G protein-coupled serotonin receptor complex

cellular response to serotonin

04020

04080

04540

TC0400002275.mm.2 Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 4 -19876837 NM_175406, BC087899 NM_175406, BC087899 45

lysosomal membrane

endosome

early endosome

early endosome

ion transport

vacuolar transport

vacuolar acidification

proton transmembrane transporter activity

membrane

apical plasma membrane

vacuolar proton-transporting V-type ATPase complex

vacuolar proton-transporting V-type ATPase complex

proton-transporting V-type ATPase, V0 domain

plasma membrane proton-transporting V-type ATPase complex

proton-transporting ATPase activity, rotational mechanism

proton transmembrane transport

00190

01100

04142

04145

04966

05323

TC1700001969.mm.2 Tcf19 transcription factor 19 17 -35512734 NM_001163763, NM_001163764, NM_025674, BC004617 NM_001163763, NM_001163764, NM_025674, BC004617 NM_001163763, NM_001163764, NM_025674, BC004617 NM_001163763, NM_001163764, NM_025674, BC004617 29

G1/S transition of mitotic cell cycle

nucleus

nucleus

regulation of gene expression

regulation of gene expression

type B pancreatic cell proliferation

 
TC1400000350.mm.2 Tmem273 transmembrane protein 273 14 32785962 NM_001163616 8

molecular_function

cellular_component

biological_process

 
TC0400001312.mm.2         NM_026932, NR_029469, BC054723, BC062876 NM_026932, NR_029469, BC054723, BC062876 NM_026932, NR_029469, BC054723, BC062876 NM_026932, NR_029469, BC054723, BC062876  

nucleus

chromosome

nucleolus

nucleolus

rRNA processing

preribosome, large subunit precursor

nuclear periphery

ribosome biogenesis

ribosomal large subunit biogenesis

 
TC1900001240.mm.2 Anxa1 annexin A1 19 -20373433 NM_010730, BC002289, BC004594 NM_010730, BC002289, BC004594 NM_010730, BC002289, BC004594 210

cornified envelope

neutrophil homeostasis

neutrophil homeostasis

adaptive immune response

immune system process

monocyte chemotaxis

regulation of leukocyte migration

regulation of leukocyte migration

single-stranded DNA binding

single-stranded RNA binding

phospholipase inhibitor activity

calcium ion binding

protein binding

phospholipid binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

extracellular region

extracellular space

extracellular space

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

endosome

cytosol

cytosol

actin filament

plasma membrane

plasma membrane

plasma membrane

cilium

phagocytosis

inflammatory response

inflammatory response

signal transduction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

regulation of cell shape

regulation of cell shape

cell surface

response to X-ray

myoblast migration involved in skeletal muscle regeneration

myoblast migration involved in skeletal muscle regeneration

membrane

apical plasma membrane

lateral plasma membrane

peptide cross-linking

phospholipase A2 inhibitor activity

phospholipase A2 inhibitor activity

extrinsic component of membrane

insulin secretion

insulin secretion

keratinocyte differentiation

keratinocyte differentiation

prostate gland development

endocrine pancreas development

extrinsic component of external side of plasma membrane

positive regulation of vesicle fusion

positive regulation of vesicle fusion

positive regulation of prostaglandin biosynthetic process

positive regulation of prostaglandin biosynthetic process

cytoplasmic vesicle

motile cilium

actin cytoskeleton reorganization

actin cytoskeleton reorganization

mitochondrial membrane

response to estradiol

DNA duplex unwinding

DNA duplex unwinding

regulation of interleukin-1 production

regulation of interleukin-1 production

negative regulation of interleukin-8 production

positive regulation of interleukin-2 production

positive regulation of interleukin-2 production

protein-containing complex

positive regulation of neutrophil apoptotic process

positive regulation of neutrophil apoptotic process

cellular response to vascular endothelial growth factor stimulus

cellular response to vascular endothelial growth factor stimulus

double-stranded DNA helicase activity

gliogenesis

positive regulation of T cell proliferation

positive regulation of T cell proliferation

regulation of cell population proliferation

sarcolemma

response to drug

mast cell granule

identical protein binding

cell projection

positive regulation of apoptotic process

response to peptide hormone

estrous cycle

innate immune response

positive regulation of T-helper 1 cell differentiation

positive regulation of T-helper 1 cell differentiation

negative regulation of T-helper 2 cell differentiation

negative regulation of T-helper 2 cell differentiation

negative regulation of exocytosis

negative regulation of exocytosis

alpha-beta T cell differentiation

alpha-beta T cell differentiation

metal ion binding

regulation of hormone secretion

regulation of hormone secretion

calcium-dependent protein binding

arachidonic acid secretion

arachidonic acid secretion

negative regulation of protein secretion

regulation of inflammatory response

regulation of inflammatory response

collagen-containing extracellular matrix

extracellular exosome

cellular response to hydrogen peroxide

cellular response to hydrogen peroxide

hepatocyte differentiation

prolactin secretion

prolactin secretion

response to interleukin-1

cellular response to glucocorticoid stimulus

cellular response to glucocorticoid stimulus

cellular response to glucocorticoid stimulus

granulocyte chemotaxis

granulocyte chemotaxis

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of wound healing

positive regulation of wound healing

synaptic membrane

neutrophil clearance

neutrophil clearance

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of G1/S transition of mitotic cell cycle

negative regulation of phospholipase A2 activity

negative regulation of phospholipase A2 activity

DNA/DNA annealing activity

 
TC0600001397.mm.2 Clec4a1 C-type lectin domain family 4, member a1 6 122921847 NM_199311, BC049354 NM_199311, BC049354 5

molecular_function

cellular_component

biological_process

 
TC1600001379.mm.2 Etv5 ets variant 5 16 -22381312, -22381312 NM_023794, BC034680 NM_023794, BC034680 283

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

neuromuscular synaptic transmission

locomotory behavior

cell differentiation

cellular response to oxidative stress

sequence-specific DNA binding

positive regulation of neuron differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

male germ-line stem cell asymmetric division

regulation of synapse organization

positive regulation of glial cell proliferation

regulation of branching involved in mammary gland duct morphogenesis

skeletal muscle acetylcholine-gated channel clustering

sequence-specific double-stranded DNA binding

 
TC0100000590.mm.2 Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 1 71557155 NM_026195, BC039925 NM_026195, BC039925 24

catalytic activity

IMP cyclohydrolase activity

IMP cyclohydrolase activity

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

mitochondrion

cytosol

cytosol

plasma membrane

purine nucleotide biosynthetic process

'de novo' IMP biosynthetic process

'de novo' IMP biosynthetic process

metabolic process

nucleoside metabolic process

ribonucleotide metabolic process

transferase activity

hydrolase activity

protein homodimerization activity

dihydrofolate metabolic process

tetrahydrofolate biosynthetic process

cellular response to interleukin-7

00230

00670

01100

TC1300001562.mm.2 H2ac22 H2A clustered histone 22 13 -21786773 NM_178184 4

DNA binding

nucleus

chromatin silencing

enzyme binding

05322

TC0300002718.mm.2 Csf1 colony stimulating factor 1 (macrophage) 3 -107745594, -107741047 NM_001113529, NM_001113530, NM_007778, BC066187, BC066200, BC066205 NM_001113529, NM_001113530, NM_007778, BC066187, BC066200, BC066205 NM_001113529, NM_001113530, NM_007778, BC066187, BC066200, BC066205 NM_001113529, NM_001113530, NM_007778, BC066187, BC066200, BC066205 NM_001113529, NM_001113530, NM_007778, BC066187, BC066200, BC066205 NM_001113529, NM_001113530, NM_007778, BC066187, BC066200, BC066205 508

ossification

positive regulation of cell-matrix adhesion

osteoclast proliferation

immune system process

response to ischemia

developmental process involved in reproduction

cytokine activity

cytokine activity

macrophage colony-stimulating factor receptor binding

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

plasma membrane

inflammatory response

transmembrane receptor protein tyrosine kinase signaling pathway

growth factor activity

cell population proliferation

positive regulation of cell population proliferation

positive regulation of gene expression

positive regulation of gene expression

positive regulation of macrophage derived foam cell differentiation

positive regulation of macrophage chemotaxis

membrane

integral component of membrane

nuclear body

macrophage differentiation

regulation of ossification

osteoclast differentiation

osteoclast differentiation

osteoclast differentiation

positive regulation of cell migration

positive regulation of cellular protein metabolic process

positive regulation of mononuclear cell proliferation

macrophage colony-stimulating factor signaling pathway

positive regulation of multicellular organism growth

odontogenesis

positive regulation of odontogenesis of dentin-containing tooth

identical protein binding

identical protein binding

protein homodimerization activity

protein homodimerization activity

innate immune response

positive regulation of macrophage differentiation

positive regulation of macrophage differentiation

positive regulation of macrophage differentiation

positive regulation of monocyte differentiation

positive regulation of osteoclast differentiation

positive regulation of osteoclast differentiation

positive regulation of osteoclast differentiation

positive regulation of osteoclast differentiation

positive regulation of protein kinase activity

positive regulation of Ras protein signal transduction

perinuclear region of cytoplasm

homeostasis of number of cells within a tissue

branching involved in mammary gland duct morphogenesis

mammary gland fat development

mammary duct terminal end bud growth

microglial cell proliferation

negative regulation of neuron death

positive regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of microglial cell migration

CSF1-CSF1R complex

04060

04380

04640

05323

TC0600001474.mm.2 D6Wsu163e DNA segment, Chr 6, Wayne State University 163, expressed 6 126939965 NM_138594, BC016429 NM_138594, BC016429 17

molecular_function

cytoplasm

cytoplasm

regulation of mast cell degranulation

regulation of mast cell degranulation

 
TC0500000888.mm.2 Septin11 septin 11 5 93093415, 93093415 NM_001009818, BC031456, BC062206, BC064466 NM_001009818, BC031456, BC062206, BC064466 NM_001009818, BC031456, BC062206, BC064466 NM_001009818, BC031456, BC062206, BC064466 38

nucleotide binding

stress fiber

GTPase activity

protein binding

GTP binding

cytoplasm

cytoskeleton

septin ring

cell cycle

microtubule cytoskeleton

cell junction

septin complex

septin complex

septin complex

cell division site

cellular protein localization

cell projection

synapse

regulation of synapse organization

cell division

molecular adaptor activity

cytoskeleton-dependent cytokinesis

postsynapse

glutamatergic synapse

GABA-ergic synapse

postsynaptic specialization of symmetric synapse

 
TC1100003771.mm.2 Nt5c3b 5'-nucleotidase, cytosolic IIIB 11 -100429351, -100439552, -100422320 NM_001102650, NM_026561, BC015307 NM_001102650, NM_026561, BC015307 NM_001102650, NM_026561, BC015307 15

nucleotide binding

magnesium ion binding

cytoplasm

nucleotide metabolic process

hydrolase activity

metal ion binding

 
TC1900000748.mm.2 Add3 adducin 3 (gamma) 19 53140442, 53142755, 53143996 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 31

condensed nuclear chromosome

actin binding

protein kinase C binding

structural constituent of cytoskeleton

calmodulin binding

cytoplasm

cytoskeleton

cytoskeleton

cytoskeleton

plasma membrane

brush border

cell-cell junction

cell cortex

postsynaptic density

postsynaptic density

membrane

response to drug

positive regulation of vasoconstriction

actin filament binding

barbed-end actin filament capping

 
TC1300001069.mm.2 Wdr41 WD repeat domain 41 13 94976343 NM_172590, BC138095, BC145144 NM_172590, BC138095, BC145144 NM_172590, BC138095, BC145144 18

guanyl-nucleotide exchange factor activity

cytoplasm

cytoplasm

autophagy

regulation of autophagy

guanyl-nucleotide exchange factor complex

Atg1/ULK1 kinase complex

 
TC1900000560.mm.2 Hells helicase, lymphoid specific 19 38930989 NM_008234, BC100394 NM_008234, BC100394 65

nucleotide binding

chromosome, centromeric region

urogenital system development

chromatin binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

pericentric heterochromatin

pericentric heterochromatin

DNA methylation

DNA methylation

chromatin silencing

DNA methylation-dependent heterochromatin assembly

DNA methylation-dependent heterochromatin assembly

cell cycle

multicellular organism development

maintenance of DNA methylation

maintenance of DNA methylation

hydrolase activity

lymphocyte differentiation

pericentric heterochromatin assembly

pericentric heterochromatin assembly

negative regulation of apoptotic process

lymphocyte proliferation

lymphocyte proliferation

cell division

cellular response to leukemia inhibitory factor

negative regulation of intrinsic apoptotic signaling pathway

 
TC0100000836.mm.2         NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969 NM_013701, NM_145079, NM_201410, NM_201641, NM_201642, NM_201643, NM_201644, NM_201645, BC026561, BC069940, BC089569, BC093516, BC138676, BC138699, BC139093, BC139094, BC141205, BC141206, BC145969, BC146021, BC165969  

retinoic acid binding

enzyme inhibitor activity

protein kinase C binding

steroid binding

fatty acid binding

mitochondrial inner membrane

endoplasmic reticulum

integral component of plasma membrane

estrogen catabolic process

drug binding

estrogen metabolic process

response to organic substance

glucuronosyltransferase activity

glucuronosyltransferase activity

membrane

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring hexosyl groups

aromatic compound catabolic process

glucuronate metabolic process

glucuronate metabolic process

enzyme binding

bile acid secretion

protein-containing complex

endoplasmic reticulum chaperone complex

protein homodimerization activity

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

protein-containing complex binding

coumarin catabolic process

protein heterodimerization activity

flavone metabolic process

cellular glucuronidation

flavonoid glucuronidation

flavonoid glucuronidation

xenobiotic glucuronidation

xenobiotic glucuronidation

cytochrome complex

vitamin D3 metabolic process

biphenyl catabolic process

negative regulation of cellular glucuronidation

 
TC1400002836.mm.2 Dok2 docking protein 2 14 70774380 NM_010071, BC004590 NM_010071, BC004590 54

transmembrane receptor protein tyrosine kinase adaptor activity

protein binding

transmembrane receptor protein tyrosine kinase signaling pathway

Ras protein signal transduction

negative regulation of MAPK cascade

 
TC0100001227.mm.2 Cyb5r1 cytochrome b5 reductase 1 1 134405780 NM_028057, BC016266, BC024618 NM_028057, BC016266, BC024618 NM_028057, BC016266, BC024618 21

cytochrome-b5 reductase activity, acting on NAD(P)H

mitochondrion

lipid metabolic process

steroid biosynthetic process

steroid metabolic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

FAD binding

00520

TC1900000171.mm.2         NM_001039959, NM_001286518, NM_009643, NR_104460, NR_105786 NM_001039959, NM_001286518, NM_009643, NR_104460, NR_105786 NM_001039959, NM_001286518, NM_009643, NR_104460, NR_105786 NM_001039959, NM_001286518, NM_009643, NR_104460, NR_105786 NM_001039959, NM_001286518, NM_009643, NR_104460, NR_105786  

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

cell-cell junction

actin cytoskeleton

actin cytoskeleton

vesicle

vesicle

sarcolemma

identical protein binding

costamere

costamere

regulation of RNA splicing

regulation of RNA splicing

cell-cell contact zone

cell-cell contact zone

S100 protein binding

membrane raft

membrane raft

extracellular exosome

structural molecule activity conferring elasticity

regulation of voltage-gated calcium channel activity

 
TC1200001314.mm.2 Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 12 117516525, 117533927 NM_175930, BC046627 NM_175930, BC046627 25

guanyl-nucleotide exchange factor activity

intracellular anatomical structure

nucleus

nucleoplasm

small GTPase mediated signal transduction

nuclear body

GTP-dependent protein binding

intracellular signal transduction

 
TC0700001122.mm.2 Fanci Fanconi anemia, complementation group I 7 79392337 NM_145946 25

nucleus

nucleoplasm

cytoplasm

cytosol

DNA repair

cellular response to DNA damage stimulus

cell cycle

positive regulation of protein ubiquitination

Fanconi anaemia nuclear complex

DNA polymerase binding

DNA polymerase binding

 
TC0200005052.mm.2 Mafb v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 2 -160363676 NM_010658, BC016434, BC038256 NM_010658, BC016434, BC038256 NM_010658, BC016434, BC038256 255

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

segment specification

respiratory gaseous exchange by respiratory system

transcription factor binding

rhombomere 5 development

rhombomere 6 development

abducens nerve formation

T cell differentiation in thymus

brain segmentation

inner ear morphogenesis

identical protein binding

sequence-specific DNA binding

protein-containing complex binding

regulation of myeloid cell differentiation

negative regulation of erythrocyte differentiation

negative regulation of osteoclast differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

thymus development

sequence-specific double-stranded DNA binding

 
TC0700002950.mm.2 Cd33 CD33 antigen 7 -43527455 NM_001111058, NM_021293, BC132379, CD33 NM_001111058, NM_021293, BC132379, CD33 NM_001111058, NM_021293, BC132379, CD33 NM_001111058, NM_021293, BC132379, CD33 24

plasma membrane

cell adhesion

external side of plasma membrane

membrane

integral component of membrane

carbohydrate binding

sialic acid binding

04640

TC0300003225.mm.2         BC145417, BC145418, NM_001173459 BC145417, BC145418, NM_001173459 BC145417, BC145418, NM_001173459  

molecular_function

plasma membrane

plasma membrane

intracellular signal transduction

positive regulation of phagocytosis

positive regulation of phagocytosis

positive regulation of T cell activation

 
TC0100002974.mm.2 Ddx18 DEAD box helicase 18 1 -121553834 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 25

nucleotide binding

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nucleic acid binding

RNA binding

helicase activity

ATP binding

nucleus

chromosome

nucleolus

nucleolus

hydrolase activity

 
TC0100000682.mm.2         NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102  

nucleotide binding

long-chain fatty acid metabolic process

long-chain fatty acid metabolic process

catalytic activity

long-chain fatty acid-CoA ligase activity

long-chain fatty acid-CoA ligase activity

ATP binding

nucleus

nucleolus

nucleolus

mitochondrion

mitochondrial outer membrane

peroxisome

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

lipid droplet

lipid droplet

cytosol

plasma membrane

rRNA processing

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

multicellular organism development

spermatogenesis

membrane

integral component of membrane

ligase activity

protein kinase binding

protein domain specific binding

cell differentiation

neuron differentiation

small-subunit processome

very-low-density lipoprotein particle assembly

long-chain fatty-acyl-CoA metabolic process

ribosome biogenesis

positive regulation of Golgi to plasma membrane protein transport

intracellular membrane-bounded organelle

long-chain fatty acid import into cell

arachidonate-CoA ligase activity

perinuclear region of cytoplasm

positive regulation of secretion

meiotic cell cycle

decanoate-CoA ligase activity

positive regulation of phosphatidylcholine biosynthetic process

 
TC0X00002993.mm.2 Timm8a1 translocase of inner mitochondrial membrane 8A1 X 11609223, -134537255 NM_013898, BC004796, BC094631 NM_013898, BC004796, BC094631 NM_013898, BC004796, BC094631 26

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial intermembrane space

protein targeting to mitochondrion

zinc ion binding

protein transport

membrane

identical protein binding

metal ion binding

chaperone-mediated protein transport

 
TC0200004568.mm.2 Bub1 BUB1, mitotic checkpoint serine/threonine kinase 2 -127800199 NM_001113179, NM_009772, BC029116 NM_001113179, NM_009772, BC029116 NM_001113179, NM_009772, BC029116 63

nucleotide binding

chromosome, centromeric region

kinetochore

kinetochore

condensed chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed chromosome, centromeric region

condensed nuclear chromosome outer kinetochore

protein kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleoplasm

chromosome

cytosol

protein phosphorylation

apoptotic process

cell cycle

chromosome segregation

regulation of sister chromatid cohesion

mitotic spindle assembly checkpoint

kinase activity

phosphorylation

transferase activity

intracellular membrane-bounded organelle

cell division

meiotic sister chromatid cohesion, centromeric

regulation of chromosome segregation

mitotic spindle checkpoint

positive regulation of intrinsic apoptotic signaling pathway

04110

04114

04914

TC0700001151.mm.2 Prc1 protein regulator of cytokinesis 1 7 80294475, 80294450 NM_001285997, NM_001285998, NM_145150, BC005475 NM_001285997, NM_001285998, NM_145150, BC005475 NM_001285997, NM_001285998, NM_145150, BC005475 NM_001285997, NM_001285998, NM_145150, BC005475 44

microtubule cytoskeleton organization

cytokinesis

microtubule bundle formation

nucleus

nucleoplasm

cytoplasm

spindle

spindle

cytoskeleton

microtubule

plasma membrane

cell cycle

microtubule binding

positive regulation of cell population proliferation

microtubule cytoskeleton

kinesin binding

protein kinase binding

midbody

regulation of cytokinesis

identical protein binding

intercellular bridge

mitotic spindle midzone assembly

cell division

contractile ring

mitotic spindle midzone

 
TC1800000265.mm.2 Wdr36 WD repeat domain 36 18 32837224, 32837224, 32837224 NM_001110015, NM_001110016, NM_144863, BC094453 NM_001110015, NM_001110016, NM_144863, BC094453 NM_001110015, NM_001110016, NM_144863, BC094453 NM_001110015, NM_001110016, NM_144863, BC094453 24

retina homeostasis

nucleolus

rRNA processing

regulation of axon extension

small-subunit processome

Pwp2p-containing subcomplex of 90S preribosome

03008

TC0100000222.mm.2 Imp4 IMP4, U3 small nucleolar ribonucleoprotein 1 34439828 NM_178601, BC069930 NM_178601, BC069930 20

fibrillar center

nucleus

nucleolus

nucleolus

rRNA processing

snoRNA binding

preribosome

small-subunit processome

Mpp10 complex

Mpp10 complex

ribosome biogenesis

03008

TC1600001527.mm.2 Umps uridine monophosphate synthetase 16 -33954781 NM_009471, BC003887, BC095981 NM_009471, BC003887, BC095981 NM_009471, BC003887, BC095981 30

catalytic activity

orotate phosphoribosyltransferase activity

orotate phosphoribosyltransferase activity

orotidine-5'-phosphate decarboxylase activity

orotidine-5'-phosphate decarboxylase activity

nucleus

cytoplasm

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine nucleotide biosynthetic process

UMP biosynthetic process

UMP biosynthetic process

metabolic process

nucleoside metabolic process

transferase activity

transferase activity, transferring glycosyl groups

lyase activity

carboxy-lyase activity

pyrimidine nucleobase biosynthetic process

identical protein binding

'de novo' UMP biosynthetic process

00240

00983

01100

TC0200003717.mm.2 Mettl8 methyltransferase like 8 2 -70964560, -70964561 NM_001110512, NM_145524, BC004636, BC057960 NM_001110512, NM_145524, BC004636, BC057960 NM_001110512, NM_145524, BC004636, BC057960 NM_001110512, NM_145524, BC004636, BC057960 18

histone acetyltransferase activity

nucleus

cytoplasm

skeletal muscle tissue development

methyltransferase activity

mRNA methyltransferase activity

mRNA methyltransferase activity

histone acetylation

transferase activity

methylation

fat cell differentiation

tRNA (cytosine-3-)-methyltransferase activity

mRNA methylation

mRNA methylation

 
TC0X00001322.mm.2 Tceal9 transcription elongation factor A like 9 X 136245079 NM_011712, BC007478 NM_011712, BC007478 19

nucleus

WW domain binding

WW domain binding

 
TC0800002878.mm.2 Nob1 NIN1/RPN12 binding protein 1 homolog 8 -107412488 NM_026277, BC103793, BC117992, BC117993 NM_026277, BC103793, BC117992, BC117993 NM_026277, BC103793, BC117992, BC117993 NM_026277, BC103793, BC117992, BC117993 23

cleavage involved in rRNA processing

nuclease activity

endonuclease activity

endoribonuclease activity

endoribonuclease activity

nucleus

nucleolus

cytoplasm

visual perception

hydrolase activity

maturation of SSU-rRNA

maturation of SSU-rRNA

preribosome, small subunit precursor

ribosomal small subunit biogenesis

metal ion binding

03008

TC1700000990.mm.2 Adgre4 adhesion G protein-coupled receptor E4 17 55749983 NM_139138, BC120538, BC120540 NM_139138, BC120538, BC120540 NM_139138, BC120538, BC120540 19

transmembrane signaling receptor activity

G protein-coupled receptor activity

calcium ion binding

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

signal transduction

cell surface receptor signaling pathway

epidermal growth factor receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cell surface

membrane

integral component of membrane

 
TC0100003500.mm.2 Nuf2 NUF2, NDC80 kinetochore complex component 1 -169497933 NM_023284, BC020026 NM_023284, BC020026 22

chromosome, centromeric region

kinetochore

condensed nuclear chromosome kinetochore

nucleus

nucleoplasm

chromosome

cytosol

cell cycle

mitotic spindle organization

attachment of spindle microtubules to kinetochore

Ndc80 complex

Ndc80 complex

protein-containing complex binding

meiotic chromosome segregation

cell division

attachment of mitotic spindle microtubules to kinetochore

kinetochore organization

 
TC0800002927.mm.2 Sf3b3 splicing factor 3b, subunit 3 8 -110810491 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 28

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

U2 snRNP

U12-type spliceosomal complex

nucleolus

mRNA processing

RNA splicing

U2 snRNA binding

negative regulation of protein catabolic process

protein-containing complex binding

U2-type precatalytic spliceosome

catalytic step 2 spliceosome

03040

TC1700001938.mm.2 D17H6S56E-5 DNA segment, Chr 17, human D6S56E 5 17 -34996723 BC027314 28    
TC0800001095.mm.2 Mt1 metallothionein 1 8 94179088 NM_013602, BC027262, BC036990 NM_013602, BC027262, BC036990 NM_013602, BC027262, BC036990 335

copper ion binding

nucleus

cytoplasm

lysosome

cytosol

cytosol

cellular metal ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

nitric oxide mediated signal transduction

zinc ion binding

detoxification of copper ion

detoxification of copper ion

negative regulation of neuron apoptotic process

metal ion binding

metal ion binding

cellular response to chromate

cellular response to cadmium ion

cellular response to copper ion

cellular response to zinc ion

cellular response to zinc ion

 
TC1300001574.mm.2 H2ac12 H2A clustered histone 12 13 -22035121 NM_175659, BC139479, BC146008 NM_175659, BC139479, BC146008 NM_175659, BC139479, BC146008 11

nucleosome

DNA binding

nucleus

chromosome

chromatin silencing

protein heterodimerization activity

05322

TC0700003592.mm.2 Man2a2 mannosidase 2, alpha 2 7 -80349096 NM_172903, BC055006 NM_172903, BC055006 23

Golgi membrane

catalytic activity

alpha-mannosidase activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Golgi apparatus

carbohydrate metabolic process

mannose metabolic process

N-glycan processing

protein deglycosylation

metabolic process

mannosidase activity

membrane

integral component of membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds

carbohydrate binding

metal ion binding

00510

01100

TC0400002007.mm.2 Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 4 151933719 NM_172704, BC085257 NM_172704, BC085257 32

SAM complex

nucleoplasm

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

membrane

nuclear speck

cristae formation

cristae formation

cristae formation

MICOS complex

MICOS complex

 
TC1900000543.mm.2 Cep55 centrosomal protein 55 19 38054983, 38054983, 38055040 NM_001164362, NM_028293, NM_028760, BC031396 NM_001164362, NM_028293, NM_028760, BC031396 NM_001164362, NM_028293, NM_028760, BC031396 NM_001164362, NM_028293, NM_028760, BC031396 31

mitotic cytokinesis

mitotic cytokinesis

protein binding

cytoplasm

centrosome

cytoskeleton

plasma membrane

cell cycle

regulation of phosphatidylinositol 3-kinase signaling

midbody

midbody

midbody

centriolar satellite

identical protein binding

intercellular bridge

establishment of protein localization

establishment of protein localization

cell division

midbody abscission

Flemming body

cranial skeletal system development

 
TC0400001465.mm.2 Clspn claspin 4 126556979 NM_175554, BC050848 NM_175554, BC050848 26

DNA replication checkpoint

DNA damage checkpoint

DNA secondary structure binding

DNA binding

nucleus

nucleoplasm

chromosome

Golgi apparatus

DNA repair

cellular response to DNA damage stimulus

cell cycle

mitotic G2 DNA damage checkpoint

mitotic G2 DNA damage checkpoint

anaphase-promoting complex binding

anaphase-promoting complex binding

peptidyl-serine phosphorylation

activation of protein kinase activity

activation of protein kinase activity

mitotic DNA replication checkpoint

mitotic DNA replication checkpoint

 
TC0900001987.mm.2 Fli1 Friend leukemia integration 1 9 -32422203 NM_008026, BC138791, BC138792 NM_008026, BC138791, BC138792 NM_008026, BC138791, BC138792 133

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

chromatin binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleus

nucleoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

blood circulation

animal organ morphogenesis

cellular process

nuclear body

cell differentiation

megakaryocyte development

sequence-specific DNA binding

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
TC1300002543.mm.2 Ccnb1 cyclin B1 13 -100778738 NM_172301, BC011478, BC080202, BC085238 NM_172301, BC011478, BC080202, BC085238 NM_172301, BC011478, BC080202, BC085238 NM_172301, BC011478, BC080202, BC085238 210

regulation of cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase holoenzyme complex

spindle pole

condensed nuclear chromosome outer kinetochore

oocyte maturation

in utero embryonic development

negative regulation of protein phosphorylation

patched binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

mitochondrial matrix

mitochondrial matrix

mitochondrial matrix

centrosome

centrosome

cytosol

cytoskeleton

protein phosphorylation

cell cycle

mitotic spindle organization

mitotic metaphase plate congression

mitotic metaphase plate congression

negative regulation of gene expression

positive regulation of G2/M transition of mitotic cell cycle

membrane

cyclin-dependent protein serine/threonine kinase regulator activity

protein kinase binding

positive regulation of mRNA 3'-end processing

positive regulation of histone phosphorylation

ubiquitin-like protein ligase binding

mitotic cell cycle phase transition

protein-containing complex binding

positive regulation of cell cycle

positive regulation of mitotic cell cycle

positive regulation of fibroblast proliferation

cell division

positive regulation of attachment of spindle microtubules to kinetochore

positive regulation of cardiac muscle cell proliferation

regulation of chromosome condensation

cyclin-dependent protein serine/threonine kinase activator activity

protein-containing complex assembly

regulation of mitotic cell cycle spindle assembly checkpoint

cyclin B1-CDK1 complex

cyclin B1-CDK1 complex

positive regulation of mitochondrial ATP synthesis coupled electron transport

histone H3-S10 phosphorylation involved in chromosome condensation

04110

04114

04115

04914

TC1100003817.mm.2 Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) 11 -101971143 NM_028207, BC016269 NM_028207, BC016269 39

inactivation of MAPK activity

in utero embryonic development

immunological synapse

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleoplasm

cytosol

cytosol

protein dephosphorylation

cytoskeletal protein binding

protein tyrosine/serine/threonine phosphatase activity

protein tyrosine/serine/threonine phosphatase activity

dephosphorylation

hydrolase activity

phosphatase activity

protein kinase binding

negative regulation of cell migration

receptor tyrosine kinase binding

MAP kinase phosphatase activity

MAP kinase phosphatase activity

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of MAPK cascade

positive regulation of mitotic cell cycle

positive regulation of mitotic cell cycle

negative regulation of JNK cascade

negative regulation of JNK cascade

negative regulation of T cell receptor signaling pathway

negative regulation of T cell receptor signaling pathway

negative regulation of T cell activation

negative regulation of T cell activation

negative regulation of chemotaxis

regulation of focal adhesion assembly

regulation of focal adhesion assembly

negative regulation of ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

cellular response to epidermal growth factor stimulus

cellular response to epidermal growth factor stimulus

positive regulation of focal adhesion disassembly

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

protein tyrosine kinase binding

04010

TC0900002036.mm.2 Chek1 checkpoint kinase 1 9 -36708481 NM_007691, BC100386 NM_007691, BC100386 117

DNA damage checkpoint

DNA damage checkpoint

DNA damage checkpoint

G2/M transition of mitotic cell cycle

nucleotide binding

chromosome, telomeric region

chromatin

condensed nuclear chromosome

inner cell mass cell proliferation

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

chromosome

cytoplasm

cytoplasm

centrosome

cytoskeleton

DNA repair

DNA repair

protein phosphorylation

protein phosphorylation

protein phosphorylation

apoptotic process

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

DNA damage induced protein phosphorylation

nucleus organization

cell cycle

mitotic cell cycle checkpoint

regulation of gene expression

regulation of double-strand break repair via homologous recombination

regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

negative regulation of G2/M transition of mitotic cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-threonine phosphorylation

protein domain specific binding

protein-containing complex

histone kinase activity (H3-T11 specific)

histone kinase activity (H3-T11 specific)

intracellular signal transduction

regulation of cell population proliferation

intracellular membrane-bounded organelle

mitotic G2/M transition checkpoint

positive regulation of cell cycle

negative regulation of mitotic nuclear division

regulation of mitotic centrosome separation

chromatin-mediated maintenance of transcription

signal transduction involved in G2 DNA damage checkpoint

apoptotic process involved in development

negative regulation of DNA biosynthetic process

regulation of histone H3-K9 acetylation

04110

04115

TC1400000777.mm.2 Dhrs4 dehydrogenase/reductase (SDR family) member 4 14 55478757, 55478757 NM_001037938, NM_030686, BC003484, BC054361 NM_001037938, NM_030686, BC003484, BC054361 NM_001037938, NM_030686, BC003484, BC054361 NM_001037938, NM_030686, BC003484, BC054361 24

3-keto sterol reductase activity

retinal dehydrogenase activity

carbonyl reductase (NADPH) activity

nucleus

mitochondrion

peroxisome

peroxisome

peroxisomal membrane

alcohol metabolic process

steroid metabolic process

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

alcohol dehydrogenase [NAD(P)+] activity

cellular ketone metabolic process

retinal metabolic process

identical protein binding

00830

01100

04146

TC0700003581.mm.2 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 7 -80094846 NM_173011, BC060030 NM_173011, BC060030 84

magnesium ion binding

isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

peroxisome

cytosol

glyoxylate cycle

tricarboxylic acid cycle

isocitrate metabolic process

NADP metabolic process

NADP biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

metal ion binding

NAD binding

negative regulation of glial cell proliferation

negative regulation of glial cell migration

negative regulation of matrix metallopeptidase secretion

00020

00480

01100

04146

TC1300002463.mm.2 Iqgap2 IQ motif containing GTPase activating protein 2 13 -95627176 NM_027711, BC150958 NM_027711, BC150958 39

GTPase activator activity

calmodulin binding

calmodulin binding

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

cytoplasm

microtubule

microvillus

signal transduction

cell surface

lamellipodium

filopodium

small GTPase binding

regulation of actin cytoskeleton organization

Arp2/3 complex-mediated actin nucleation

regulation of GTPase activity

actin filament binding

actin filament binding

thrombin-activated receptor signaling pathway

Arp2/3 complex binding

regulation of actin cytoskeleton reorganization

04810

TC1400001671.mm.2 Stab1 stabilin 1 14 -31139016 NM_138672 42

low-density lipoprotein particle receptor activity

scavenger receptor activity

calcium ion binding

hyaluronic acid binding

cytoplasm

integral component of plasma membrane

inflammatory response

cell adhesion

cell-cell signaling

membrane

integral component of membrane

negative regulation of angiogenesis

low-density lipoprotein particle binding

defense response to bacterium

 
TC0600001398.mm.2 Clec4a3 C-type lectin domain family 4, member a3 6 122952514, 122952643 NM_001204241, NM_153197, BC034893 NM_001204241, NM_153197, BC034893 NM_001204241, NM_153197, BC034893 11

molecular_function

cellular_component

biological_process

 
TC0900002451.mm.2 Kif23 kinesin family member 23 9 -61917277 NM_024245, BC047273 NM_024245, BC047273 34

nucleotide binding

mitotic cytokinesis

actomyosin contractile ring assembly

microtubule motor activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

centrosome

spindle

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

cell cycle

microtubule binding

microtubule binding

ATPase activity

midbody

positive regulation of cytokinesis

intercellular bridge

mitotic spindle midzone assembly

mitotic spindle midzone assembly

cell division

plus-end-directed vesicle transport along microtubule

mitotic spindle

Flemming body

centralspindlin complex

 
TC0100002772.mm.2         NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379  

chromosome, centromeric region

chromosome, centromeric region

condensed chromosome kinetochore

DNA binding

nucleus

nucleoplasm

chromosome

nucleolus

mitochondrion

cell cycle

chromosome segregation

CENP-A containing nucleosome assembly

histone binding

identical protein binding

regulation of protein-containing complex assembly

regulation of DNA binding

 
TC1000001546.mm.2 Cdk4 cyclin-dependent kinase 4 10 127063534 NM_009870, BC046336, BC052694 NM_009870, BC046336, BC052694 NM_009870, BC046336, BC052694 327

G1/S transition of mitotic cell cycle

nucleotide binding

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase holoenzyme complex

chromatin

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

nucleolus

cytoplasm

cytosol

bicellular tight junction

protein phosphorylation

protein phosphorylation

protein phosphorylation

cell cycle

signal transduction

positive regulation of cell population proliferation

RNA polymerase II CTD heptapeptide repeat kinase activity

response to organic substance

response to lead ion

regulation of gene expression

positive regulation of G2/M transition of mitotic cell cycle

membrane

kinase activity

phosphorylation

mediator complex

transferase activity

cyclin binding

cyclin binding

nuclear membrane

cellular response to insulin stimulus

protein-containing complex

response to testosterone

regulation of multicellular organism growth

regulation of cell population proliferation

positive regulation of apoptotic process

protein-containing complex binding

positive regulation of translation

positive regulation of cell size

regulation of insulin receptor signaling pathway

regulation of lipid biosynthetic process

positive regulation of fibroblast proliferation

perinuclear region of cytoplasm

regulation of lipid catabolic process

cell division

regulation of cell cycle

regulation of cell cycle

adipose tissue development

negative regulation of cell cycle arrest

cellular response to lipopolysaccharide

cellular response to interleukin-4

cyclin D2-CDK4 complex

cellular response to phorbol 13-acetate 12-myristate

cellular response to ionomycin

04110

04115

04530

04660

05200

05212

05214

05218

05219

05220

05222

05223

TC1400001665.mm.2         NM_153547, NR_028523, NR_104298, BC037996 NM_153547, NR_028523, NR_104298, BC037996 NM_153547, NR_028523, NR_104298, BC037996 NM_153547, NR_028523, NR_104298, BC037996  

nucleotide binding

molecular_function

protein binding

GTP binding

GTP binding

cellular_component

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

nucleolus

biological_process

cell population proliferation

nuclear body

stem cell division

stem cell population maintenance

midbody

positive regulation of telomere maintenance

positive regulation of protein sumoylation

regulation of cell population proliferation

mRNA 5'-UTR binding

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of protein localization to chromosome, telomeric region

 
TC0600003268.mm.2 Ybx3 Y box protein 3 6 -131364857 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 53

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

in utero embryonic development

nucleic acid binding

DNA binding

single-stranded DNA binding

single-stranded DNA binding

RNA binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytosol

gap junction

spermatogenesis

male gonad development

fertilization

regulation of gene expression

ribonucleoprotein complex binding

negative regulation of apoptotic process

positive regulation of organ growth

negative regulation of skeletal muscle tissue development

negative regulation of necroptotic process

cellular response to tumor necrosis factor

cellular hyperosmotic response

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

polysome binding

04530

TC0300002797.mm.2 S1pr1 sphingosine-1-phosphate receptor 1 3 -115710432 NM_007901, BC049094, BC051023 NM_007901, BC049094, BC051023 NM_007901, BC049094, BC051023 252

angiogenesis

angiogenesis

G protein-coupled receptor binding

blood vessel maturation

cardiac muscle tissue growth involved in heart morphogenesis

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

G protein-coupled receptor activity

G protein-coupled receptor activity

nucleoplasm

cytoplasm

endosome

plasma membrane

chemotaxis

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

brain development

positive regulation of cell population proliferation

external side of plasma membrane

membrane

integral component of membrane

cell migration

regulation of metabolic process

lamellipodium assembly

regulation of cell adhesion

positive regulation of cell migration

regulation of bone mineralization

leukocyte chemotaxis

intrinsic component of plasma membrane

actin cytoskeleton reorganization

sphingosine-1-phosphate receptor activity

sphingosine-1-phosphate receptor activity

sphingosine-1-phosphate receptor activity

intracellular membrane-bounded organelle

positive regulation of GTPase activity

regulation of bone resorption

positive regulation of transcription by RNA polymerase II

sphingolipid binding

positive regulation of smooth muscle cell proliferation

positive regulation of positive chemotaxis

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

negative regulation of stress fiber assembly

heart trabecula morphogenesis

T cell migration

04080

TC1100003399.mm.2 Ccl6 chemokine (C-C motif) ligand 6 11 -83587885 NM_009139, BC002073 NM_009139, BC002073 34

monocyte chemotaxis

cytokine activity

extracellular region

extracellular space

chemotaxis

inflammatory response

immune response

G protein-coupled receptor signaling pathway

chemokine activity

chemokine activity

neutrophil chemotaxis

positive regulation of GTPase activity

CCR chemokine receptor binding

lymphocyte chemotaxis

cell chemotaxis

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

04060

04062

TC0900001792.mm.2 Fat3 FAT atypical cadherin 3 9 -15910189 NM_001080814 25

cell morphogenesis involved in differentiation

neuron migration

calcium ion binding

plasma membrane

cell adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

multicellular organism development

retina layer formation

membrane

integral component of membrane

dendrite

cell-cell adhesion

negative regulation of dendrite development

 
TC0500003169.mm.2 Tpcn1 two pore channel 1 5 -120534156 NM_145853, BC058951 NM_145853, BC058951 40

ion channel activity

voltage-gated ion channel activity

voltage-gated calcium channel activity

voltage-gated sodium channel activity

calcium channel activity

lysosome

lysosomal membrane

lysosomal membrane

endosome

ion transport

calcium ion transport

endosome membrane

endosome membrane

positive regulation of autophagy

ligand-gated sodium channel activity

membrane

integral component of membrane

regulation of ion transmembrane transport

sodium ion transmembrane transport

identical protein binding

protein homodimerization activity

transmembrane transport

calcium ion transmembrane transport

NAADP-sensitive calcium-release channel activity

NAADP-sensitive calcium-release channel activity

phosphatidylinositol-3,5-bisphosphate binding

 
TC0900002044.mm.2 Slc37a2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 9 -37229148 NM_001145960, NM_020258, BC063326 NM_001145960, NM_020258, BC063326 NM_001145960, NM_020258, BC063326 18

endoplasmic reticulum

glycerol-3-phosphate metabolic process

glycerophosphate shuttle

carbohydrate transport

glycerol-3-phosphate transmembrane transporter activity

antiporter activity

glucose-6-phosphate transport

glucose-6-phosphate transport

glycerol-3-phosphate transmembrane transport

membrane

integral component of membrane

transmembrane transporter activity

integral component of endoplasmic reticulum membrane

integral component of endoplasmic reticulum membrane

phosphate ion transmembrane transport

phosphate ion transmembrane transport

transmembrane transport

glucose 6-phosphate:inorganic phosphate antiporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

 
TC0100001058.mm.2 Nifk nucleolar protein interacting with the FHA domain of MKI67 1 118321842 NM_026472, BC058559 NM_026472, BC058559 21

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

condensed nuclear chromosome

nucleic acid binding

RNA binding

RNA binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

cytoplasm

 
TC0700000896.mm.2 Nav2 neuron navigator 2 7 49246188, 48959072 NM_001111016, NM_175272, XR_105111, XR_105112 NM_001111016, NM_175272, XR_105111, XR_105112 NM_001111016, NM_175272, XR_105111, XR_105112 NM_001111016, NM_175272, XR_105111, XR_105112 34

regulation of systemic arterial blood pressure by baroreceptor feedback

interstitial matrix

nucleoplasm

nervous system development

nervous system development

sensory perception of sound

sensory perception of smell

locomotory behavior

heparin binding

optic nerve development

glossopharyngeal nerve development

vagus nerve development

cerebellar cortex development

extracellular matrix

3'-5' DNA helicase activity

 
TC0300002955.mm.2 Hadh hydroxyacyl-Coenzyme A dehydrogenase 3 -131233419 NM_008212, BC064712 NM_008212, BC064712 40

3-hydroxyacyl-CoA dehydrogenase activity

3-hydroxyacyl-CoA dehydrogenase activity

protein binding

nucleoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

response to activity

oxidoreductase activity

response to drug

identical protein binding

negative regulation of insulin secretion

regulation of insulin secretion

NAD+ binding

positive regulation of cold-induced thermogenesis

00062

00071

00280

00310

00380

00650

01100

TC0500002231.mm.2 Mxd4 Max dimerization protein 4 5 -34176579 NM_010753, BC011303 NM_010753, BC011303 31

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

protein binding

nucleus

regulation of transcription by RNA polymerase II

negative regulation of transcription, DNA-templated

protein dimerization activity

RNA polymerase II transcription regulator complex

 
TC0300001757.mm.2 Ect2 ect2 oncogene 3 -27097221, -27097221 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 48

mitotic cytokinesis

mitotic cytokinesis

cell morphogenesis

guanyl-nucleotide exchange factor activity

GTPase activator activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytoskeleton

cell-cell junction

bicellular tight junction

cell cortex

cell cycle

nervous system development

protein transport

nuclear body

cell junction

cell differentiation

midbody

small GTPase binding

activation of protein kinase activity

cleavage furrow

positive regulation of cytokinesis

regulation of Rho protein signal transduction

intracellular signal transduction

positive regulation of protein import into nucleus

protein homodimerization activity

positive regulation of apoptotic process

positive regulation of GTPase activity

positive regulation of neuron differentiation

regulation of protein kinase activity

protein homooligomerization

cell division

regulation of attachment of spindle microtubules to kinetochore

cellular response to hydrogen peroxide

bicellular tight junction assembly

cellular response to calcium ion

cellular response to ionizing radiation

mitotic spindle

activation of GTPase activity

activation of GTPase activity

centralspindlin complex

regulation of cytokinesis, actomyosin contractile ring assembly

 
TC1000001579.mm.2 Prim1 DNA primase, p49 subunit 10 128015214 NM_008921, BC089544 NM_008921, BC089544 29

DNA primase activity

DNA primase activity

DNA-directed 5'-3' RNA polymerase activity

protein binding

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

DNA replication

DNA replication, synthesis of RNA primer

DNA replication, synthesis of RNA primer

DNA replication, synthesis of RNA primer

transferase activity

nucleotidyltransferase activity

metal ion binding

primosome complex

00230

00240

01100

03030

TC1100004157.mm.2 Timp2 tissue inhibitor of metalloproteinase 2 11 -118301060 NM_011594, BC049126 NM_011594, BC049126 152

protease binding

protease binding

enzyme inhibitor activity

integrin binding

integrin binding

extracellular region

basement membrane

extracellular space

extracellular space

extracellular space

enzyme activator activity

metalloendopeptidase inhibitor activity

metalloendopeptidase inhibitor activity

metalloendopeptidase inhibitor activity

metalloendopeptidase inhibitor activity

zinc ion binding

negative regulation of cell population proliferation

negative regulation of cell population proliferation

response to hormone

cell surface

cell surface

response to organic substance

negative regulation of peptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

growth cone

extracellular matrix

regulation of Rap protein signal transduction

response to cytokine

neuron projection

neuronal cell body

regulation of MAPK cascade

positive regulation of MAPK cascade

regulation of neuron differentiation

regulation of neuron differentiation

positive regulation of neuron differentiation

positive regulation of adenylate cyclase activity

negative regulation of proteolysis

negative regulation of mitotic cell cycle

negative regulation of Ras protein signal transduction

metal ion binding

negative regulation of membrane protein ectodomain proteolysis

cellular response to organic substance

negative regulation of metallopeptidase activity

 
TC0200003109.mm.2 Hnmt histamine N-methyltransferase 2 -24002912 NM_080462, BC033928 NM_080462, BC033928 21

regulation of neurotransmitter levels

histamine metabolic process

histamine catabolic process

nucleoplasm

cytoplasm

centrosome

cytosol

methyltransferase activity

N-methyltransferase activity

transferase activity

methylation

neuron projection

histamine N-methyltransferase activity

00340

TC0500003516.mm.2 Gna12 guanine nucleotide binding protein, alpha 12 5 -140759943 NM_010302, BC111810 NM_010302, BC111810 87

nucleotide binding

G protein-coupled receptor binding

in utero embryonic development

GTPase activity

GTPase activity

GTPase activity

GTP binding

cytoplasm

heterotrimeric G-protein complex

heterotrimeric G-protein complex

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Rho protein signal transduction

Rho protein signal transduction

regulation of cell shape

regulation of fibroblast migration

membrane

guanyl nucleotide binding

cell differentiation

brush border membrane

brush border membrane

G-protein beta/gamma-subunit complex binding

D5 dopamine receptor binding

D5 dopamine receptor binding

regulation of TOR signaling

regulation of TOR signaling

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal ubiquitin-dependent protein catabolic process

intracellular signal transduction

embryonic digit morphogenesis

metal ion binding

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of vascular associated smooth muscle cell migration

04010

04270

04730

04810

TC0600000772.mm.2 Mad2l1 MAD2 mitotic arrest deficient-like 1 6 66535220 NM_019499, BC089012 NM_019499, BC089012 81

mitotic sister chromatid segregation

establishment of mitotic spindle orientation

chromosome, centromeric region

kinetochore

kinetochore

kinetochore

spindle pole

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

cytoplasm

cytosol

cytoskeleton

cell cycle

mitotic cell cycle checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

protein C-terminus binding

negative regulation of protein catabolic process

identical protein binding

protein homodimerization activity

negative regulation of apoptotic process

negative regulation of apoptotic process

nuclear pore nuclear basket

negative regulation of mitotic metaphase/anaphase transition

negative regulation of mitotic cell cycle

perinuclear region of cytoplasm

cell division

establishment of centrosome localization

mitotic spindle

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of mitotic cell cycle spindle assembly checkpoint

negative regulation of ubiquitin protein ligase activity

04110

04114

04914

TC0200004207.mm.2 Ldlrad3 low density lipoprotein receptor class A domain containing 3 2 -101950200 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 17

amyloid-beta binding

plasma membrane

receptor-mediated endocytosis

membrane

integral component of membrane

regulation of protein processing

 
TC0200001906.mm.2 Blvra biliverdin reductase A 2 127070656 NM_026678, BC052146 NM_026678, BC052146 37

nucleotide binding

biliverdin reductase (NAD(P)+) activity

biliverdin reductase (NAD(P)+) activity

biliverdin reductase (NAD(P)+) activity

cytoplasm

cytosol

zinc ion binding

oxidoreductase activity

heme catabolic process

metal ion binding

00860

TC0100003679.mm.2 Ephx1 epoxide hydrolase 1, microsomal 1 -180989555 NM_010145, BC029636, BC045194, BC057857, BC061493 NM_010145, BC029636, BC045194, BC057857, BC061493 NM_010145, BC029636, BC045194, BC057857, BC061493 NM_010145, BC029636, BC045194, BC057857, BC061493 NM_010145, BC029636, BC045194, BC057857, BC061493 51

catalytic activity

epoxide hydrolase activity

endoplasmic reticulum

plasma membrane

cellular aromatic compound metabolic process

response to toxic substance

response to organic cyclic compound

membrane

integral component of membrane

hydrolase activity

arachidonic acid metabolic process

aromatic compound catabolic process

enzyme binding

cis-stilbene-oxide hydrolase activity

diol biosynthetic process

intracellular membrane-bounded organelle

epoxide metabolic process

00980

04976

TC0600001448.mm.2 Nop2 NOP2 nucleolar protein 6 125131882 NM_138747, BC004733, BC007151 NM_138747, BC004733, BC007151 NM_138747, BC004733, BC007151 37

ribosomal large subunit assembly

maturation of LSU-rRNA

RNA methylation

blastocyst formation

RNA binding

nucleus

nucleolus

nucleolus

rRNA processing

methyltransferase activity

positive regulation of cell population proliferation

S-adenosylmethionine-dependent methyltransferase activity

rRNA (cytosine-C5-)-methyltransferase activity

transferase activity

methylation

ribosome biogenesis

rRNA base methylation

regulation of signal transduction by p53 class mediator

 
TC0300000693.mm.2 Cd5l CD5 antigen-like 3 87357880 NM_009690, BC006799, BC094459, CD5-like NM_009690, BC006799, BC094459, CD5-like NM_009690, BC006799, BC094459, CD5-like NM_009690, BC006799, BC094459, CD5-like 46

immune system process

serine-type endopeptidase activity

scavenger receptor activity

extracellular region

cytoplasm

plasma membrane

plasma membrane

apoptotic process

inflammatory response

cell surface

cell surface

membrane

regulation of complement activation

zymogen activation

positive regulation of complement-dependent cytotoxicity

 
TC0600001508.mm.2         NM_008021, NM_027697, BC065067, BC075723 NM_008021, NM_027697, BC065067, BC075723 NM_008021, NM_027697, BC065067, BC075723 NM_008021, NM_027697, BC065067, BC075723  

G2/M transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

vasculogenesis

liver development

molecular_function

DNA binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

cellular_component

nucleus

nucleus

DNA repair

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cell cycle

biological_process

positive regulation of cell population proliferation

positive regulation of cell population proliferation

protein kinase binding

negative regulation of stress-activated MAPK cascade

regulation of cell population proliferation

regulation of cell population proliferation

sequence-specific DNA binding

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of Ras protein signal transduction

regulation of cell cycle arrest

regulation of cell cycle arrest

negative regulation of cell aging

regulation of reactive oxygen species metabolic process

positive regulation of double-strand break repair

positive regulation of double-strand break repair

 
TC1200001030.mm.2 Ifi27 interferon, alpha-inducible protein 27 12 103434188 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 21

negative regulation of transcription by RNA polymerase II

RNA polymerase II activating transcription factor binding

lamin binding

nuclear inner membrane

mitochondrion

regulation of protein export from nucleus

apoptotic signaling pathway

 
TC0600001033.mm.2 Ruvbl1 RuvB-like protein 1 6 88465408 NM_019685, BC004718 NM_019685, BC004718 53

nucleotide binding

box C/D snoRNP assembly

Swr1 complex

Swr1 complex

TFIID-class transcription factor complex binding

DNA helicase activity

DNA helicase activity

transcription coactivator activity

helicase activity

protein binding

ATP binding

nucleus

nucleoplasm

cytosol

DNA repair

DNA recombination

chromatin organization

chromatin remodeling

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

cell cycle

positive regulation of plasminogen activation

nuclear matrix

histone acetylation

hydrolase activity

ATPase activity

TBP-class protein binding

Ino80 complex

Ino80 complex

protein-containing complex

NuA4 histone acetyltransferase complex

NuA4 histone acetyltransferase complex

regulation of growth

3'-5' DNA helicase activity

5'-3' DNA helicase activity

ADP binding

histone H4 acetylation

histone H2A acetylation

ATPase binding

cell division

MLL1 complex

positive regulation of canonical Wnt signaling pathway

R2TP complex

R2TP complex

ribonucleoprotein complex

regulation of fibroblast apoptotic process

04310

TC1100003059.mm.2         NM_001034097, NM_001159503, NM_001159505, NM_011614, NM_023517, BC069900, BC096441 NM_001034097, NM_001159503, NM_001159505, NM_011614, NM_023517, BC069900, BC096441 NM_001034097, NM_001159503, NM_001159505, NM_011614, NM_023517, BC069900, BC096441 NM_001034097, NM_001159503, NM_001159505, NM_011614, NM_023517, BC069900, BC096441 NM_001034097, NM_001159503, NM_001159505, NM_011614, NM_023517, BC069900, BC096441 NM_001034097, NM_001159503, NM_001159505, NM_011614, NM_023517, BC069900, BC096441 NM_001034097, NM_001159503, NM_001159505, NM_011614, NM_023517, BC069900, BC096441  

angiogenesis

immune system process

immunoglobulin production in mucosal tissue

positive regulation of germinal center formation

cytokine activity

tumor necrosis factor receptor binding

extracellular region

extracellular region

extracellular space

cytoplasm

plasma membrane

apoptotic process

immune response

multicellular organism development

positive regulation of cell population proliferation

external side of plasma membrane

membrane

integral component of membrane

immunoglobulin mediated immune response

cell differentiation

positive regulation of protein catabolic process

receptor ligand activity

positive regulation of isotype switching to IgA isotypes

positive regulation of isotype switching to IgA isotypes

positive regulation of isotype switching to IgA isotypes

perinuclear region of cytoplasm

regulation of immune response

extrinsic apoptotic signaling pathway

extrinsic apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

 
TC1300002654.mm.2 Gapt Grb2-binding adaptor, transmembrane 13 -110352614 NM_177713, BC116629, BC118005 NM_177713, BC116629, BC118005 NM_177713, BC116629, BC118005 14

B cell homeostasis

B cell homeostasis

B cell proliferation involved in immune response

B cell proliferation involved in immune response

immunoglobulin production involved in immunoglobulin-mediated immune response

immunoglobulin production involved in immunoglobulin-mediated immune response

Golgi apparatus

plasma membrane

membrane

integral component of membrane

B cell activation

intracellular membrane-bounded organelle

 
TC1600001320.mm.2 Cdc45 cell division cycle 45 16 -18780446 NM_001161623, NM_009862, BC028635 NM_001161623, NM_009862, BC028635 NM_001161623, NM_009862, BC028635 41

double-strand break repair via break-induced replication

chromatin binding

DNA replication origin binding

single-stranded DNA binding

nucleus

nucleoplasm

centrosome

DNA replication

DNA replication initiation

cell cycle

DNA replication preinitiation complex

regulation of chromatin silencing at telomere

ciliary basal body

mitotic DNA replication preinitiation complex assembly

04110

TC0200001056.mm.2 Cdca7 cell division cycle associated 7 2 72476218 NM_025866, BC066169 NM_025866, BC066169 36

molecular_function

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

regulation of transcription, DNA-templated

apoptotic process

regulation of cell population proliferation

 
TC1100002694.mm.2 Hnrnpab heterogeneous nuclear ribonucleoprotein A/B 11 -51600099 NM_001048061, NM_010448, BC043069 NM_001048061, NM_010448, BC043069 NM_001048061, NM_010448, BC043069 55

negative regulation of transcription by RNA polymerase II

epithelial to mesenchymal transition

nucleic acid binding

DNA binding

RNA binding

RNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

regulation of gene expression

positive regulation of transcription, DNA-templated

RNA polymerase II transcription regulator complex

presynaptic cytosol

ribonucleoprotein complex

 
TC0100003505.mm.2 Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 1 -169949536 NM_010476 38

3-keto sterol reductase activity

3-keto sterol reductase activity

3-keto sterol reductase activity

estradiol 17-beta-dehydrogenase activity

estradiol 17-beta-dehydrogenase activity

prolactin receptor binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

estrogen biosynthetic process

estrogen biosynthetic process

nervous system development

brain development

androgen metabolic process

androgen metabolic process

membrane

integral component of membrane

oxidoreductase activity

cell differentiation

5alpha-androstane-3beta,17beta-diol dehydrogenase activity

5alpha-androstane-3beta,17beta-diol dehydrogenase activity

embryonic organ development

embryonic skeletal system development

00100

00140

01100

TC1000000402.mm.2 Cd24a CD24a antigen 10 43579168 NM_009846, BC075622, CD24a NM_009846, BC075622, CD24a NM_009846, BC075622, CD24a 167

response to hypoxia

cell activation

regulation of cytokine-mediated signaling pathway

response to molecule of bacterial origin

pre-B cell differentiation

immune system process

leukocyte migration involved in inflammatory response

positive regulation of T cell mediated immune response to tumor cell

positive regulation of inflammatory response to antigenic stimulus

positive regulation of B cell apoptotic process

protein binding

plasma membrane

plasma membrane

cell adhesion

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

leukocyte cell-cell adhesion

cell surface receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

neuromuscular synaptic transmission

neuromuscular synaptic transmission

negative regulation of neuroblast proliferation

apoptotic mitochondrial changes

external side of plasma membrane

external side of plasma membrane

cell surface

positive regulation of neuron projection development

positive regulation of neuron projection development

membrane

membrane

cell migration

protein kinase binding

regulation of cell-cell adhesion

positive regulation of cell-cell adhesion

carbohydrate binding

apoptotic nuclear changes

protein tyrosine kinase activator activity

Hsp70 protein binding

negative regulation of B cell proliferation

neuron projection development

neuron projection development

anchored component of membrane

T cell costimulation

anchored component of external side of plasma membrane

anchored component of external side of plasma membrane

anchored component of external side of plasma membrane

microvillus membrane

chemokine receptor transport out of membrane raft

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

negative regulation of transforming growth factor beta3 production

positive regulation of integrin activation

positive regulation of integrin activation

positive regulation of cell adhesion mediated by integrin

positive regulation of cell adhesion mediated by integrin

regulation of cell-cell adhesion mediated by integrin

positive regulation of cell-cell adhesion mediated by integrin

negative regulation of erythrocyte clearance

homotypic cell-cell adhesion

negative regulation of erythrocyte aggregation

positive regulation of T cell homeostatic proliferation

positive regulation of activated T cell proliferation

regulation of phosphorylation

cholesterol homeostasis

positive regulation of MAP kinase activity

regulation of MAPK cascade

response to estrogen

innate immune response

membrane raft

membrane raft

regulation of B cell differentiation

negative regulation of neuron differentiation

respiratory burst

negative regulation of T cell homeostatic proliferation

positive regulation of alpha-beta T cell proliferation

positive regulation of alpha-beta T cell proliferation

synaptic vesicle endocytosis

positive regulation of peptidyl-tyrosine phosphorylation

negative regulation of neurogenesis

positive regulation of calcium-mediated signaling

Hsp90 protein binding

ciliary membrane

negative regulation of monocyte chemotactic protein-1 production

apoptotic signaling pathway

negative regulation of inflammatory response to wounding

positive regulation of inflammatory response to wounding

04640

TC1100001634.mm.2 Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 11 101010397, 101009440, 101009440, 101009440 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 48

vacuolar proton-transporting V-type ATPase, V0 domain

protein binding

cytoplasm

Golgi apparatus

cytosol

plasma membrane

plasma membrane

ion transport

vacuolar acidification

synaptic vesicle

proton transmembrane transporter activity

membrane

integral component of membrane

regulation of macroautophagy

vacuolar proton-transporting V-type ATPase complex

nuclear speck

integral component of synaptic vesicle membrane

cytoplasmic vesicle

proton-transporting V-type ATPase, V0 domain

intracellular organelle

intracellular membrane-bounded organelle

proton-transporting ATPase activity, rotational mechanism

perinuclear region of cytoplasm

ATPase binding

ATPase binding

toxin transport

proton transmembrane transport

00190

01100

04142

04145

04966

05323

TC1100003434.mm.2 Brip1 BRCA1 interacting protein C-terminal helicase 1 11 -86058135 NM_178309, BC094252 NM_178309, BC094252 22

nucleotide binding

nucleic acid binding

DNA binding

DNA helicase activity

chromatin binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

nucleobase-containing compound metabolic process

DNA repair

nucleotide-excision repair

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

homologous chromosome pairing at meiosis

spermatogenesis

spermatogonial cell division

spermatid development

negative regulation of cell population proliferation

male gonad development

negative regulation of gene expression

meiotic DNA double-strand break processing involved in reciprocal meiotic recombination

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

nuclear membrane

metal ion binding

chiasma assembly

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

seminiferous tubule development

double-strand break repair involved in meiotic recombination

double-strand break repair involved in meiotic recombination

 
TC0100001381.mm.2 Rgs16 regulator of G-protein signaling 16 1 153740352 NM_011267, BC010980, BC049968, BC055459 NM_011267, BC010980, BC049968, BC055459 NM_011267, BC010980, BC049968, BC055459 NM_011267, BC010980, BC049968, BC055459 45

GTPase activator activity

GTPase activator activity

GTPase activator activity

protein binding

cytoplasm

cytoplasm

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

negative regulation of signal transduction

membrane

intrinsic component of membrane

positive regulation of GTPase activity

positive regulation of GTPase activity

membrane raft

 
TC1200001460.mm.2 Lpin1 lipin 1 12 -16535668, -16535668 NM_001130412, NM_015763, NM_172950, BC042462 NM_001130412, NM_015763, NM_172950, BC042462 NM_001130412, NM_015763, NM_172950, BC042462 NM_001130412, NM_015763, NM_172950, BC042462 127

negative regulation of transcription by RNA polymerase II

mitochondrial fission

RNA polymerase II transcription factor binding

transcription coactivator activity

transcription coactivator activity

protein binding

nucleus

nucleus

transcription regulator complex

cytoplasm

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

DNA replication

regulation of transcription by RNA polymerase II

lipid metabolic process

triglyceride mobilization

immune response

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

fatty acid catabolic process

fatty acid catabolic process

membrane

hydrolase activity

triglyceride biosynthetic process

positive regulation of histone deacetylation

ruffle organization

actin cytoskeleton reorganization

negative regulation of myelination

nuclear membrane

cellular response to insulin stimulus

cellular response to insulin stimulus

cellular response to insulin stimulus

histone deacetylase binding

peroxisome proliferator activated receptor binding

cellular lipid metabolic process

cellular lipid metabolic process

fat cell differentiation

regulation of fat cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

phosphatidic acid metabolic process

positive regulation of cold-induced thermogenesis

regulation of phosphatidate phosphatase activity

 
TC0500000008.mm.2 Cdk6 cyclin-dependent kinase 6 5 3343892 NM_009873, BC119360, BC120595 NM_009873, BC119360, BC120595 NM_009873, BC119360, BC120595 139

negative regulation of transcription by RNA polymerase II

nucleotide binding

cyclin-dependent protein kinase holoenzyme complex

ruffle

positive regulation of cell-matrix adhesion

hematopoietic progenitor cell differentiation

type B pancreatic cell development

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

centrosome

cytosol

cytoskeleton

protein phosphorylation

protein phosphorylation

cell cycle

Notch signaling pathway

Notch signaling pathway

RNA polymerase II CTD heptapeptide repeat kinase activity

regulation of gene expression

positive regulation of gene expression

kinase activity

phosphorylation

mediator complex

transferase activity

hemopoiesis

cell differentiation

cyclin binding

T cell differentiation in thymus

response to 5-fluorouracil

gliogenesis

regulation of cell population proliferation

cell projection

cell dedifferentiation

cell quiescence

negative regulation of myeloid cell differentiation

regulation of erythrocyte differentiation

negative regulation of monocyte differentiation

negative regulation of osteoblast differentiation

negative regulation of cell cycle

positive regulation of fibroblast proliferation

negative regulation of epithelial cell proliferation

cell division

regulation of cell cycle

hematopoietic stem cell differentiation

cyclin D2-CDK6 complex

FBXO family protein binding

regulation of hematopoietic stem cell differentiation

negative regulation of cellular senescence

04110

04115

05200

05212

05214

05218

05220

05222

05223

TC1400001031.mm.2 Rcbtb2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 14 73142509, 73142784 NM_001170694, NM_134083, NR_033185, BC003224 NM_001170694, NM_134083, NR_033185, BC003224 NM_001170694, NM_134083, NR_033185, BC003224 NM_001170694, NM_134083, NR_033185, BC003224 17

acrosomal vesicle

molecular_function

biological_process

cytoplasmic vesicle

 
TC1200000596.mm.2 Frmd6 FERM domain containing 6 12 70825513 NM_028127, BC053929 NM_028127, BC053929 24

apical constriction

protein binding

cytoplasm

cytoskeleton

plasma membrane

membrane

actomyosin structure organization

regulation of actin filament-based process

cellular protein localization

apical junction complex

 
TC0400001158.mm.2 Kti12 KTI12 homolog, chromatin associated 4 108847856 NM_029571, BC021493 NM_029571, BC021493 12

nucleotide binding

tRNA wobble uridine modification

molecular_function

ATP binding

regulation of transcription by RNA polymerase II

elongator holoenzyme complex

 
TC1300000260.mm.2 H2ac4 H2A clustered histone 4 13 23751087 NM_175660, BC117110, BC153047 NM_175660, BC117110, BC153047 NM_175660, BC117110, BC153047 7

DNA binding

nucleus

chromatin silencing

05322

TC1000000422.mm.2 Prep prolyl endopeptidase 10 45067215 NM_011156, BC012869, BC050830 NM_011156, BC012869, BC050830 NM_011156, BC012869, BC050830 58

endopeptidase activity

endopeptidase activity

serine-type endopeptidase activity

nucleus

cytoplasm

cytosol

cytosol

proteolysis

peptidase activity

serine-type peptidase activity

hydrolase activity

protein metabolic process

peptide binding

serine-type exopeptidase activity

oligopeptidase activity

 
TC1400002231.mm.2 Msra methionine sulfoxide reductase A 14 -64122620, -64122620, -64122620, -64122620, -64122620 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 79

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

cytosol

plasma membrane

aging

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

actin cytoskeleton

membrane

oxidoreductase activity

cellular response to oxidative stress

L-methionine-(S)-S-oxide reductase activity

 
TC0400001129.mm.2 Ndc1 NDC1 transmembrane nucleoporin 4 107368046 NM_028355, BC021337 NM_028355, BC021337 28

nucleus

nuclear pore

nuclear pore

cytoplasm

plasma membrane

nuclear pore organization

homologous chromosome pairing at meiosis

spermatogenesis

protein transport

actin cytoskeleton

membrane

integral component of membrane

structural constituent of nuclear pore

protein-macromolecule adaptor activity

nuclear membrane

mRNA transport

nuclear pore complex assembly

nuclear pore localization

nuclear pore transmembrane ring

03013

TC1400000980.mm.2 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 14 69337150, 69555400 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 23

Golgi membrane

autophagosome membrane

guanosine-diphosphatase activity

guanosine-diphosphatase activity

Golgi apparatus

UDP catabolic process

nucleoside diphosphate catabolic process

membrane

nucleoside-diphosphatase activity

nucleoside-diphosphatase activity

nucleoside-triphosphatase activity

integral component of Golgi membrane

cytidine-diphosphatase activity

CTPase activity

uridine-diphosphatase activity

uridine-diphosphatase activity

integral component of autophagosome membrane

00230

00240

04142

TC1100000573.mm.2 Nhp2 NHP2 ribonucleoprotein 11 51619772 NM_026631, BC024944 NM_026631, BC024944 29

cleavage involved in rRNA processing

maturation of LSU-rRNA

RNA binding

RNA binding

protein binding

nucleus

telomerase holoenzyme complex

nucleolus

rRNA processing

telomere maintenance via telomerase

rRNA pseudouridine synthesis

snRNA pseudouridine synthesis

box H/ACA snoRNP complex

box H/ACA snoRNP complex

box H/ACA snoRNA binding

box H/ACA snoRNA binding

ribosome biogenesis

telomerase RNA binding

box H/ACA telomerase RNP complex

03008

TC0600000570.mm.2 Tmem176a transmembrane protein 176A 6 48841655, 48841482 NM_001098271, NM_025326, BC010831 NM_001098271, NM_025326, BC010831 NM_001098271, NM_025326, BC010831 18

protein binding

membrane

integral component of membrane

negative regulation of dendritic cell differentiation

negative regulation of dendritic cell differentiation

 
TC0300001488.mm.2 Mcoln3 mucolipin 3 3 146121790 NM_134160, BC106856, BC106857 NM_134160, BC106856, BC106857 NM_134160, BC106856, BC106857 53

cation channel activity

cytoplasm

lysosomal membrane

endosome

plasma membrane

plasma membrane

ion transport

sensory perception of sound

locomotory behavior

lipid binding

membrane

integral component of membrane

cytoplasmic vesicle

inner ear auditory receptor cell differentiation

cell projection

NAADP-sensitive calcium-release channel activity

 
TC1100004128.mm.2 Srsf2 serine and arginine-rich splicing factor 2 11 -116849896 NM_011358, BC005493 NM_011358, BC005493 92

regulation of alternative mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

protein kinase C binding

protein binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

cytosol

mRNA processing

RNA splicing

nuclear speck

nuclear speck

nuclear speck

interchromatin granule

pre-mRNA binding

regulation of RNA splicing

03040

TC0600001852.mm.2 Ica1 islet cell autoantigen 1 6 -8630526, -8630526 NM_001252266, NM_010492, BC002030 NM_001252266, NM_010492, BC002030 NM_001252266, NM_010492, BC002030 37

Golgi membrane

protein binding

cytoplasm

Golgi apparatus

Golgi stack

cytosol

cytosol

neurotransmitter transport

membrane

protein domain specific binding

cell junction

dendrite

secretory granule membrane

synaptic vesicle membrane

cytoplasmic vesicle

intracellular membrane-bounded organelle

regulation of protein-containing complex assembly

synapse

regulation of neurotransmitter secretion

perinuclear region of cytoplasm

regulation of insulin secretion

regulation of transport

membrane curvature sensor activity

04940

TC0200001972.mm.2         NM_024193, NR_028528, BC021355 NM_024193, NR_028528, BC021355 NM_024193, NR_028528, BC021355  

fibrillar center

molecular_function

RNA binding

cellular_component

nucleus

sno(s)RNA-containing ribonucleoprotein complex

cytoplasm

biological_process

snoRNA binding

snoRNA binding

box C/D RNP complex

small-subunit processome

ribosome biogenesis

pre-snoRNP complex

histone methyltransferase binding

 
TC1600002082.mm.2 Gart phosphoribosylglycinamide formyltransferase 16 -91621396 NM_010256, BC070465 NM_010256, BC070465 40

nucleotide binding

catalytic activity

phosphoribosylamine-glycine ligase activity

phosphoribosylamine-glycine ligase activity

phosphoribosylformylglycinamidine cyclo-ligase activity

phosphoribosylformylglycinamidine cyclo-ligase activity

phosphoribosylglycinamide formyltransferase activity

ATP binding

cytosol

purine nucleotide biosynthetic process

'de novo' IMP biosynthetic process

glycine metabolic process

metabolic process

biosynthetic process

purine nucleobase biosynthetic process

ribonucleoside monophosphate biosynthetic process

response to organic substance

response to inorganic substance

transferase activity

hydroxymethyl-, formyl- and related transferase activity

ligase activity

adenine biosynthetic process

tetrahydrofolate biosynthetic process

metal ion binding

00230

00670

01100

TC0900001210.mm.2 Tfdp2 transcription factor Dp 2 9 96259247, 96196274, 96258704 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 37

mitotic cell cycle

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

transcription coregulator activity

protein binding

nucleus

nuclear envelope

nucleoplasm

nucleoplasm

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cell cycle

transcription factor binding

protein domain specific binding

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of cell cycle

mitotic spindle

RNA polymerase II transcription regulator complex

04110

TC1300000240.mm.2         NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303  

nuclear chromosome

nucleosome

DNA binding

nucleus

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

chromatin silencing

negative regulation of cell population proliferation

enzyme binding

protein-containing complex

regulation of gene silencing

 
TC0100002481.mm.2 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 1 -65158615, -65158615 NM_001111320, NM_010497, BC088986 NM_001111320, NM_010497, BC088986 NM_001111320, NM_010497, BC088986 147

magnesium ion binding

isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

peroxisome

peroxisome

cytosol

cytosol

cytosol

glyoxylate cycle

tricarboxylic acid cycle

isocitrate metabolic process

isocitrate metabolic process

2-oxoglutarate metabolic process

NADP metabolic process

glutathione metabolic process

response to oxidative stress

response to organic cyclic compound

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

identical protein binding

protein homodimerization activity

metal ion binding

response to steroid hormone

NADP binding

NAD binding

regulation of phospholipid catabolic process

regulation of phospholipid biosynthetic process

00020

00480

01100

04146

TC1200001348.mm.2 Efr3b EFR3 homolog B 12 -3962553 NM_001082483, BC147643, BC157968 NM_001082483, BC147643, BC157968 NM_001082483, BC147643, BC157968 14

molecular_function

cytoplasm

cytosol

plasma membrane

plasma membrane

actin cytoskeleton

membrane

phosphatidylinositol phosphorylation

protein localization to plasma membrane

protein localization to plasma membrane

 
TC0900000854.mm.2 Pclaf PCNA clamp associated factor 9 65890322 NM_026515, BC021413, BC096393 NM_026515, BC021413, BC096393 NM_026515, BC021413, BC096393 31

chromatin binding

chromatin binding

nucleus

nucleus

cytoplasm

centrosome

DNA replication

DNA repair

cellular response to DNA damage stimulus

centrosome cycle

response to UV

translesion synthesis

translesion synthesis

perinuclear region of cytoplasm

regulation of cell cycle

 
TC0700003024.mm.2 Grwd1 glutamate-rich WD repeat containing 1 7 -45825225, -45825222 NM_153419, BC028896 NM_153419, BC028896 19

chromatin binding

DNA replication origin binding

nucleus

nucleoplasm

chromosome

nucleolus

cytosol

DNA replication

nucleosome assembly

nucleosome disassembly

protein-containing complex

histone binding

 
TC0600000711.mm.2 Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) 6 58596671, 58584532, 58640545, 58595959 NM_011920, BC053730 NM_011920, BC053730 176

nucleotide binding

ATP binding

nucleus

nucleoplasm

mitochondrion

plasma membrane

plasma membrane

plasma membrane

cytoskeletal protein binding

organic anion transmembrane transporter activity

ABC-type xenobiotic transporter activity

urate transmembrane transporter activity

biotin transmembrane transporter activity

efflux transmembrane transporter activity

efflux transmembrane transporter activity

organic anion transport

urate transport

biotin transport

membrane

integral component of membrane

apical plasma membrane

apical plasma membrane

ATPase activity

glucuronoside metabolic process

brush border membrane

riboflavin transmembrane transporter activity

riboflavin transmembrane transporter activity

riboflavin transport

riboflavin transport

ATPase-coupled transmembrane transporter activity

identical protein binding

protein homodimerization activity

amide transmembrane transporter activity

xenobiotic transmembrane transporter activity

membrane raft

urate metabolic process

transmembrane transport

embryonic process involved in female pregnancy

protein-containing complex assembly

transepithelial transport

urate salt excretion

external side of apical plasma membrane

export across plasma membrane

negative regulation of intestinal absorption

cellular detoxification

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

02010

04976

TC1500002223.mm.2 Lima1 LIM domain and actin binding 1 15 -99778467, -99778467 NM_001113545, NM_023063, BC031490 NM_001113545, NM_023063, BC031490 NM_001113545, NM_023063, BC031490 51

stress fiber

ruffle

actin binding

actin monomer binding

protein binding

cytoplasm

cytosol

cytoskeleton

plasma membrane

plasma membrane

brush border

focal adhesion

lipid metabolic process

steroid metabolic process

cholesterol metabolic process

actin cytoskeleton

actin cytoskeleton

actin cytoskeleton

membrane

cell migration

intestinal cholesterol absorption

negative regulation of actin filament depolymerization

brush border membrane

ruffle organization

ruffle organization

cleavage furrow

cholesterol homeostasis

cell projection

metal ion binding

actin filament binding

actin filament binding

actin filament binding

actin filament bundle assembly

actin filament bundle assembly

 
TC1000002493.mm.2 Gamt guanidinoacetate methyltransferase 10 -80258150 NM_010255, BC049233 NM_010255, BC049233 39

nucleus

cytoplasm

cytosol

creatine biosynthetic process

creatine biosynthetic process

creatine biosynthetic process

spermatogenesis

methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

animal organ morphogenesis

transferase activity

guanidinoacetate N-methyltransferase activity

guanidinoacetate N-methyltransferase activity

methylation

regulation of multicellular organism growth

identical protein binding

cell projection

S-adenosylhomocysteine metabolic process

S-adenosylmethionine metabolic process

00260

00330

01100

TC1200002411.mm.2 Ckb creatine kinase, brain 12 -111669354 NM_021273, BC015271, BC106109 NM_021273, BC015271, BC106109 NM_021273, BC015271, BC106109 78

nucleotide binding

catalytic activity

creatine kinase activity

creatine kinase activity

protein binding

ATP binding

extracellular space

nucleus

cytoplasm

mitochondrion

cytosol

kinase activity

transferase activity

transferase activity, transferring phosphorus-containing groups

dendrite

cellular chloride ion homeostasis

ubiquitin protein ligase binding

neuronal cell body

myelin sheath

phosphocreatine biosynthetic process

00330

01100

TC1400001174.mm.2 Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 14 101653966 NM_016723, BC048481 NM_016723, BC048481 43

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

intracellular anatomical structure

nucleoplasm

cytoplasm

cytosol

proteolysis

ubiquitin-dependent protein catabolic process

adult walking behavior

peptidase activity

peptidase activity

cysteine-type peptidase activity

protein deubiquitination

protein deubiquitination

protein deubiquitination

protein deubiquitination

hydrolase activity

protein catabolic process

protein catabolic process

cellular response to insulin stimulus

eating behavior

ubiquitin binding

positive regulation of fat cell differentiation

retina development in camera-type eye

ubiquitinyl hydrolase activity

 
TC0200001951.mm.2 Slc20a1 solute carrier family 20, member 1 2 129198772, 129207095, 129198772 NM_001159593, NM_015747, BC015085 NM_001159593, NM_015747, BC015085 NM_001159593, NM_015747, BC015085 63

inorganic phosphate transmembrane transporter activity

high-affinity inorganic phosphate:sodium symporter activity

plasma membrane

integral component of plasma membrane

sodium ion transport

phosphate ion transport

symporter activity

membrane

integral component of membrane

biomineral tissue development

phosphate ion transmembrane transport

 
TC0700000798.mm.2         NM_025880, NR_028533, BC016099, BC059896 NM_025880, NR_028533, BC016099, BC059896 NM_025880, NR_028533, BC016099, BC059896 NM_025880, NR_028533, BC016099, BC059896  

molecular_function

cellular_component

biological_process

 
TC0300001181.mm.2 Dph5 diphthamide biosynthesis 5 3 115888182 NM_027193, BC060372 NM_027193, BC060372 16

diphthine synthase activity

cellular_component

methyltransferase activity

transferase activity

peptidyl-diphthamide biosynthetic process from peptidyl-histidine

methylation

 
TC0800002153.mm.2 Ankrd37 ankyrin repeat domain 37 8 -45996907 NM_001039562, BC039642, BC092377 NM_001039562, BC039642, BC092377 NM_001039562, BC039642, BC092377 14

protein binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

biological_process

 
TC0800001258.mm.2 Utp4 UTP4 small subunit processome component 8 106893639 NM_011574, BC027399, BC068113 NM_011574, BC027399, BC068113 NM_011574, BC027399, BC068113 28

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

fibrillar center

nucleus

chromosome

nucleolus

regulation of transcription, DNA-templated

rRNA processing

maturation of SSU-rRNA

90S preribosome

small-subunit processome

t-UTP complex

t-UTP complex

ribosome biogenesis

03008

TC0800001493.mm.2 Cdt1 chromatin licensing and DNA replication factor 1 8 122568014 NM_026014, BC048076 NM_026014, BC048076 45

DNA replication checkpoint

DNA replication checkpoint

DNA replication checkpoint

mitotic cell cycle

mitotic cell cycle

chromosome, centromeric region

kinetochore

DNA binding

DNA binding

chromatin binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

DNA replication

cell cycle

chromosome segregation

nuclear body

regulation of DNA-dependent DNA replication initiation

regulation of DNA-dependent DNA replication initiation

regulation of DNA-dependent DNA replication initiation

positive regulation of protein-containing complex assembly

regulation of chromosome organization

regulation of nuclear cell cycle DNA replication

positive regulation of chromatin binding

positive regulation of DNA replication

cell division

attachment of mitotic spindle microtubules to kinetochore

kinetochore organization

DNA polymerase binding

DNA replication preinitiation complex assembly

DNA replication preinitiation complex assembly

response to sorbitol

deactivation of mitotic spindle assembly checkpoint

regulation of DNA replication origin binding

negative regulation of protein localization to kinetochore

positive regulation of protein localization to kinetochore

positive regulation of DNA-dependent DNA replication

 
TC0100001244.mm.2 Ptpn7 protein tyrosine phosphatase, non-receptor type 7 1 135133308, 135132699 NM_177081, BC098475, BC138194, BC145190 NM_177081, BC098475, BC138194, BC145190 NM_177081, BC098475, BC138194, BC145190 NM_177081, BC098475, BC138194, BC145190 17

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

cytoplasm

cytosol

cytoskeleton

protein dephosphorylation

protein dephosphorylation

cytoplasmic side of plasma membrane

microtubule cytoskeleton

dephosphorylation

hydrolase activity

phosphatase activity

mitotic spindle

04010

TC0900001979.mm.2 Aplp2 amyloid beta (A4) precursor-like protein 2 9 -31149556 NM_001102455, NM_001102456, NM_009691, BC051999, BC052396 NM_001102455, NM_001102456, NM_009691, BC051999, BC052396 NM_001102455, NM_001102456, NM_009691, BC051999, BC052396 NM_001102455, NM_001102456, NM_009691, BC051999, BC052396 NM_001102455, NM_001102456, NM_009691, BC051999, BC052396 111

suckling behavior

DNA binding

protein binding

nucleus

plasma membrane

cellular copper ion homeostasis

regulation of epidermal growth factor-activated receptor activity

mating behavior

locomotory behavior

heparin binding

cholesterol metabolic process

embryo development

membrane

integral component of membrane

extracellular matrix organization

forebrain development

midbrain development

identical protein binding

regulation of protein binding

metal ion binding

transition metal ion binding

neuromuscular process controlling balance

 
TC1300001634.mm.2 H2ac8 H2A clustered histone 8 13 -23570662 NM_178187, BC058544, BC076498 NM_178187, BC058544, BC076498 NM_178187, BC058544, BC076498 12

DNA binding

nucleus

chromatin silencing

enzyme binding

05322

TC0X00003361.mm.2 Prps2 phosphoribosyl pyrophosphate synthetase 2 X -167346319 NM_026662, BC024942 NM_026662, BC024942 23

nucleotide binding

magnesium ion binding

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ATP binding

ATP binding

cytoplasm

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate biosynthetic process

purine nucleotide biosynthetic process

AMP biosynthetic process

nucleoside metabolic process

ribonucleoside monophosphate biosynthetic process

nucleotide biosynthetic process

AMP binding

kinase activity

phosphorylation

transferase activity

GDP binding

ribose phosphate metabolic process

carbohydrate binding

protein-containing complex

identical protein binding

ADP binding

cellular biosynthetic process

metal ion binding

00030

00230

01100

TC1700002414.mm.2 Rab31 RAB31, member RAS oncogene family 17 -65651725 NM_133685, BC013063 NM_133685, BC013063 25

nucleotide binding

phagocytic cup

GTPase activity

protein binding

GTP binding

cytoplasm

endosome

early endosome

late endosome

Golgi apparatus

trans-Golgi network

intracellular protein transport

endomembrane system

membrane

GDP binding

cytoplasmic vesicle

receptor internalization

trans-Golgi network membrane

trans-Golgi network membrane

cellular response to insulin stimulus

early phagosome membrane

Golgi to plasma membrane protein transport

Golgi to plasma membrane protein transport

regulated exocytosis

phagocytic vesicle

Golgi vesicle transport

positive regulation of phagocytosis, engulfment

phagosome maturation

04144

TC1600001308.mm.2 Ranbp1 RAN binding protein 1 16 -18239978 NM_011239, BC061140 NM_011239, BC061140 59

GDP-dissociation inhibitor activity

GTPase activator activity

nucleus

nuclear pore

cytoplasm

cytoplasm

cytoplasm

centrosome

centrosome

cytosol

spindle organization

positive regulation of neuron projection development

plasma membrane bounded cell projection cytoplasm

positive regulation of mitotic centrosome separation

positive regulation of mitotic centrosome separation

intracellular transport

cellular response to leptomycin B

axon cytoplasm

 
TC0X00001272.mm.2         NM_133196, NR_037299, BC036719 NM_133196, NR_037299, BC036719 NM_133196, NR_037299, BC036719  

nucleic acid binding

RNA binding

mRNA binding

nucleus

nucleoplasm

mRNA cleavage and polyadenylation specificity factor complex

mRNA cleavage and polyadenylation specificity factor complex

mRNA polyadenylation

mRNA processing

nuclear body

mRNA 3'-end processing

cleavage body

pre-mRNA cleavage required for polyadenylation

 
TC0500002420.mm.2 Sel1l3 sel-1 suppressor of lin-12-like 3 (C. elegans) 5 -53107082 NM_172710, BC094607, BC117915, BC117916 NM_172710, BC094607, BC117915, BC117916 NM_172710, BC094607, BC117915, BC117916 NM_172710, BC094607, BC117915, BC117916 18

molecular_function

nucleoplasm

biological_process

membrane

integral component of membrane

 
TC0500001648.mm.2 Nxpe5 neurexophilin and PC-esterase domain family, member 5 5 138225903 NM_001013773, BC055004, BC106195 NM_001013773, BC055004, BC106195 NM_001013773, BC055004, BC106195 10

molecular_function

cellular_component

biological_process

 
TC0400003349.mm.2 Mmachc methylmalonic aciduria cblC type, with homocystinuria 4 -116702433 NM_025962, BC054756 NM_025962, BC054756 21

cytoplasm

cytoplasm

mitochondrion

glutathione metabolic process

cobalamin metabolic process

cobalamin metabolic process

oxidoreductase activity

transferase activity

cobalamin binding

demethylase activity

demethylase activity

cyanocobalamin reductase (cyanide-eliminating) activity

cyanocobalamin reductase (cyanide-eliminating) activity

protein homodimerization activity

glutathione binding

demethylation

FAD binding

FAD binding

04977

TC0800003249.mm.2 Emc8 ER membrane protein complex subunit 8 8 -120653913 NM_010926, BC009103 NM_010926, BC009103 21

cytoplasm

mitochondrion

cytosol

membrane insertase activity

protein insertion into ER membrane by stop-transfer membrane-anchor sequence

tail-anchored membrane protein insertion into ER membrane

EMC complex

EMC complex

 
TC0100003204.mm.2 Rgs2 regulator of G-protein signaling 2 1 -143999337 NM_009061, BC023001 NM_009061, BC023001 111

G-protein alpha-subunit binding

GTPase activator activity

GTPase activator activity

protein binding

nucleus

nucleus

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

regulation of translation

cell cycle

G protein-coupled receptor signaling pathway

spermatogenesis

regulation of G protein-coupled receptor signaling pathway

cytoplasmic side of plasma membrane

cytoplasmic side of plasma membrane

negative regulation of signal transduction

negative regulation of phospholipase activity

negative regulation of cardiac muscle hypertrophy

positive regulation of neuron projection development

membrane

negative regulation of translation

neuron projection

negative regulation of MAP kinase activity

negative regulation of cAMP-mediated signaling

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway

beta-tubulin binding

brown fat cell differentiation

relaxation of cardiac muscle

relaxation of vascular associated smooth muscle

positive regulation of cardiac muscle contraction

negative regulation of cell growth involved in cardiac muscle cell development

negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process

negative regulation of glycine import across plasma membrane

 
TC0800000972.mm.2         NM_010062, NR_103491, BC058609, XR_106146, BC060661 NM_010062, NR_103491, BC058609, XR_106146, BC060661 NM_010062, NR_103491, BC058609, XR_106146, BC060661 NM_010062, NR_103491, BC058609, XR_106146, BC060661 NM_010062, NR_103491, BC058609, XR_106146, BC060661  

DNA catabolic process, endonucleolytic

nuclease activity

endonuclease activity

endodeoxyribonuclease activity

deoxyribonuclease II activity

deoxyribonuclease II activity

lysosome

DNA metabolic process

DNA catabolic process

apoptotic DNA fragmentation

apoptotic process

multicellular organism development

hydrolase activity

erythrocyte differentiation

regulation of immune response

 
TC0900001302.mm.2 Topbp1 topoisomerase (DNA) II binding protein 1 9 103305326 NM_176979, BC049797 NM_176979, BC049797 50

condensed nuclear chromosome

male germ cell nucleus

DNA binding

nucleus

nucleoplasm

chromosome

chromosome

cytoplasm

cytoskeleton

plasma membrane

DNA replication initiation

DNA repair

cellular response to DNA damage stimulus

mitotic G2 DNA damage checkpoint

reciprocal meiotic recombination

response to ionizing radiation

actin cytoskeleton

nuclear body

PML body

mitotic DNA replication checkpoint

identical protein binding

intracellular membrane-bounded organelle

 
TC0800001541.mm.2 Urb2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 8 124021496 NM_001029876, BC151125 NM_001029876, BC151125 13

molecular_function

nucleolus

nucleolus

aggresome

midbody

ribosome biogenesis

 
TC0700001871.mm.2 Fus fused in sarcoma 7 127967478 NM_139149, BC040827, BC058247 NM_139149, BC040827, BC058247 NM_139149, BC040827, BC058247 143

transcription coregulator activity

RNA binding

RNA binding

RNA binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

polysome

RNA splicing

gene expression

gene expression

estrogen receptor binding

dendrite

myosin V binding

ionotropic glutamate receptor binding

neuronal cell body

dendritic spine

perikaryon

dendritic spine head

retinoid X receptor binding

thyroid hormone receptor binding

mRNA stabilization

perinuclear region of cytoplasm

cellular response to calcium ion

 
TC1500001585.mm.2 Mtss1 MTSS I-BAR domain containing 1 15 -58941233 NM_001146180, NM_144800, BC024131 NM_001146180, NM_144800, BC024131 NM_001146180, NM_144800, BC024131 51

in utero embryonic development

actin binding

actin monomer binding

signaling receptor binding

protein binding

cytoplasm

cytoskeleton

adherens junction

plasma membrane organization

actin filament organization

nervous system development

muscle organ development

magnesium ion homeostasis

actin cytoskeleton

actin cytoskeleton organization

actin filament polymerization

bone mineralization

positive regulation of actin filament bundle assembly

adherens junction maintenance

identical protein binding

identical protein binding

negative regulation of epithelial cell proliferation

actin filament binding

renal tubule morphogenesis

cellular response to fluid shear stress

glomerulus morphogenesis

nephron tubule epithelial cell differentiation

metanephric tubule development

epithelial cell proliferation involved in renal tubule morphogenesis

 
TC0800001031.mm.2 Adcy7 adenylate cyclase 7 8 88282991, 88289065, 88272402, 88294203 NM_001037723, NM_001037724, NM_001109756, NM_007406, BC115833 NM_001037723, NM_001037724, NM_001109756, NM_007406, BC115833 NM_001037723, NM_001037724, NM_001109756, NM_007406, BC115833 NM_001037723, NM_001037724, NM_001109756, NM_007406, BC115833 NM_001037723, NM_001037724, NM_001109756, NM_007406, BC115833 30

nucleotide binding

regulation of adaptive immune response

adenylate cyclase activity

adenylate cyclase activity

adenylate cyclase activity

adenylate cyclase activity

adenylate cyclase activity

ATP binding

plasma membrane

integral component of plasma membrane

cAMP biosynthetic process

cAMP biosynthetic process

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

activation of adenylate cyclase activity

cyclic nucleotide biosynthetic process

membrane

integral component of membrane

lyase activity

phosphorus-oxygen lyase activity

intracellular signal transduction

metal ion binding

cellular response to lithium ion

cellular response to ethanol

negative regulation of cytokine production involved in inflammatory response

00230

04020

04062

04114

04270

04540

04912

04914

04916

04970

04971

04972

04976

05414

TC1100002069.mm.2 Metrnl meteorin, glial cell differentiation regulator-like 11 121702426 NM_144797, BC019776, BC024445, BC024497, BC026646 NM_144797, BC019776, BC024445, BC024497, BC026646 NM_144797, BC019776, BC024445, BC024497, BC026646 NM_144797, BC019776, BC024445, BC024497, BC026646 NM_144797, BC019776, BC024445, BC024497, BC026646 27

hormone activity

hormone activity

extracellular region

extracellular space

extracellular space

extracellular space

response to cold

response to muscle activity

fat cell differentiation

negative regulation of inflammatory response

brown fat cell differentiation

positive regulation of brown fat cell differentiation

positive regulation of brown fat cell differentiation

energy homeostasis

energy homeostasis

 
TC1900000312.mm.2 Prune2 prune homolog 2 19 16956117 NM_181348, BC095978 NM_181348, BC095978 29

exopolyphosphatase activity

cytoplasm

polyphosphate catabolic process

apoptotic process

pyrophosphatase activity

 
TC1300002269.mm.2 Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 13 -68560779, -68560779 NM_172480, BC025942 NM_172480, BC025942 26

NADPH-hemoprotein reductase activity

nucleoplasm

cytoplasm

cytosol

cytosol

DNA methylation

cellular amino acid biosynthetic process

methionine biosynthetic process

methionine biosynthetic process

methionine biosynthetic process

FMN binding

FMN binding

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

[methionine synthase] reductase activity

[methionine synthase] reductase activity

[methionine synthase] reductase activity

S-adenosylmethionine cycle

homocysteine catabolic process

intermediate filament cytoskeleton

folic acid metabolic process

folic acid metabolic process

flavin adenine dinucleotide binding

flavin adenine dinucleotide binding

homocysteine metabolic process

homocysteine metabolic process

protein stabilization

NADPH binding

FAD binding

negative regulation of cystathionine beta-synthase activity

 
TC1400001783.mm.2 Tspan14 tetraspanin 14 14 -40906426, -40906426 NM_145928, BC024611, BC025568, BC026574 NM_145928, BC024611, BC025568, BC026574 NM_145928, BC024611, BC025568, BC026574 NM_145928, BC024611, BC025568, BC026574 24

plasma membrane

integral component of plasma membrane

cell surface

membrane

integral component of membrane

enzyme binding

enzyme binding

positive regulation of Notch signaling pathway

protein maturation

protein maturation

protein localization to plasma membrane

tetraspanin-enriched microdomain

 
TC0900001101.mm.2 Ttk Ttk protein kinase 9 83834688, 83834688 NM_001110265, NM_001284272, NM_009445, BC058851 NM_001110265, NM_001284272, NM_009445, BC058851 NM_001110265, NM_001284272, NM_009445, BC058851 NM_001110265, NM_001284272, NM_009445, BC058851 34

nucleotide binding

kinetochore

kinetochore

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity

protein serine/threonine/tyrosine kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

cytoplasm

spindle

protein phosphorylation

chromosome segregation

mitotic cell cycle checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

membrane

kinase activity

phosphorylation

female meiosis chromosome segregation

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

peptidyl-tyrosine phosphorylation

meiotic spindle assembly checkpoint

meiotic spindle assembly checkpoint

protein localization to kinetochore

protein localization to kinetochore

protein localization to chromosome

identical protein binding

kinetochore binding

protein autophosphorylation

chromosome separation

meiotic prometaphase I

protein localization to meiotic spindle midzone

04110

TC0500001894.mm.2 Cyp51 cytochrome P450, family 51 5 -4080673 NM_020010, BC031813 NM_020010, BC031813 55

monooxygenase activity

iron ion binding

endoplasmic reticulum

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

sterol 14-demethylase activity

sterol 14-demethylase activity

membrane

integral component of membrane

sterol metabolic process

sterol biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

heme binding

cholesterol biosynthetic process via 24,25-dihydrolanosterol

negative regulation of protein catabolic process

intracellular membrane-bounded organelle

metal ion binding

negative regulation of protein secretion

negative regulation of amyloid-beta clearance

00100

01100

TC0300003221.mm.2 Wdr77 WD repeat domain 77 3 105959497 NM_027432, BC005755 NM_027432, BC005755 39

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

cytosol

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

pole plasm assembly

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

methyl-CpG binding

methyl-CpG binding

nuclear receptor coactivator activity

nuclear receptor coactivator activity

methylosome

methylosome

pole plasm

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of epithelial cell proliferation involved in prostate gland development

 
TC1800001087.mm.2 Tpgs2 tubulin polyglutamylase complex subunit 2 18 -25136038, -25127222, -25136038 NM_001004361, NM_001142697, NM_001142698, BC080777 NM_001004361, NM_001142697, NM_001142698, BC080777 NM_001004361, NM_001142697, NM_001142698, BC080777 NM_001004361, NM_001142697, NM_001142698, BC080777 19

molecular_function

cellular_component

cytoplasm

cytosol

cytoskeleton

microtubule

biological_process

protein polyglutamylation

protein polyglutamylation

 
TC0100003478.mm.2 Uck2 uridine-cytidine kinase 2 1 -167226083 NM_030724, BC023789 NM_030724, BC023789 24

nucleotide binding

uridine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

cytosol

CMP salvage

phosphorylation

transferase activity

nucleoside kinase activity

identical protein binding

intracellular membrane-bounded organelle

UMP salvage

00240

00983

01100

TC0700004363.mm.2 Rgs10 regulator of G-protein signalling 10 7 -128373624 NM_026418, BC109178 NM_026418, BC109178 37

G-protein alpha-subunit binding

GTPase activator activity

protein binding

nucleus

cytoplasm

cytosol

G protein-coupled acetylcholine receptor signaling pathway

regulation of G protein-coupled receptor signaling pathway

negative regulation of signal transduction

neuronal cell body

dendritic spine

positive regulation of GTPase activity

axon terminus

 
TC1100001973.mm.2 Birc5 baculoviral IAP repeat-containing 5 11 117849236 NM_001012273, NM_009689, BC004702 NM_001012273, NM_009689, BC004702 NM_001012273, NM_009689, BC004702 215

G2/M transition of mitotic cell cycle

microtubule cytoskeleton organization

nuclear chromosome

mitotic cytokinesis

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

cysteine-type endopeptidase inhibitor activity

protein binding

nucleus

nucleus

chromosome

cytoplasm

cytoplasm

cytoplasm

centriole

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cytoplasmic microtubule

protein phosphorylation

apoptotic process

cell cycle

chromosome segregation

mitotic spindle assembly checkpoint

regulation of mitotic cell cycle

microtubule binding

zinc ion binding

embryo development

negative regulation of peptidase activity

tubulin binding

apical plasma membrane

enzyme binding

peptidase inhibitor activity

midbody

interphase microtubule organizing center

small GTPase binding

protein-containing complex localization

positive regulation of exit from mitosis

chromosome passenger complex

protein-containing complex

identical protein binding

protein homodimerization activity

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cell cycle

negative regulation of transcription, DNA-templated

positive regulation of mitotic cell cycle

metal ion binding

protein heterodimerization activity

chaperone binding

cell division

establishment of chromosome localization

regulation of cell cycle

regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of type B pancreatic cell proliferation

05200

05210

TC0900001652.mm.2 Kif15 kinesin family member 15 9 122951080 NM_010620, BC060710 NM_010620, BC060710 26

nucleotide binding

microtubule motor activity

ATP binding

cytoplasm

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

microtubule binding

ATPase activity

 
TC1500002217.mm.2 Racgap1 Rac GTPase-activating protein 1 15 -99620495 NM_001253808, NM_001253809, NM_012025, BC010715 NM_001253808, NM_001253809, NM_012025, BC010715 NM_001253808, NM_001253809, NM_012025, BC010715 NM_001253808, NM_001253809, NM_012025, BC010715 52

mitotic cytokinesis

actomyosin contractile ring assembly

GTPase activator activity

phosphatidylinositol-3,4,5-trisphosphate binding

nucleus

nucleoplasm

cytoplasm

spindle

cytoskeleton

plasma membrane

ion transport

cell cycle

signal transduction

multicellular organism development

spermatogenesis

neuroblast proliferation

microtubule binding

sulfate transport

lipid binding

membrane

protein kinase binding

cell differentiation

midbody

extrinsic component of cytoplasmic side of plasma membrane

cytoplasmic vesicle

cleavage furrow

positive regulation of cytokinesis

intracellular signal transduction

alpha-tubulin binding

gamma-tubulin binding

regulation of embryonic development

metal ion binding

beta-tubulin binding

spindle midzone

mitotic spindle midzone assembly

cell division

regulation of attachment of spindle microtubules to kinetochore

mitotic spindle

centralspindlin complex

 
TC0600003373.mm.2 Recql RecQ protein-like 6 -142350341, -142361375, -142356946, -142361375 NM_001204906, NM_001204907, NM_023042, BC014735 NM_001204906, NM_001204907, NM_023042, BC014735 NM_001204906, NM_001204907, NM_023042, BC014735 NM_001204906, NM_001204907, NM_023042, BC014735 21

nucleotide binding

double-strand break repair via homologous recombination

DNA strand renaturation

nucleic acid binding

DNA binding

DNA helicase activity

helicase activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

DNA unwinding involved in DNA replication

DNA repair

DNA recombination

four-way junction helicase activity

hydrolase activity

DNA duplex unwinding

annealing helicase activity

annealing helicase activity

3'-5' DNA helicase activity

 
TC1200000647.mm.2 Prkch protein kinase C, eta 12 73584795 NM_008856, BC031121 NM_008856, BC031121 43

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein kinase C activity

calcium-independent protein kinase C activity

protein binding

ATP binding

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

cell-cell junction

protein phosphorylation

positive regulation of macrophage derived foam cell differentiation

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

enzyme binding

cell differentiation

small GTPase binding

negative regulation of glial cell apoptotic process

intracellular signal transduction

positive regulation of keratinocyte differentiation

metal ion binding

positive regulation of B cell receptor signaling pathway

positive regulation of NF-kappaB transcription factor activity

positive regulation of glial cell proliferation

protein kinase C signaling

regulation of bicellular tight junction assembly

04270

04530

TC0600000788.mm.2 Serbp1 serpine1 mRNA binding protein 1 6 67266978 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 38

RNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

PML body organization

SUMO binding

 
TC1300001353.mm.2 Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 13 119690350 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 44

catalytic activity

hydroxymethylglutaryl-CoA synthase activity

hydroxymethylglutaryl-CoA synthase activity

cytoplasm

cytosol

cytosol

acetyl-CoA metabolic process

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

isoprenoid biosynthetic process

farnesyl diphosphate biosynthetic process, mevalonate pathway

response to purine-containing compound

sterol biosynthetic process

transferase activity

isomerase activity

small molecule binding

protein homodimerization activity

organic acid binding

cellular response to low-density lipoprotein particle stimulus

00072

00280

00650

00900

01100

TC0300002203.mm.2 Tmem144 transmembrane protein 144 3 -79812563, -79812563, -79812563, -79812563 NM_027495, BC018493 NM_027495, BC018493 11

molecular_function

cellular_component

biological_process

carbohydrate transmembrane transporter activity

membrane

integral component of membrane

carbohydrate transmembrane transport

 
TC1500000053.mm.2 Nup155 nucleoporin 155 15 8109312 NM_133227, BC050919 NM_133227, BC050919 28

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

nucleus

nuclear envelope

nuclear pore

cytoplasm

RNA export from nucleus

mRNA export from nucleus

protein import into nucleus

protein import into nucleus

nucleocytoplasmic transport

nuclear envelope organization

protein transport

membrane

structural constituent of nuclear pore

nuclear membrane

protein localization to nuclear inner membrane

nuclear pore inner ring

mRNA transport

atrial cardiac muscle cell action potential

03013

TC0300000586.mm.2 Nmd3 NMD3 ribosome export adaptor 3 69722054 NM_133787, BC003842, NMD3(S NM_133787, BC003842, NMD3(S NM_133787, BC003842, NMD3(S 20

ribosomal large subunit export from nucleus

ribosomal large subunit export from nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

protein transport

protein-macromolecule adaptor activity

positive regulation of protein binding

ribosomal large subunit binding

ribosomal large subunit binding

positive regulation of RNA biosynthetic process

positive regulation of protein localization to nucleolus

03008

03013

TC0800003233.mm.2 Trmt1 tRNA methyltransferase 1 8 84689283, 84689246, 84686323 NM_001164559, NM_001164560, NM_198020, BC027404 NM_001164559, NM_001164560, NM_198020, BC027404 NM_001164559, NM_001164560, NM_198020, BC027404 NM_001164559, NM_001164560, NM_198020, BC027404 21

tRNA binding

tRNA N2-guanine methylation

RNA binding

tRNA (guanine-N2-)-methyltransferase activity

tRNA (guanine-N2-)-methyltransferase activity

nucleus

tRNA processing

methyltransferase activity

transferase activity

methylation

metal ion binding

 
TC1800000704.mm.2 Tubb6 tubulin, beta 6 class V 18 67390730 NM_026473, BC008225 NM_026473, BC008225 38

nucleotide binding

microtubule cytoskeleton organization

mitotic cell cycle

GTPase activity

structural constituent of cytoskeleton

GTP binding

cytoplasm

cytoskeleton

microtubule

microtubule

microtubule-based process

04145

04540

TC0800000987.mm.2 Orc6 origin recognition complex, subunit 6 8 85299631 NM_001163791, NM_019716, NR_028268, BC080739 NM_001163791, NM_019716, NR_028268, BC080739 NM_001163791, NM_019716, NR_028268, BC080739 NM_001163791, NM_019716, NR_028268, BC080739 21

origin recognition complex

fibrillar center

DNA binding

nucleus

nucleoplasm

nuclear origin of replication recognition complex

DNA replication

DNA-dependent DNA replication

DNA replication initiation

negative regulation of cell division

04110

TC0500001865.mm.2 Brca2 breast cancer 2, early onset 5 150522620 NM_001081001, NM_009765, BC172649 NM_001081001, NM_009765, BC172649 NM_001081001, NM_009765, BC172649 178

telomere maintenance via recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

chromosome, telomeric region

lateral element

oocyte maturation

inner cell mass cell proliferation

protease binding

DNA binding

single-stranded DNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

centrosome

cytosol

cytoskeleton

DNA repair

nucleotide-excision repair

double-strand break repair

double-strand break repair

DNA recombination

regulation of transcription, DNA-templated

cellular response to DNA damage stimulus

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cell cycle

male meiosis I

male meiosis I

spermatogenesis

spermatogenesis

brain development

cell aging

protein C-terminus binding

cell population proliferation

female gonad development

intrinsic apoptotic signaling pathway in response to DNA damage

response to X-ray

response to UV-C

response to gamma radiation

H3 histone acetyltransferase activity

H4 histone acetyltransferase activity

hemopoiesis

secretory granule

mammary gland development

homologous chromosome orientation involved in meiotic metaphase I plate congression

regulation of cytokinesis

protein-containing complex

BRCA2-MAGE-D1 complex

negative regulation of mammary gland epithelial cell proliferation

multicellular organism growth

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

chordate embryonic development

gamma-tubulin binding

histone H3 acetylation

histone H4 acetylation

positive regulation of transcription, DNA-templated

positive regulation of mitotic cell cycle

replication fork protection

chromosome organization

centrosome duplication

establishment of protein localization to telomere

establishment of protein localization to telomere

mitotic recombination-dependent replication fork processing

03440

05200

05212

TC1100004296.mm.2 Nme1 NME/NM23 nucleoside diphosphate kinase 1 11 -93958924, -93958924 NM_008704, BC005629, NME/NM23 NM_008704, BC005629, NME/NM23 NM_008704, BC005629, NME/NM23 75

nucleotide binding

magnesium ion binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

negative regulation of myeloid leukocyte differentiation

single-stranded DNA binding

deoxyribonuclease activity

nucleoside diphosphate kinase activity

nucleoside diphosphate kinase activity

ATP binding

GTP binding

nucleus

cytoplasm

mitochondrion

mitochondrial outer membrane

centrosome

cytosol

intermediate filament

nucleoside diphosphate phosphorylation

GTP biosynthetic process

UTP biosynthetic process

CTP biosynthetic process

endocytosis

nervous system development

lactation

nucleotide metabolic process

negative regulation of gene expression

positive regulation of neuron projection development

membrane

kinase activity

phosphorylation

transferase activity

intermediate filament binding

enzyme binding

protein kinase binding

cell differentiation

mammary gland development

ruffle membrane

identical protein binding

gamma-tubulin binding

ribosomal small subunit binding

myelin sheath

positive regulation of DNA binding

metal ion binding

perinuclear region of cytoplasm

positive regulation of epithelial cell proliferation

00230

00240

01100

TC0700004451.mm.2 Mki67 antigen identified by monoclonal antibody Ki 67 7 -135689787 NM_001081117 1917

nucleotide binding

chromosome, centromeric region

condensed chromosome

condensed chromosome

DNA binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

cytoplasm

cell cycle

regulation of mitotic nuclear division

protein C-terminus binding

cell population proliferation

nuclear body

meiotic cell cycle

regulation of chromosome segregation

hepatocyte proliferation

regulation of chromatin organization

cholangiocyte proliferation

 
TC1400002057.mm.2 Prmt5 protein arginine N-methyltransferase 5 14 -54507181 NM_013768, BC023905 NM_013768, BC023905 104

negative regulation of transcription by RNA polymerase II

spliceosomal snRNP assembly

p53 binding

chromatin binding

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

Golgi apparatus

cytosol

cytosol

chromatin organization

DNA-templated transcription, termination

regulation of transcription, DNA-templated

protein methylation

methyltransferase activity

methyl-CpG binding

histone-arginine N-methyltransferase activity

protein-arginine N-methyltransferase activity

transferase activity

peptidyl-arginine methylation

methylation

circadian regulation of gene expression

protein-containing complex

methylosome

histone arginine methylation

histone methyltransferase complex

histone methyltransferase complex

protein-arginine omega-N symmetric methyltransferase activity

peptidyl-arginine N-methylation

endothelial cell activation

identical protein binding

ribonucleoprotein complex binding

histone H4-R3 methylation

histone methyltransferase activity (H4-R3 specific)

regulation of DNA methylation

protein-containing complex binding

negative regulation of cell differentiation

protein heterodimerization activity

rhythmic process

positive regulation of oligodendrocyte differentiation

regulation of ERK1 and ERK2 cascade

E-box binding

Golgi ribbon formation

positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway

03013

TC0800000146.mm.2 Cln8 CLN8 transmembrane ER and ERGIC protein 8 14888535 NM_012000, BC021625 NM_012000, BC021625 85

age-dependent response to oxidative stress

protein binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

phospholipid metabolic process

phospholipid metabolic process

phospholipid metabolic process

ceramide metabolic process

mitochondrial membrane organization

lysosome organization

nervous system development

nervous system development

visual perception

adult walking behavior

cholesterol metabolic process

associative learning

adult locomotory behavior

regulation of cell size

membrane

integral component of membrane

spinal cord motor neuron differentiation

somatic motor neuron differentiation

social behavior

negative regulation of apoptotic process

cellular protein catabolic process

cellular macromolecule catabolic process

cellular protein metabolic process

photoreceptor cell maintenance

musculoskeletal movement

neuromuscular process controlling posture

neuromuscular process controlling balance

negative regulation of transferase activity

glutamate reuptake

lipid homeostasis

retina development in camera-type eye

neurofilament cytoskeleton organization

ceramide binding

ceramide binding

 
TC0400002457.mm.2 Nol6 nucleolar protein family 6 (RNA-associated) 4 -41114426 NM_139236, BC059820 NM_139236, BC059820 24

condensed nuclear chromosome

RNA binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

mitochondrion

rRNA processing

tRNA export from nucleus

small-subunit processome

CURI complex

UTP-C complex

03008

TC1000003152.mm.2 Pa2g4 proliferation-associated 2G4 10 -128557765 NM_011119, BC046532 NM_011119, BC046532 52

nucleic acid binding

transcription corepressor activity

RNA binding

nucleus

nucleolus

cytoplasm

rRNA processing

regulation of translation

ubiquitin protein ligase binding

negative regulation of apoptotic process

positive regulation of cell differentiation

negative regulation of transcription, DNA-templated

ribonucleoprotein complex

 
TC1300000033.mm.2 Pitrm1 pitrilysin metallepetidase 1 13 6548156, 6548156 NM_145131, BC006917 NM_145131, BC006917 28

catalytic activity

metalloendopeptidase activity

metalloendopeptidase activity

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial matrix

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

protein processing

hydrolase activity

metal ion binding

 
TC0800003236.mm.2 Usp10 ubiquitin specific peptidase 10 8 119910359 NM_009462, BC007134 NM_009462, BC007134 38

p53 binding

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

nucleus

nucleus

nucleoplasm

cytoplasm

endosome

early endosome

early endosome

cytosol

cytosol

DNA repair

ubiquitin-dependent protein catabolic process

autophagy

cellular response to DNA damage stimulus

peptidase activity

cysteine-type peptidase activity

regulation of autophagy

regulation of autophagy

protein deubiquitination

protein deubiquitination

hydrolase activity

DNA damage response, signal transduction by p53 class mediator

DNA damage response, signal transduction by p53 class mediator

protein-containing complex

negative regulation of I-kappaB kinase/NF-kappaB signaling

ion channel binding

intermediate filament cytoskeleton

cellular response to interleukin-1

 
TC0400002222.mm.2 Cibar1 CBY1 interacting BAR domain containing 1 4 -12153141 NM_026558, BC020162 NM_026558, BC020162 19

protein binding

phospholipid binding

nucleus

cytoplasm

mitochondrial inner membrane

centriole

cytoskeleton

cilium

inner mitochondrial membrane organization

cell projection organization

limb morphogenesis

limb morphogenesis

ciliary transition zone

ciliary basal body

cell projection

positive regulation of smoothened signaling pathway

cilium assembly

cilium assembly

membrane organization

ciliary base

 
TC0600000648.mm.2 Chn2 chimerin 2 6 54039931, 54272821, 54269155, 54264857 NM_001163640, NM_023543, BC051139, BC141060 NM_001163640, NM_023543, BC051139, BC141060 NM_001163640, NM_023543, BC051139, BC141060 NM_001163640, NM_023543, BC051139, BC141060 32

GTPase activator activity

GTPase activator activity

signal transduction

membrane

intracellular signal transduction

regulation of GTPase activity

synapse

metal ion binding

 
TC1400001314.mm.2 Ipo5 importin 5 14 120915846, 120911193 NM_023579, BC052392, BC054814 NM_023579, BC052392, BC054814 NM_023579, BC052392, BC054814 40

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

protein import into nucleus

NLS-bearing protein import into nucleus

ribosomal protein import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transport

small GTPase binding

positive regulation of protein import into nucleus

nuclear import signal receptor activity

nuclear import signal receptor activity

cellular response to amino acid stimulus

 
TC1700000777.mm.2 Olfr111 olfactory receptor 111 17 37529956 NM_001005485, BC139116, BC139117 NM_001005485, BC139116, BC139117 NM_001005485, BC139116, BC139117 6

olfactory receptor activity

G protein-coupled receptor signaling pathway

sensory perception of smell

integral component of membrane

 
TC1900000212.mm.2 Prpf19 pre-mRNA processing factor 19 19 10898644, 10895230 NM_001253843, NM_001253844, NM_134129, BC004070 NM_001253843, NM_001253844, NM_134129, BC004070 NM_001253843, NM_001253844, NM_134129, BC004070 NM_001253843, NM_001253844, NM_134129, BC004070 38

protein polyubiquitination

spliceosomal tri-snRNP complex assembly

spliceosomal complex assembly

generation of catalytic spliceosome for first transesterification step

mRNA splicing, via spliceosome

Prp19 complex

Prp19 complex

inner cell mass cell proliferation

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

DNA replication factor A complex

spliceosomal complex

cytoplasm

cytoplasm

lipid droplet

cytoskeleton

DNA repair

double-strand break repair via nonhomologous end joining

mRNA processing

cellular response to DNA damage stimulus

RNA splicing

lipid biosynthetic process

proteasomal protein catabolic process

proteasomal protein catabolic process

nuclear speck

transferase activity

ubiquitin-ubiquitin ligase activity

cellular protein localization

site of double-strand break

identical protein binding

negative regulation of neuron differentiation

positive regulation of neuron differentiation

positive regulation of mRNA splicing, via spliceosome

positive regulation of astrocyte differentiation

positive regulation of astrocyte differentiation

ubiquitin protein ligase activity

protein K63-linked ubiquitination

U2-type catalytic step 1 spliceosome

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

catalytic step 2 spliceosome

signal transduction involved in DNA damage checkpoint

03040

04120

TC0100001858.mm.2 Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 1 191821472 NM_010892, BC010302, BC011316, BC057576 NM_010892, BC010302, BC011316, BC057576 NM_010892, BC010302, BC011316, BC057576 NM_010892, BC010302, BC011316, BC057576 48

mitotic sister chromatid segregation

nucleotide binding

chromosome, centromeric region

kinetochore

condensed nuclear chromosome

spindle pole

blastocyst development

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

centrosome

cytoskeleton

microtubule

protein phosphorylation

protein phosphorylation

cell cycle

chromosome segregation

chromosome segregation

chromosome segregation

kinase activity

phosphorylation

transferase activity

protein phosphatase binding

midbody

positive regulation of telomere maintenance via telomerase

protein-containing complex

negative regulation of DNA binding

regulation of mitotic centrosome separation

protein autophosphorylation

metal ion binding

centrosome separation

cell division

meiotic cell cycle

positive regulation of telomerase activity

regulation of attachment of spindle microtubules to kinetochore

mitotic spindle assembly

negative regulation of centriole-centriole cohesion

positive regulation of telomere capping

 
TC0400003633.mm.2 Nkain1 Na+/K+ transporting ATPase interacting 1 4 -130530130 NM_025998, BC116391 NM_025998, BC116391 18

regulation of sodium ion transport

plasma membrane

membrane

integral component of membrane

ATPase binding

 
TC0100003280.mm.2 Npl N-acetylneuraminate pyruvate lyase 1 -153503015 NM_028749, BC022734 NM_028749, BC022734 23

catalytic activity

cellular_component

cytoplasm

carbohydrate metabolic process

N-acetylneuraminate lyase activity

N-acetylneuraminate lyase activity

lyase activity

N-acetylneuraminate catabolic process

identical protein binding

00520

TC1800001083.mm.2 Slc39a6 solute carrier family 39 (metal ion transporter), member 6 18 -24579880 NM_139143, BC054780, BC055012 NM_139143, BC054780, BC055012 NM_139143, BC054780, BC055012 27

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

endoplasmic reticulum

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

ion transport

zinc ion transport

cellular zinc ion homeostasis

cellular zinc ion homeostasis

membrane

integral component of membrane

metal ion transport

lamellipodium membrane

metal ion transmembrane transporter activity

transmembrane transport

zinc ion transmembrane transport

zinc ion import across plasma membrane

zinc ion import across plasma membrane

 
TC0100002308.mm.2 Myo1b myosin IB 1 -51749757 NM_001161817, NM_010863, BC046300, BC054786 NM_001161817, NM_010863, BC046300, BC054786 NM_001161817, NM_010863, BC046300, BC054786 NM_001161817, NM_010863, BC046300, BC054786 41

microfilament motor activity

microfilament motor activity

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

phosphatidylinositol-4,5-bisphosphate binding

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

cytoplasm

early endosome

actin filament

plasma membrane

plasma membrane

microvillus

brush border

brush border

brush border

post-Golgi vesicle-mediated transport

actin filament organization

actin filament organization

endosome membrane

actin cytoskeleton

myosin complex

actin filament-based movement

vesicle transport along actin filament

filopodium

actin-dependent ATPase activity

actin-dependent ATPase activity

vesicle

trans-Golgi network membrane

transferrin transport

apical part of cell

perinuclear region of cytoplasm

actin filament binding

actin filament binding

actin filament bundle assembly

cell periphery

 
TC1300001751.mm.2 Gmds GDP-mannose 4, 6-dehydratase 13 -31819585 NM_146041, BC031788, BC093502 NM_146041, BC031788, BC093502 NM_146041, BC031788, BC093502 21

cytoplasm

GDP-mannose 4,6-dehydratase activity

lyase activity

GDP-mannose metabolic process

'de novo' GDP-L-fucose biosynthetic process

00051

00520

01100

TC0900000505.mm.2 H2ax H2A.X variant histone 9 44334714 NM_010436, BC005468, BC010336, H2A, NM_010436, BC005468, BC010336, H2A, NM_010436, BC005468, BC010336, H2A, NM_010436, BC005468, BC010336, H2A, 476

double-strand break repair via homologous recombination

chromosome, telomeric region

chromatin

nucleosome

condensed nuclear chromosome

male germ cell nucleus

XY body

DNA binding

damaged DNA binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

chromosome

centrosome

DNA repair

DNA repair

DNA recombination

chromatin silencing

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

cell cycle

spermatogenesis

nuclear speck

enzyme binding

site of double-strand break

site of double-strand break

histone binding

protein heterodimerization activity

meiotic cell cycle

cellular response to gamma radiation

site of DNA damage

05322

TC1500000736.mm.2 Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 15 82016368 NM_010247, BC031422 NM_010247, BC031422 137

nucleotide binding

telomere maintenance

transcription regulatory region sequence-specific DNA binding

activation of innate immune response

immune system process

DNA binding

DNA helicase activity

damaged DNA binding

double-stranded DNA binding

double-stranded DNA binding

double-stranded DNA binding

double-stranded telomeric DNA binding

catalytic activity

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

transcription regulator complex

chromosome

nucleolus

cytoplasm

cytoplasm

DNA repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

DNA recombination

cellular response to DNA damage stimulus

protein C-terminus binding

DNA-dependent ATPase activity

metabolic process

response to ionizing radiation

hydrolase activity

lyase activity

cyclin binding

protein-containing complex

protein-DNA complex

V(D)J recombination

telomeric DNA binding

Ku70:Ku80 complex

Ku70:Ku80 complex

protein-containing complex binding

DNA end binding

innate immune response

positive regulation of lymphocyte differentiation

positive regulation of protein kinase activity

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of smooth muscle cell proliferation

positive regulation of neurogenesis

5'-deoxyribose-5-phosphate lyase activity

nonhomologous end joining complex

cellular hyperosmotic salinity response

cellular response to gamma radiation

cellular response to gamma radiation

cellular response to X-ray

cellular response to X-ray

double-strand break repair via classical nonhomologous end joining

03450

TC1800000063.mm.2 Colec12 collectin sub-family member 12 18 9707647 NM_130449, BC057936 NM_130449, BC057936 19

scavenger receptor activity

collagen trimer

phagocytosis, recognition

phagocytosis, recognition

immune response

membrane

integral component of membrane

low-density lipoprotein particle binding

low-density lipoprotein particle binding

carbohydrate binding

toll-like receptor 3 signaling pathway

signaling receptor activity

pattern recognition receptor activity

pattern recognition receptor activity

defense response to bacterium

metal ion binding

positive regulation of cell adhesion molecule production

collagen-containing extracellular matrix

04145

TC0500002580.mm.2 Tec tec protein tyrosine kinase 5 -72755717 NM_001113460, NM_001113461, NM_001113464, NM_013689, BC037071, BC062884 NM_001113460, NM_001113461, NM_001113464, NM_013689, BC037071, BC062884 NM_001113460, NM_001113461, NM_001113464, NM_013689, BC037071, BC062884 NM_001113460, NM_001113461, NM_001113464, NM_013689, BC037071, BC062884 NM_001113460, NM_001113461, NM_001113464, NM_013689, BC037071, BC062884 NM_001113460, NM_001113461, NM_001113464, NM_013689, BC037071, BC062884 74

nucleotide binding

adaptive immune response

immune system process

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

cytoskeleton

plasma membrane

cell-cell junction

protein phosphorylation

integrin-mediated signaling pathway

integrin-mediated signaling pathway

lipid binding

regulation of platelet activation

regulation of platelet activation

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

intracellular signal transduction

peptidyl-tyrosine autophosphorylation

peptidyl-tyrosine autophosphorylation

tissue regeneration

metal ion binding

positive regulation of peptidyl-tyrosine phosphorylation

T cell receptor signaling pathway

B cell receptor signaling pathway

B cell receptor signaling pathway

04380

04660

TC0300000714.mm.2 Iqgap3 IQ motif containing GTPase activating protein 3 3 88082050 NM_001033484, BC151102, BC172704 NM_001033484, BC151102, BC172704 NM_001033484, BC151102, BC172704 20

G1/S transition of mitotic cell cycle

activation of MAPK activity

positive regulation of protein phosphorylation

GTPase activator activity

protein binding

calmodulin binding

calmodulin binding

cytoplasm

cytoplasm

cell-cell junction

Ras protein signal transduction

regulation of cell size

positive regulation of gene expression

negative regulation of gene expression

lateral plasma membrane

small GTPase binding

regulation of actin cytoskeleton organization

positive regulation of mammary gland epithelial cell proliferation

actin filament binding

ERK1 and ERK2 cascade

myosin VI light chain binding

cellular response to organic substance

04810

TC1300000173.mm.2 H2ac13 H2A clustered histone 13 13 21716411 NM_178182, BC099406 NM_178182, BC099406 16

DNA binding

nucleus

chromatin silencing

negative regulation of cell population proliferation

05322

TC1800001138.mm.2 Stard4 StAR-related lipid transfer (START) domain containing 4 18 -33199137 NM_133774, BC005642 NM_133774, BC005642 24

cytoplasm

mitochondrion

endoplasmic reticulum

endoplasmic reticulum

cytosol

cytosol

lipid transport

lipid binding

positive regulation of cholesterol esterification

cholesterol transport involved in cholesterol storage

cholesterol transport involved in cholesterol storage

cholesterol binding

cholesterol binding

cholesterol binding

cytoplasmic vesicle

intracellular cholesterol transport

intracellular cholesterol transport

cholesterol esterification

cholesterol import

cholesterol import

positive regulation of bile acid biosynthetic process

cholesterol transfer activity

cholesterol transfer activity

 
TC0800001094.mm.2 Mt2 metallothionein 2 8 94172617 NM_008630, BC031758 NM_008630, BC031758 217

nucleus

cytoplasm

cytosol

cellular zinc ion homeostasis

cellular zinc ion homeostasis

nitric oxide mediated signal transduction

zinc ion binding

response to bacterium

detoxification of copper ion

detoxification of copper ion

metal ion binding

cellular response to cadmium ion

cellular response to copper ion

cellular response to zinc ion

 
TC0800003059.mm.2 Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 8 -121881145 NM_011404, BC026131 NM_011404, BC026131 56

amino acid transmembrane transport

lysosome

cytosol

plasma membrane

amino acid transport

basal plasma membrane

negative regulation of gene expression

amino acid transmembrane transporter activity

aromatic amino acid transmembrane transporter activity

neutral amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-leucine transmembrane transporter activity

L-tryptophan transmembrane transporter activity

thyroid hormone transmembrane transporter activity

L-amino acid transport

phenylalanine transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

transmembrane transporter activity

microvillus membrane

positive regulation of interferon-gamma production

positive regulation of interleukin-17 production

positive regulation of interleukin-4 production

xenobiotic transport

intracellular membrane-bounded organelle

transmembrane transport

thyroid hormone transport

amino acid import across plasma membrane

external side of apical plasma membrane

leucine import across plasma membrane

L-leucine import across plasma membrane

L-tryptophan transmembrane transport

amino acid transport complex

 
TC0400000913.mm.2 Mtap methylthioadenosine phosphorylase 4 89137369 NM_024433, BC003858 NM_024433, BC003858 37

catalytic activity

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

purine ribonucleoside salvage

nucleoside metabolic process

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring pentosyl groups

S-methyl-5-thioadenosine phosphorylase activity

L-methionine salvage from methylthioadenosine

methylation

00270

01100

TC1100003221.mm.2 Rpa1 replication protein A1 11 -75300258 NM_001164223, NM_026653, BC019119 NM_001164223, NM_026653, BC019119 NM_001164223, NM_026653, BC019119 73

telomere maintenance

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

condensed chromosome

condensed nuclear chromosome

lateral element

male germ cell nucleus

in utero embryonic development

nucleic acid binding

DNA binding

chromatin binding

damaged DNA binding

damaged DNA binding

single-stranded DNA binding

nucleus

nucleus

nucleoplasm

nucleoplasm

DNA replication factor A complex

DNA replication factor A complex

DNA replication

DNA unwinding involved in DNA replication

DNA repair

base-excision repair

nucleotide-excision repair

nucleotide-excision repair

mismatch repair

DNA recombination

cellular response to DNA damage stimulus

telomere maintenance via telomerase

positive regulation of cell population proliferation

PML body

hemopoiesis

protein localization to chromosome

single-stranded telomeric DNA binding

metal ion binding

homeostasis of number of cells within a tissue

chromosome organization

meiotic cell cycle

meiotic cell cycle

site of DNA damage

G-rich strand telomeric DNA binding

03030

03420

03430

03440

TC0600001807.mm.2 Pon3 paraoxonase 3 6 -5216255 NM_173006, BC099416 NM_173006, BC099416 29

aryldialkylphosphatase activity

arylesterase activity

arylesterase activity

extracellular region

extracellular space

extracellular space

response to toxic substance

phenylacetate catabolic process

hydrolase activity

3,4-dihydrocoumarin hydrolase activity

aromatic compound catabolic process

negative regulation of superoxide anion generation

protein homodimerization activity

intracellular membrane-bounded organelle

coumarin catabolic process

carboxylic acid catabolic process

metal ion binding

acyl-L-homoserine-lactone lactonohydrolase activity

01100

TC1500000710.mm.2 Adsl adenylosuccinate lyase 15 80948489 NM_009634, BC020187 NM_009634, BC020187 34

catalytic activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

mitochondrion

cytosol

cytosol

purine nucleotide metabolic process

purine nucleotide biosynthetic process

AMP biosynthetic process

AMP biosynthetic process

response to nutrient

aerobic respiration

purine ribonucleotide biosynthetic process

ribonucleoside monophosphate biosynthetic process

lyase activity

protein-containing complex

identical protein binding

'de novo' AMP biosynthetic process

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

00230

00250

01100

TC0400003849.mm.2 Mrto4 mRNA turnover 4, ribosome maturation factor 4 -139347439 NM_023536, BC005734, BC138221, BC145205 NM_023536, BC005734, BC138221, BC145205 NM_023536, BC005734, BC138221, BC145205 NM_023536, BC005734, BC138221, BC145205 26

ribosomal large subunit assembly

nuclear-transcribed mRNA catabolic process

intracellular anatomical structure

nucleus

nucleolus

cytoplasm

rRNA processing

preribosome, large subunit precursor

ribosome biogenesis

ribosomal large subunit biogenesis

 
TC0X00001069.mm.2 Tlr13 toll-like receptor 13 X 106143274 NM_205820, BC117913, BC117914 NM_205820, BC117913, BC117914 NM_205820, BC117913, BC117914 31

toll-like receptor signaling pathway

immune system process

MyD88-dependent toll-like receptor signaling pathway

RNA binding

protein binding

cytoplasm

endosome

integral component of plasma membrane

inflammatory response

signal transduction

response to virus

membrane

integral component of membrane

hydrolase activity

rRNA binding

toll-like receptor 13 signaling pathway

signaling receptor activity

identical protein binding

regulation of MAPK cascade

innate immune response

NAD(P)+ nucleosidase activity

NAD+ nucleotidase, cyclic ADP-ribose generating

 
TC0700004321.mm.2 Sephs2 selenophosphate synthetase 2 7 -127271878 NM_009266, BC016508, BC028966, BC043334 NM_009266, BC016508, BC028966, BC043334 NM_009266, BC016508, BC028966, BC043334 NM_009266, BC016508, BC028966, BC043334 20

nucleotide binding

selenium compound metabolic process

selenium compound metabolic process

selenide, water dikinase activity

selenide, water dikinase activity

ATP binding

cytoplasm

selenocysteine biosynthetic process

selenocysteine biosynthetic process

kinase activity

phosphorylation

transferase activity

metal ion binding

00450

01100

TC0700001951.mm.2 Dock1 dedicator of cytokinesis 1 7 134670686 NM_001033420 46

hematopoietic progenitor cell differentiation

guanyl-nucleotide exchange factor activity

GTPase activator activity

protein binding

nucleoplasm

cytoplasm

cytosol

phagocytosis

apoptotic process

cytoskeleton organization

small GTPase mediated signal transduction

positive regulation of epithelial cell migration

membrane

cell migration

nuclear speck

SH3 domain binding

guanyl-nucleotide exchange factor complex

positive regulation of substrate adhesion-dependent cell spreading

04510

04810

05100

TC0700002999.mm.2 Cd37 CD37 antigen 7 -45233631, -45233631 NM_007645, BC019402, CD37 NM_007645, BC019402, CD37 NM_007645, BC019402, CD37 34

immunological synapse

positive regulation of immunoglobulin production

regulation of humoral immune response

integral component of plasma membrane

negative regulation of cell population proliferation

membrane

integral component of membrane

negative regulation of myeloid dendritic cell activation

defense response to protozoan

regulation of defense response to virus

04640

TC0200002478.mm.2 Mybl2 myeloblastosis oncogene-like 2 2 163054634 NM_008652, BC050842 NM_008652, BC050842 77

mitotic cell cycle

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

nucleoplasm

nucleoplasm

regulation of transcription, DNA-templated

Myb complex

positive regulation of neuron apoptotic process

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

mitotic spindle assembly

cellular response to leukemia inhibitory factor

sequence-specific double-stranded DNA binding

 
TC1900000718.mm.2 Pdcd11 programmed cell death 11 19 47090765 NM_011053, BC070468 NM_011053, BC070468 30

nucleic acid binding

RNA binding

nucleus

nucleolus

cytosol

rRNA processing

RNA processing

mRNA processing

transcription factor binding

small-subunit processome

 
TC0600002045.mm.2         NM_009658, NR_037965, BC004725, BC021655, BC085310 NM_009658, NR_037965, BC004725, BC021655, BC085310 NM_009658, NR_037965, BC004725, BC021655, BC085310 NM_009658, NR_037965, BC004725, BC021655, BC085310 NM_009658, NR_037965, BC004725, BC021655, BC085310  

retinoid metabolic process

retinal dehydrogenase activity

tissue homeostasis

epithelial cell maturation

renal water homeostasis

alditol:NADP+ 1-oxidoreductase activity

alditol:NADP+ 1-oxidoreductase activity

alditol:NADP+ 1-oxidoreductase activity

extracellular space

nucleoplasm

cytoplasm

cytosol

cytosol

monosaccharide metabolic process

sorbitol biosynthetic process

response to water deprivation

response to organic substance

oxidoreductase activity

naphthalene metabolic process

stress-activated protein kinase signaling cascade

plasma membrane bounded cell projection cytoplasm

paranodal junction

regulation of urine volume

regulation of urine volume

norepinephrine metabolic process

mast cell granule

negative regulation of apoptotic process

Schmidt-Lanterman incisure

glyceraldehyde oxidoreductase activity

daunorubicin metabolic process

doxorubicin metabolic process

positive regulation of receptor signaling pathway via JAK-STAT

allyl-alcohol dehydrogenase activity

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

NADP-retinol dehydrogenase activity

cellular response to hydrogen peroxide

cellular hyperosmotic salinity response

inner medullary collecting duct development

metanephric collecting duct development

cellular response to methylglyoxal

Schwann cell microvillus

 
TC1100000822.mm.2 Pmp22 peripheral myelin protein 22 11 63131456, 63128981, 63132568, 63132802 NM_008885, BC010765 NM_008885, BC010765 199

motor activity

protein binding

plasma membrane

plasma membrane

bicellular tight junction

autophagy

immune response

cell cycle

cell cycle arrest

cell adhesion

peripheral nervous system development

mating

adult walking behavior

cholesterol metabolic process

cell death

negative regulation of cell population proliferation

integrin complex

adult locomotory behavior

response to bacterium

cell surface

multicellular organism aging

regulation of gene expression

proteasomal protein catabolic process

regulation of Schwann cell proliferation

positive regulation of gene expression

negative regulation of gene expression

fibroblast migration

negative regulation of neuron projection development

Schwann cell differentiation

Schwann cell development

membrane

integral component of membrane

transmission of nerve impulse

transmission of nerve impulse

neuronal action potential propagation

neuronal action potential

myelination in peripheral nervous system

myelination in peripheral nervous system

lamellipodium assembly

actin cytoskeleton organization

cell differentiation

paranodal junction assembly

membrane raft organization

bleb assembly

myelin assembly

myelin assembly

regulation of glial cell apoptotic process

cellular response to heat

cellular response to unfolded protein

response to endoplasmic reticulum stress

multicellular organism growth

Schwann cell migration

gliogenesis

myelination

myelination

proteasome-mediated ubiquitin-dependent protein catabolic process

compact myelin

compact myelin

laminin complex

cellular lipid metabolic process

neuronal ion channel clustering

perinuclear region of cytoplasm

muscle fiber development

peripheral nervous system neuron axonogenesis

regulation of inflammatory response

neuromuscular process

striated muscle cell differentiation

cellular localization

vestibular reflex

axon development

motor behavior

aggresome assembly

basement membrane organization

regulation of protein serine/threonine kinase activity

neuromuscular junction development, skeletal muscle fiber

regulation of apoptotic signaling pathway

 
TC0500001399.mm.2 P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 5 122643926, 122643926, 122650382, 122643926 NM_001038839, NM_001038845, NM_001038887, NM_001284402, NM_011027, BC141120 NM_001038839, NM_001038845, NM_001038887, NM_001284402, NM_011027, BC141120 NM_001038839, NM_001038845, NM_001038887, NM_001284402, NM_011027, BC141120 NM_001038839, NM_001038845, NM_001038887, NM_001284402, NM_011027, BC141120 NM_001038839, NM_001038845, NM_001038887, NM_001284402, NM_011027, BC141120 NM_001038839, NM_001038845, NM_001038887, NM_001284402, NM_011027, BC141120 515

activation of MAPK activity

cell morphogenesis

lipopolysaccharide binding

purinergic nucleotide receptor activity

positive regulation of cytokine production

phagolysosome assembly

positive regulation of T cell mediated cytotoxicity

positive regulation of protein phosphorylation

extracellularly ATP-gated cation channel activity

extracellularly ATP-gated cation channel activity

extracellularly ATP-gated cation channel activity

ion channel activity

protein binding

ATP binding

integral component of nuclear inner membrane

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

cell-cell junction

protein phosphorylation

membrane protein ectodomain proteolysis

phospholipid transfer to membrane

ion transport

cation transport

calcium ion transport

cell volume homeostasis

vesicle budding from membrane

inflammatory response

mitochondrion organization

plasma membrane organization

cell death

cell death

response to mechanical stimulus

response to bacterium

external side of plasma membrane

response to organic substance

response to zinc ion

gene expression

positive regulation of calcium ion transport into cytosol

positive regulation of gene expression

programmed cell death

programmed cell death

positive regulation of glutamate secretion

positive regulation of gamma-aminobutyric acid secretion

response to organic cyclic compound

channel activity

channel activity

membrane

membrane

integral component of membrane

synaptic vesicle exocytosis

protein processing

plasma membrane phospholipid scrambling

sensory perception of pain

protein catabolic process

positive regulation of bone mineralization

neuromuscular junction

cellular response to extracellular stimulus

bleb assembly

bleb assembly

positive regulation of prostaglandin secretion

response to lipopolysaccharide

response to lipopolysaccharide

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-6 production

collagen metabolic process

response to ATP

response to ATP

response to ATP

response to fluid shear stress

positive regulation of ion transmembrane transport

purinergic nucleotide receptor signaling pathway

signaling receptor activity

T cell proliferation

response to drug

identical protein binding

neuronal cell body

T cell homeostasis

positive regulation of apoptotic process

positive regulation of catalytic activity

NAD transport

negative regulation of MAPK cascade

positive regulation of MAPK cascade

synapse

phospholipid translocation

positive regulation of ossification

negative regulation of bone resorption

negative regulation of cell volume

negative regulation of cell volume

positive regulation of glycolytic process

ceramide biosynthetic process

pore complex assembly

pore complex assembly

skeletal system morphogenesis

homeostasis of number of cells within a tissue

positive regulation of protein secretion

defense response to Gram-positive bacterium

release of sequestered calcium ion into cytosol

response to calcium ion

response to calcium ion

response to electrical stimulus

membrane depolarization

positive regulation of mitochondrial depolarization

positive regulation of lymphocyte apoptotic process

cellular response to dsRNA

cellular response to organic cyclic compound

reactive oxygen species metabolic process

extrinsic apoptotic signaling pathway

positive regulation of bleb assembly

04020

04080

TC1000001716.mm.2 Sash1 SAM and SH3 domain containing 1 10 -8722218 NM_175155, BC152995 NM_175155, BC152995 22

protein polyubiquitination

G-protein alpha-subunit binding

cytoplasm

protein C-terminus binding

positive regulation of endothelial cell migration

regulation of epithelial cell migration

membrane

protein kinase binding

mitogen-activated protein kinase kinase kinase binding

mitogen-activated protein kinase kinase kinase binding

positive regulation of lipopolysaccharide-mediated signaling pathway

protein-containing complex

positive regulation of JUN kinase activity

positive regulation of JUN kinase activity

positive regulation of angiogenesis

molecular adaptor activity

regulation of protein K63-linked ubiquitination

positive regulation of p38MAPK cascade

positive regulation of NIK/NF-kappaB signaling

positive regulation of NIK/NF-kappaB signaling

regulation of protein autoubiquitination

 
TC1100003118.mm.2 C1qbp complement component 1, q subcomponent binding protein 11 -70977845 NM_007573, BC038075 NM_007573, BC038075 67

negative regulation of transcription by RNA polymerase II

complement component C1q complex binding

complement component C1q complex binding

adaptive immune response

immune system process

transcription corepressor activity

transcription corepressor activity

mRNA binding

mRNA binding

protein kinase C binding

protein binding

hyaluronic acid binding

hyaluronic acid binding

extracellular region

extracellular space

nucleus

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

cytosol

plasma membrane

plasma membrane

mRNA processing

apoptotic process

complement activation, classical pathway

transcription factor binding

transcription factor binding

RNA splicing

translation activator activity

cell surface

cell surface

phosphatidylinositol 3-kinase signaling

membrane

regulation of complement activation

regulation of complement activation

kininogen binding

kininogen binding

adrenergic receptor binding

negative regulation of interferon-gamma production

negative regulation of interleukin-12 production

negative regulation of MDA-5 signaling pathway

negative regulation of RIG-I signaling pathway

ribosome biogenesis

mature ribosome assembly

mature ribosome assembly

mature ribosome assembly

positive regulation of apoptotic process

innate immune response

positive regulation of cell adhesion

negative regulation of mRNA splicing, via spliceosome

negative regulation of mRNA splicing, via spliceosome

presynaptic active zone

negative regulation of defense response to virus

positive regulation of protein kinase B signaling

positive regulation of mitochondrial translation

positive regulation of mitochondrial translation

positive regulation of neutrophil chemotaxis

mitochondrial ribosome binding

mitochondrial ribosome binding

presynapse

glutamatergic synapse

GABA-ergic synapse

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of trophoblast cell migration

positive regulation of dendritic cell chemotaxis

 
TC0400002479.mm.2 Sigmar1 sigma non-opioid intracellular receptor 1 4 -41738492 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 NM_001286538, NM_001286539, NM_001286540, NM_001286541, NM_001286542, NM_001286551, NM_001286605, NM_011014, BC002000, BC019930 145

opioid receptor activity

protein binding

nucleus

nuclear envelope

endoplasmic reticulum

endoplasmic reticulum

lipid droplet

plasma membrane

lipid transport

nervous system development

postsynaptic density

postsynaptic density

membrane

integral component of membrane

cell junction

cytoplasmic vesicle

cell death in response to hydrogen peroxide

signaling receptor activity

identical protein binding

cell projection

regulation of neuron apoptotic process

synapse

postsynaptic membrane

protein homotrimerization

 
TC1100001047.mm.2 Cluh clustered mitochondria (cluA/CLU1) homolog 11 74649503 NM_001081158, BC072573 NM_001081158, BC072573 19

mRNA binding

mRNA binding

cytoplasm

cytoplasm

mitochondrion organization

intracellular distribution of mitochondria

intracellular distribution of mitochondria

 
TC0700001689.mm.2 Xylt1 xylosyltransferase 1 7 117380978 NM_175645, BC157033 NM_175645, BC157033 18

Golgi cis cisterna

Golgi membrane

extracellular space

Golgi apparatus

glycosaminoglycan biosynthetic process

acetylglucosaminyltransferase activity

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein xylosyltransferase activity

protein xylosyltransferase activity

protein xylosyltransferase activity

proteoglycan biosynthetic process

chondroitin sulfate biosynthetic process

cellular response to heat

ossification involved in bone maturation

metal ion binding

negative regulation of axon regeneration

embryonic skeletal system development

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan biosynthetic process

00532

00534

01100

TC0600002858.mm.2 Shq1 SHQ1 homolog (S. cerevisiae) 6 -100571810 NM_181590, BC052657 NM_181590, BC052657 18

box H/ACA snoRNP assembly

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytosol

ribonucleoprotein complex assembly

positive regulation of apoptotic process

unfolded protein binding

negative regulation of rRNA processing

 
TC1100004233.mm.2 Fasn fatty acid synthase 11 -120805957 NM_007988, BC046513 NM_007988, BC046513 153

glandular epithelial cell development

catalytic activity

fatty acid synthase activity

fatty acid synthase activity

fatty acid synthase activity

[acyl-carrier-protein] S-acetyltransferase activity

[acyl-carrier-protein] S-malonyltransferase activity

3-oxoacyl-[acyl-carrier-protein] synthase activity

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

oleoyl-[acyl-carrier-protein] hydrolase activity

cytoplasm

mitochondrion

Golgi apparatus

cytosol

plasma membrane

acetyl-CoA metabolic process

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

fatty acid biosynthetic process

metabolic process

ether lipid biosynthetic process

biosynthetic process

tissue development

myristoyl-[acyl-carrier-protein] hydrolase activity

palmitoyl-[acyl-carrier-protein] hydrolase activity

acyl-[acyl-carrier-protein] hydrolase activity

oxidoreductase activity

transferase activity

hydrolase activity

hydrolase activity, acting on ester bonds

lyase activity

3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

neutrophil differentiation

monocyte differentiation

mammary gland development

phosphopantetheine binding

glycogen granule

identical protein binding

enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity

cellular response to interleukin-4

establishment of endothelial intestinal barrier

3-oxo-glutaryl-[acp] methyl ester reductase activity

3-oxo-pimeloyl-[acp] methyl ester reductase activity

00061

01100

04910

TC1100001010.mm.2 Atp2a3 ATPase, Ca++ transporting, ubiquitous 11 72961168 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 37

nucleotide binding

calcium transmembrane transporter activity, phosphorylative mechanism

calcium transmembrane transporter activity, phosphorylative mechanism

calcium ion binding

protein binding

ATP binding

endoplasmic reticulum

endoplasmic reticulum

ion transport

calcium ion transport

cellular calcium ion homeostasis

cellular calcium ion homeostasis

activation of cysteine-type endopeptidase activity involved in apoptotic process

proton-exporting ATPase activity, phosphorylative mechanism

cysteine-type endopeptidase activator activity involved in apoptotic process

calcium ion transmembrane transporter activity

membrane

integral component of membrane

sarcoplasmic reticulum

ATPase activity

calcium-dependent ATPase activity

organelle membrane

endoplasmic reticulum calcium ion homeostasis

sarcoplasmic reticulum membrane

ion channel binding

metal ion binding

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

calcium ion transmembrane transport

calcium ion transmembrane transport

negative regulation of receptor binding

calcium ion transport from cytosol to endoplasmic reticulum

04020

04972

05010

TC0500000785.mm.2 Stap1 signal transducing adaptor family member 1 5 86071745 NM_019992, BC145550, BC145828, BC145830 NM_019992, BC145550, BC145828, BC145830 NM_019992, BC145550, BC145828, BC145830 NM_019992, BC145550, BC145828, BC145830 26

phosphotyrosine residue binding

transmembrane receptor protein tyrosine kinase adaptor activity

macrophage colony-stimulating factor receptor binding

protein binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

transmembrane receptor protein tyrosine kinase signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway

response to bacterium

positive regulation of gene expression

negative regulation of macrophage chemotaxis

protein kinase binding

protein kinase binding

myeloid cell differentiation

protein-macromolecule adaptor activity

receptor tyrosine kinase binding

protein-containing complex

signaling adaptor activity

signaling adaptor activity

negative regulation of phosphorylation

intracellular membrane-bounded organelle

positive regulation of B cell receptor signaling pathway

positive regulation of B cell receptor signaling pathway

positive regulation of phagocytosis, engulfment

cellular response to lipopolysaccharide

negative regulation of ruffle assembly

negative regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of microglial cell activation

positive regulation of non-membrane spanning protein tyrosine kinase activity

negative regulation of microglial cell migration

positive regulation of microglial cell mediated cytotoxicity

positive regulation of actin cytoskeleton reorganization

 
TC0X00001276.mm.2 Cenpi centromere protein I X 134308083 NM_145924, BC030328 NM_145924, BC030328 14

chromosome, centromeric region

kinetochore

kinetochore

molecular_function

nucleus

chromosome

cytosol

cytosol

biological_process

nuclear body

nuclear body

centromere complex assembly

 
TC0800001231.mm.2         NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773  

nuclear outer membrane

nucleoplasm

cytosol

protein import into nucleus

protein import into nucleus

protein import into nucleus

protein export from nucleus

nucleocytoplasmic transport

structural constituent of nuclear pore

small GTPase binding

nuclear membrane

positive regulation of protein import into nucleus

identical protein binding

nuclear pore central transport channel

nuclear pore central transport channel

nuclear import signal receptor activity

protein localization to nuclear pore

nucleocytoplasmic carrier activity

negative regulation of vascular endothelial growth factor production

 
TC1500002221.mm.2 Cers5 ceramide synthase 5 15 -99735591 NM_028015, BC043059, BC046797 NM_028015, BC043059, BC046797 NM_028015, BC043059, BC046797 46

DNA binding

endoplasmic reticulum

endoplasmic reticulum

lipid metabolic process

sphingolipid metabolic process

membrane

integral component of membrane

N-acyltransferase activity

transferase activity

sphingolipid biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

 
TC0700000225.mm.2 Zc3h4 zinc finger CCCH-type containing 4 7 16401195 NM_198631, BC057627 NM_198631, BC057627 35

nucleus

nucleoplasm

cytosol

metal ion binding

 
TC0200001047.mm.2 Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 2 71873223, 71874903 NM_172665, BC027196 NM_172665, BC027196 52

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

ATP binding

mitochondrion

mitochondrion

plasma membrane

mitochondrial pyruvate dehydrogenase complex

carbohydrate metabolic process

glucose metabolic process

protein phosphorylation

protein phosphorylation

cell surface receptor signaling pathway

cell population proliferation

intrinsic apoptotic signaling pathway in response to oxidative stress

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of glucose metabolic process

regulation of glucose metabolic process

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

intracellular signal transduction

identical protein binding

protein-containing complex binding

pyruvate dehydrogenase complex

hypoxia-inducible factor-1alpha signaling pathway

04660

04664

04722

05145

05160

TC1500000420.mm.2 Trmt12 tRNA methyltransferase 12 15 58872648 NM_026642, BC052533, BC055850 NM_026642, BC052533, BC055850 NM_026642, BC052533, BC055850 12

cytoplasm

tRNA processing

tRNA methyltransferase activity

transferase activity

tRNA methylation

tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity

 
TC1800001632.mm.2 Haus1 HAUS augmin-like complex, subunit 1 18 -77757293, -77757293, -77757293 NM_146089, BC024400 NM_146089, BC024400 17

molecular_function

cytoplasm

centrosome

cytosol

cytosol

cytoskeleton

microtubule

cell cycle

centrosome cycle

centrosome cycle

spindle assembly

spindle assembly

cell division

HAUS complex

HAUS complex

mitotic spindle microtubule

 
TC1600001390.mm.2 Rfc4 replication factor C (activator 1) 4 16 -23113947 NM_145480, BC003335 NM_145480, BC003335 29

nucleotide binding

DNA binding

DNA clamp loader activity

DNA clamp loader activity

ATP binding

nucleus

nucleoplasm

DNA replication factor C complex

DNA replication factor C complex

DNA replication

DNA-dependent DNA replication

DNA repair

single-stranded DNA helicase activity

enzyme binding

Ctf18 RFC-like complex

Elg1 RFC-like complex

positive regulation of DNA-directed DNA polymerase activity

03030

03420

03430

TC1700001084.mm.2 Ddx11 DEAD/H box helicase 11 17 66123519 NM_001003919, BC079656 NM_001003919, BC079656 19

nucleotide binding

chromatin

spindle pole

fibrillar center

nucleic acid binding

DNA binding

DNA helicase activity

DNA helicase activity

chromatin binding

DNA replication origin binding

double-stranded DNA binding

single-stranded DNA binding

RNA binding

single-stranded RNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

centrosome

cytoskeleton

nucleobase-containing compound metabolic process

DNA replication

DNA repair

cellular response to DNA damage stimulus

sister chromatid cohesion

multicellular organism development

DNA-dependent ATPase activity

RNA-dependent ATPase activity

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

midbody

replication fork processing

Ctf18 RFC-like complex

positive regulation of endodeoxyribonuclease activity

negative regulation of protein binding

DNA duplex unwinding

DNA duplex unwinding

establishment of sister chromatid cohesion

positive regulation of chromatin binding

G-quadruplex DNA unwinding

triplex DNA binding

positive regulation of sister chromatid cohesion

metal ion binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

G-quadruplex DNA binding

cellular response to hydroxyurea

cellular response to cisplatin

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

cellular response to bleomycin

nucleolar chromatin organization

positive regulation of double-strand break repair

 
TC1900000099.mm.2 Cdca5 cell division cycle associated 5 19 6085096 NM_026410, BC052904 NM_026410, BC052904 34

mitotic cell cycle

mitotic cell cycle

chromatin

protein binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

double-strand break repair

double-strand break repair

cell cycle

mitotic sister chromatid cohesion

mitotic sister chromatid cohesion

mitotic sister chromatid cohesion

mitotic chromosome condensation

mitotic metaphase plate congression

mitotic metaphase plate congression

positive regulation of exit from mitosis

positive regulation of exit from mitosis

protein-containing complex binding

cell division

regulation of cohesin loading

regulation of cohesin loading

 
TC0300002549.mm.2 Phgdh 3-phosphoglycerate dehydrogenase 3 -98313170 NM_016966, BC086668, BC110673 NM_016966, BC086668, BC110673 NM_016966, BC086668, BC110673 59

phosphoglycerate dehydrogenase activity

phosphoglycerate dehydrogenase activity

phosphoglycerate dehydrogenase activity

glutamine metabolic process

glycine metabolic process

L-serine metabolic process

L-serine biosynthetic process

threonine metabolic process

cellular amino acid biosynthetic process

gamma-aminobutyric acid metabolic process

regulation of gene expression

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

taurine metabolic process

spinal cord development

glial cell development

neural tube development

neurogenesis

neuron projection development

myelin sheath

NAD binding

G1 to G0 transition

00260

01100

TC0700000861.mm.2 Dbp D site albumin promoter binding protein 7 45705246 NM_016974, BC018323 NM_016974, BC018323 76

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

circadian rhythm

positive regulation of transcription by RNA polymerase II

rhythmic process

sequence-specific double-stranded DNA binding

 
TC1900001131.mm.2 Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 19 -11321038, -11321038 NM_001025610, NM_001276398, NM_027836, BC024402 NM_001025610, NM_001276398, NM_027836, BC024402 NM_001025610, NM_001276398, NM_027836, BC024402 NM_001025610, NM_001276398, NM_027836, BC024402 12

molecular_function

trans-Golgi network

biological_process

 
TC0200004366.mm.2 Arhgap11a Rho GTPase activating protein 11A 2 -113831491 NM_181416, BC050875 NM_181416, BC050875 18

GTPase activator activity

signal transduction

 
TC1500001750.mm.2 Eef1d eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 15 -75894795, -75894795 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 35

fibrillar center

DNA binding

translation elongation factor activity

guanyl-nucleotide exchange factor activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

endoplasmic reticulum

cytosol

cytosol

eukaryotic translation elongation factor 1 complex

translation

translational elongation

mRNA transcription

regulation of cell death

heat shock protein binding

activating transcription factor binding

synapse

synapse

cellular response to ionizing radiation

glutamatergic synapse

glutamatergic synapse

 
TC0600001813.mm.2 Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 6 -6041217 NM_001177572, NM_015829, BC016571 NM_001177572, NM_015829, BC016571 NM_001177572, NM_015829, BC016571 49

L-glutamate transmembrane transporter activity

L-glutamate transmembrane transporter activity

L-glutamate transmembrane transporter activity

calcium ion binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

ATP biosynthetic process

transport

L-aspartate transmembrane transporter activity

L-aspartate transmembrane transporter activity

aspartate transmembrane transport

aspartate transmembrane transport

aspartate transmembrane transport

L-glutamate transmembrane transport

L-glutamate transmembrane transport

membrane

integral component of membrane

transmembrane transporter activity

identical protein binding

malate-aspartate shuttle

malate-aspartate shuttle

malate-aspartate shuttle

cellular respiration

metal ion binding

response to calcium ion

transmembrane transport

 
TC0400001770.mm.2 Padi2 peptidyl arginine deiminase, type II 4 140906359 NM_008812, BC040350, BC049947 NM_008812, BC040350, BC049947 NM_008812, BC040350, BC049947 50

protein-arginine deiminase activity

protein-arginine deiminase activity

calcium ion binding

nucleus

cytoplasm

cytoplasm

regulation of chromatin disassembly

hydrolase activity

protein citrullination

estrogen receptor binding

intracellular estrogen receptor signaling pathway

transcriptionally active chromatin

histone H3-R26 citrullination

histone citrullination

protein homodimerization activity

metal ion binding

chromatin-mediated maintenance of transcription

negative regulation of chemokine-mediated signaling pathway

negative regulation of lymphocyte chemotaxis

cellular response to leukemia inhibitory factor

 
TC1000002655.mm.2 Gas2l3 growth arrest-specific 2 like 3 10 -89408822 NM_001033331, NM_001079876, NM_001284344 NM_001033331, NM_001079876, NM_001284344 NM_001033331, NM_001079876, NM_001284344 22

microtubule cytoskeleton organization

microtubule cytoskeleton organization

actin binding

cytoplasm

cytoskeleton

microtubule

actin filament

microtubule binding

microtubule binding

cytoskeletal anchor activity

response to bacterium

actin cytoskeleton

microtubule cytoskeleton

actin cytoskeleton organization

actin filament binding

actin crosslink formation

 
TC0800002869.mm.2         NM_026513, NM_139229, BC094654 NM_026513, NM_139229, BC094654 NM_026513, NM_139229, BC094654  

molecular_function

mitochondrion

mitochondrion

Golgi apparatus

intra-Golgi vesicle-mediated transport

positive regulation of cell population proliferation

protein transport

membrane

Golgi transport complex

Golgi transport complex

peptidyl-methionine modification

peptidyl-methionine modification

N-terminal protein amino acid modification

N-terminal protein amino acid modification

peptide deformylase activity

peptide deformylase activity

co-translational protein modification

 
TC0700000057.mm.2 U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 7 5062142 NM_001205231, NM_133671, BC007487, BC043071, BC106134, U2(U2AF) NM_001205231, NM_133671, BC007487, BC043071, BC106134, U2(U2AF) NM_001205231, NM_133671, BC007487, BC043071, BC106134, U2(U2AF) NM_001205231, NM_133671, BC007487, BC043071, BC106134, U2(U2AF) NM_001205231, NM_133671, BC007487, BC043071, BC106134, U2(U2AF) NM_001205231, NM_133671, BC007487, BC043071, BC106134, U2(U2AF) 42

commitment complex

mRNA splicing, via spliceosome

Prp19 complex

nucleic acid binding

RNA binding

protein binding

nucleus

spliceosomal complex

mRNA processing

poly-pyrimidine tract binding

RNA splicing

nuclear speck

nuclear speck

nuclear speck

enzyme binding

pre-mRNA 3'-splice site binding

pre-mRNA 3'-splice site binding

negative regulation of protein ubiquitination

positive regulation of RNA splicing

negative regulation of mRNA splicing, via spliceosome

C2H2 zinc finger domain binding

U2-type prespliceosome

U2-type prespliceosome

U2AF complex

U2AF complex

03040

TC0700002635.mm.2 Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 7 -25461701 NM_001039185, NM_001039186, NM_001039187, NM_011926 NM_001039185, NM_001039186, NM_001039187, NM_011926 NM_001039185, NM_001039186, NM_001039187, NM_011926 NM_001039185, NM_001039186, NM_001039187, NM_011926 145

blood vessel development

virus receptor activity

negative regulation of cytokine production

positive regulation of immunoglobulin production

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

actin binding

granulocyte colony-stimulating factor receptor binding

protein binding

calmodulin binding

extracellular space

plasma membrane

plasma membrane

cell-cell junction

adherens junction

negative regulation of protein kinase activity

homophilic cell adhesion via plasma membrane adhesion molecules

external side of plasma membrane

basal plasma membrane

cell surface

cell surface

regulation of endothelial cell migration

bile acid transmembrane transporter activity

membrane

integral component of membrane

viral process

apical plasma membrane

lateral plasma membrane

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

kinase binding

protein kinase binding

protein phosphatase binding

cell junction

negative regulation of granulocyte differentiation

filamin binding

cytoplasmic vesicle

brush border membrane

negative regulation of interleukin-1 production

negative regulation of interleukin-2 production

Toll-like receptor binding

common myeloid progenitor cell proliferation

granulocyte colony-stimulating factor signaling pathway

regulation of epidermal growth factor receptor signaling pathway

T cell receptor complex

positive regulation of T cell proliferation

negative regulation of T cell proliferation

identical protein binding

protein homodimerization activity

cell projection

negative regulation of vascular permeability

positive regulation of MAP kinase activity

negative regulation by host of viral process

negative regulation by host of viral process

positive regulation by host of viral process

negative regulation by host of viral genome replication

cell-cell junction organization

regulation of endothelial cell differentiation

negative regulation of osteoclast differentiation

negative regulation of bone resorption

negative regulation of JNK cascade

positive regulation of JNK cascade

viral entry into host cell

virion binding

protein dimerization activity

Peyer's patch development

negative regulation of lipid biosynthetic process

ciliary membrane

regulation of blood vessel remodeling

positive regulation of activation-induced cell death of T cells

positive regulation of calcineurin-NFAT signaling cascade

negative regulation of platelet aggregation

insulin catabolic process

regulation of sprouting angiogenesis

protein tyrosine kinase binding

protein tyrosine kinase binding

negative regulation of hepatocyte proliferation

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of CD4-positive, alpha-beta T cell proliferation

positive regulation of CD8-positive, alpha-beta T cell activation

positive regulation of vasculogenesis

 
TC0700000904.mm.2 Prmt3 protein arginine N-methyltransferase 3 7 49778357 NM_133740, BC050775 NM_133740, BC050775 35

protein binding

cytoplasm

cytosol

protein methylation

methyltransferase activity

protein-arginine N-methyltransferase activity

protein-arginine N-methyltransferase activity

transferase activity

peptidyl-arginine methylation

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

negative regulation of protein ubiquitination

methylation

protein-arginine omega-N asymmetric methyltransferase activity

ribosome binding

metal ion binding

dendritic spine morphogenesis

modified amino acid binding

 
TC0300003106.mm.2 Prkacb protein kinase, cAMP dependent, catalytic, beta 3 -146729578, -146729578, -146729578, -146729578 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 67

nucleotide binding

magnesium ion binding

magnesium ion binding

neural tube closure

protein kinase activity

protein serine/threonine kinase activity

cAMP-dependent protein kinase activity

cAMP-dependent protein kinase activity

ATP binding

ATP binding

nucleus

nucleus

cytoplasm

centrosome

cytosol

cytosol

plasma membrane

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase complex

protein phosphorylation

protein phosphorylation

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

protein kinase A signaling

membrane

kinase activity

phosphorylation

transferase activity

ubiquitin protein ligase binding

protein kinase A regulatory subunit binding

perinuclear region of cytoplasm

negative regulation of meiotic cell cycle

regulation of protein processing

ciliary base

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

04010

04020

04062

04114

04210

04270

04310

04340

04540

04720

04740

04742

04910

04912

04914

04916

04962

04970

04971

04976

05020

05146

05414

TC0400001274.mm.2 Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 4 117019401, 117019401 NM_001111277, NM_175135, BC115657, BC115658 NM_001111277, NM_175135, BC115657, BC115658 NM_001111277, NM_175135, BC115657, BC115658 NM_001111277, NM_175135, BC115657, BC115658 22

cytoplasmic translational initiation

translation initiation factor activity

translation initiation factor activity

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

cytoplasm

eukaryotic translation initiation factor 2B complex

eukaryotic translation initiation factor 2B complex

translational initiation

translation factor activity, RNA binding

response to heat

response to glucose

oligodendrocyte development

guanyl-nucleotide exchange factor complex

response to peptide hormone

T cell receptor signaling pathway

03013

TC0700003829.mm.2 P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 7 -100937633 NM_183168, BC027331, BC064095 NM_183168, BC027331, BC064095 NM_183168, BC027331, BC064095 54

G protein-coupled ADP receptor activity

G protein-coupled receptor activity

plasma membrane

phagocytosis

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of smooth muscle cell migration

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

pyrimidine nucleotide binding

transepithelial chloride transport

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

positive regulation of inositol trisphosphate biosynthetic process

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled UDP receptor activity

G protein-coupled UDP receptor activity

G protein-coupled UTP receptor activity

positive regulation of ERK1 and ERK2 cascade

cellular response to prostaglandin E stimulus

cellular response to organic cyclic compound

cellular response to purine-containing compound

positive regulation of vascular associated smooth muscle cell proliferation

cellular response to pyrimidine ribonucleotide

04080

TC1300001190.mm.2 Dimt1 DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) 13 106947128 NM_025447, BC019799 NM_025447, BC019799 18

rRNA modification

rRNA (adenine-N6,N6-)-dimethyltransferase activity

rRNA (adenine-N6,N6-)-dimethyltransferase activity

RNA binding

nucleus

nucleoplasm

nucleolus

mitochondrial matrix

cytosol

rRNA processing

methyltransferase activity

rRNA methyltransferase activity

transferase activity

rRNA methylation

rRNA methylation

methylation

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity

positive regulation of rRNA processing

 
TC0300001289.mm.2 Zgrf1 zinc finger, GRF-type containing 1 3 127553488 NM_197997 15

RNA binding

cytoplasm

zinc ion binding

membrane

integral component of membrane

5'-flap endonuclease activity

metal ion binding

replication fork reversal

 
TC0300002730.mm.2 Ampd2 adenosine monophosphate deaminase 2 3 -108074061, -108074058, -108074061 NM_001289719, NM_001289720, NM_028779, BC049119 NM_001289719, NM_001289720, NM_028779, BC049119 NM_001289719, NM_001289720, NM_028779, BC049119 NM_001289719, NM_001289720, NM_028779, BC049119 31

AMP deaminase activity

AMP deaminase activity

AMP deaminase activity

cytosol

cytosol

IMP biosynthetic process

IMP biosynthetic process

IMP biosynthetic process

nucleotide metabolic process

purine ribonucleoside monophosphate biosynthetic process

hydrolase activity

deaminase activity

IMP salvage

cholesterol homeostasis

identical protein binding

AMP metabolic process

AMP metabolic process

ATP metabolic process

ATP metabolic process

GTP metabolic process

GTP metabolic process

metal ion binding

cyclic purine nucleotide metabolic process

glomerular visceral epithelial cell development

energy homeostasis

energy homeostasis

00230

01100

TC1400002600.mm.2 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 14 -99076633 NM_028315, BC027357 NM_028315, BC027357 27

3'-5'-exoribonuclease activity

3'-5'-exoribonuclease activity

nuclear exosome (RNase complex)

nuclear exosome (RNase complex)

cytoplasmic exosome (RNase complex)

exosome (RNase complex)

RNA binding

nuclease activity

endonuclease activity

endonuclease activity

exonuclease activity

ribonuclease activity

guanyl-nucleotide exchange factor activity

nucleus

nucleoplasm

cytoplasm

cytosol

rRNA processing

rRNA catabolic process

rRNA catabolic process

hydrolase activity

CUT catabolic process

03018

TC0800001436.mm.2 6430548M08Rik RIKEN cDNA 6430548M08 gene 8 120114151, 120114151, 120144928 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 15

molecular_function

cellular_component

biological_process

 
TC1000000240.mm.2 Arhgap18 Rho GTPase activating protein 18 10 26772511 NM_176837, BC030858 NM_176837, BC030858 22

ruffle

GTPase activator activity

GTPase activator activity

cytoplasm

cytoplasm

cytosol

cytoplasmic microtubule

plasma membrane

signal transduction

small GTPase mediated signal transduction

regulation of cell shape

nuclear speck

regulation of actin filament polymerization

regulation of actin filament polymerization

regulation of actin cytoskeleton organization

regulation of small GTPase mediated signal transduction

regulation of small GTPase mediated signal transduction

regulation of cell motility

 
TC1100004054.mm.2 Cd300c2 CD300C molecule 2 11 -114996768 NM_134158, BC006801 NM_134158, BC006801 21

positive regulation of cytokine production

immune system process

transmembrane signaling receptor activity

protein binding

plasma membrane

plasma membrane

plasma membrane

membrane

integral component of membrane

 
TC0700001348.mm.2 Alg8 asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase) 7 97371616 NM_199035, BC061244 NM_199035, BC061244 20

alpha-1,3-mannosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

protein N-linked glycosylation

protein N-linked glycosylation

oligosaccharide-lipid intermediate biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring hexosyl groups

protein N-linked glycosylation via asparagine

dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

00510

01100

TC0100003814.mm.2 Dtl denticleless E3 ubiquitin protein ligase 1 -191537355 NM_029766 33

protein polyubiquitination

ubiquitin-protein transferase activity

nucleus

nucleoplasm

chromosome

nucleolus

cytoplasm

centrosome

cytosol

cytoskeleton

DNA replication

ubiquitin-dependent protein catabolic process

protein monoubiquitination

cellular response to DNA damage stimulus

response to UV

positive regulation of G2/M transition of mitotic cell cycle

membrane

translesion synthesis

Cul4A-RING E3 ubiquitin ligase complex

Cul4B-RING E3 ubiquitin ligase complex

positive regulation of protein catabolic process

rhythmic process

regulation of cell cycle

signal transduction involved in G2 DNA damage checkpoint

Cul4-RING E3 ubiquitin ligase complex

 
TC1500001192.mm.2 Skp2 S-phase kinase-associated protein 2 15 -9111981, -9111981 NM_001285980, NM_013787, BC092236, NM_145468 NM_001285980, NM_013787, BC092236, NM_145468 NM_001285980, NM_013787, BC092236, NM_145468 NM_001285980, NM_013787, BC092236, NM_145468 133

G1/S transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

protein polyubiquitination

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

cytosol

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

positive regulation of intracellular estrogen receptor signaling pathway

identical protein binding

regulation of apoptotic process

proteasome-mediated ubiquitin-dependent protein catabolic process

innate immune response

positive regulation of smooth muscle cell proliferation

defense response to virus

regulation of cell cycle

regulation of cell cycle

protein K48-linked ubiquitination

positive regulation of protein polyubiquitination

04110

04120

05200

05222

TC1400002215.mm.2 Fdft1 farnesyl diphosphate farnesyl transferase 1 14 -63145150, -63145150 NM_010191, BC054722, BC138301, BC138302 NM_010191, BC054722, BC138301, BC138302 NM_010191, BC054722, BC138301, BC138302 NM_010191, BC054722, BC138301, BC138302 44

catalytic activity

farnesyl-diphosphate farnesyltransferase activity

farnesyl-diphosphate farnesyltransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

ergosterol biosynthetic process

metabolic process

steroid metabolic process

cholesterol metabolic process

isoprenoid biosynthetic process

lipid biosynthetic process

biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

transferase activity

transferase activity, transferring alkyl or aryl (other than methyl) groups

intracellular membrane-bounded organelle

farnesyl diphosphate metabolic process

farnesyl diphosphate metabolic process

metal ion binding

squalene synthase activity

00100

01100

TC1400001785.mm.2 Prxl2a peroxiredoxin like 2A 14 -40993734, -40993734, -40993734, -40993734, -40993734 NM_027464, BC056635 NM_027464, BC056635 25

extracellular region

cytoplasm

cytoplasm

mitochondrion

antioxidant activity

antioxidant activity

regulation of osteoclast differentiation

 
TC0700001455.mm.2 Rrm1 ribonucleotide reductase M1 7 102441694 NM_009103, BC016450, BC066217 NM_009103, BC016450, BC066217 NM_009103, BC016450, BC066217 53

nucleotide binding

catalytic activity

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

protein binding

ATP binding

nuclear envelope

cytoplasm

cytosol

ribonucleoside-diphosphate reductase complex

ribonucleoside-diphosphate reductase complex

DNA replication

metabolic process

deoxyribonucleotide biosynthetic process

deoxyribonucleotide biosynthetic process

oxidoreductase activity

purine nucleotide binding

identical protein binding

cell projection

neuronal cell body

protein heterotetramerization

ribonucleoside-diphosphate reductase activity

disordered domain specific binding

00230

00240

00480

01100

TC0100000469.mm.2 Cyp20a1 cytochrome P450, family 20, subfamily a, polypeptide 1 1 60343299 NM_030013, BC049147 NM_030013, BC049147 17

monooxygenase activity

iron ion binding

membrane

integral component of membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

heme binding

metal ion binding

 
TC0900001851.mm.2 Dnmt1 DNA methyltransferase (cytosine-5) 1 9 -20907205, -20907205, -20907205 NM_001199431, NM_001199432, NM_001199433, NM_010066, BC048148, BC053047 NM_001199431, NM_001199432, NM_001199433, NM_010066, BC048148, BC053047 NM_001199431, NM_001199432, NM_001199433, NM_010066, BC048148, BC053047 NM_001199431, NM_001199432, NM_001199433, NM_010066, BC048148, BC053047 NM_001199431, NM_001199432, NM_001199433, NM_010066, BC048148, BC053047 NM_001199431, NM_001199432, NM_001199433, NM_010066, BC048148, BC053047 442

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

heterochromatin

DNA binding

DNA binding

chromatin binding

RNA binding

catalytic activity

DNA (cytosine-5-)-methyltransferase activity

DNA (cytosine-5-)-methyltransferase activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

replication fork

pericentric heterochromatin

cytoplasm

DNA methylation

DNA methylation

chromatin organization

Ras protein signal transduction

metabolic process

methyltransferase activity

zinc ion binding

methyl-CpG binding

DNA-methyltransferase activity

DNA-methyltransferase activity

maintenance of DNA methylation

maintenance of DNA methylation

DNA methylation on cytosine within a CG sequence

regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

gene silencing

transferase activity

protein domain specific binding

estrogen receptor binding

methylation

DNA methylation on cytosine

DNA methylation on cytosine

protein-containing complex

regulation of cell population proliferation

response to drug

histone deacetylase binding

neuronal cell body

DNA methylation involved in embryo development

DNA hypermethylation

negative regulation of transcription, DNA-templated

S-adenosylmethionine metabolic process

metal ion binding

positive regulation of histone H3-K4 methylation

negative regulation of histone H3-K9 methylation

DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

cellular response to amino acid stimulus

cellular response to transforming growth factor beta stimulus

C-5 methylation of cytosine

positive regulation of DNA methylation-dependent heterochromatin assembly

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of vascular associated smooth muscle cell apoptotic process

negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching

promoter-specific chromatin binding

00270

01100

TC1100000774.mm.2 Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 11 61142483, 61126754 NM_021349, BC139392, BC139393, BC141867, BC141868 NM_021349, BC139392, BC139393, BC141867, BC141868 NM_021349, BC139392, BC139393, BC141867, BC141868 NM_021349, BC139392, BC139393, BC141867, BC141868 NM_021349, BC139392, BC139393, BC141867, BC141868 81

B cell homeostasis

B cell homeostasis

B cell homeostasis

hematopoietic progenitor cell differentiation

hematopoietic progenitor cell differentiation

adaptive immune response

immune system process

integral component of plasma membrane

external side of plasma membrane

membrane

integral component of membrane

negative regulation of B cell proliferation

negative regulation of B cell proliferation

04060

04672

05340

TC0100000297.mm.2 Il1rl2 interleukin 1 receptor-like 2 1 40324588 NM_133193, BC117797 NM_133193, BC117797 33

immune system process

cytokine receptor activity

interleukin-1 receptor activity

interleukin-1, type I, activating receptor activity

cellular_component

inflammatory response

signal transduction

membrane

integral component of membrane

hydrolase activity

positive regulation of interleukin-6 production

innate immune response

positive regulation of T cell differentiation

NAD(P)+ nucleosidase activity

regulation of inflammatory response

regulation of inflammatory response

NAD+ nucleotidase, cyclic ADP-ribose generating

 
TC0700001736.mm.2 Eef2k eukaryotic elongation factor-2 kinase 7 120843599, 120851188, 120842830 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 47

nucleotide binding

protein serine/threonine kinase activity

elongation factor-2 kinase activity

elongation factor-2 kinase activity

calcium ion binding

calmodulin binding

calmodulin binding

ATP binding

translational elongation

protein phosphorylation

translation factor activity, RNA binding

postsynaptic density

kinase activity

phosphorylation

transferase activity

regulation of protein autophosphorylation

negative regulation of apoptotic process

dendritic spine

positive regulation of endocytosis

protein autophosphorylation

positive regulation of synapse assembly

positive regulation of dendritic spine morphogenesis

 
TC0500001270.mm.2 Cit citron 5 115845655 NM_007708, BC023775, BC051165 NM_007708, BC023775, BC051165 NM_007708, BC023775, BC051165 52

mitotic sister chromatid segregation

G2/M transition of mitotic cell cycle

nucleotide binding

mitotic cell cycle

mitotic cytokinesis

cytokinesis

transcription coactivator binding

ruffle

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

vacuole

cytosol

cytosol

cytoskeleton

plasma membrane

protein phosphorylation

Golgi organization

cell cycle

metaphase/anaphase transition of mitotic cell cycle

multicellular organism development

spermatogenesis

nervous system development

regulation of actin polymerization or depolymerization

actin cytoskeleton

kinase activity

phosphorylation

dendrite development

transferase activity

SH3 domain binding

peptidyl-threonine phosphorylation

protein kinase binding

cell differentiation

PDZ domain binding

protein serine/threonine kinase inhibitor activity

midbody

actomyosin structure organization

Golgi cisterna

cleavage furrow

positive regulation of cytokinesis

negative regulation of hippo signaling

intracellular signal transduction

neuronal cell body

negative regulation of neuron differentiation

metal ion binding

generation of neurons

negative regulation of dendrite morphogenesis

cell division

neuron apoptotic process

scaffold protein binding

 
TC1100001051.mm.2 Tsr1 TSR1 20S rRNA accumulation 11 74898079 NM_177325, BC031531 NM_177325, BC031531 25

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GTPase activity

GTP binding

nucleus

preribosome, small subunit precursor

U3 snoRNA binding

ribosome biogenesis

 
TC0100001602.mm.2 Cd84 CD84 antigen 1 171839696, 171839696 NM_001252472, NM_001289470, NM_013489, BC140952, BC144736, CD84 NM_001252472, NM_001289470, NM_013489, BC140952, BC144736, CD84 NM_001252472, NM_001289470, NM_013489, BC140952, BC144736, CD84 NM_001252472, NM_001289470, NM_013489, BC140952, BC144736, CD84 NM_001252472, NM_001289470, NM_013489, BC140952, BC144736, CD84 NM_001252472, NM_001289470, NM_013489, BC140952, BC144736, CD84 34

adaptive immune response

immune system process

plasma membrane

autophagy

cell adhesion

membrane

integral component of membrane

regulation of lipopolysaccharide-mediated signaling pathway

negative regulation of granulocyte macrophage colony-stimulating factor production

negative regulation of interleukin-10 production

negative regulation of interleukin-18 production

negative regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

negative regulation of mast cell activation

identical protein binding

regulation of macrophage activation

intracellular membrane-bounded organelle

negative regulation of mast cell degranulation

positive regulation of MAPK cascade

innate immune response

positive regulation of NF-kappaB transcription factor activity

positive regulation of monocyte chemotactic protein-1 production

regulation of store-operated calcium entry

 
TC0200005334.mm.2         NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480  

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

cellular_component

regulation of transcription by RNA polymerase II

 
TC1000002686.mm.2 Nedd1 neural precursor cell expressed, developmentally down-regulated gene 1 10 -92684744 NM_008682, BC052430, BC066870 NM_008682, BC052430, BC066870 NM_008682, BC052430, BC066870 34

pericentriolar material

pericentriolar material

spindle pole

spindle pole

gamma-tubulin ring complex, centrosomal

nucleoplasm

cytoplasm

centrosome

centrosome

centriole

centriole

cytoskeleton

plasma membrane

microtubule depolymerization

cell cycle

microtubule polymerization or depolymerization

ciliary basal body

ciliary basal body

apical part of cell

cell division

regulation of establishment of protein localization

protein localization to centrosome

 
TC0200001675.mm.2 Aven apoptosis, caspase activation inhibitor 2 112571612, 112492963, 112559681, 112559281, 112618416 NM_001165935, NM_028844, BC100725 NM_001165935, NM_028844, BC100725 NM_001165935, NM_028844, BC100725 21

molecular_function

apoptotic process

negative regulation of G2/M transition of mitotic cell cycle

membrane

membrane

negative regulation of apoptotic process

negative regulation of apoptotic process

 
TC0100001114.mm.2 Mgat5 mannoside acetylglucosaminyltransferase 5 1 127204985 NM_145128, BC125533, BC125535 NM_145128, BC125533, BC125535 NM_145128, BC125533, BC125535 63

protein phosphatase inhibitor activity

extracellular region

Golgi apparatus

Golgi apparatus

protein N-linked glycosylation

protein N-linked glycosylation

protein N-linked glycosylation

protein N-linked glycosylation

acetylglucosaminyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein N-linked glycosylation via asparagine

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

manganese ion binding

positive regulation of cell migration

negative regulation of protein tyrosine phosphatase activity

positive regulation of receptor signaling pathway via STAT

00510

01100

TC1000002944.mm.2 Nup107 nucleoporin 107 10 -117750642 NM_134010, BC057591, BC092261 NM_134010, BC057591, BC092261 NM_134010, BC057591, BC092261 26

chromosome, centromeric region

kinetochore

posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery

nucleus

nuclear pore

chromosome

regulation of transcription, DNA-templated

mRNA export from nucleus

mRNA export from nucleus

protein import into nucleus

female gonad development

protein transport

membrane

structural constituent of nuclear pore

structural constituent of nuclear pore

nuclear pore outer ring

nuclear pore outer ring

nuclear membrane

nuclear periphery

mRNA transport

nuclear pore complex assembly

nephron development

03013

TC0700004291.mm.2 Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 7 -126672864 NM_133670, BC005413 NM_133670, BC005413 40

nucleotide binding

aryl sulfotransferase activity

aryl sulfotransferase activity

cytoplasm

cytosol

catecholamine metabolic process

lipid metabolic process

xenobiotic metabolic process

sulfotransferase activity

sulfotransferase activity

sulfotransferase activity

steroid metabolic process

estrogen metabolic process

transferase activity

tyrosine-ester sulfotransferase activity

drug metabolic process

4-nitrophenol metabolic process

identical protein binding

3'-phosphoadenosine 5'-phosphosulfate binding

response to glucocorticoid

sulfation

sulfation

sulfation

00920

TC1800000794.mm.2 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 18 74779211 NM_177470, BC028901 NM_177470, BC028901 34

catalytic activity

acetyl-CoA C-acetyltransferase activity

acetyl-CoA C-acetyltransferase activity

acetyl-CoA hydrolase activity

acetyl-CoA C-acyltransferase activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

acetyl-CoA metabolic process

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation

palmitoyl-CoA hydrolase activity

transferase activity

transferase activity, transferring acyl groups

transferase activity, transferring acyl groups other than amino-acyl groups

hydrolase activity

acyl-CoA hydrolase activity

cellular response to hypoxia

myristoyl-CoA hydrolase activity

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of mitochondrial membrane permeability involved in apoptotic process

00062

00071

00280

01100

TC1400000578.mm.2         NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843  

angiogenesis

angiogenesis

response to hypoxia

response to yeast

response to yeast

positive regulation of endothelial cell proliferation

nucleic acid binding

DNA binding

RNA binding

actin binding

nuclease activity

endonuclease activity

ribonuclease activity

ribonuclease activity

ribonuclease activity

signaling receptor binding

copper ion binding

extracellular region

extracellular region

extracellular region

basement membrane

extracellular space

extracellular space

extracellular space

nucleus

chromosome

nucleolus

diacylglycerol biosynthetic process

activation of phospholipase C activity

multicellular organism development

central nervous system development

heparin binding

cellular response to starvation

rRNA transcription

response to hormone

actin cytoskeleton

cell migration

hydrolase activity

negative regulation of translation

antibacterial humoral response

antibacterial humoral response

antibacterial humoral response

antifungal humoral response

antifungal humoral response

cell differentiation

growth cone

cytoplasmic vesicle

activation of protein kinase B activity

angiogenin-PRI complex

activation of phospholipase A2 activity

peptide binding

positive regulation of phosphorylation

protein homodimerization activity

neuronal cell body

innate immune response

innate immune response

innate immune response

negative regulation of smooth muscle cell proliferation

positive regulation of protein secretion

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

RNA phosphodiester bond hydrolysis

 
TC0700000647.mm.2 Pepd peptidase D 7 34912406 NM_008820, BC086644, BC131945, BC131973 NM_008820, BC086644, BC131945, BC131973 NM_008820, BC086644, BC131945, BC131973 NM_008820, BC086644, BC131945, BC131973 40

aminopeptidase activity

peptidase activity

peptidase activity

metallopeptidase activity

hydrolase activity

dipeptidase activity

manganese ion binding

collagen catabolic process

metal ion binding

proline dipeptidase activity

 
TC0600003474.mm.2 Sinhcaf SIN3-HDAC complex associated factor 6 -148921058, -148921058 NM_019643, BC076599 NM_019643, BC076599 28

protein binding

nucleus

positive regulation of cell population proliferation

Sin3 complex

Sin3 complex

negative regulation of cell migration

negative regulation of cell migration

negative regulation of cell differentiation

 
TC0100003483.mm.2 Mgst3 microsomal glutathione S-transferase 3 1 -167371965 NM_025569, BC029669 NM_025569, BC029669 28

glutathione transferase activity

leukotriene-C4 synthase activity

glutathione peroxidase activity

glutathione peroxidase activity

nuclear envelope

endoplasmic reticulum

lipid metabolic process

membrane

integral component of membrane

oxidoreductase activity

transferase activity

leukotriene biosynthetic process

identical protein binding

intracellular membrane-bounded organelle

00480

00980

00982

TC1200001598.mm.2 Dus4l dihydrouridine synthase 4-like (S. cerevisiae) 12 -31640054 NM_028002, BC109351 NM_028002, BC109351 15

catalytic activity

tRNA processing

oxidoreductase activity

tRNA dihydrouridine synthase activity

flavin adenine dinucleotide binding

 
TC0400002271.mm.2 Wwp1 WW domain containing E3 ubiquitin protein ligase 1 4 -19608299 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 40

protein polyubiquitination

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

protein binding

nucleus

cytoplasm

cytosol

plasma membrane

ubiquitin-dependent protein catabolic process

membrane

protein ubiquitination

protein ubiquitination

protein ubiquitination

transferase activity

T cell differentiation

lung development

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

positive regulation of protein catabolic process

negative regulation of transcription, DNA-templated

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

04120

04144

TC1400001935.mm.2 Dlgap5 DLG associated protein 5 14 -47387778 NM_144553, BC058087, NM_001145949 NM_144553, BC058087, NM_001145949 NM_144553, BC058087, NM_001145949 24

nucleus

nucleus

cytoplasm

mitochondrion

cytosol

cytoskeleton

cell cycle

mitotic spindle organization

chromosome segregation

regulation of mitotic cell cycle

microtubule binding

signaling

spindle pole centrosome

spindle pole centrosome

centriolar satellite

kinetochore assembly

centrosome localization

 
TC0200000651.mm.2 Ptgs1 prostaglandin-endoperoxide synthase 1 2 36230425 NM_008969, BC005573, BC023322 NM_008969, BC005573, BC023322 NM_008969, BC005573, BC023322 299

prostaglandin biosynthetic process

prostaglandin biosynthetic process

photoreceptor outer segment

peroxidase activity

prostaglandin-endoperoxide synthase activity

nuclear envelope

cytoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

prostaglandin metabolic process

inflammatory response

response to oxidative stress

learning

memory

regulation of blood pressure

negative regulation of norepinephrine secretion

membrane

oxidoreductase activity

sensory perception of pain

cyclooxygenase pathway

heme binding

keratinocyte differentiation

negative regulation of epinephrine secretion

maintenance of blood-brain barrier

regulation of cell population proliferation

intracellular membrane-bounded organelle

positive regulation of vasoconstriction

positive regulation of smooth muscle contraction

metal ion binding

dioxygenase activity

00590

01100

TC0800000114.mm.2 F7 coagulation factor VII 8 13026033 NM_010172, BC061149 NM_010172, BC061149 48

positive regulation of leukocyte chemotaxis

positive regulation of leukocyte chemotaxis

endopeptidase activity

serine-type endopeptidase activity

signaling receptor binding

calcium ion binding

extracellular region

extracellular region

extracellular space

extracellular space

proteolysis

blood coagulation

blood coagulation

blood coagulation

hemostasis

peptidase activity

serine-type peptidase activity

positive regulation of platelet-derived growth factor receptor signaling pathway

protein processing

hydrolase activity

positive regulation of blood coagulation

response to nutrient levels

vesicle

positive regulation of positive chemotaxis

positive regulation of protein kinase B signaling

response to anticoagulant

response to cholesterol

response to astaxanthin

serine-type peptidase complex

04610

TC0400000662.mm.2 Snx30 sorting nexin family member 30 4 59805649 NM_172468, BC099674 NM_172468, BC099674 14

cytoplasm

protein transport

phosphatidylinositol binding

 
TC1000003220.mm.2 Nt5dc3 5'-nucleotidase domain containing 3 10 86779004 NM_175331, BC172705 NM_175331, BC172705 20

mitochondrion

cytosol

5'-nucleotidase activity

hydrolase activity

receptor complex

metal ion binding

 
TC1300000330.mm.2 Mboat1 membrane bound O-acyltransferase domain containing 1 13 30136489 NM_153546, BC023845, BC024653 NM_153546, BC023845, BC024653 NM_153546, BC023845, BC024653 18

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

phospholipid biosynthetic process

regulation of neuron projection development

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

lipid modification

phosphatidylserine acyl-chain remodeling

phosphatidylethanolamine acyl-chain remodeling

1-acylglycerophosphocholine O-acyltransferase activity

1-acylglycerophosphoethanolamine O-acyltransferase activity

1-acylglycerophosphoethanolamine O-acyltransferase activity

1-acylglycerophosphoserine O-acyltransferase activity

00561

00564

01100

TC0900001582.mm.2 Exog endo/exonuclease (5'-3'), endonuclease G-like 9 119444959 NM_001172136, NM_172456, BC119024 NM_001172136, NM_172456, BC119024 NM_001172136, NM_172456, BC119024 20

single-stranded DNA endodeoxyribonuclease activity

nucleic acid binding

nuclease activity

endonuclease activity

endonuclease activity

endoribonuclease activity

nucleus

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

apoptotic DNA fragmentation

5'-3' exonuclease activity

5'-3' exonuclease activity

membrane

hydrolase activity

protein-containing complex

metal ion binding

04210

TC1000000830.mm.2 Wdr18 WD repeat domain 18 10 79960151 NM_175450, BC095984 NM_175450, BC095984 29

molecular_function

nucleus

nucleoplasm

nuclear pre-replicative complex

cytoplasm

rRNA processing

multicellular organism development

regulation of DNA-dependent DNA replication initiation

Rix1 complex

 
TC1800001437.mm.2 Adrb2 adrenergic receptor, beta 2 18 -62177712 NM_007420, BC032883 NM_007420, BC032883 345

amyloid-beta binding

G-protein alpha-subunit binding

regulation of systemic arterial blood pressure by norepinephrine-epinephrine

diet induced thermogenesis

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

regulation of sodium ion transport

desensitization of G protein-coupled receptor signaling pathway by arrestin

diaphragm contraction

positive regulation of the force of heart contraction by epinephrine

G protein-coupled receptor activity

adrenergic receptor activity

beta2-adrenergic receptor activity

beta2-adrenergic receptor activity

beta2-adrenergic receptor activity

protein binding

nucleus

nucleus

cytoplasm

endosome

Golgi apparatus

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

caveola

receptor-mediated endocytosis

regulation of smooth muscle contraction

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

activation of adenylate cyclase activity

adenylate cyclase binding

positive regulation of cell population proliferation

associative learning

response to cold

positive regulation of protein kinase A signaling

positive regulation of protein kinase A signaling

positive regulation of sodium ion transport

potassium channel regulator activity

membrane

membrane

integral component of membrane

apical plasma membrane

negative regulation of angiogenesis

enzyme binding

negative regulation of ossification

axon

dendrite

positive regulation of bone mineralization

heat generation

B2 bradykinin receptor binding

positive regulation of ATPase activity

neuronal cell body membrane

synaptic transmission, glutamatergic

ionotropic glutamate receptor binding

negative regulation of urine volume

negative regulation of multicellular organism growth

wound healing

sarcolemma

identical protein binding

protein homodimerization activity

positive regulation of apoptotic process

dendritic spine

intracellular membrane-bounded organelle

receptor complex

positive regulation of potassium ion transport

positive regulation of MAPK cascade

protein-containing complex binding

bone resorption

positive regulation of heart contraction

positive regulation of transcription by RNA polymerase II

negative regulation of smooth muscle contraction

negative regulation of smooth muscle contraction

positive regulation of skeletal muscle tissue growth

negative regulation of inflammatory response

brown fat cell differentiation

norepinephrine binding

norepinephrine binding

protein phosphatase 2A binding

regulation of calcium ion transport

regulation of sensory perception of pain

excitatory postsynaptic potential

positive regulation of mini excitatory postsynaptic potential

cellular response to hypoxia

adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

positive regulation of protein serine/threonine kinase activity

negative regulation of platelet aggregation

receptor-receptor interaction

blood vessel diameter maintenance

glutamatergic synapse

positive regulation of cold-induced thermogenesis

positive regulation of autophagosome maturation

positive regulation of lipophagy

cellular response to amyloid-beta

cellular response to amyloid-beta

positive regulation of calcium ion import across plasma membrane

regulation of synaptic vesicle exocytosis

positive regulation of AMPA receptor activity

04020

04080

04144

04970

TC1900001336.mm.2 Ak3 adenylate kinase 3 19 -29020831 NM_021299, BC016432, BC019174, BC024871, BC058191 NM_021299, BC016432, BC019174, BC024871, BC058191 NM_021299, BC016432, BC019174, BC024871, BC058191 NM_021299, BC016432, BC019174, BC024871, BC058191 NM_021299, BC016432, BC019174, BC024871, BC058191 23

nucleotide binding

adenylate kinase activity

adenylate kinase activity

ATP binding

GTP binding

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial intermembrane space

mitochondrial matrix

mitochondrial matrix

mitochondrial matrix

nucleobase-containing compound metabolic process

ADP biosynthetic process

AMP phosphorylation

nucleoside triphosphate biosynthetic process

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, phosphate group as acceptor

nucleobase-containing compound kinase activity

identical protein binding

AMP metabolic process

AMP metabolic process

ATP metabolic process

GTP metabolic process

ITP metabolic process

UTP metabolic process

dATP metabolic process

nucleoside triphosphate adenylate kinase activity

nucleoside triphosphate adenylate kinase activity

00240

TC1500000742.mm.2 Srebf2 sterol regulatory element binding factor 2 15 82147268 NM_033218, BC167259 NM_033218, BC167259 149

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

lipid metabolic process

protein C-terminus binding

steroid metabolic process

cholesterol metabolic process

cellular response to starvation

response to hormone

positive regulation of cholesterol storage

positive regulation of cholesterol storage

membrane

integral component of membrane

dendrite

cytoplasmic vesicle

SREBP signaling pathway

SREBP-SCAP-Insig complex

cholesterol homeostasis

intracellular membrane-bounded organelle

sequence-specific DNA binding

positive regulation of cholesterol biosynthetic process

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein dimerization activity

E-box binding

negative regulation of cholesterol efflux

positive regulation of pri-miRNA transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
TC1900001514.mm.2 Exosc1 exosome component 1 19 -41922979 NM_001164561, NM_025644, BC024423 NM_001164561, NM_025644, BC024423 NM_001164561, NM_025644, BC024423 25

nuclear exosome (RNase complex)

exosome (RNase complex)

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

rRNA processing

RNA processing

03018

TC0100003449.mm.2 Mpzl1 myelin protein zero-like 1 1 -165592175, -165592180 NM_001001880, NM_001083897, BC072563 NM_001001880, NM_001083897, BC072563 NM_001001880, NM_001083897, BC072563 23

protein binding

integral component of plasma membrane

signal transduction

membrane

integral component of membrane

positive regulation of cell migration

04514

TC0100002838.mm.2 Dtymk deoxythymidylate kinase 1 -93792575, -93800494 NM_001105667, NM_023136, BC030178, BC069902 NM_001105667, NM_023136, BC030178, BC069902 NM_001105667, NM_023136, BC030178, BC069902 NM_001105667, NM_023136, BC030178, BC069902 24

nucleotide binding

nucleoside diphosphate kinase activity

thymidylate kinase activity

thymidylate kinase activity

thymidylate kinase activity

ATP binding

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrial intermembrane space

mitochondrial matrix

cytosol

dUDP biosynthetic process

dTDP biosynthetic process

dTDP biosynthetic process

dTDP biosynthetic process

dTTP biosynthetic process

dTTP biosynthetic process

uridylate kinase activity

nucleotide biosynthetic process

kinase activity

phosphorylation

transferase activity

cellular response to growth factor stimulus

00240

01100

TC0800000328.mm.2 Plpp5 phospholipid phosphatase 5 8 25720047 NM_028000 16

diacylglycerol diphosphate phosphatase activity

plasma membrane

lipid metabolic process

phosphatidate phosphatase activity

phosphatidate phosphatase activity

membrane

integral component of membrane

hydrolase activity

phospholipid dephosphorylation

phospholipid dephosphorylation

 
TC0300001046.mm.2 Dennd2c DENN/MADD domain containing 2C 3 103140325, 103127555, 103102658 NM_177857, BC060666 NM_177857, BC060666 21

guanyl-nucleotide exchange factor activity

nucleoplasm

 
TC1500001181.mm.2                
TC0200004598.mm.2 Ckap2l cytoskeleton associated protein 2-like 2 -129268209 NM_181589, BC053443 NM_181589, BC053443 18

molecular_function

cytoplasm

centrosome

centrosome

cytosol

cytosol

cytoskeleton

biological_process

mitotic spindle

mitotic spindle

 
TC0800001863.mm.2 Ckap2 cytoskeleton associated protein 2 8 -22168151 NM_001004140, BC145666, BC146023 NM_001004140, BC145666, BC146023 NM_001004140, BC145666, BC146023 26

mitotic cytokinesis

molecular_function

cytoplasm

centrosome

cytosol

cytoskeleton

microtubule

apoptotic process

negative regulation of microtubule depolymerization

cell cycle

microtubule cytoskeleton

microtubule cytoskeleton

positive regulation of transcription by RNA polymerase II

 
TC0600001401.mm.2 Clec4a2 C-type lectin domain family 4, member a2 6 123122689, 123123315 NM_001170332, NM_001170333, NM_011999, BC006623, BC075729, BC096565 NM_001170332, NM_001170333, NM_011999, BC006623, BC075729, BC096565 NM_001170332, NM_001170333, NM_011999, BC006623, BC075729, BC096565 NM_001170332, NM_001170333, NM_011999, BC006623, BC075729, BC096565 NM_001170332, NM_001170333, NM_011999, BC006623, BC075729, BC096565 NM_001170332, NM_001170333, NM_011999, BC006623, BC075729, BC096565 24

negative regulation of cytokine production

adaptive immune response

immune system process

plasmacytoid dendritic cell antigen processing and presentation

calcium ion binding

mannose binding

plasma membrane

membrane

integral component of membrane

carbohydrate binding

carbohydrate binding

negative regulation of tumor necrosis factor production

CD8-positive, alpha-beta T cell activation

antigen processing and presentation of exogenous peptide antigen via MHC class I

innate immune response

metal ion binding

 
TC0200005476.mm.2 Nup35 nucleoporin 35 2 80639263, 80638811 NM_001190179, NM_027091, BC048814 NM_001190179, NM_027091, BC048814 NM_001190179, NM_027091, BC048814 22

nucleic acid binding

single-stranded DNA binding

phospholipid binding

nucleus

nuclear pore

nuclear lamina

nucleoplasm

plasma membrane

regulation of transcription, DNA-templated

NLS-bearing protein import into nucleus

nuclear pore organization

protein transport

membrane

structural constituent of nuclear pore

nuclear membrane

identical protein binding

nuclear pore central transport channel

nuclear pore nuclear basket

mRNA transport

cellular response to leukemia inhibitory factor

03013

TC1000002175.mm.2 Man1a mannosidase 1, alpha 10 -53904784 NM_008548, BC015265 NM_008548, BC015265 30

Golgi membrane

Golgi membrane

catalytic activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

Golgi apparatus

cytosol

N-glycan processing

metabolic process

membrane

integral component of membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

ubiquitin-dependent ERAD pathway

cytoplasmic vesicle

protein targeting to ER

metal ion binding

mannose trimming involved in glycoprotein ERAD pathway

00510

01100

04141

TC1200002242.mm.2 Fbln5 fibulin 5 12 -101746564, -101746564 NM_011812, BC006636 NM_011812, BC006636 75

negative regulation of transcription by RNA polymerase II

integrin binding

calcium ion binding

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

cell adhesion

protein C-terminus binding

negative regulation of angiogenesis

extracellular matrix constituent conferring elasticity

extracellular matrix organization

positive regulation of osteoblast proliferation

protein localization to cell surface

protein homodimerization activity

positive regulation of transcription by RNA polymerase II

secretion

elastic fiber assembly

elastic fiber assembly

elastic fiber assembly

collagen-containing extracellular matrix

collagen-containing extracellular matrix

collagen-containing extracellular matrix

elastic fiber

intramembranous bone growth

regulation of removal of superoxide radicals

 
TC1300000838.mm.2 Fastkd3 FAST kinase domains 3 13 68582209 NM_027123, BC042506, BC060688 NM_027123, BC042506, BC060688 NM_027123, BC042506, BC060688 14

protein kinase activity

nucleoplasm

mitochondrion

mitochondrion

mitochondrial cytochrome c oxidase assembly

regulation of mitochondrial mRNA stability

positive regulation of mitochondrial translation

 
TC1300002204.mm.2 Ctsl cathepsin L 13 -64361889 NM_009984, BC068163 NM_009984, BC068163 210

endopeptidase activity

aminopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

protein binding

extracellular region

extracellular space

extracellular space

nucleus

nucleolus

cytoplasm

lysosome

lysosome

lysosome

vacuole

plasma membrane

microvillus

proteolysis

proteolysis

thyroid hormone generation

immune response

cell communication

peptidase activity

cysteine-type peptidase activity

external side of plasma membrane

external side of plasma membrane

negative regulation of keratinocyte proliferation

membrane

protein processing

protein processing

protein autoprocessing

hydrolase activity

cysteine-type carboxypeptidase activity

secretory granule

collagen catabolic process

kininogen binding

hair follicle morphogenesis

cytoplasmic vesicle

peptide binding

histone binding

catagen

neuron projection

perikaryon

CD4-positive, alpha-beta T cell lineage commitment

protein-containing complex binding

apical part of cell

decidualization

antigen processing and presentation of peptide antigen

proteolysis involved in cellular protein catabolic process

proteolysis involved in cellular protein catabolic process

elastin catabolic process

collagen-containing extracellular matrix

regulation of actin cytoskeleton reorganization

04142

04145

04612

05323

TC0700003988.mm.2 Rrp8 ribosomal RNA processing 8 7 -105731729, -105731729 NM_025897, NM_133951, BC022923, BC046799 NM_025897, NM_133951, BC022923, BC046799 NM_025897, NM_133951, BC022923, BC046799 NM_025897, NM_133951, BC022923, BC046799 23

rDNA heterochromatin assembly

rDNA heterochromatin assembly

nucleus

nucleoplasm

chromatin silencing complex

chromatin silencing complex

nucleolus

nucleolus

cytosol

plasma membrane

chromatin organization

rRNA processing

methyltransferase activity

transferase activity

methylation

rDNA heterochromatin

rDNA heterochromatin

methylated histone binding

methylated histone binding

cellular response to glucose starvation

cellular response to glucose starvation

regulation of transcription by glucose

regulation of transcription by glucose

positive regulation of cell cycle arrest

intrinsic apoptotic signaling pathway by p53 class mediator

 
TC0700004665.mm.2 Vkorc1 vitamin K epoxide reductase complex, subunit 1 7 -127893062 NM_178600, BC031732 NM_178600, BC031732 34

endoplasmic reticulum

blood coagulation

blood coagulation

blood coagulation

response to organonitrogen compound

response to organic cyclic compound

membrane

integral component of membrane

oxidoreductase activity

drug metabolic process

peptidyl-glutamic acid carboxylation

peptidyl-glutamic acid carboxylation

regulation of blood coagulation

vitamin K biosynthetic process

vitamin K metabolic process

vitamin K metabolic process

vitamin K metabolic process

vitamin K metabolic process

intracellular membrane-bounded organelle

response to antibiotic

vitamin-K-epoxide reductase (warfarin-sensitive) activity

vitamin-K-epoxide reductase (warfarin-sensitive) activity

vitamin-K-epoxide reductase (warfarin-sensitive) activity

vitamin-K-epoxide reductase (warfarin-insensitive) activity

quinone binding

positive regulation of coagulation

bone development

 
TC0800003162.mm.2 Nup133 nucleoporin 133 8 -123897122 NM_172288, BC023915, BC026845 NM_172288, BC023915, BC026845 NM_172288, BC023915, BC026845 23

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

condensed chromosome outer kinetochore

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

nucleus

nuclear pore

nuclear pore

nuclear pore

chromosome

mRNA export from nucleus

mRNA export from nucleus

protein import into nucleus

nuclear pore organization

protein transport

poly(A)+ mRNA export from nucleus

structural constituent of nuclear pore

structural constituent of nuclear pore

structural constituent of nuclear pore

neural tube development

neurogenesis

nuclear pore outer ring

nuclear pore outer ring

nuclear membrane

paraxial mesoderm development

mRNA transport

somite development

nephron development

03013

TC0600001404.mm.2 Clec4d C-type lectin domain family 4, member d 6 123262106 NM_001163161, NM_010819, BC099471 NM_001163161, NM_010819, BC099471 NM_001163161, NM_010819, BC099471 34

adaptive immune response

T cell differentiation involved in immune response

immune system process

plasma membrane

membrane

integral component of membrane

carbohydrate binding

positive regulation of myeloid dendritic cell activation

immunoglobulin receptor binding

Fc-gamma receptor signaling pathway

defense response to bacterium

innate immune response

metal ion binding

 
TC0200002232.mm.2 Gins1 GINS complex subunit 1 (Psf1 homolog) 2 150909593, 150909593 NM_001163476, NM_027014, BC027537 NM_001163476, NM_027014, BC027537 NM_001163476, NM_027014, BC027537 20

GINS complex

inner cell mass cell proliferation

protein binding

nucleus

nucleus

chromosome

cytoplasm

cytoplasm

DNA replication

DNA strand elongation involved in mitotic DNA replication

 
TC0X00003301.mm.2 Reps2 RALBP1 associated Eps domain containing protein 2 X -162411951, -162411951 NM_178256, BC139012, BC145500 NM_178256, BC139012, BC145500 NM_178256, BC139012, BC145500 19

molecular_function

calcium ion binding

cytoplasm

plasma membrane

endocytosis

endosomal transport

metal ion binding

 
TC0200005349.mm.2         NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

molecular_function

cellular_component

nucleus

regulation of transcription by RNA polymerase II

biological_process

 
TC0500001548.mm.2 Gtf2ird2 GTF2I repeat domain containing 2 5 134184037 NM_053266, BC132157, BC132159 NM_053266, BC132157, BC132159 NM_053266, BC132157, BC132159 18

DNA binding

protein binding

nucleus

nucleus

transition between fast and slow fiber

 
TC1800001741.mm.2         NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188  

molecular_function

calcium ion binding

protein binding

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

cell-cell junction

cell-cell junction

cell adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

homophilic cell adhesion via plasma membrane adhesion molecules

biological_process

endosome to lysosome transport

membrane

integral component of membrane

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

growth cone

synapse organization

lipid tube assembly involved in organelle fusion

 
TC0100003027.mm.2 Dars aspartyl-tRNA synthetase 1 -128412117, -128363706 NM_145507, NM_177445, BC008638 NM_145507, NM_177445, BC008638 NM_145507, NM_177445, BC008638 31

nucleotide binding

nucleic acid binding

RNA binding

aminoacyl-tRNA ligase activity

aspartate-tRNA ligase activity

aspartate-tRNA ligase activity

ATP binding

cytoplasm

cytosol

cytosol

translation

tRNA aminoacylation for protein translation

aspartyl-tRNA aminoacylation

aspartyl-tRNA aminoacylation

ligase activity

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

synapse

00970

TC0900001056.mm.2 Cd109 CD109 antigen 9 78615545 NM_153098, BC052443, CD109 NM_153098, BC052443, CD109 NM_153098, BC052443, CD109 36

negative regulation of protein phosphorylation

hair follicle development

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

extracellular region

extracellular space

cytosol

plasma membrane

negative regulation of peptidase activity

negative regulation of keratinocyte proliferation

membrane

peptidase inhibitor activity

negative regulation of transforming growth factor beta receptor signaling pathway

anchored component of membrane

regulation of keratinocyte differentiation

transforming growth factor beta binding

negative regulation of wound healing

osteoclast fusion

 
TC1300000763.mm.2         NR_029530, NR_029531, NR_029575, BC141279, NM_028079, XM_003688907 NR_029530, NR_029531, NR_029575, BC141279, NM_028079, XM_003688907 NR_029530, NR_029531, NR_029575, BC141279, NM_028079, XM_003688907 NR_029530, NR_029531, NR_029575, BC141279, NM_028079, XM_003688907 NR_029530, NR_029531, NR_029575, BC141279, NM_028079, XM_003688907 NR_029530, NR_029531, NR_029575, BC141279, NM_028079, XM_003688907  

RNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

aminopeptidase activity

nucleus

nucleolus

nucleolus

cytoplasm

proteolysis

cell aging

sensory perception of sound

peptidase activity

metallopeptidase activity

zinc ion binding

positive regulation of cell population proliferation

response to bacterium

regulation of gene expression

negative regulation of gene expression

Wnt signaling pathway

hydrolase activity

myelination

regulation of viral genome replication

regulation of viral genome replication

positive regulation of angiogenesis

metal ion binding

long-term synaptic potentiation

retina vasculature development in camera-type eye

metalloaminopeptidase activity

cellular response to lipopolysaccharide

cellular response to inorganic substance

cellular response to forskolin

cellular response to leukemia inhibitory factor

regulation of semaphorin-plexin signaling pathway

 
TC0800003037.mm.2 Gins2 GINS complex subunit 2 (Psf2 homolog) 8 -120581265 NM_178856, BC082565 NM_178856, BC082565 19

double-strand break repair via break-induced replication

GINS complex

nucleus

chromosome

DNA replication

 
TC1100003397.mm.2 Ccl9 chemokine (C-C motif) ligand 9 11 -83572916 NM_011338, BC139318, BC145962 NM_011338, BC139318, BC145962 NM_011338, BC139318, BC145962 52

monocyte chemotaxis

cytokine activity

extracellular region

extracellular space

chemotaxis

inflammatory response

immune response

G protein-coupled receptor signaling pathway

chemokine activity

neutrophil chemotaxis

positive regulation of GTPase activity

negative regulation of myoblast differentiation

CCR chemokine receptor binding

lymphocyte chemotaxis

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

04060

04062

TC0800002558.mm.2         NM_001163029, NM_001163030, NM_001163031, NM_011925, NR_106188, BC006676, CD97 NM_001163029, NM_001163030, NM_001163031, NM_011925, NR_106188, BC006676, CD97 NM_001163029, NM_001163030, NM_001163031, NM_011925, NR_106188, BC006676, CD97 NM_001163029, NM_001163030, NM_001163031, NM_011925, NR_106188, BC006676, CD97 NM_001163029, NM_001163030, NM_001163031, NM_011925, NR_106188, BC006676, CD97 NM_001163029, NM_001163030, NM_001163031, NM_011925, NR_106188, BC006676, CD97 NM_001163029, NM_001163030, NM_001163031, NM_011925, NR_106188, BC006676, CD97  

transmembrane signaling receptor activity

G protein-coupled receptor activity

calcium ion binding

extracellular region

plasma membrane

integral component of plasma membrane

cell adhesion

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

external side of plasma membrane

membrane

integral component of membrane

positive regulation of synapse assembly

 
TC0200000393.mm.2 Pnpla7 patatin-like phospholipase domain containing 7 2 24976032 NM_146251, BC141365, BC141366 NM_146251, BC141365, BC141366 NM_146251, BC141365, BC141366 25

lysophospholipase activity

lysophospholipase activity

lysophospholipase activity

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid droplet

lipid metabolic process

membrane

integral component of membrane

lipid catabolic process

hydrolase activity

phosphatidylcholine catabolic process

carboxylic ester hydrolase activity

 
TC1100001730.mm.2 Itgb3 integrin beta 3 11 104607999 NM_016780, BC125518, BC125520 NM_016780, BC125518, BC125520 NM_016780, BC125518, BC125520 424

positive regulation of endothelial cell proliferation

positive regulation of cell-matrix adhesion

fibronectin binding

fibronectin binding

protease binding

positive regulation of leukocyte migration

protein disulfide isomerase activity

protein kinase C binding

integrin binding

integrin binding

integrin binding

protein binding

nucleus

nucleoplasm

plasma membrane

cell-cell junction

focal adhesion

focal adhesion

focal adhesion

cell-substrate junction assembly

cell adhesion

cell-matrix adhesion

cell-matrix adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

regulation of G protein-coupled receptor signaling pathway

integrin complex

integrin complex

external side of plasma membrane

cell surface

cell surface

cell surface

positive regulation of endothelial cell migration

positive regulation of gene expression

negative regulation of macrophage derived foam cell differentiation

positive regulation of fibroblast migration

positive regulation of fibroblast migration

negative regulation of lipid storage

smooth muscle cell migration

positive regulation of smooth muscle cell migration

membrane

integral component of membrane

apical plasma membrane

apical plasma membrane

cell migration

fibroblast growth factor binding

enzyme binding

enzyme binding

C-X3-C chemokine binding

cell junction

platelet activation

regulation of cell migration

positive regulation of cell migration

lamellipodium membrane

filopodium membrane

microvillus membrane

cell-substrate adhesion

insulin-like growth factor I binding

activation of protein kinase activity

negative regulation of lipid transport

ruffle membrane

regulation of protein localization

regulation of actin cytoskeleton organization

protein-containing complex

cell adhesion mediated by integrin

cell adhesion mediated by integrin

positive regulation of cell adhesion mediated by integrin

positive regulation of osteoblast proliferation

heterotypic cell-cell adhesion

substrate adhesion-dependent cell spreading

integrin alpha9-beta1 complex

integrin alphav-beta3 complex

alphav-beta3 integrin-PKCalpha complex

alphav-beta3 integrin-PKCalpha complex

alphav-beta3 integrin-IGF-1-IGF1R complex

alphav-beta3 integrin-HMGB1 complex

cellular response to platelet-derived growth factor stimulus

apolipoprotein A-I-mediated signaling pathway

neuregulin binding

melanosome

identical protein binding

cell projection

vascular endothelial growth factor receptor 2 binding

receptor complex

apoptotic cell clearance

apoptotic cell clearance

synapse

postsynaptic membrane

positive regulation of osteoclast differentiation

positive regulation of angiogenesis

positive regulation of bone resorption

positive regulation of bone resorption

viral entry into host cell

platelet-derived growth factor receptor signaling pathway

positive regulation of fibroblast proliferation

positive regulation of smooth muscle cell proliferation

cell projection morphogenesis

positive regulation of peptidyl-tyrosine phosphorylation

negative regulation of lipoprotein metabolic process

cell adhesion molecule binding

extracellular matrix binding

negative chemotaxis

regulation of release of sequestered calcium ion into cytosol

regulation of serotonin uptake

negative regulation of cell death

regulation of protein tyrosine kinase activity

fibrinogen binding

fibrinogen binding

positive regulation of ERK1 and ERK2 cascade

platelet aggregation

alpha9-beta1 integrin-ADAM8 complex

positive regulation of glomerular mesangial cell proliferation

glutamatergic synapse

glutamatergic synapse

regulation of postsynaptic neurotransmitter receptor internalization

integral component of synaptic membrane

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway

regulation of extracellular matrix organization

negative regulation of low-density lipoprotein receptor activity

positive regulation of T cell migration

04145

04380

04510

04512

04640

04810

05410

05412

05414

TC0200002395.mm.2 Epb41l1 erythrocyte membrane protein band 4.1 like 1 2 156475533, 156420908, 156421090, 156475548 NM_001006664, NM_013510, BC034751, NM_001003815 NM_001006664, NM_013510, BC034751, NM_001003815 NM_001006664, NM_013510, BC034751, NM_001003815 NM_001006664, NM_013510, BC034751, NM_001003815 50

actin binding

signaling receptor binding

structural molecule activity

protein binding

cytoplasm

cytoskeleton

plasma membrane

plasma membrane

cytoskeletal protein binding

postsynaptic density

cortical actin cytoskeleton organization

actomyosin structure organization

protein-containing complex

synaptic membrane

04530

TC0500000850.mm.2 Cxcl2 chemokine (C-X-C motif) ligand 2 5 90903898 NM_009140, BC119511, BC119512 NM_009140, BC119511, BC119512 NM_009140, BC119511, BC119512 162

response to molecule of bacterial origin

cytokine activity

extracellular region

extracellular space

extracellular space

extracellular space

chemotaxis

defense response

inflammatory response

immune response

positive regulation of cytosolic calcium ion concentration

chemokine activity

chemokine activity

neutrophil chemotaxis

neutrophil chemotaxis

leukocyte chemotaxis

killing of cells of other organism

CXCR chemokine receptor binding

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

neuron death

cellular response to lipopolysaccharide

04060

04062

04621

TC1100001741.mm.2 Mettl2 methyltransferase like 2 11 105126424 NM_172567, BC089591 NM_172567, BC089591 23

cellular_component

tRNA processing

methyltransferase activity

transferase activity

tRNA methylation

tRNA methylation

methylation

tRNA (cytosine-3-)-methyltransferase activity

tRNA (cytosine-3-)-methyltransferase activity

tRNA (cytosine-3-)-methyltransferase activity

00340

00350

TC0X00001382.mm.2 Prps1 phosphoribosyl pyrophosphate synthetase 1 X 140456602 NM_021463, BC054772 NM_021463, BC054772 35

nucleotide binding

magnesium ion binding

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ATP binding

ATP binding

cytoplasm

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate biosynthetic process

purine nucleobase metabolic process

purine nucleotide biosynthetic process

purine nucleotide biosynthetic process

AMP biosynthetic process

nervous system development

nucleoside metabolic process

ribonucleoside monophosphate biosynthetic process

nucleotide biosynthetic process

AMP binding

kinase activity

phosphorylation

transferase activity

GDP binding

ribose phosphate metabolic process

carbohydrate binding

protein-containing complex

urate biosynthetic process

identical protein binding

protein homodimerization activity

ADP binding

cellular biosynthetic process

hypoxanthine biosynthetic process

metal ion binding

00030

00230

01100

TC0500001576.mm.2 Tbl2 transducin (beta)-like 2 5 135149685 NM_013763, BC039273, BC048185 NM_013763, BC039273, BC048185 NM_013763, BC039273, BC048185 25

endoplasmic reticulum

protein kinase binding

endoplasmic reticulum unfolded protein response

translation initiation factor binding

cellular response to glucose starvation

phosphoprotein binding

cellular response to hypoxia

 
TC1100001882.mm.2 Cd300a CD300A molecule 11 114890040 NM_170758, BC139296, BC139297, CD300A NM_170758, BC139296, BC139297, CD300A NM_170758, BC139296, BC139297, CD300A NM_170758, BC139296, BC139297, CD300A 31

phosphatidylserine binding

immune system process

serotonin secretion by mast cell

transmembrane signaling receptor activity

protein binding

plasma membrane

plasma membrane

receptor-mediated endocytosis

phosphatidylethanolamine binding

negative regulation of serotonin secretion

membrane

integral component of membrane

phosphatase binding

negative regulation of B cell proliferation

positive regulation of phosphoprotein phosphatase activity

negative regulation of mast cell activation involved in immune response

negative regulation of MyD88-dependent toll-like receptor signaling pathway

signaling receptor activity

negative regulation of mast cell degranulation

negative regulation of mast cell degranulation

negative regulation of MAP kinase activity

negative regulation of fibroblast proliferation

regulation of T cell receptor signaling pathway

negative regulation of B cell receptor signaling pathway

negative regulation of NK T cell activation

negative regulation of phagocytosis, engulfment

negative regulation of neutrophil activation

negative regulation of eosinophil activation

negative regulation of activation of Janus kinase activity

negative regulation of eosinophil migration

 
TC0700003831.mm.2 P2ry2 purinergic receptor P2Y, G-protein coupled 2 7 -100996567, -100996567 NM_008773, BC006613 NM_008773, BC006613 136

G protein-coupled receptor activity

ATP binding

mitochondrion

lysosome

early endosome

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of neuron projection development

positive regulation of smooth muscle cell migration

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

sensory perception of pain

negative regulation of ossification

A1 adenosine receptor binding

positive regulation of prostaglandin secretion

positive regulation of chemokine production

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled UTP receptor activity

positive regulation of penile erection

positive regulation of mucus secretion

blood vessel diameter maintenance

glutamatergic synapse

integral component of presynaptic active zone membrane

regulation of presynaptic cytosolic calcium ion concentration

regulation of synaptic vesicle exocytosis

04080

TC1500000002.mm.2 Selenop selenoprotein P 15 3270766, 3270976, 3270810 NM_001042613, NM_001042614, NM_009155, BC001991 NM_001042613, NM_001042614, NM_009155, BC001991 NM_001042613, NM_001042614, NM_009155, BC001991 NM_001042613, NM_001042614, NM_009155, BC001991 74

selenium compound metabolic process

selenium compound metabolic process

selenium compound metabolic process

protein binding

extracellular region

extracellular region

extracellular space

brain development

locomotory behavior

selenium binding

selenium binding

post-embryonic development

sexual reproduction

regulation of growth

 
TC0800000621.mm.2 Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) 8 56294551 NM_008278, BC021157 NM_008278, BC021157 43

prostaglandin E receptor activity

extracellular space

nucleoplasm

cytoplasm

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

prostaglandin metabolic process

prostaglandin metabolic process

transforming growth factor beta receptor signaling pathway

female pregnancy

female pregnancy

parturition

basolateral plasma membrane

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

identical protein binding

positive regulation of apoptotic process

response to ethanol

negative regulation of cell cycle

NAD binding

NAD+ binding

ductus arteriosus closure

positive regulation of vascular associated smooth muscle cell proliferation

regulation of prostaglandin catabolic process

 
TC1100000995.mm.2 Mybbp1a MYB binding protein (P160) 1a 11 72441326 NM_016776, BC048858, BC052889 NM_016776, BC048858, BC052889 NM_016776, BC048858, BC052889 63

DNA binding

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleolus

nucleolus

nucleolus

cytoplasm

regulation of transcription, DNA-templated

transcription factor binding

zinc ion binding

respiratory electron transport chain

circadian regulation of gene expression

cellular response to glucose starvation

ribosome biogenesis

NLS-dependent protein nuclear import complex

intracellular membrane-bounded organelle

sequence-specific DNA binding

sequence-specific DNA binding

negative regulation of transcription, DNA-templated

rhythmic process

E-box binding

positive regulation of cell cycle arrest

intrinsic apoptotic signaling pathway by p53 class mediator

positive regulation of anoikis

 
TC1300002036.mm.2 Nop16 NOP16 nucleolar protein 13 -54584190 NM_178605, BC012213 NM_178605, BC012213 21

nucleus

nucleoplasm

nucleolus

nucleolus

ribosomal large subunit biogenesis

intracellular membrane-bounded organelle

 
TC1900000683.mm.2 Nolc1 nucleolar and coiled-body phosphoprotein 1 19 46075846 NM_001039351, NM_001039352, NM_001039353, NM_053086 NM_001039351, NM_001039352, NM_001039353, NM_053086 NM_001039351, NM_001039352, NM_001039353, NM_053086 NM_001039351, NM_001039352, NM_001039353, NM_053086 29

protein binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

cytoplasm

nucleolus organization

Cajal body

small nuclear ribonucleoprotein complex

 
TC0400000207.mm.2 Mms22l MMS22-like, DNA repair protein 4 24496450 NM_199467, BC137910, BC145028 NM_199467, BC137910, BC145028 NM_199467, BC137910, BC145028 19

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

molecular_function

nucleus

nucleoplasm

cytosol

DNA repair

cellular response to DNA damage stimulus

replication fork processing

replication fork processing

FACT complex

MCM complex

MCM complex

nuclear replication fork

nuclear replication fork

 
TC1200000132.mm.2 E2f6 E2F transcription factor 6 12 16810964 NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F 48

regulation of transcription involved in G1/S transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleoplasm

DNA replication factor A complex

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cell cycle

protein dimerization activity

MLL1 complex

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

 
TC0800001116.mm.2 Arl2bp ADP-ribosylation factor-like 2 binding protein 8 94667090, 94666599 NM_024191, NM_024269, BC002131, BC024708 NM_024191, NM_024269, BC002131, BC024708 NM_024191, NM_024269, BC002131, BC024708 NM_024191, NM_024269, BC002131, BC024708 23

transcription coactivator activity

protein binding

nucleus

cytoplasm

mitochondrion

mitochondrial intermembrane space

mitochondrial intermembrane space

centrosome

cytoskeleton

cilium

midbody

GTPase regulator activity

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

cell projection

maintenance of protein location in nucleus

maintenance of protein location in nucleus

 
TC1400002259.mm.2 Elp3 elongator acetyltransferase complex subunit 3 14 -65530445 NM_001253812, NM_028811, NR_045599, BC057453 NM_001253812, NM_028811, NR_045599, BC057453 NM_001253812, NM_028811, NR_045599, BC057453 NM_001253812, NM_028811, NR_045599, BC057453 39

tRNA binding

neuron migration

tRNA wobble uridine modification

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation

RNA binding

catalytic activity

nucleus

nucleolus

cytoplasm

cytoplasm

cytosol

regulation of transcription by RNA polymerase II

nervous system development

central nervous system development

tRNA processing

phosphorylase kinase regulator activity

acetyltransferase activity

transferase activity

transferase activity, transferring acyl groups

positive regulation of cell migration

elongator holoenzyme complex

elongator holoenzyme complex

metal ion binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

 
TC1100001049.mm.2 Mettl16 methyltransferase like 16 11 74770862 NM_026197, BC049897, BC054724 NM_026197, BC049897, BC054724 NM_026197, BC049897, BC054724 23

RNA methylation

mRNA (N6-adenosine)-methyltransferase activity

mRNA (N6-adenosine)-methyltransferase activity

RNA binding

nucleus

nucleus

cytoplasm

mRNA catabolic process

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

methyltransferase activity

posttranscriptional regulation of gene expression

posttranscriptional regulation of gene expression

transferase activity

U6 snRNA 3'-end binding

methylation

RNA stem-loop binding

23S rRNA (adenine(1618)-N(6))-methyltransferase activity

mRNA destabilization

rRNA base methylation

mRNA methylation

mRNA methylation

U6 snRNA (adenine-(43)-N(6))-methyltransferase activity

snRNA (adenine-N6)-methylation

negative regulation of 3'-UTR-mediated mRNA stabilization

 
TC0500000260.mm.2 Insig1 insulin induced gene 1 5 28071411 NM_153526, BC132167, BC132499 NM_153526, BC132167, BC132499 NM_153526, BC132167, BC132499 37

protein binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

lipid metabolic process

triglyceride metabolic process

cholesterol biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

response to sterol depletion

oxysterol binding

steroid metabolic process

cholesterol metabolic process

lipid binding

negative regulation of steroid biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

sterol biosynthetic process

cellular response to insulin stimulus

SREBP signaling pathway

SREBP signaling pathway

SREBP-SCAP-Insig complex

SREBP-SCAP-Insig complex

cellular response to sterol

SREBP-SCAP complex retention in endoplasmic reticulum

SREBP-SCAP complex retention in endoplasmic reticulum

inner ear morphogenesis

middle ear morphogenesis

cholesterol homeostasis

negative regulation of fat cell differentiation

negative regulation of fatty acid biosynthetic process

roof of mouth development

cranial suture morphogenesis

negative regulation of protein exit from endoplasmic reticulum

negative regulation of cargo loading into COPII-coated vesicle

 
TC0500000494.mm.2 Ncapg non-SMC condensin I complex, subunit G 5 45669924 NM_019438, BC137834, BC144960 NM_019438, BC137834, BC144960 NM_019438, BC137834, BC144960 26

condensed chromosome, centromeric region

condensed chromosome

condensed chromosome

condensin complex

condensin complex

condensin complex

molecular_function

cytoplasm

cytoplasm

mitotic chromosome condensation

mitotic chromosome condensation

 
TC1900000529.mm.2 Kif11 kinesin family member 11 19 37376381 NM_010615, BC060670 NM_010615, BC060670 58

nucleotide binding

spindle pole

microtubule motor activity

ATP binding

nucleus

cytoplasm

spindle

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

microtubule-based movement

cell cycle

spindle organization

mitotic centrosome separation

microtubule binding

ATP-dependent microtubule motor activity, plus-end-directed

protein kinase binding

protein-containing complex

regulation of mitotic centrosome separation

spindle assembly

cell division

mitotic spindle

mitotic spindle assembly

mitotic spindle assembly

 
TC1400002515.mm.2 Diaph3 diaphanous related formin 3 14 -86655356 NM_019670, BC028920, BC085191 NM_019670, BC028920, BC085191 NM_019670, BC028920, BC085191 64

actin binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytoskeleton organization

cellular component organization

actin cytoskeleton organization

actin filament polymerization

small GTPase binding

04810

TC1000002003.mm.2 Amd2 S-adenosylmethionine decarboxylase 2 10 -40287464 NM_007444 17

adenosylmethionine decarboxylase activity

adenosylmethionine decarboxylase activity

adenosylmethionine decarboxylase activity

cytosol

cytosol

polyamine biosynthetic process

spermine biosynthetic process

spermidine biosynthetic process

lyase activity

carboxy-lyase activity

putrescine binding

putrescine binding

identical protein binding

 
TC1300001641.mm.2 Hfe homeostatic iron regulator 13 -23702033 NM_010424, BC116744, BC116746 NM_010424, BC116744, BC116746 NM_010424, BC116744, BC116746 179

negative regulation of T cell antigen processing and presentation

negative regulation of T cell cytokine production

signaling receptor binding

extracellular space

extracellular space

nucleoplasm

early endosome

plasma membrane

ion transport

cellular iron ion homeostasis

external side of plasma membrane

external side of plasma membrane

response to iron ion

positive regulation of gene expression

positive regulation of pathway-restricted SMAD protein phosphorylation

membrane

integral component of membrane

BMP signaling pathway

beta-2-microglobulin binding

cytoplasmic vesicle

positive regulation of protein binding

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of iron ion transport

regulation of iron ion transport

co-receptor binding

hormone biosynthetic process

apical part of cell

basal part of cell

positive regulation of receptor-mediated endocytosis

perinuclear region of cytoplasm

recycling endosome

iron ion homeostasis

iron ion homeostasis

multicellular organismal iron ion homeostasis

cellular response to iron ion

positive regulation of peptide hormone secretion

iron ion import across plasma membrane

negative regulation of receptor binding

positive regulation of receptor binding

negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I

positive regulation of ferrous iron binding

positive regulation of transferrin receptor binding

terminal web

transferrin receptor binding

transferrin receptor binding

transferrin receptor binding

response to iron ion starvation

HFE-transferrin receptor complex

HFE-transferrin receptor complex

regulation of protein localization to cell surface

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of signaling receptor activity

positive regulation of signaling receptor activity

negative regulation of CD8-positive, alpha-beta T cell activation

 
TC0200000492.mm.2 Ak8 adenylate kinase 8 2 28700160 NM_001033874, BC100481, BC109352 NM_001033874, BC100481, BC109352 NM_001033874, BC100481, BC109352 19

nucleotide binding

adenylate kinase activity

adenylate kinase activity

cytidylate kinase activity

cytidylate kinase activity

nucleoside diphosphate kinase activity

nucleoside diphosphate kinase activity

ATP binding

cytoplasm

axoneme

nucleobase-containing compound metabolic process

nucleoside diphosphate phosphorylation

nucleoside diphosphate phosphorylation

nucleoside triphosphate biosynthetic process

nucleoside triphosphate biosynthetic process

kinase activity

phosphorylation

transferase activity

nucleobase-containing compound kinase activity

ventricular system development

sperm flagellum

 
TC0300001247.mm.2 Bcar3 breast cancer anti-estrogen resistance 3 3 122483568, 122419756 NM_013867, BC023930 NM_013867, BC023930 26

phosphotyrosine residue binding

lens morphogenesis in camera-type eye

guanyl-nucleotide exchange factor activity

cytoplasm

focal adhesion

signal transduction

small GTPase mediated signal transduction

insulin receptor signaling pathway

membrane

kinase binding

cell junction

positive regulation of peptidyl-serine phosphorylation

positive regulation of peptidyl-serine phosphorylation

positive regulation of MAPK cascade

positive regulation of GTPase activity

positive regulation of DNA replication

positive regulation of epidermal growth factor receptor signaling pathway

endothelin receptor signaling pathway

 
TC1200000334.mm.2 Agmo alkylglycerol monooxygenase 12 37241638 NM_178767, BC148840 NM_178767, BC148840 14

iron ion binding

endoplasmic reticulum

endoplasmic reticulum

membrane lipid metabolic process

membrane lipid metabolic process

lipid biosynthetic process

membrane

integral component of membrane

oxidoreductase activity

ether lipid metabolic process

glyceryl-ether monooxygenase activity

glyceryl-ether monooxygenase activity

 
TC0700002980.mm.2 Prmt1 protein arginine N-methyltransferase 1 7 -44976754 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 104

in utero embryonic development

protein binding

nucleus

nucleus

cytoplasm

cytosol

protein methylation

methyltransferase activity

N-methyltransferase activity

protein methyltransferase activity

protein methyltransferase activity

positive regulation of cell population proliferation

methyl-CpG binding

histone-arginine N-methyltransferase activity

membrane

protein-arginine N-methyltransferase activity

protein-arginine N-methyltransferase activity

[cytochrome c]-arginine N-methyltransferase activity

histone methylation

transferase activity

peptidyl-arginine methylation

enzyme binding

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

snoRNP binding

neuron projection development

methylation

protein-containing complex

methylosome

protein-arginine omega-N monomethyltransferase activity

protein-arginine omega-N asymmetric methyltransferase activity

protein-arginine omega-N asymmetric methyltransferase activity

peptidyl-arginine omega-N-methylation

histone methyltransferase activity

histone methyltransferase activity

identical protein binding

histone H4-R3 methylation

histone H4-R3 methylation

histone methyltransferase activity (H4-R3 specific)

positive regulation of erythrocyte differentiation

regulation of megakaryocyte differentiation

negative regulation of megakaryocyte differentiation

positive regulation of hemoglobin biosynthetic process

mitogen-activated protein kinase p38 binding

protein homooligomerization

positive regulation of p38MAPK cascade

S-adenosyl-L-methionine binding

 
TC1700002541.mm.2 Fam98a family with sequence similarity 98, member A 17 -75537084, -75537085 NM_133747, BC004626 NM_133747, BC004626 26

protein binding

protein methylation

protein methyltransferase activity

positive regulation of cell population proliferation

positive regulation of gene expression

lysosome localization

tRNA-splicing ligase complex

positive regulation of ruffle assembly

 
TC0700002168.mm.2 Tmem150b transmembrane protein 150B 7 -4716001, -4706831 NM_001142792, NM_177887, BC022651 NM_001142792, NM_177887, BC022651 NM_001142792, NM_177887, BC022651 13

molecular_function

lysosome

endosome

plasma membrane

integral component of plasma membrane

autophagy

regulation of autophagy

membrane

integral component of membrane

cytoplasmic vesicle

 
TC0400000085.mm.2 Ccne2 cyclin E2 4 11191708, 11191350 NM_001037134, NM_001282943, NM_009830, BC053727 NM_001037134, NM_001282943, NM_009830, BC053727 NM_001037134, NM_001282943, NM_009830, BC053727 NM_001037134, NM_001282943, NM_009830, BC053727 79

regulation of cyclin-dependent protein serine/threonine kinase activity

G1/S transition of mitotic cell cycle

cyclin-dependent protein kinase holoenzyme complex

telomere maintenance

nucleus

cytoplasm

centrosome

DNA replication initiation

cell cycle

homologous chromosome pairing at meiosis

cyclin-dependent protein serine/threonine kinase regulator activity

cyclin-dependent protein serine/threonine kinase regulator activity

protein kinase binding

mitotic cell cycle phase transition

cell division

regulation of cell cycle

chromosome organization involved in meiotic cell cycle

cyclin E1-CDK2 complex

cyclin E2-CDK2 complex

cyclin E2-CDK2 complex

cyclin E2-CDK2 complex

regulation of cellular protein localization

04110

04114

04115

05200

05215

05222

TC0300001364.mm.2 Cenpe centromere protein E 3 135212562 NM_173762 44

nucleotide binding

mitotic cell cycle

mitotic cell cycle

chromosome, centromeric region

kinetochore

kinetochore

condensed nuclear chromosome kinetochore

condensed chromosome, centromeric region

condensed chromosome outer kinetochore

microtubule motor activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

kinetochore microtubule

cytosol

cytoskeleton

microtubule

microtubule

microtubule-based movement

cell cycle

mitotic spindle organization

spindle assembly involved in female meiosis I

chromosome segregation

mitotic chromosome movement towards spindle pole

mitotic metaphase plate congression

regulation of mitotic nuclear division

mitotic spindle assembly checkpoint

multicellular organism development

microtubule binding

microtubule binding

ATP-dependent microtubule motor activity, plus-end-directed

attachment of spindle microtubules to kinetochore

attachment of spindle microtubules to kinetochore

microtubule cytoskeleton

protein kinase binding

regulation of mitotic metaphase/anaphase transition

midbody

regulation of protein stability

kinetochore binding

kinetochore binding

establishment of protein localization

positive regulation of mitotic metaphase/anaphase transition

positive regulation of protein kinase activity

positive regulation of protein kinase activity

regulation of developmental process

spindle midzone

cell division

metaphase plate congression

attachment of mitotic spindle microtubules to kinetochore

kinetochore assembly

positive regulation of chromosome segregation

positive regulation of attachment of spindle microtubules to kinetochore

microtubule plus-end directed mitotic chromosome migration

lateral attachment of mitotic spindle microtubules to kinetochore

mitotic spindle midzone

 
TC0200002010.mm.2 Cdc25b cell division cycle 25B 2 131186947 NM_001111075, NM_023117, BC057568 NM_001111075, NM_023117, BC057568 NM_001111075, NM_023117, BC057568 69

G2/M transition of mitotic cell cycle

mitotic cell cycle

spindle pole

oocyte maturation

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein binding

intracellular anatomical structure

nucleus

nucleus

cytoplasm

cytoplasm

centrosome

cytoskeleton

protein phosphorylation

protein dephosphorylation

cell cycle

female meiosis I

positive regulation of G2/M transition of mitotic cell cycle

hydrolase activity

protein kinase binding

positive regulation of cytokinesis

positive regulation of protein kinase activity

positive regulation of mitotic cell cycle

cell division

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition

04010

04110

04914

TC0200000591.mm.2 Sh2d3c SH2 domain containing 3C 2 32721054, 32727688 NM_001252547, NM_013781, NR_045535, BC113203 NM_001252547, NM_013781, NR_045535, BC113203 NM_001252547, NM_013781, NR_045535, BC113203 NM_001252547, NM_013781, NR_045535, BC113203 25

transmembrane receptor protein tyrosine kinase adaptor activity

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

plasma membrane

signal transduction

small GTPase mediated signal transduction

membrane

positive regulation of peptidyl-serine phosphorylation

cell projection

 
TC1700000402.mm.2 Pgap6 post-glycosylphosphatidylinositol attachment to proteins 6 17 26113315 NM_021793, BC005722 NM_021793, BC005722 20

molecular_function

phospholipase A2 activity

lysosome

plasma membrane

integral component of plasma membrane

biological_process

membrane

integral component of membrane

hydrolase activity

 
TC0100000456.mm.2 Nop58 NOP58 ribonucleoprotein 1 59685005 NM_018868, BC076604, BC085135 NM_018868, BC076604, BC085135 NM_018868, BC076604, BC085135 31

TFIID-class transcription factor complex binding

fibrillar center

nucleus

nucleoplasm

nucleolus

sno(s)RNA-containing ribonucleoprotein complex

cytosol

Cajal body

snoRNA binding

snoRNA binding

box C/D RNP complex

small-subunit processome

ribosome biogenesis

snoRNA localization

ATPase binding

pre-snoRNP complex

03008

TC0100001877.mm.2 Plxna2 plexin A2 1 194619828 NM_008882, BC068155 NM_008882, BC068155 130

somitogenesis

semaphorin receptor complex

protein binding

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

negative regulation of cell adhesion

signal transduction

cell surface receptor signaling pathway

regulation of cell shape

membrane

integral component of membrane

semaphorin receptor activity

semaphorin receptor activity

semaphorin receptor activity

semaphorin receptor activity

neural tube development

cerebellar granule cell precursor tangential migration

regulation of cell migration

regulation of cell migration

identical protein binding

regulation of GTPase activity

positive regulation of axonogenesis

centrosome localization

pharyngeal system development

limb bud formation

collagen-containing extracellular matrix

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway involved in axon guidance

04360

TC1800000509.mm.2 Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 18 50128200 NM_008292, BC022175 NM_008292, BC022175 55

very long-chain fatty acid metabolic process

3-hydroxyacyl-CoA dehydrogenase activity

3-hydroxyacyl-CoA dehydrogenase activity

enoyl-CoA hydratase activity

enoyl-CoA hydratase activity

estradiol 17-beta-dehydrogenase activity

protein binding

mitochondrion

peroxisome

peroxisome

peroxisome

peroxisomal matrix

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation

fatty acid beta-oxidation

androgen metabolic process

estrogen metabolic process

oxidoreductase activity

long-chain-enoyl-CoA hydratase activity

lyase activity

isomerase activity

3-hydroxyacyl-CoA dehydratase activity

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity

very long-chain fatty-acyl-CoA metabolic process

medium-chain fatty-acyl-CoA metabolic process

identical protein binding

protein homodimerization activity

17-beta-hydroxysteroid dehydrogenase (NAD+) activity

17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Sertoli cell development

00120

01100

04146

TC0200001006.mm.2 Dhrs9 dehydrogenase/reductase (SDR family) member 9 2 69380461 NM_175512, BC118029 NM_175512, BC118029 16

retinoic acid biosynthetic process

alcohol dehydrogenase (NAD+) activity

retinol dehydrogenase activity

endoplasmic reticulum

lipid metabolic process

steroid metabolic process

androgen metabolic process

membrane

oxidoreductase activity

integral component of endoplasmic reticulum membrane

progesterone metabolic process

9-cis-retinoic acid biosynthetic process

intracellular membrane-bounded organelle

androsterone dehydrogenase activity

testosterone dehydrogenase (NAD+) activity

androstan-3-alpha,17-beta-diol dehydrogenase activity

00830

01100

TC0200004547.mm.2 Ncaph non-SMC condensin I complex, subunit H 2 -127103809 NM_144818, BC021499, BC025060 NM_144818, BC021499, BC025060 NM_144818, BC021499, BC025060 31

condensin complex

condensin complex

condensin complex

condensin complex

chromatin binding

chromatin binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

female meiotic nuclear division

meiotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

DNA topoisomerase binding

meiotic chromosome segregation

cell division

female meiosis chromosome separation

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity

 
TC1500000659.mm.2 Nol12 nucleolar protein 12 15 78934932 NM_133800, BC013701, BC094424 NM_133800, BC013701, BC094424 NM_133800, BC013701, BC094424 20

single-stranded DNA binding

RNA binding

RNA binding

nucleus

nucleolus

nucleolus

nucleolus

rRNA binding

identical protein binding

 
TC1700001881.mm.2 Kifc1 kinesin family member C1 17 -33875665 NM_001195298, BC003753, BC057162, BC100328 NM_001195298, BC003753, BC057162, BC100328 NM_001195298, BC003753, BC057162, BC100328 NM_001195298, BC003753, BC057162, BC100328 35

microtubule motor activity

microtubule motor activity

protein binding

nucleus

nucleus

microtubule organizing center

kinesin complex

kinesin complex

microtubule

microtubule-based movement

microtubule binding

ATP-dependent microtubule motor activity, minus-end-directed

negative regulation of centrosome duplication

ATPase activity

endocytic vesicle

spindle pole centrosome

vesicle transport along microtubule

minus-end-directed vesicle transport along microtubule

mitotic spindle

mitotic spindle

mitotic spindle assembly

 
TC0300000902.mm.2 Ctsk cathepsin K 3 95499209 NM_007802, BC046320 NM_007802, BC046320 199

fibronectin binding

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

collagen binding

extracellular region

extracellular space

extracellular space

extracellular space

nucleoplasm

cytoplasm

lysosome

lysosome

lysosome

plasma membrane

proteolysis

thyroid hormone generation

thyroid hormone generation

immune response

peptidase activity

cysteine-type peptidase activity

external side of plasma membrane

membrane

hydrolase activity

collagen catabolic process

collagen catabolic process

intracellular membrane-bounded organelle

proteoglycan binding

bone resorption

bone resorption

proteolysis involved in cellular protein catabolic process

proteolysis involved in cellular protein catabolic process

proteolysis involved in cellular protein catabolic process

negative regulation of cartilage development

04142

04380

04620

05323

TC1100002549.mm.2 Hmmr hyaluronan mediated motility receptor (RHAMM) 11 -40701387 NM_013552, BC021427 NM_013552, BC021427 47

hyaluronic acid binding

cytoplasm

centrosome

cytosol

microtubule cytoskeleton

04512

TC0400002110.mm.2 Noc2l NOC2 like nucleolar associated transcriptional repressor 4 156236014, 156236009 NM_021303, BC020013 NM_021303, BC020013 25

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

p53 binding

negative regulation of B cell apoptotic process

chromatin binding

transcription corepressor activity

transcription corepressor activity

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

nucleolus

nucleolus

cytosol

apoptotic process

Noc1p-Noc2p complex

Noc2p-Noc3p complex

nucleosome binding

nucleosomal histone binding

chromatin assembly

cellular response to UV

negative regulation of histone acetylation

negative regulation of histone acetylation

negative regulation of histone acetylation

ribosomal large subunit biogenesis

histone binding

histone binding

histone binding

repressing transcription factor binding

repressing transcription factor binding

negative regulation of intrinsic apoptotic signaling pathway

 
TC1000000752.mm.2 Slc19a1 solute carrier family 19 (folate transporter), member 1 10 77033211, 77032738 NM_001199271, NM_031196, BC015263 NM_001199271, NM_031196, BC015263 NM_001199271, NM_031196, BC015263 60

folic acid binding

folic acid binding

plasma membrane

plasma membrane

integral component of plasma membrane

organic anion transmembrane transporter activity

folic acid transmembrane transporter activity

folic acid transmembrane transporter activity

folate:anion antiporter activity

folate:anion antiporter activity

antiporter activity

methotrexate transmembrane transporter activity

methotrexate transmembrane transporter activity

organic anion transport

folic acid transport

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

apical plasma membrane

brush border membrane

vitamin transport

methotrexate transport

methotrexate transport

transmembrane transport

cyclic-GMP-AMP binding

vitamin transmembrane transporter activity

folate transmembrane transport

folate transmembrane transport

folate transmembrane transport

folate import across plasma membrane

folate import across plasma membrane

04977

TC0500001798.mm.2 Gtf3a general transcription factor III A 5 146948656 NM_025652, BC032292 NM_025652, BC032292 24

RNA polymerase III general transcription initiation factor activity

nucleic acid binding

DNA binding

DNA binding

RNA binding

nucleus

nucleoplasm

5S rRNA binding

ribosome biogenesis

ribosomal large subunit biogenesis

metal ion binding

 
TC0600003074.mm.2 Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 6 -122727808 NM_011401, BC034122, BC058811 NM_011401, BC034122, BC058811 NM_011401, BC034122, BC058811 133

acrosomal membrane

transporter activity

glucose transmembrane transporter activity

glucose binding

cytoplasm

cytoplasm

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

caveola

carbohydrate transport

monosaccharide transmembrane transporter activity

membrane

integral component of membrane

galactoside binding

kinase binding

transmembrane transporter activity

synaptic vesicle membrane

xylose binding

dehydroascorbic acid transmembrane transporter activity

dehydroascorbic acid transmembrane transporter activity

cell projection

D-glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

transmembrane transport

dehydroascorbic acid transport

glucose import across plasma membrane

glutamatergic synapse

integral component of synaptic membrane

transport across blood-brain barrier

glucose transmembrane transport

glucose transmembrane transport

glucose transmembrane transport

 
TC1800000708.mm.2 Psmg2 proteasome (prosome, macropain) assembly chaperone 2 18 67641586 NM_134138, BC016606 NM_134138, BC016606 21

nucleus

nucleus

cytosol

mitotic spindle assembly checkpoint

negative regulation of apoptotic process

proteasome assembly

chaperone-mediated protein complex assembly

regulation of cell cycle

molecular adaptor activity

chaperone complex

 
TC0700004361.mm.2         NM_145590, NR_037290, BC017158 NM_145590, NR_037290, BC017158 NM_145590, NR_037290, BC017158  

molecular_function

biological_process

membrane

integral component of membrane

 
TC1900001217.mm.2 Gcnt1 glucosaminyl (N-acetyl) transferase 1, core 2 19 -17326140, -17326140, -17326140 NM_001136484, NM_010265, NM_173442, BC039126 NM_001136484, NM_010265, NM_173442, BC039126 NM_001136484, NM_010265, NM_173442, BC039126 NM_001136484, NM_010265, NM_173442, BC039126 68

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

extracellular space

Golgi apparatus

trans-Golgi network

acetylglucosaminyltransferase activity

acetylglucosaminyltransferase activity

glycoprotein biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

Golgi cisterna

tissue morphogenesis

leukocyte tethering or rolling

cell adhesion molecule production

kidney morphogenesis

00512

01100

TC0300002357.mm.2 Il6ra interleukin 6 receptor, alpha 3 -89869323 NM_010559 145

cytokine receptor activity

ciliary neurotrophic factor receptor activity

interleukin-6 receptor activity

interleukin-6 receptor activity

interleukin-11 receptor activity

interleukin-6 receptor binding

extracellular region

extracellular space

plasma membrane

interleukin-6 receptor complex

interleukin-6 receptor complex

positive regulation of cell population proliferation

positive regulation of cell population proliferation

external side of plasma membrane

cell surface

positive regulation of activation of Janus kinase activity

positive regulation of activation of Janus kinase activity

vascular endothelial growth factor production

membrane

integral component of membrane

apical plasma membrane

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

enzyme binding

cytokine binding

interleukin-11 binding

interleukin-6 binding

interleukin-6 binding

interleukin-6 binding

endocrine pancreas development

positive regulation of chemokine production

positive regulation of interleukin-6 production

neuronal cell body membrane

negative regulation of collagen biosynthetic process

response to cytokine

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

protein homodimerization activity

receptor complex

positive regulation of MAPK cascade

developmental growth

positive regulation of smooth muscle cell proliferation

positive regulation of peptidyl-tyrosine phosphorylation

interleukin-6-mediated signaling pathway

interleukin-6-mediated signaling pathway

interleukin-6-mediated signaling pathway

ciliary neurotrophic factor receptor complex

ciliary neurotrophic factor binding

ciliary neurotrophic factor-mediated signaling pathway

positive regulation of glomerular mesangial cell proliferation

T-helper 17 cell lineage commitment

04060

04630

04640

TC0200003753.mm.2 Gpr155 G protein-coupled receptor 155 2 -73341505 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 13

molecular_function

cognition

 
TC1100003659.mm.2 Plxdc1 plexin domain containing 1 11 -97923236 NM_001163608, NM_028199, BC114352 NM_001163608, NM_028199, BC114352 NM_001163608, NM_028199, BC114352 24

angiogenesis

protein binding

cytoplasm

plasma membrane

plasma membrane

bicellular tight junction

membrane

integral component of membrane

cell junction

dendrite

neuronal cell body

receptor complex

 
TC0100003783.mm.2 Cenpf centromere protein F 1 -189640613 NM_001081363 56

mitotic cell cycle

mitotic cell cycle

chromosome, centromeric region

chromosome, centromeric region

spindle pole

spindle pole

condensed chromosome outer kinetochore

kidney development

nucleus

nucleus

nucleus

nucleus

nuclear envelope

nucleoplasm

cytoplasm

centrosome

spindle

axoneme

chromosome segregation

protein C-terminus binding

transcription factor binding

regulation of G2/M transition of mitotic cell cycle

regulation of G2/M transition of mitotic cell cycle

protein transport

regulation of striated muscle tissue development

nuclear matrix

ventricular system development

midbody

ciliary basal body

protein homodimerization activity

pronucleus

negative regulation of transcription, DNA-templated

metaphase plate congression

metaphase plate congression

dynein complex binding

dynein complex binding

ciliary transition fiber

ciliary transition fiber

 
TC0500002232.mm.2 Zfyve28 zinc finger, FYVE domain containing 28 5 -34194893 NM_001015039, BC139050, BC139051 NM_001015039, BC139050, BC139051 NM_001015039, BC139050, BC139051 20

cytoplasm

endosome

cytosol

negative regulation of epidermal growth factor-activated receptor activity

negative regulation of epidermal growth factor-activated receptor activity

membrane

early endosome membrane

early endosome membrane

phosphatidylinositol-3-phosphate binding

negative regulation of epidermal growth factor receptor signaling pathway

metal ion binding

 
TC1100001156.mm.2 Aldoc aldolase C, fructose-bisphosphate 11 78324197, 78323072 NM_009657, BC004802, BC008184 NM_009657, BC004802, BC008184 NM_009657, BC004802, BC008184 84

catalytic activity

fructose-bisphosphate aldolase activity

fructose-bisphosphate aldolase activity

fructose-bisphosphate aldolase activity

cytoplasm

mitochondrion

cytosol

glycolytic process

apoptotic process

aging

cytoskeletal protein binding

lyase activity

fructose 1,6-bisphosphate metabolic process

fructose 1,6-bisphosphate metabolic process

axon

identical protein binding

protein-containing complex binding

postsynaptic cytosol

00010

00030

00051

01100

TC1500001933.mm.2 Polr3h polymerase (RNA) III (DNA directed) polypeptide H 15 -81915029 NM_030229, BC010793 NM_030229, BC010793 23

immune system process

DNA binding

DNA-directed 5'-3' RNA polymerase activity

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase III complex

RNA polymerase III complex

centrosome

nucleobase-containing compound metabolic process

transcription, DNA-templated

transcription by RNA polymerase III

transcription initiation from RNA polymerase III promoter

intracellular membrane-bounded organelle

innate immune response

defense response to virus

00230

00240

01100

03020

04623

TC1500001005.mm.2 Troap trophinin associated protein 15 99074972 NM_001162506, NM_030159, BC145227 NM_001162506, NM_030159, BC145227 NM_001162506, NM_030159, BC145227 12

molecular_function

cellular_component

cytoplasm

cell adhesion

biological_process

 
TC1100001849.mm.2 Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 11 111066163 NM_008425, BC137841, BC137842 NM_008425, BC137841, BC137842 NM_008425, BC137841, BC137842 120

inward rectifier potassium channel activity

inward rectifier potassium channel activity

voltage-gated ion channel activity

protein binding

phosphatidylinositol-4,5-bisphosphate binding

smooth endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

ion transport

potassium ion transport

voltage-gated potassium channel complex

intercalated disc

regulation of skeletal muscle contraction via regulation of action potential

magnesium ion transport

membrane

integral component of membrane

T-tubule

dendrite

intrinsic component of membrane

regulation of ion transmembrane transport

identical protein binding

identical protein binding

neuronal cell body

dendritic spine

protein homotetramerization

relaxation of cardiac muscle

regulation of membrane repolarization

potassium ion transmembrane transport

cardiac muscle cell action potential

cardiac muscle cell action potential involved in contraction

regulation of cardiac muscle cell contraction

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

membrane repolarization during action potential

membrane repolarization during cardiac muscle cell action potential

regulation of heart rate by cardiac conduction

relaxation of skeletal muscle

positive regulation of potassium ion transmembrane transport

potassium ion import across plasma membrane

potassium ion import across plasma membrane

04971

TC0X00002671.mm.2 Las1l LAS1-like (S. cerevisiae) X -95935312, -95935320 NM_152822, BC141155 NM_152822, BC141155 25

maturation of 5.8S rRNA

maturation of LSU-rRNA

nucleus

cytoplasm

rRNA processing

preribosome, large subunit precursor

MLL1 complex

 
TC0800003160.mm.2 Ccsap centriole, cilia and spindle associated protein 8 -123840843, -123839973, -123839973 NM_028536, BC024705, BC036300 NM_028536, BC024705, BC036300 NM_028536, BC024705, BC036300 14

cytoplasm

centrosome

centriole

centriole

spindle

spindle

cytoskeleton

microtubule

cilium

axoneme

axoneme

cell cycle

multicellular organism development

microtubule binding

microtubule binding

axon

axon

ciliary transition zone

ciliary transition zone

ciliary basal body

ciliary basal body

cell projection

cell division

mitotic spindle astral microtubule

mitotic spindle

regulation of mitotic spindle assembly

regulation of mitotic spindle assembly

mitotic spindle microtubule depolymerization

 
TC0100003639.mm.2 Adss adenylosuccinate synthetase, non muscle 1 -177763177 NM_007422, BC139404, BC139417 NM_007422, BC139404, BC139417 NM_007422, BC139404, BC139417 23

nucleotide binding

adenylosuccinate synthase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

GTP binding

cytoplasm

mitochondrion

cytosol

purine nucleotide biosynthetic process

AMP biosynthetic process

AMP biosynthetic process

aspartate metabolic process

ligase activity

'de novo' AMP biosynthetic process

IMP metabolic process

IMP metabolic process

metal ion binding

00230

00250

01100

TC1100001586.mm.2 Cdc6 cell division cycle 6 11 98907800, 98908150 NM_001025779, NM_011799, BC052434 NM_001025779, NM_011799, BC052434 NM_001025779, NM_011799, BC052434 42

nucleotide binding

mitotic cell cycle

spindle pole

chromatin binding

DNA replication origin binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

spindle

cytosol

DNA replication

DNA replication initiation

cell cycle

kinase binding

regulation of mitotic metaphase/anaphase transition

positive regulation of cytokinesis

mitotic DNA replication checkpoint

intercellular bridge

positive regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of fibroblast proliferation

spindle midzone

cell division

positive regulation of chromosome segregation

mitotic spindle

04110

TC0100003279.mm.2 Dhx9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 1 -153455757 NM_007842 54

nucleotide binding

alternative mRNA splicing, via spliceosome

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II complex binding

regulatory region RNA binding

regulatory region RNA binding

RNA polymerase II transcription factor binding

immune system process

nucleic acid binding

DNA binding

DNA helicase activity

DNA replication origin binding

double-stranded DNA binding

single-stranded DNA binding

transcription coregulator activity

transcription coactivator activity

RNA binding

RNA binding

RNA helicase activity

double-stranded RNA binding

single-stranded RNA binding

mRNA binding

helicase activity

protein binding

ATP binding

intracellular anatomical structure

nucleus

nucleus

nucleoplasm

perichromatin fibrils

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

centrosome

polysome

cytoskeleton

DNA-templated transcription, termination

regulation of transcription by RNA polymerase II

mRNA processing

regulation of translation

inflammatory response

circadian rhythm

RNA splicing

RNA secondary structure unwinding

actin cytoskeleton

RISC complex

nuclear body

hydrolase activity

ATPase activity

targeting of mRNA for destruction involved in RNA interference

gene silencing by RNA

chromatin DNA binding

DNA duplex unwinding

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interleukin-18 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

protein-containing complex

3'-5' DNA/RNA helicase activity

3'-5' RNA helicase activity

cellular response to heat

cellular protein-containing complex assembly

siRNA binding

RNA stem-loop binding

cytoplasmic ribonucleoprotein granule

DNA-templated viral transcription

polysomal ribosome

3'-5' DNA helicase activity

3'-5' DNA helicase activity

G-quadruplex DNA unwinding

innate immune response

positive regulation of innate immune response

triplex DNA binding

positive regulation of DNA repair

positive regulation of DNA replication

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of RNA export from nucleus

metal ion binding

nucleoside-triphosphate diphosphatase activity

positive regulation of fibroblast proliferation

rhythmic process

positive regulation of viral transcription

regulation of mRNA processing

regulation of mRNA processing

regulation of defense response to virus by host

positive regulation of inflammatory response

mRNA transport

positive regulation of NF-kappaB transcription factor activity

positive regulation of response to cytokine stimulus

importin-alpha family protein binding

RNA polymerase binding

pyroptosis

RISC-loading complex

small RNA loading onto RISC

CRD-mediated mRNA stabilization

CRD-mediated mRNA stability complex

cellular response to tumor necrosis factor

cellular response to exogenous dsRNA

nuclear stress granule

protein localization to cytoplasmic stress granule

positive regulation of viral translation

RISC complex binding

polysome binding

positive regulation of polysome binding

single-stranded 3'-5' DNA helicase activity

sequence-specific mRNA binding

promoter-specific chromatin binding

ribonucleoprotein complex

ribonucleoprotein complex

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

positive regulation of gene silencing by miRNA

regulation of cytoplasmic translation

positive regulation of cytoplasmic translation

 
TC0100000282.mm.2 Npas2 neuronal PAS domain protein 2 1 39194271 NM_008719, BC109166 NM_008719, BC109166 63

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

cytosol

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

circadian rhythm

circadian regulation of gene expression

circadian regulation of gene expression

response to drug

circadian sleep/wake cycle

regulation of circadian rhythm

locomotor rhythm

positive regulation of DNA repair

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

metal ion binding

protein dimerization activity

rhythmic process

response to redox state

response to redox state

Hsp90 protein binding

negative regulation of cell death

CLOCK-BMAL transcription complex

sequence-specific double-stranded DNA binding

positive regulation of behavioral fear response

regulation of response to DNA damage stimulus

04710

TC1900001691.mm.2 Gpam glycerol-3-phosphate acyltransferase, mitochondrial 19 -55067635, -55067635 NM_008149, BC019201 NM_008149, BC019201 58

regulation of cytokine production

glycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

plasma membrane

glycerol-3-phosphate metabolic process

lipid metabolic process

fatty acid metabolic process

fatty acid metabolic process

acyl-CoA metabolic process

triglyceride metabolic process

glycerophospholipid metabolic process

diacylglycerol biosynthetic process

phosphatidic acid biosynthetic process

phosphatidylglycerol biosynthetic process

O-acyltransferase activity

phospholipid biosynthetic process

response to glucose

positive regulation of triglyceride biosynthetic process

response to activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

triglyceride biosynthetic process

triglyceride biosynthetic process

mitochondrial membrane

mitochondrial membrane

interleukin-2 production

cellular response to insulin stimulus

positive regulation of multicellular organism growth

positive regulation of activated T cell proliferation

cellular lipid metabolic process

defense response to virus

fatty acid homeostasis

phospholipid homeostasis

negative regulation of activation-induced cell death of T cells

00561

00564

01100

TC1600001770.mm.2 St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 16 -58469741, -58469741 NM_018784, BC052338 NM_018784, BC052338 23

Golgi apparatus

cellular protein modification process

protein glycosylation

glycolipid metabolic process

sialyltransferase activity

sialyltransferase activity

oligosaccharide metabolic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

beta-galactoside alpha-2,3-sialyltransferase activity

beta-galactoside alpha-2,3-sialyltransferase activity

00601

01100

TC0100000447.mm.2 Cdk15 cyclin-dependent kinase 15 1 59256905 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 15

regulation of transcription involved in G1/S transition of mitotic cell cycle

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

cytosol

protein phosphorylation

kinase activity

phosphorylation

transferase activity

cyclin binding

metal ion binding

 
TC1700001689.mm.2 Nme4 NME/NM23 nucleoside diphosphate kinase 4 17 -26091744 NM_019731, BC027277, NME/NM23 NM_019731, BC027277, NME/NM23 NM_019731, BC027277, NME/NM23 24

nucleotide binding

nucleoside diphosphate kinase activity

ATP binding

mitochondrion

mitochondrion

mitochondrial intermembrane space

GTP biosynthetic process

UTP biosynthetic process

CTP biosynthetic process

lipid transport

lipid binding

nucleotide metabolic process

membrane

kinase activity

phosphorylation

transferase activity

protein-containing complex binding

metal ion binding

GTPase binding

cardiolipin binding

00230

00240

01100

TC1700002208.mm.2 Bysl bystin-like 17 -47599330 NM_016859, BC017530 NM_016859, BC017530 24

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

in utero embryonic development

blastocyst formation

trophectodermal cell differentiation

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

cytoplasm

cytoplasmic microtubule

rRNA processing

cell population proliferation

snoRNA binding

preribosome, small subunit precursor

ribosome biogenesis

cell projection

intracellular membrane-bounded organelle

apical part of cell

perinuclear region of cytoplasm

 
MG-1-pos-10341793_st                
TC0X00002266.mm.2         NM_146234, NR_039576, BC032271 NM_146234, NR_039576, BC032271 NM_146234, NR_039576, BC032271  

Golgi membrane

cytoplasm

endosome

early endosome

early endosome

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

plasma membrane

plasma membrane

cation transport

cobalt ion transport

copper ion transport

iron ion transport

cobalt ion transmembrane transporter activity

ferrous iron transmembrane transporter activity

magnesium ion transmembrane transporter activity

magnesium ion transport

membrane

integral component of membrane

inorganic cation transmembrane transporter activity

inorganic cation transmembrane transporter activity

integral component of endoplasmic reticulum membrane

membrane insertase activity

protein insertion into ER membrane by stop-transfer membrane-anchor sequence

tail-anchored membrane protein insertion into ER membrane

EMC complex

EMC complex

 
TC0100000237.mm.2 Hs6st1 heparan sulfate 6-O-sulfotransferase 1 1 36068399 NM_015818, BC052316 NM_015818, BC052316 45

angiogenesis

sulfotransferase activity

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

membrane

integral component of membrane

transferase activity

heparan sulfate 6-O-sulfotransferase activity

heparan sulfate 6-O-sulfotransferase activity

lung alveolus development

neuron development

labyrinthine layer blood vessel development

00534

TC1100000892.mm.2 Aurkb aurora kinase B 11 69045636 NM_011496, BC003261 NM_011496, BC003261 114

negative regulation of transcription by RNA polymerase II

nucleotide binding

chromosome, centromeric region

kinetochore

condensed chromosome, centromeric region

condensed chromosome, centromeric region

negative regulation of B cell apoptotic process

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

spindle

cytoskeleton

spindle microtubule

protein phosphorylation

cell cycle

spindle organization

mitotic spindle organization

mitotic spindle assembly checkpoint

chromocenter

kinase activity

phosphorylation

transferase activity

kinase binding

midbody

midbody

spindle pole centrosome

negative regulation of protein binding

chromosome passenger complex

chromosome passenger complex

chromosome passenger complex

positive regulation of telomere maintenance via telomerase

regulation of cytokinesis

positive regulation of cytokinesis

protein localization to kinetochore

cellular response to UV

histone serine kinase activity

histone serine kinase activity

cleavage furrow formation

histone H3-S28 phosphorylation

metal ion binding

spindle midzone

mitotic spindle midzone assembly

cell division

positive regulation of telomerase activity

mitotic spindle pole

mitotic spindle pole

positive regulation of telomere capping

positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore

mitotic spindle midzone

 
TC0X00001634.mm.2 Phka2 phosphorylase kinase alpha 2 X 160502161, 160502161, 160502161 NM_001177878, NM_001177879, NM_172783, BC050040 NM_001177878, NM_001177879, NM_172783, BC050040 NM_001177878, NM_001177879, NM_172783, BC050040 NM_001177878, NM_001177879, NM_172783, BC050040 27

catalytic activity

calmodulin binding

plasma membrane

phosphorylase kinase complex

phosphorylase kinase complex

carbohydrate metabolic process

glycogen metabolic process

protein phosphorylation

membrane

04020

04910

TC0200003865.mm.2 Calcrl calcitonin receptor-like 2 -84330626 NM_018782, BC138537, BC138540 NM_018782, BC138537, BC138540 NM_018782, BC138537, BC138540 41

angiogenesis

angiogenesis

adrenomedullin receptor activity

adrenomedullin receptor activity

calcitonin gene-related peptide receptor activity

calcitonin gene-related peptide receptor activity

calcitonin gene-related peptide receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

calcitonin receptor activity

cytoplasm

lysosome

endosome

endoplasmic reticulum

plasma membrane

plasma membrane

calcium ion transport

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

heart development

positive regulation of cell population proliferation

G protein-coupled peptide receptor activity

protein transport

membrane

integral component of membrane

receptor internalization

negative regulation of smooth muscle contraction

positive regulation of smooth muscle cell proliferation

negative regulation of inflammatory response

cellular response to sucrose stimulus

adrenomedullin receptor complex

CGRP receptor complex

calcitonin gene-related peptide receptor signaling pathway

adrenomedullin binding

adrenomedullin receptor signaling pathway

04080

04270

TC0900001099.mm.2 Sh3bgrl2 SH3 domain binding glutamic acid-rich protein like 2 9 83548337 NM_172507, BC038473 NM_172507, BC038473 17

protein binding

nucleus

nucleoplasm

biological_process

SH3 domain binding

nuclear membrane

 
TC0900001345.mm.2 Dusp7 dual specificity phosphatase 7 9 106368631 NM_153459, BC010207 NM_153459, BC010207 22

inactivation of MAPK activity

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

cytoplasm

cytosol

cytosol

protein dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

protein tyrosine/threonine phosphatase activity

dephosphorylation

hydrolase activity

phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-threonine dephosphorylation

negative regulation of MAP kinase activity

mitogen-activated protein kinase binding

04010

TC1400002150.mm.2 Ska3 spindle and kinetochore associated complex subunit 3 14 -57806560 NM_198605, BC117500, BC117501 NM_198605, BC117500, BC117501 NM_198605, BC117500, BC117501 19

mitotic cell cycle

mitotic cell cycle

chromosome, centromeric region

kinetochore

condensed chromosome outer kinetochore

condensed chromosome outer kinetochore

molecular_function

chromosome

cytoplasm

centrosome

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cell cycle

chromosome segregation

chromosome segregation

regulation of microtubule polymerization or depolymerization

cell division

mitotic spindle

 
TC0200002869.mm.2 Mcm10 minichromosome maintenance 10 replication initiation factor 2 -4990723, -4990723 NM_027290, BC094576, BC120687, BC120689 NM_027290, BC094576, BC120687, BC120689 NM_027290, BC094576, BC120687, BC120689 NM_027290, BC094576, BC120687, BC120689 29

DNA binding

DNA replication origin binding

double-stranded DNA binding

single-stranded DNA binding

nucleus

nucleoplasm

nucleolus

DNA replication

DNA replication initiation

cellular response to DNA damage stimulus

cell population proliferation

enzyme binding

replication fork protection complex

identical protein binding

metal ion binding

 
TC0300000711.mm.2 Nes nestin 3 87971092 NM_016701, BC060693, BC062893 NM_016701, BC060693, BC062893 NM_016701, BC060693, BC062893 988

protein binding

cytoplasm

intermediate filament

intermediate filament

intermediate filament

multicellular organism development

nervous system development

intermediate filament binding

positive regulation of intermediate filament depolymerization

CCR5 chemokine receptor binding

CCR5 chemokine receptor binding

negative regulation of neuron apoptotic process

cell projection morphogenesis

 
TC1000002212.mm.2 Mcu mitochondrial calcium uniporter 10 -59446983 NM_001033259, BC139254, BC139257 NM_001033259, BC139254, BC139257 NM_001033259, BC139254, BC139257 80

calcium channel activity

calcium channel activity

protein binding

mitochondrion

mitochondrion

mitochondrial inner membrane

ion transport

calcium ion transport

mitochondrial calcium ion transmembrane transport

mitochondrial calcium ion transmembrane transport

uniporter activity

uniporter activity

membrane

integral component of membrane

calcium-mediated signaling

integral component of mitochondrial inner membrane

integral component of mitochondrial inner membrane

positive regulation of insulin secretion

calcium channel complex

calcium channel complex

calcium import into the mitochondrion

calcium import into the mitochondrion

glucose homeostasis

identical protein binding

identical protein binding

protein complex oligomerization

mitochondrial calcium ion homeostasis

mitochondrial calcium ion homeostasis

positive regulation of mitochondrial calcium ion concentration

positive regulation of mitochondrial calcium ion concentration

calcium ion transmembrane transport

positive regulation of neutrophil chemotaxis

positive regulation of mitochondrial fission

actin filament reorganization

uniplex complex

uniplex complex

 
MG-1-neg-10339860_st                
TC1600001280.mm.2 Sdf2l1 stromal cell-derived factor 2-like 1 16 -17130137 NM_022324, BC053425 NM_022324, BC053425 21

dolichyl-phosphate-mannose-protein mannosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

membrane

endoplasmic reticulum chaperone complex

response to endoplasmic reticulum stress

protein O-linked mannosylation

regulation of apoptotic process

chaperone cofactor-dependent protein refolding

chaperone binding

ATPase binding

misfolded protein binding

cellular response to misfolded protein

ER-associated misfolded protein catabolic process

chaperone complex

 
TC0100002411.mm.2 Wdr12 WD repeat domain 12 1 -60076867, -60076867, -60076867 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 23

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

protein binding

nucleus

nucleoplasm

nucleolus

rRNA processing

Notch signaling pathway

preribosome, large subunit precursor

preribosome, large subunit precursor

ribosome biogenesis

regulation of cell cycle

PeBoW complex

PeBoW complex

 
TC1300002360.mm.2 Polr3g polymerase (RNA) III (DNA directed) polypeptide G 13 -81673836 NM_001081176, BC030063, BC066818 NM_001081176, BC030063, BC066818 NM_001081176, BC030063, BC066818 24

immune system process

chromatin binding

chromatin binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase III complex

RNA polymerase III complex

cytoplasm

cytosol

transcription by RNA polymerase III

cell population proliferation

cell population proliferation

cell population proliferation

nuclear body

positive regulation of interferon-beta production

innate immune response

positive regulation of innate immune response

defense response to virus

00230

00240

01100

03020

04623

TC1000001204.mm.2 Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 10 99108134 NM_015737, BC057882 NM_015737, BC057882 21

polypeptide N-acetylgalactosaminyltransferase activity

Golgi apparatus

Golgi apparatus

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein O-linked glycosylation via serine

protein O-linked glycosylation via threonine

manganese ion binding

carbohydrate binding

metal ion binding

perinuclear region of cytoplasm

00512

01100

TC1000002586.mm.2 Appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 10 -83600033 NM_145220, BC048906 NM_145220, BC048906 34

ruffle

phosphatidylserine binding

diet induced thermogenesis

protein binding

nucleus

cytoplasm

cytoplasm

endosome

plasma membrane

plasma membrane

protein import into nucleus

cell cycle

transforming growth factor beta receptor signaling pathway

cell population proliferation

cold acclimation

endosome membrane

endosome membrane

regulation of fibroblast migration

membrane

signaling

small GTPase binding

cytoplasmic vesicle

vesicle

early phagosome

ruffle membrane

adiponectin-activated signaling pathway

regulation of toll-like receptor 4 signaling pathway

phosphatidylinositol binding

cellular response to hepatocyte growth factor stimulus

early phagosome membrane

glucose homeostasis

identical protein binding

protein homodimerization activity

cell projection

macropinosome

protein-containing complex binding

regulation of innate immune response

negative regulation of fatty acid oxidation

negative regulation of glucose import

negative regulation of glucose import

negative regulation of neurogenesis

protein homotetramerization

positive regulation of phagocytosis, engulfment

positive regulation of cold-induced thermogenesis

negative regulation of cytokine production involved in inflammatory response

negative regulation of cellular response to insulin stimulus

positive regulation of macropinocytosis

positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis

regulation of G1/S transition of mitotic cell cycle

negative regulation of neural precursor cell proliferation

 
TC1100000609.mm.2 Kif3a kinesin family member 3A 11 53567368 NM_008443, BC052707 NM_008443, BC052707 175

nucleotide binding

in utero embryonic development

kidney development

heart looping

cilium movement

microtubule motor activity

protein binding

ATP binding

cytoplasm

centrosome

centriole

centriole

cytosol

cytoskeleton

kinesin complex

microtubule

spindle microtubule

cilium

axoneme

microtubule-based movement

smoothened signaling pathway

determination of left/right symmetry

heart development

microtubule binding

microtubule binding

anterograde axonal transport

epidermis development

anterior/posterior pattern specification

dorsal/ventral pattern formation

centriole-centriole cohesion

protein transport

microtubule cytoskeleton

ATPase activity

kinesin II complex

kinesin II complex

kinesin binding

protein phosphatase binding

dentate gyrus development

dorsal/ventral neural tube patterning

dorsal/ventral neural tube patterning

neural tube development

cell projection organization

spectrin binding

forebrain development

small GTPase binding

motile cilium

photoreceptor connecting cilium

microtubule anchoring at centrosome

epidermal stem cell homeostasis

cell projection

neuron projection

neuronal cell body

motile cilium assembly

protein-containing complex binding

positive regulation of receptor-mediated endocytosis

positive regulation of epithelial cell proliferation

inner ear receptor cell stereocilium organization

cilium assembly

cilium assembly

neural precursor cell proliferation

positive regulation of intracellular protein transport

ribbon synapse

intraciliary transport particle B binding

protein localization to cell junction

axon cytoplasm

positive regulation of axo-dendritic protein transport

non-motile cilium assembly

positive regulation of establishment or maintenance of cell polarity regulating cell shape

 
TC0600001440.mm.2 Pianp PILR alpha associated neural protein 6 124998609, 124996719, 124998436 NM_001145926, NM_001145927, NM_175696, BC065170 NM_001145926, NM_001145927, NM_175696, BC065170 NM_001145926, NM_001145927, NM_175696, BC065170 NM_001145926, NM_001145927, NM_175696, BC065170 18

molecular_function

biological_process

membrane

integral component of membrane

basolateral plasma membrane

regulation of immune response

 
TC1500001791.mm.2 Arhgap39 Rho GTPase activating protein 39 15 -76723984 NM_001168288, NM_198420, BC060637 NM_001168288, NM_198420, BC060637 NM_001168288, NM_198420, BC060637 31

GTPase activator activity

nucleus

cytoplasm

cytoskeleton

signal transduction

postsynapse

glutamatergic synapse

postsynapse organization

 
TC1400000179.mm.2 Adk adenosine kinase 14 21076151, 21052573 NM_001243041, NM_134079, BC009659 NM_001243041, NM_134079, BC009659 NM_001243041, NM_134079, BC009659 58

nucleotide binding

adenosine kinase activity

adenosine kinase activity

adenosine kinase activity

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

cytosol

plasma membrane

purine ribonucleoside salvage

dATP biosynthetic process

positive regulation of cardiac muscle hypertrophy

kinase activity

transferase activity

phosphotransferase activity, alcohol group as acceptor

positive regulation of T cell proliferation

type B pancreatic cell proliferation

adenosine metabolic process

metal ion binding

00230

01100

TC1200001262.mm.2 Adssl1 adenylosuccinate synthetase like 1 12 112620046 NM_007421, BC039943 NM_007421, BC039943 28

nucleotide binding

GTPase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

protein binding

GTP binding

cytoplasm

cytoplasm

cytoplasm

purine nucleotide metabolic process

purine nucleotide biosynthetic process

AMP biosynthetic process

aspartate metabolic process

purine ribonucleoside monophosphate biosynthetic process

membrane

ligase activity

identical protein binding

'de novo' AMP biosynthetic process

IMP metabolic process

IMP metabolic process

metal ion binding

actin filament binding

00230

00250

01100

TC0100003709.mm.2 Degs1 delta(4)-desaturase, sphingolipid 1 1 -182275963, -182275963 NM_007853, BC003751 NM_007853, BC003751 39

mitochondrion

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

membrane

integral component of membrane

oxidoreductase activity

sphingolipid biosynthetic process

sphingolipid delta-4 desaturase activity

sphingolipid delta-4 desaturase activity

sphingolipid delta-4 desaturase activity

positive regulation of apoptotic process

myelin maintenance

ceramide biosynthetic process

ceramide biosynthetic process

retinol isomerase activity

retinol isomerase activity

00600

01100

TC1100000028.mm.2 Pes1 pescadillo ribosomal biogenesis factor 1 11 3963974 NM_022889, BC004844, BC011142 NM_022889, BC004844, BC011142 NM_022889, BC004844, BC011142 35

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

condensed chromosome

RNA binding

protein binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

cytosol

rRNA processing

rRNA processing

rRNA processing

nucleolus organization

cell population proliferation

preribosome, large subunit precursor

protein localization to organelle

ribosome biogenesis

regulation of cell cycle

PeBoW complex

PeBoW complex

PeBoW complex

 
TC0X00003209.mm.2 Kctd12b potassium channel tetramerisation domain containing 12b X -153685153 NM_175429, BC064459 NM_175429, BC064459 12

molecular_function

regulation of G protein-coupled receptor signaling pathway

receptor complex

 
TC0600003072.mm.2 Gdf3 growth differentiation factor 3 6 -122605402 NM_008108, BC101963, BC101964, BC103565 NM_008108, BC101963, BC101964, BC103565 NM_008108, BC101963, BC101964, BC103565 NM_008108, BC101963, BC101964, BC103565 46

skeletal system development

eye development

in utero embryonic development

in utero embryonic development

response to dietary excess

cytokine activity

protein binding

extracellular region

extracellular space

cytoplasm

signal transduction

multicellular organism development

endoderm development

endoderm development

mesoderm development

mesoderm development

growth factor activity

regulation of cell fate commitment

positive regulation of pathway-restricted SMAD protein phosphorylation

protein kinase binding

BMP signaling pathway

negative regulation of BMP signaling pathway

notochord development

somite rostral/caudal axis specification

positive regulation of fat cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of myoblast differentiation

formation of anatomical boundary

SMAD protein signal transduction

primitive streak formation

 
TC0X00003371.mm.2 Msl3 MSL complex subunit 3 X -168651266, -168651266 NM_010832, BC010226 NM_010832, BC010226 22

histone acetyltransferase complex

DNA binding

nucleus

chromatin organization

chromatin silencing

regulation of transcription, DNA-templated

histone acetylation

histone deacetylation

methylated histone binding

NuA4 histone acetyltransferase complex

histone H4 acetylation

histone H2A acetylation

histone H4-K16 acetylation

histone H4-K16 acetylation

histone acetyltransferase activity (H4-K16 specific)

MSL complex

MSL complex

 
TC0500003395.mm.2 Hip1 huntingtin interacting protein 1 5 -135406518, -135406495 NM_146001, BC017516 NM_146001, BC017516 55

actin binding

protein binding

phospholipid binding

nucleus

cytoplasm

Golgi apparatus

endocytosis

endocytosis

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

actin filament organization

membrane

clathrin-coated vesicle

clathrin-coated vesicle

cell differentiation

clathrin binding

extrinsic component of cytoplasmic side of plasma membrane

cytoplasmic vesicle

clathrin light chain binding

clathrin light chain binding

phosphatidylinositol-3-phosphate binding

phosphatidylinositol binding

AP-2 adaptor complex binding

clathrin adaptor activity

protein homodimerization activity

regulation of apoptotic process

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

phosphatidylinositol-3,4-bisphosphate binding

phosphatidylinositol-3,4-bisphosphate binding

postsynaptic membrane

positive regulation of epidermal growth factor receptor signaling pathway

protein heterodimerization activity

positive regulation of receptor-mediated endocytosis

positive regulation of receptor-mediated endocytosis

clathrin coat assembly

clathrin coat assembly

protein stabilization

actin filament binding

actin filament binding

clathrin-dependent endocytosis

phosphatidylinositol-3,5-bisphosphate binding

phosphatidylinositol-3,5-bisphosphate binding

apoptotic signaling pathway

presynapse

presynapse

postsynapse

extrinsic component of presynaptic membrane

extrinsic component of postsynaptic membrane

extrinsic component of postsynaptic membrane

glutamatergic synapse

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

05016

TC1200002497.mm.2 D430020J02Rik RIKEN cDNA D430020J02 gene 12 -116401946 NR_028421 10

molecular_function

cellular_component

biological_process

 
TC0200002729.mm.2         NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480  

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

cellular_component

regulation of transcription by RNA polymerase II

 
TC0100001844.mm.2 Pacc1 proton activated chloride channel 1 1 191325901 NM_025864, BC027151 NM_025864, BC027151 15

chloride channel activity

plasma membrane

integral component of plasma membrane

ion transport

chloride transport

chloride transport

membrane

integral component of membrane

chloride channel complex

pH-gated chloride channel activity

pH-gated chloride channel activity

 
TC1200002413.mm.2 Bag5 BCL2-associated athanogene 5 12 -111709489, -111709490 NM_027404, BC037642 NM_027404, BC037642 20

adenyl-nucleotide exchange factor activity

protein binding

nucleus

nucleus

cytoplasm

mitochondrion

cytosol

cytosol

Golgi organization

negative regulation of neuron projection development

membrane

inclusion body

inclusion body

protein kinase binding

heat shock protein binding

negative regulation of protein ubiquitination

negative regulation of protein ubiquitination

negative regulation of protein ubiquitination

ubiquitin protein ligase binding

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

perinuclear region of cytoplasm

perinuclear region of cytoplasm

protein stabilization

protein stabilization

chaperone binding

chaperone binding

chaperone binding

negative regulation of ubiquitin-protein transferase activity

negative regulation of ubiquitin-protein transferase activity

negative regulation of protein refolding

negative regulation of protein refolding

neuron death

neuron death

regulation of inclusion body assembly

regulation of inclusion body assembly

regulation of inclusion body assembly

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

 
TC1700000070.mm.2 Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 17 7170114 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 56

nucleotide binding

magnesium ion binding

oocyte maturation

brain renin-angiotensin system

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ribosomal protein S6 kinase activity

ribosomal protein S6 kinase activity

protein serine/threonine/tyrosine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

spindle

protein phosphorylation

heart development

negative regulation of cell population proliferation

positive regulation of gene expression

cardiac muscle cell apoptotic process

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

intracellular signal transduction

positive regulation of apoptotic process

negative regulation of cell cycle

negative regulation of meiotic nuclear division

heart contraction

regulation of protein processing

regulation of protein processing

cellular response to carbohydrate stimulus

meiotic spindle

04010

04114

04150

04720

04722

04914

TC1100004267.mm.2 Trim16 tripartite motif-containing 16 11 62820252 NM_053169, BC052821 NM_053169, BC052821 20

DNA binding

cytoplasm

cytoplasm

cytosol

plasma membrane

zinc ion binding

PML body

transferase activity

interleukin-1 binding

NACHT domain binding

positive regulation of interleukin-1 beta production

histone H3 acetylation

histone H4 acetylation

positive regulation of keratinocyte differentiation

positive regulation of transcription, DNA-templated

metal ion binding

positive regulation of retinoic acid receptor signaling pathway

response to growth hormone

 
TC1000001686.mm.2 Fbxo5 F-box protein 5 10 -5799157 NM_025995, BC053434 NM_025995, BC053434 29

oocyte maturation

oocyte maturation

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

spindle

cytoskeleton

regulation of DNA replication

cell cycle

spindle assembly involved in female meiosis I

regulation of mitotic nuclear division

regulation of mitotic cell cycle

positive regulation of cell population proliferation

positive regulation of G2/M transition of mitotic cell cycle

anaphase-promoting complex binding

vesicle organization

protein kinase binding

negative regulation of DNA endoreduplication

regulation of meiotic nuclear division

positive regulation of osteoblast differentiation

negative regulation of meiotic nuclear division

negative regulation of meiotic nuclear division

negative regulation of mitotic metaphase/anaphase transition

microtubule polymerization

metal ion binding

spindle assembly

cell division

negative regulation of ubiquitin-protein transferase activity

positive regulation of meiosis I

positive regulation of biomineral tissue development

meiotic spindle

negative regulation of ubiquitin protein ligase activity

positive regulation of mesenchymal stem cell migration

ubiquitin ligase inhibitor activity

negative regulation of cellular senescence

negative regulation of response to DNA damage stimulus

04114

TC1000001593.mm.2 Timeless timeless circadian clock 1 10 128232062, 128238065 NM_001136082, NM_001164080, NM_001164081, NM_011589, BC058641, BC082770 NM_001136082, NM_001164080, NM_001164081, NM_011589, BC058641, BC082770 NM_001136082, NM_001164080, NM_001164081, NM_011589, BC058641, BC082770 NM_001136082, NM_001164080, NM_001164081, NM_011589, BC058641, BC082770 NM_001136082, NM_001164080, NM_001164081, NM_011589, BC058641, BC082770 NM_001136082, NM_001164080, NM_001164081, NM_011589, BC058641, BC082770 45

DNA replication checkpoint

negative regulation of transcription by RNA polymerase II

chromatin

branching involved in ureteric bud morphogenesis

kidney development

morphogenesis of an epithelium

DNA binding

protein binding

nucleus

nucleus

nucleoplasm

chromosome

DNA repair

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

cell cycle

multicellular organism development

circadian rhythm

embryo development

lung development

replication fork protection complex

site of double-strand break

regulation of circadian rhythm

regulation of circadian rhythm

positive regulation of circadian rhythm

identical protein binding

replication fork arrest

cell cycle phase transition

negative regulation of transcription, DNA-templated

replication fork protection

rhythmic process

branching morphogenesis of an epithelial tube

cell division

cellular response to hydroxyurea

cellular response to cisplatin

cellular response to bleomycin

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair

 
TC0100002964.mm.2 Dbi diazepam binding inhibitor 1 -120113279, -120113279 NM_001037999, NM_007830, BC028874 NM_001037999, NM_007830, BC028874 NM_001037999, NM_007830, BC028874 65

fatty-acyl-CoA binding

behavioral fear response

hair follicle development

extracellular space

nucleus

cytoplasm

mitochondrion

endoplasmic reticulum

Golgi apparatus

plasma membrane

triglyceride metabolic process

learning or memory

synaptic vesicle

lipid binding

glial cell proliferation

lateral ventricle development

benzodiazepine receptor binding

negative regulation of fatty acid beta-oxidation

regulation of synaptic transmission, GABAergic

protein-lipid complex

long-chain fatty acyl-CoA binding

phosphatidylcholine acyl-chain remodeling

identical protein binding

contractile fiber

skin development

positive regulation of lipid biosynthetic process

positive regulation of release of sequestered calcium ion into cytosol

long-term synaptic potentiation

perinuclear endoplasmic reticulum

negative regulation of protein lipidation

positive regulation of CoA-transferase activity

positive regulation of phospholipid transport

03320

TC1500000524.mm.2 Ptp4a3 protein tyrosine phosphatase 4a3 15 73723144, 73748025, 73724929, 73724796 NM_001166388, NM_001166389, NM_001166390, NM_008975, BC027445, BC066043 NM_001166388, NM_001166389, NM_001166390, NM_008975, BC027445, BC066043 NM_001166388, NM_001166389, NM_001166390, NM_008975, BC027445, BC066043 NM_001166388, NM_001166389, NM_001166390, NM_008975, BC027445, BC066043 NM_001166388, NM_001166389, NM_001166390, NM_008975, BC027445, BC066043 NM_001166388, NM_001166389, NM_001166390, NM_008975, BC027445, BC066043 42

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleus

cytoplasm

cytoplasm

endosome

plasma membrane

regulation of transcription, DNA-templated

protein dephosphorylation

Notch signaling pathway

membrane

dephosphorylation

hydrolase activity

phosphatase activity

positive regulation of vascular permeability

endothelial cell migration

endothelial cell migration

endothelial cell migration

regulation of vascular endothelial growth factor signaling pathway

positive regulation of NIK/NF-kappaB signaling

positive regulation of establishment of protein localization

cellular response to leukemia inhibitory factor

 
TC0700001897.mm.2 Wdr11 WD repeat domain 11 7 129591862 NM_172255, BC037177 NM_172255, BC037177 23

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

Golgi apparatus

trans-Golgi network

cytosol

cytoskeleton

cilium

axoneme

intracellular protein transport

heart development

regulation of smoothened signaling pathway

microtubule cytoskeleton

cytoplasmic vesicle

multicellular organism growth

ciliary basal body

ciliary basal body

cell projection

cilium assembly

head development

vesicle tethering to Golgi

 
TC1300002609.mm.2 Rnf180 ring finger protein 180 13 -105147493, -105130569 NM_027934, BC046775, BC075700 NM_027934, BC046775, BC075700 NM_027934, BC046775, BC075700 19

protein polyubiquitination

protein binding

nucleus

endoplasmic reticulum

membrane

integral component of membrane

transferase activity

adult behavior

intrinsic component of endoplasmic reticulum membrane

intrinsic component of endoplasmic reticulum membrane

positive regulation of protein ubiquitination

ubiquitin conjugating enzyme binding

ubiquitin conjugating enzyme binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

norepinephrine metabolic process

norepinephrine metabolic process

serotonin metabolic process

serotonin metabolic process

metal ion binding

regulation of catalytic activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

organic cyclic compound metabolic process

 
TC1600001471.mm.2 Xxylt1 xyloside xylosyltransferase 1 16 -30955502 NM_198626, BC031419 NM_198626, BC031419 16

magnesium ion binding

protein binding

endoplasmic reticulum

membrane

integral component of membrane

O-glycan processing

O-glycan processing

transferase activity

transferase activity, transferring glycosyl groups

manganese ion binding

manganese ion binding

integral component of endoplasmic reticulum membrane

UDP-xylosyltransferase activity

UDP-xylosyltransferase activity

metal ion binding

 
TC0400000743.mm.2 Tlr4 toll-like receptor 4 4 66827550 NM_021297, BC029856 NM_021297, BC029856 2990

activation of MAPK activity

lipopolysaccharide binding

lipopolysaccharide binding

microglial cell activation

lipopolysaccharide immune receptor activity

lipopolysaccharide immune receptor activity

lipopolysaccharide immune receptor activity

phagocytic cup

activation of innate immune response

toll-like receptor signaling pathway

toll-like receptor signaling pathway

B cell proliferation involved in immune response

immune system process

nitric oxide production involved in inflammatory response

regulation of dendritic cell cytokine production

MyD88-dependent toll-like receptor signaling pathway

innate immune response-activating signal transduction

signaling receptor binding

protein binding

cytoplasm

endosome

Golgi apparatus

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

leukotriene metabolic process

phagocytosis

inflammatory response

response to oxidative stress

signal transduction

activation of NF-kappaB-inducing kinase activity

I-kappaB phosphorylation

I-kappaB phosphorylation

response to bacterium

external side of plasma membrane

cell surface

positive regulation of platelet activation

positive regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

positive regulation of keratinocyte proliferation

astrocyte development

membrane

integral component of membrane

hydrolase activity

positive regulation of B cell proliferation

intrinsic component of plasma membrane

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

response to lipopolysaccharide

response to lipopolysaccharide

response to lipopolysaccharide

detection of lipopolysaccharide

detection of lipopolysaccharide

detection of lipopolysaccharide

interferon-gamma production

interleukin-1 beta production

regulation of tumor necrosis factor production

negative regulation of interferon-gamma production

negative regulation of interleukin-17 production

negative regulation of interleukin-23 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

positive regulation of chemokine production

positive regulation of chemokine production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

positive regulation of interferon-gamma production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 production

positive regulation of interleukin-1 production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-12 production

positive regulation of interleukin-13 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of stress-activated MAPK cascade

toll-like receptor 4 signaling pathway

TRIF-dependent toll-like receptor signaling pathway

signaling receptor activity

macrophage activation

macrophage activation

macrophage activation

defense response to bacterium

identical protein binding

cell projection

positive regulation of macrophage activation

positive regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

receptor complex

receptor complex

positive regulation of DNA binding

phosphatidylinositol 3-kinase binding

innate immune response

membrane raft

positive regulation of MHC class II biosynthetic process

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide biosynthetic process

response to ethanol

mast cell activation

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

positive regulation of JNK cascade

lipopolysaccharide receptor complex

protein heterodimerization activity

perinuclear region of cytoplasm

NAD(P)+ nucleosidase activity

positive regulation of lymphocyte proliferation

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of peptidyl-tyrosine phosphorylation

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception of pain

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of nitric-oxide synthase biosynthetic process

regulation of sensory perception of pain

intestinal epithelial structure maintenance

positive regulation of macrophage cytokine production

NAD+ nucleotidase, cyclic ADP-ribose generating

negative regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

response to fatty acid

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipoteichoic acid

cellular response to interferon-gamma

negative regulation of cold-induced thermogenesis

cellular response to oxidised low-density lipoprotein particle stimulus

positive regulation of cytokine production involved in inflammatory response

positive regulation of cytokine production involved in inflammatory response

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of NIK/NF-kappaB signaling

positive regulation of oxidative stress-induced neuron death

positive regulation of reactive oxygen species biosynthetic process

positive regulation of cellular response to macrophage colony-stimulating factor stimulus

positive regulation of matrix metallopeptidase secretion

cellular response to amyloid-beta

positive regulation of chemokine (C-X-C motif) ligand 2 production

04145

04620

05140

05142

05144

05145

05146

05323

TC0100003786.mm.2 Smyd2 SET and MYND domain containing 2 1 -189880491 NM_026796, BC023119 NM_026796, BC023119 30

negative regulation of transcription by RNA polymerase II

RNA polymerase II complex binding

p53 binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

chromatin organization

methyltransferase activity

negative regulation of cell population proliferation

protein-lysine N-methyltransferase activity

histone methylation

transferase activity

histone-lysine N-methyltransferase activity

peptidyl-lysine monomethylation

peptidyl-lysine dimethylation

methylation

histone lysine methylation

regulation of DNA damage response, signal transduction by p53 class mediator

metal ion binding

histone methyltransferase activity (H3-K36 specific)

 
TC1800000583.mm.2 Slc12a2 solute carrier family 12, member 2 18 57878677 NM_009194 193

transporter activity

protein binding

cytosol

plasma membrane

ion transport

potassium ion transport

sodium ion transport

chloride transport

cellular sodium ion homeostasis

cell volume homeostasis

cell volume homeostasis

hyperosmotic response

gamma-aminobutyric acid signaling pathway

sodium:potassium:chloride symporter activity

sodium:potassium:chloride symporter activity

sodium:potassium:chloride symporter activity

ammonium transmembrane transporter activity

ammonium transmembrane transporter activity

basal plasma membrane

T cell chemotaxis

T cell chemotaxis

potassium ion transmembrane transporter activity

symporter activity

cation:chloride symporter activity

potassium:chloride symporter activity

ammonium transport

ammonium transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

apical plasma membrane

lateral plasma membrane

protein kinase binding

cellular potassium ion homeostasis

transepithelial chloride transport

cellular chloride ion homeostasis

cytoplasmic vesicle membrane

multicellular organism growth

maintenance of blood-brain barrier

sodium ion transmembrane transport

cellular response to potassium ion

cell projection

neuron projection

neuronal cell body

neuronal cell body

cell body

positive regulation of cell volume

metal ion transmembrane transporter activity

detection of mechanical stimulus involved in sensory perception of sound

chaperone binding

Hsp90 protein binding

chloride ion homeostasis

potassium ion homeostasis

sodium ion homeostasis

transmembrane transport

branching involved in mammary gland duct morphogenesis

mammary duct terminal end bud growth

negative regulation of vascular wound healing

transepithelial ammonium transport

cell periphery

cell periphery

inorganic anion import across plasma membrane

inorganic cation import across plasma membrane

sodium ion import across plasma membrane

regulation of spontaneous synaptic transmission

regulation of spontaneous synaptic transmission

regulation of spontaneous synaptic transmission

chloride transmembrane transport

chloride transmembrane transport

positive regulation of aspartate secretion

regulation of matrix metallopeptidase secretion

potassium ion import across plasma membrane

potassium ion import across plasma membrane

cellular response to chemokine

cellular response to chemokine

04970

04972

MG-1-pos-10343494_st                
TC0X00000181.mm.2 Maoa monoamine oxidase A X 16619697 NM_173740, BC029100 NM_173740, BC029100 136

protein binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

cytosol

catecholamine metabolic process

primary amine oxidase activity

primary amine oxidase activity

positive regulation of signal transduction

membrane

integral component of membrane

oxidoreductase activity

neurotransmitter catabolic process

dopamine catabolic process

serotonin metabolic process

phenylethylamine metabolic process

flavin adenine dinucleotide binding

serotonin binding

00260

00330

00340

00350

00360

00380

00982

01100

TC1100001095.mm.2 Tlcd3a TLC domain containing 3A 11 76202091, 76179670, 76179670 NM_027773, BC115519, BC115520 NM_027773, BC115519, BC115520 NM_027773, BC115519, BC115520 15

molecular_function

endoplasmic reticulum

plasma membrane

membrane

integral component of membrane

lipid homeostasis

 
TC1400001032.mm.2 Lpar6 lysophosphatidic acid receptor 6 14 73237890 NM_175116, BC047931, BC069991, BC145940, BC145942 NM_175116, BC047931, BC069991, BC145940, BC145942 NM_175116, BC047931, BC069991, BC145940, BC145942 NM_175116, BC047931, BC069991, BC145940, BC145942 NM_175116, BC047931, BC069991, BC145940, BC145942 28

blastocyst hatching

G protein-coupled receptor activity

plasma membrane

integral component of plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

positive regulation of Rho protein signal transduction

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

lysophosphatidic acid receptor activity

04080

TC0900000050.mm.2 Mmp8 matrix metallopeptidase 8 9 7558428 NM_008611, BC042742 NM_008611, BC042742 93

endopeptidase activity

metalloendopeptidase activity

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular space

extracellular space

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

positive regulation of gene expression

negative regulation of gene expression

hydrolase activity

extracellular matrix organization

collagen catabolic process

extracellular matrix

negative regulation of interleukin-10 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of DNA binding

positive regulation of MAPK cascade

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide biosynthetic process

positive regulation of JNK cascade

metal ion binding

positive regulation of neuroinflammatory response

positive regulation of neuroinflammatory response

positive regulation of NIK/NF-kappaB signaling

positive regulation of reactive oxygen species biosynthetic process

positive regulation of microglial cell activation

 
TC0100001351.mm.2 Ivns1abp influenza virus NS1A binding protein 1 151344485, 151344497, 151344497 NM_001039511, NM_001039512, NM_054102, BC004092 NM_001039511, NM_001039512, NM_054102, BC004092 NM_001039511, NM_001039512, NM_054102, BC004092 NM_001039511, NM_001039512, NM_054102, BC004092 29

protein binding

nucleus

cytoplasm

cytosol

cytoskeleton

RNA splicing

response to virus

negative regulation of protein ubiquitination

negative regulation of intrinsic apoptotic signaling pathway

 
TC0200000319.mm.2 Etl4 enhancer trap locus 4 2 20519512, 20289912, 20510046 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 46

protein binding

cytoplasm

cytoplasm

multicellular organism development

enzyme regulator activity

embryonic skeletal system development

 
TC0800002339.mm.2 Psd3 pleckstrin and Sec7 domain containing 3 8 -67689081, -67689081, -67689081 NM_027626, NM_030263, NM_177698 NM_027626, NM_030263, NM_177698 NM_027626, NM_030263, NM_177698 22

guanyl-nucleotide exchange factor activity

plasma membrane

membrane

cell junction

ARF protein signal transduction

regulation of ARF protein signal transduction

ruffle membrane

ruffle membrane

cell projection

synapse

04144

TC1900000399.mm.2 Dock8 dedicator of cytokinesis 8 19 24999528 NM_028785, BC141358 NM_028785, BC141358 43

immunological synapse formation

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

plasma membrane

small GTPase mediated signal transduction

membrane

cell leading edge

leading edge membrane

dendritic cell migration

dendritic cell migration

cell projection

positive regulation of GTPase activity

memory T cell proliferation

negative regulation of T cell apoptotic process

positive regulation of establishment of T cell polarity

positive regulation of establishment of T cell polarity

cellular response to chemokine

positive regulation of T cell migration

positive regulation of T cell migration

 
TC0800003176.mm.2 2810004N23Rik RIKEN cDNA 2810004N23 gene 8 -124839354 NM_025615, BC023675 NM_025615, BC023675 19

chromosome

biological_process

 
TC1000001020.mm.2 Tcp11l2 t-complex 11 (mouse) like 2 10 84576946 NM_146008, BC029663 NM_146008, BC029663 14

molecular_function

cellular_component

signal transduction

 
TC1300000967.mm.2 Mblac2 metallo-beta-lactamase domain containing 2 13 81711416 NM_028372, BC160254 NM_028372, BC160254 12

biological_process

hydrolase activity

metal ion binding

 
TC1500001596.mm.2 Washc5 WASH complex subunit 5 15 -59331996 NM_153548, BC034070, BC040815, BC067035 NM_153548, BC034070, BC040815, BC067035 NM_153548, BC034070, BC040815, BC067035 NM_153548, BC034070, BC040815, BC067035 31

oocyte maturation

nucleoplasm

cytoplasm

endosome

endosome

endosome

early endosome

endoplasmic reticulum

exocytosis

phagocytosis

endosome organization

lysosome organization

lysosome organization

positive regulation of neuron projection development

protein transport

endosomal transport

actin filament polymerization

cellular protein-containing complex localization

polar body extrusion after meiotic divisions

cholesterol homeostasis

identical protein binding

neuron projection

neuronal cell body

protein-containing complex subunit organization

protein-containing complex subunit organization

regulation of actin nucleation

regulation of actin nucleation

WASH complex

WASH complex

WASH complex

spindle assembly involved in meiosis

regulation of vesicle size

endosome fission

endosome fission

 
TC0400000519.mm.2 Tgfbr1 transforming growth factor, beta receptor I 4 47353221, 47386215 NM_009370, BC063260 NM_009370, BC063260 328

nucleotide binding

activation of MAPKK activity

skeletal system development

angiogenesis

in utero embryonic development

kidney development

blastocyst development

epithelial to mesenchymal transition

negative regulation of endothelial cell proliferation

lens development in camera-type eye

ventricular trabecula myocardium morphogenesis

ventricular compact myocardium morphogenesis

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta-activated receptor activity

transforming growth factor beta-activated receptor activity

transforming growth factor beta-activated receptor activity

transforming growth factor beta receptor activity, type I

transforming growth factor beta receptor activity, type I

signaling receptor binding

type II transforming growth factor beta receptor binding

protein binding

ATP binding

nucleus

endosome

endosome

plasma membrane

plasma membrane

caveola

bicellular tight junction

regulation of transcription, DNA-templated

protein phosphorylation

protein phosphorylation

apoptotic process

signal transduction

transmembrane receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

nervous system development

heart development

heart development

positive regulation of cell population proliferation

germ cell migration

male gonad development

embryo development

post-embryonic development

anterior/posterior pattern specification

cell surface

regulation of gene expression

positive regulation of gene expression

positive regulation of epithelial to mesenchymal transition

positive regulation of pathway-restricted SMAD protein phosphorylation

membrane

integral component of membrane

kinase activity

phosphorylation

basolateral plasma membrane

apical plasma membrane

activin receptor activity, type I

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

growth factor binding

cell junction

cell differentiation

collagen fibril organization

positive regulation of cell growth

positive regulation of cell migration

regulation of protein ubiquitination

ubiquitin protein ligase binding

negative regulation of chondrocyte differentiation

activin receptor signaling pathway

protein-containing complex

regulation of growth

positive regulation of apoptotic process

negative regulation of apoptotic process

receptor complex

receptor complex

regulation of protein binding

endothelial cell migration

response to estrogen

protein-containing complex binding

membrane raft

negative regulation of endothelial cell differentiation

positive regulation of transcription, DNA-templated

SMAD binding

SMAD binding

SMAD binding

protein autophosphorylation

metal ion binding

activin receptor complex

activin binding

thymus development

neuron fate commitment

embryonic cranial skeleton morphogenesis

skeletal system morphogenesis

artery morphogenesis

cell motility

transforming growth factor beta binding

transforming growth factor beta binding

positive regulation of cellular component movement

positive regulation of filopodium assembly

positive regulation of stress fiber assembly

positive regulation of protein kinase B signaling

parathyroid gland development

roof of mouth development

roof of mouth development

pharyngeal system development

regulation of cardiac muscle cell proliferation

pathway-restricted SMAD protein phosphorylation

positive regulation of SMAD protein signal transduction

ventricular septum morphogenesis

angiogenesis involved in coronary vascular morphogenesis

coronary artery morphogenesis

I-SMAD binding

response to cholesterol

response to cholesterol

cellular response to growth factor stimulus

cellular response to transforming growth factor beta stimulus

cellular response to transforming growth factor beta stimulus

negative regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

positive regulation of tight junction disassembly

epicardium morphogenesis

positive regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway

04010

04060

04144

04350

04380

04520

05142

05200

05210

05212

05220

TC0100001836.mm.2 Nsl1 NSL1, MIS12 kinetochore complex component 1 191063020 NM_198654, BC029086 NM_198654, BC029086 14

mitotic sister chromatid segregation

MIS12/MIND type complex

MIS12/MIND type complex

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

molecular_function

nucleus

chromosome

cell cycle

chromosome segregation

nuclear speck

cell division

 
TC1000001074.mm.2 Nup37 nucleoporin 37 10 88146991, 88147070 NM_027191, NM_028334, BC011102, BC032180 NM_027191, NM_028334, BC011102, BC032180 NM_027191, NM_028334, BC011102, BC032180 NM_027191, NM_028334, BC011102, BC032180 19

chromosome, centromeric region

kinetochore

molecular_function

nucleus

nuclear pore

nucleoplasm

chromosome

cell cycle

chromosome segregation

protein transport

nuclear pore outer ring

nuclear pore outer ring

mRNA transport

cell division

03013

TC1600001254.mm.2 Mcm4 minichromosome maintenance complex component 4 16 -15623896 NM_008565, BC013094 NM_008565, BC013094 66

nucleotide binding

double-strand break repair via break-induced replication

DNA binding

DNA helicase activity

DNA helicase activity

DNA replication origin binding

single-stranded DNA binding

single-stranded DNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

DNA unwinding involved in DNA replication

DNA replication initiation

DNA strand elongation involved in DNA replication

cell cycle

hydrolase activity

MCM complex

MCM complex

mitotic DNA replication initiation

03030

04110

TC1600000530.mm.2 Polq polymerase (DNA directed), theta 16 37011785 NM_001159369, NM_029977, BC138360, BC157900 NM_001159369, NM_029977, BC138360, BC157900 NM_001159369, NM_029977, BC138360, BC157900 NM_001159369, NM_029977, BC138360, BC157900 34

nucleotide binding

nucleic acid binding

DNA binding

chromatin binding

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

Golgi apparatus

cytosol

DNA replication

DNA-dependent DNA replication

DNA repair

DNA repair

base-excision repair

double-strand break repair

cellular response to DNA damage stimulus

5'-3' exonuclease activity

somatic hypermutation of immunoglobulin genes

transferase activity

nucleotidyltransferase activity

single-stranded DNA helicase activity

identical protein binding

protein homooligomerization

5'-deoxyribose-5-phosphate lyase activity

double-strand break repair via alternative nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

 
TC0900000255.mm.2 Ncapd3 non-SMC condensin II complex, subunit D3 9 27030164, 27060415 NM_178113, BC048190 NM_178113, BC048190 20

condensed chromosome kinetochore

condensed chromosome, centromeric region

condensed chromosome

condensin complex

condensin complex

condensin complex

chromatin binding

nucleus

nucleoplasm

pericentric heterochromatin

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

methylated histone binding

histone binding

germinal vesicle

cell division

meiotic chromosome separation

 
TC0100003531.mm.2 Pcp4l1 Purkinje cell protein 4-like 1 1 -171173263 NM_025557 17

molecular_function

cellular_component

biological_process

 
TC0300001076.mm.2 Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 3 104638663 NM_009196, BC014777 NM_009196, BC014777 88

mitochondrion

centrosome

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

lipid metabolic process

centrosome cycle

monocarboxylic acid transmembrane transporter activity

monocarboxylic acid transmembrane transporter activity

basal plasma membrane

lactate transmembrane transporter activity

symporter activity

monocarboxylic acid transport

monocarboxylic acid transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

lateral plasma membrane

cell junction

response to food

lactate transmembrane transport

plasma membrane lactate transport

plasma membrane lactate transport

glucose homeostasis

identical protein binding

intracellular membrane-bounded organelle

synapse

synapse

carboxylic acid transmembrane transporter activity

regulation of insulin secretion

behavioral response to nutrient

transmembrane transport

cellular response to organic cyclic compound

organic cyclic compound binding

carboxylic acid transmembrane transport

 
TC1100002813.mm.2 Gemin5 gem nuclear organelle associated protein 5 11 -58120000, -58120000 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 23

RNA 7-methylguanosine cap binding

spliceosomal snRNP assembly

RNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

nucleus

nucleoplasm

cytoplasm

cytosol

mRNA processing

translation

regulation of translation

RNA splicing

nuclear body

snRNA binding

U1 snRNA binding

U4 snRNA binding

U4atac snRNA binding

SMN complex

SMN-Gemin2 complex

SMN-Sm protein complex

ribosome binding

03013

TC0900002115.mm.2 Sc5d sterol-C5-desaturase 9 -42254176 NM_172769, BC024132 NM_172769, BC024132 30

C-5 sterol desaturase activity

C-5 sterol desaturase activity

iron ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

steroid metabolic process

lipid biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

cholesterol biosynthetic process via lathosterol

cholesterol biosynthetic process via lathosterol

intracellular membrane-bounded organelle

00100

01100

TC0900003342.mm.2 Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein 9 -88449363, -88455581 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 66

nucleic acid binding

RNA binding

mRNA binding

nucleus

spliceosomal complex

cytoplasm

endoplasmic reticulum

mRNA processing

poly(A) binding

RNA splicing

negative regulation of translation

intracellular membrane-bounded organelle

mRNA 5'-UTR binding

CRD-mediated mRNA stabilization

CRD-mediated mRNA stabilization

CRD-mediated mRNA stability complex

CRD-mediated mRNA stability complex

catalytic step 2 spliceosome

histone pre-mRNA 3'end processing complex

cellular response to interferon-gamma

GAIT complex

ribonucleoprotein complex

ribonucleoprotein complex

 
TC0500002508.mm.2 Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 5 -66298724, -66298724 NM_001201413, NM_001201414, NM_001201415, NM_001201416, NM_009686, BC076587 NM_001201413, NM_001201414, NM_001201415, NM_001201416, NM_009686, BC076587 NM_001201413, NM_001201414, NM_001201415, NM_001201416, NM_009686, BC076587 NM_001201413, NM_001201414, NM_001201415, NM_001201416, NM_009686, BC076587 NM_001201413, NM_001201414, NM_001201415, NM_001201416, NM_009686, BC076587 NM_001201413, NM_001201414, NM_001201415, NM_001201416, NM_009686, BC076587 36

amyloid-beta binding

neuron migration

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

cell cycle arrest

axon guidance

transcription factor binding

transcription factor binding

actin filament-based movement

extracellular matrix organization

negative regulation of cell growth

histone acetyltransferase binding

positive regulation of apoptotic process

negative regulation of apoptotic process

protein stabilization

 
MG-1-neg-10339217_st                
TC0900003248.mm.2 Cx3cr1 chemokine (C-X3-C motif) receptor 1 9 -120048682 NM_009987, BC012653 NM_009987, BC012653 1010

microglial cell activation

positive regulation of neuroblast proliferation

microglial cell activation involved in immune response

negative regulation of chronic inflammatory response to non-antigenic stimulus

response to ischemia

cytokine receptor activity

G protein-coupled receptor activity

chemokine receptor activity

plasma membrane

chemotaxis

immune response

cell adhesion

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

memory

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

C-C chemokine receptor activity

C-X3-C chemokine receptor activity

negative regulation of angiogenesis

cytokine-mediated signaling pathway

calcium-mediated signaling

C-C chemokine binding

C-X3-C chemokine binding

C-X3-C chemokine binding

central nervous system maturation

cerebral cortex cell migration

negative regulation of cell migration

regulation of tumor necrosis factor production

negative regulation of interleukin-1 beta production

neuronal cell body membrane

social behavior

autocrine signaling

neuron projection

innate immune response

regulation of nitric oxide biosynthetic process

positive regulation of angiogenesis

macrophage chemotaxis

perinuclear region of cytoplasm

positive regulation of neurogenesis

modulation of chemical synaptic transmission

leukocyte tethering or rolling

positive regulation of NF-kappaB transcription factor activity

positive regulation of protein kinase B signaling

synapse maturation

cell chemotaxis

cell chemotaxis

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

dendritic tree

negative regulation of hippocampal neuron apoptotic process

multiple spine synapse organization, single dendrite

negative regulation of long-term synaptic potentiation

positive regulation of I-kappaB phosphorylation

positive regulation of microglial cell migration

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

04060

04062

TC1300001349.mm.2 Tmem267 transmembrane protein 267 13 119488472, 119488085 NM_001039244, NM_001177666, BC021422, BC103784 NM_001039244, NM_001177666, BC021422, BC103784 NM_001039244, NM_001177666, BC021422, BC103784 NM_001039244, NM_001177666, BC021422, BC103784 12

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC1200000719.mm.2 Rad51b RAD51 paralog B 12 79297281, 79297350 NM_001252562, NM_009014, BC058184 NM_001252562, NM_009014, BC058184 NM_001252562, NM_009014, BC058184 22

nucleotide binding

four-way junction DNA binding

four-way junction DNA binding

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

in utero embryonic development

in utero embryonic development

blastocyst growth

DNA binding

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

ATP binding

nucleus

replication fork

replication fork

DNA repair

DNA recombination

cellular response to DNA damage stimulus

DNA-dependent ATPase activity

DNA-dependent ATPase activity

positive regulation of cell population proliferation

positive regulation of G2/M transition of mitotic cell cycle

Rad51B-Rad51C-Rad51D-XRCC2 complex

Rad51B-Rad51C-Rad51D-XRCC2 complex

somite development

03440

TC1300001445.mm.2 Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase 13 -12186539 NM_001081128, BC145683, BC145685 NM_001081128, BC145683, BC145685 NM_001081128, BC145683, BC145685 25

folic acid binding

cytoplasm

cytosol

cytosol

protein methylation

methionine metabolic process

methyltransferase activity

zinc ion binding

cellular amino acid biosynthetic process

methionine synthase activity

methionine synthase activity

methionine synthase activity

methionine biosynthetic process

methionine biosynthetic process

cobalamin metabolic process

amino acid binding

transferase activity

axon regeneration

cobalamin binding

methylation

pteridine-containing compound metabolic process

cellular metabolic process

tetrahydrofolate metabolic process

metal ion binding

response to axon injury

homocysteine metabolic process

cellular response to nitric oxide

00270

00450

00670

01100

TC1000003078.mm.2 Slc16a7 solute carrier family 16 (monocarboxylic acid transporters), member 7 10 -125219269, -125219269 NM_011391, BC117803, BC117804, BC126960 NM_011391, BC117803, BC117804, BC126960 NM_011391, BC117803, BC117804, BC126960 NM_011391, BC117803, BC117804, BC126960 44

nucleoplasm

cytoplasm

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

monocarboxylic acid transmembrane transporter activity

lactate transmembrane transporter activity

symporter activity

monocarboxylic acid transport

membrane

integral component of membrane

lactate transmembrane transport

plasma membrane lactate transport

pyruvate transmembrane transporter activity

transmembrane transport

Schaffer collateral - CA1 synapse

hippocampal mossy fiber to CA3 synapse

parallel fiber to Purkinje cell synapse

glutamatergic synapse

integral component of postsynaptic density membrane

pyruvate transmembrane transport

 
TC0200005378.mm.2 Gm14326 predicted gene 14326 2 -177944590, -177935992 NM_001190302, NM_001282028 NM_001190302, NM_001282028 9

molecular_function

cellular_component

biological_process

 
TC0800001263.mm.2 Nip7 NIP7, nucleolar pre-rRNA processing protein 8 107056876 NM_001164472, NM_025391, NR_028367, BC003972 NM_001164472, NM_025391, NR_028367, BC003972 NM_001164472, NM_025391, NR_028367, BC003972 NM_001164472, NM_025391, NR_028367, BC003972 19

RNA binding

nucleus

nucleoplasm

nucleolus

nucleolus

cytosol

preribosome, large subunit precursor

ribosome biogenesis

ribosome assembly

ribosomal large subunit biogenesis

 
TC1700002794.mm.2         NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983  

molecular_function

protein binding

cellular_component

cytosol

cytoplasmic dynein complex

microtubule-based movement

biological_process

extrinsic component of membrane

sperm flagellum

 
TC1700002497.mm.2 Ndc80 NDC80 kinetochore complex component 17 -71496099 NM_023294, BC020131 NM_023294, BC020131 29

mitotic sister chromatid segregation

establishment of mitotic spindle orientation

chromosome, centromeric region

kinetochore

kinetochore

condensed chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed nuclear chromosome outer kinetochore

protein binding

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

centrosome

cell cycle

mitotic spindle organization

spindle assembly involved in female meiosis I

spindle assembly involved in female meiosis I

chromosome segregation

G2/MI transition of meiotic cell cycle

attachment of spindle microtubules to kinetochore

cyclin binding

Ndc80 complex

Ndc80 complex

regulation of protein stability

identical protein binding

centrosome duplication

cell division

metaphase plate congression

attachment of mitotic spindle microtubules to kinetochore

attachment of mitotic spindle microtubules to kinetochore

kinetochore organization

kinetochore organization

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of protein localization to kinetochore

 
TC0100002739.mm.2 Ncl nucleolin 1 -86344718 NM_010880, BC005460 NM_010880, BC005460 127

angiogenesis

fibrillar center

dense fibrillar component

nucleic acid binding

DNA binding

single-stranded DNA binding

RNA binding

RNA binding

signaling receptor binding

calcium ion binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

spliceosomal complex

chromosome

nucleolus

nucleolus

cytoplasm

cell cortex

endocytosis

protein C-terminus binding

cell surface

negative regulation of translation

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

selenocysteine insertion sequence binding

cytoplasmic ribonucleoprotein granule

rRNA primary transcript binding

telomeric DNA binding

histone binding

identical protein binding

negative regulation of apoptotic process

laminin binding

sequence-specific DNA binding

DNA topoisomerase binding

positive regulation of transcription by RNA polymerase II

positive regulation of mRNA splicing, via spliceosome

mRNA 5'-UTR binding

cellular response to lipopolysaccharide

cellular response to epidermal growth factor stimulus

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

ErbB-4 class receptor binding

cellular response to leukemia inhibitory factor

ribonucleoprotein complex

regulation of rRNA processing

 
TC1400000174.mm.2 Zswim8 zinc finger SWIM-type containing 8 14 20707551 NM_001252081, NM_001252082, NM_027996, BC151046, BC151056, BC151173, BC172103 NM_001252081, NM_001252082, NM_027996, BC151046, BC151056, BC151173, BC172103 NM_001252081, NM_001252082, NM_027996, BC151046, BC151056, BC151173, BC172103 NM_001252081, NM_001252082, NM_027996, BC151046, BC151056, BC151173, BC172103 NM_001252081, NM_001252082, NM_027996, BC151046, BC151056, BC151173, BC172103 NM_001252081, NM_001252082, NM_027996, BC151046, BC151056, BC151173, BC172103 NM_001252081, NM_001252082, NM_027996, BC151046, BC151056, BC151173, BC172103 20

molecular_function

cytosol

zinc ion binding

Cul2-RING ubiquitin ligase complex

metal ion binding

regulation of axon guidance

 
TC0900001908.mm.2 Anln anillin, actin binding protein 9 -22331213 NM_028390, BC030489, BC032164 NM_028390, BC030489, BC032164 NM_028390, BC030489, BC032164 47

mitotic cytokinesis

mitotic cytokinesis

actomyosin contractile ring assembly

hematopoietic progenitor cell differentiation

actin binding

nucleus

nucleoplasm

cytoplasm

actomyosin contractile ring

actomyosin contractile ring

cytoskeleton

cell cycle

actin cytoskeleton

midbody

septin ring organization

bleb

cell projection

cell division

glomerular visceral epithelial cell migration

cell cortex region

positive regulation of bleb assembly

 
TC1300000383.mm.2 Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 13 33967152, 33964658 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 32

dihydronicotinamide riboside quinone reductase activity

NAD(P)H dehydrogenase (quinone) activity

nucleoplasm

cytoplasm

cytosol

cytosol

zinc ion binding

electron transfer activity

oxidoreductase activity

oxidoreductase activity, acting on other nitrogenous compounds as donors

chloride ion binding

protein homodimerization activity

positive regulation of neuron apoptotic process

metal ion binding

positive regulation of ERK1 and ERK2 cascade

FAD binding

melatonin binding

positive regulation of vascular associated smooth muscle cell proliferation

resveratrol binding

positive regulation of reactive oxygen species metabolic process

 
TC1100003693.mm.2 Top2a topoisomerase (DNA) II alpha 11 -98992946 NM_011623 101

nucleotide binding

nuclear chromosome

magnesium ion binding

resolution of meiotic recombination intermediates

chromosome, centromeric region

condensed chromosome

condensed chromosome

sister chromatid segregation

hematopoietic progenitor cell differentiation

DNA binding

chromatin binding

DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

protein kinase C binding

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

cytoplasm

centriole

DNA metabolic process

DNA topological change

DNA topological change

DNA ligation

cellular response to DNA damage stimulus

chromosome segregation

chromosome segregation

chromosome segregation

female meiotic nuclear division

protein C-terminus binding

DNA-dependent ATPase activity

DNA binding, bending

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

isomerase activity

enzyme binding

chromosome condensation

apoptotic chromosome condensation

apoptotic chromosome condensation

protein-containing complex

embryonic cleavage

regulation of circadian rhythm

protein homodimerization activity

histone deacetylase binding

positive regulation of apoptotic process

ubiquitin binding

sequence-specific DNA binding

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of transcription by RNA polymerase II

metal ion binding

protein heterodimerization activity

rhythmic process

female meiosis chromosome separation

negative regulation of DNA duplex unwinding

ribonucleoprotein complex

 
TC1600001380.mm.2 Dgkg diacylglycerol kinase, gamma 16 -22466568 NM_138650, BC015278 NM_138650, BC015278 36

nucleotide binding

NAD+ kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

calcium ion binding

ATP binding

cytoplasm

cytosol

cytoskeleton

plasma membrane

phosphatidic acid biosynthetic process

phosphatidic acid biosynthetic process

signal transduction

protein kinase C-activating G protein-coupled receptor signaling pathway

lipid binding

membrane

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

diacylglycerol metabolic process

diacylglycerol metabolic process

diacylglycerol metabolic process

glycerolipid metabolic process

lipid phosphorylation

lipid phosphorylation

lipid phosphorylation

metal ion binding

regulation of dendrite development

negative regulation of protein kinase C signaling

00561

00564

01100

04070

TC0X00002826.mm.2 Taf9b TATA-box binding protein associated factor 9B X -106206873, -106206873 NM_001001176, NM_001167988, BC066223 NM_001001176, NM_001167988, BC066223 NM_001001176, NM_001167988, BC066223 20

negative regulation of transcription by RNA polymerase II

nucleus

transcription factor TFIID complex

transcription factor TFIID complex

DNA-templated transcription, initiation

transcription by RNA polymerase II

RNA polymerase II general transcription initiation factor activity

positive regulation of cell growth

transcription factor TFTC complex

negative regulation of apoptotic process

protein heterodimerization activity

protein stabilization

03022

TC0600000989.mm.2 C87436 expressed sequence C87436 6 86438673, 86438397, 86438645, 86438375 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 18

molecular_function

nucleus

nucleoplasm

biological_process

 
TC0700002311.mm.2 Zik1 zinc finger protein interacting with K protein 1 7 -10487223 NM_009577, BC050942, BC067196 NM_009577, BC050942, BC067196 NM_009577, BC050942, BC067196 21

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

intracellular anatomical structure

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

metal ion binding

 
TC1300000928.mm.2 Mctp1 multiple C2 domains, transmembrane 1 13 76384138, 76579596 NM_030174 13

calcium ion binding

calcium ion binding

endosome

endoplasmic reticulum

membrane

integral component of membrane

integral component of membrane

cell junction

negative regulation of cell migration

synaptic vesicle membrane

synaptic vesicle membrane

cytoplasmic vesicle

synapse

negative regulation of endocytosis

metal ion binding

regulation of neurotransmitter secretion

recycling endosome

negative regulation of response to oxidative stress

 
TC0500000928.mm.2 Anxa3 annexin A3 5 96793384 NM_013470, BC090634, BC141167 NM_013470, BC090634, BC141167 NM_013470, BC090634, BC141167 28

phospholipase inhibitor activity

calcium ion binding

calcium-dependent phospholipid binding

cytoplasm

cytoplasm

plasma membrane

phagocytosis

positive regulation of endothelial cell migration

membrane

phospholipase A2 inhibitor activity

axon

dendrite

phagocytic vesicle membrane

specific granule

defense response to bacterium

neuronal cell body

neutrophil degranulation

positive regulation of angiogenesis

calcium-dependent protein binding

positive regulation of DNA metabolic process

positive regulation of DNA-binding transcription factor activity

collagen-containing extracellular matrix

 
TC0400002460.mm.2 Ubap2 ubiquitin-associated protein 2 4 -41194314 NM_026872, BC007179 NM_026872, BC007179 25

nucleus

cytoplasm

 
TC0500001428.mm.2 Kntc1 kinetochore associated 1 5 123749725 NM_001042421 20

chromosome, centromeric region

kinetochore

spindle pole

molecular_function

nucleus

chromosome

cytoplasm

kinetochore microtubule

cytosol

cytoskeleton

plasma membrane

cell cycle

mitotic spindle assembly checkpoint

actin cytoskeleton

cell division

RZZ complex

 
TC0500000324.mm.2 Gpn1 GPN-loop GTPase 1 5 31494740 NM_133756, BC020174, BC096466 NM_133756, BC020174, BC096466 NM_133756, BC020174, BC096466 17

nucleotide binding

GTPase activity

GTP binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

hydrolase activity

 
TC0200001947.mm.2 Polr1b polymerase (RNA) I polypeptide B 2 129100995 NM_009086, BC060656 NM_009086, BC060656 35

DNA binding

DNA-directed 5'-3' RNA polymerase activity

DNA-directed 5'-3' RNA polymerase activity

protein binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

RNA polymerase I complex

RNA polymerase I complex

RNA polymerase I complex

cytosol

transcription, DNA-templated

embryo implantation

rRNA transcription

rRNA transcription

embryo development

transferase activity

nucleotidyltransferase activity

nucleologenesis

ribonucleoside binding

metal ion binding

00230

00240

01100

03020

TC0400001596.mm.2 Rpa2 replication protein A2 4 132768359 NM_011284, BC004578 NM_011284, BC004578 46

telomere maintenance

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

chromosome, telomeric region

chromosome, telomeric region

chromatin

DNA binding

damaged DNA binding

single-stranded DNA binding

single-stranded DNA binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

DNA replication factor A complex

DNA replication factor A complex

DNA replication

DNA replication

DNA repair

base-excision repair

nucleotide-excision repair

nucleotide-excision repair

mismatch repair

DNA recombination

cellular response to DNA damage stimulus

regulation of double-strand break repair via homologous recombination

nuclear body

PML body

enzyme binding

protein phosphatase binding

mitotic G1 DNA damage checkpoint

ubiquitin protein ligase binding

protein localization to chromosome

site of double-strand break

site of double-strand break

protein N-terminus binding

G-rich strand telomeric DNA binding

regulation of DNA damage checkpoint

03030

03420

03430

03440

TC1100003124.mm.2 Nlrp1a NLR family, pyrin domain containing 1A 11 -71091196 NM_001004142 38

nucleotide binding

protein binding

ATP binding

cytoplasm

activation of cysteine-type endopeptidase activity involved in apoptotic process

inflammatory response

response to muramyl dipeptide

positive regulation of interleukin-1 beta production

protein-containing complex

defense response to bacterium

regulation of apoptotic process

neuronal cell body

innate immune response

inflammasome complex

scaffold protein binding

programmed necrotic cell death

04621

TC1100003945.mm.2 Nol11 nucleolar protein 11 11 -107166652 NM_001161329, NM_133702, BC024874 NM_001161329, NM_133702, BC024874 NM_001161329, NM_133702, BC024874 19

nucleus

nucleolus

nucleolus

rRNA processing

maturation of SSU-rRNA

maturation of SSU-rRNA

t-UTP complex

ribosome biogenesis

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

 
TC0200003182.mm.2 Qsox2 quiescin Q6 sulfhydryl oxidase 2 2 -26209123 NM_153559, BC030934 NM_153559, BC030934 17

protein disulfide isomerase activity

extracellular space

nucleoplasm

Golgi apparatus

protein folding

membrane

integral component of membrane

oxidoreductase activity

flavin-linked sulfhydryl oxidase activity

thiol oxidase activity

integral component of Golgi membrane

cell redox homeostasis

 
TC0800002960.mm.2 Adat1 adenosine deaminase, tRNA-specific 1 8 -111970864, -111966897 NM_013925, BC019976 NM_013925, BC019976 14

RNA binding

adenosine deaminase activity

cellular_component

RNA processing

tRNA processing

tRNA-specific adenosine deaminase activity

tRNA-specific adenosine deaminase activity

hydrolase activity

metal ion binding

 
TC0700002102.mm.2 Dhcr7 7-dehydrocholesterol reductase 7 143830213, 143823166, 143823398 NM_007856, BC006854 NM_007856, BC006854 56

blood vessel development

nuclear outer membrane

endoplasmic reticulum

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

post-embryonic development

sterol delta7 reductase activity

membrane

integral component of membrane

sterol biosynthetic process

sterol biosynthetic process

brassinosteroid biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

cell differentiation

integral component of endoplasmic reticulum membrane

lung development

multicellular organism growth

regulation of cell population proliferation

intracellular membrane-bounded organelle

regulation of cholesterol biosynthetic process

7-dehydrocholesterol reductase activity

7-dehydrocholesterol reductase activity

7-dehydrocholesterol reductase activity

00100

01100

TC1000000047.mm.2 Nup43 nucleoporin 43 10 7667503 NM_145706, BC011060 NM_145706, BC011060 16

chromosome, centromeric region

kinetochore

molecular_function

nucleus

nuclear pore

nucleoplasm

chromosome

cytosol

cell cycle

chromosome segregation

protein transport

nuclear speck

nuclear pore outer ring

nuclear pore outer ring

mRNA transport

cell division

03013

TC0800001390.mm.2 Cenpn centromere protein N 8 116921739 NM_028131, BC058243 NM_028131, BC058243 14

chromosome, centromeric region

kinetochore

molecular_function

nucleus

nucleoplasm

chromosome

chromosome segregation

kinetochore assembly

 
MG-1-neg-10338216_st                
TC0200004808.mm.2 Thbd thrombomodulin 2 -148404470 NM_009378, BC019154 NM_009378, BC019154 120

transmembrane signaling receptor activity

calcium ion binding

extracellular space

vacuolar membrane

plasma membrane

plasma membrane

integral component of plasma membrane

female pregnancy

blood coagulation

hemostasis

embryo development

external side of plasma membrane

cell surface

membrane

integral component of membrane

apicolateral plasma membrane

negative regulation of blood coagulation

negative regulation of coagulation

04610

TC0800002313.mm.2 Msmo1 methylsterol monoxygenase 1 8 -64718122 NM_025436, BC006802 NM_025436, BC006802 31

C-4 methylsterol oxidase activity

iron ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

lipid biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

00100

01100

TC0X00003412.mm.2 Ccdc22 coiled-coil domain containing 22 X -7593808 NM_138603, BC011195 NM_138603, BC011195 17

protein binding

endosome

cellular copper ion homeostasis

Golgi to plasma membrane transport

cytoplasmic sequestering of NF-kappaB

protein transport

endocytic recycling

cholesterol homeostasis

positive regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of I-kappaB kinase/NF-kappaB signaling

regulation of plasma lipoprotein particle levels

cullin family protein binding

cullin family protein binding

retrograde transport, endosome to plasma membrane

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process

 
TC0600001462.mm.2 Vwf Von Willebrand factor 6 125552947 NM_011708 313

liver development

placenta development

protease binding

integrin binding

extracellular matrix structural constituent

protein binding

collagen binding

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

endoplasmic reticulum

cell adhesion

blood coagulation

blood coagulation

blood coagulation

hemostasis

hemostasis

hemostasis

external side of plasma membrane

immunoglobulin binding

platelet activation

extracellular matrix

cell-substrate adhesion

cell-substrate adhesion

cell-substrate adhesion

Weibel-Palade body

identical protein binding

protein N-terminus binding

chaperone binding

collagen-containing extracellular matrix

collagen-containing extracellular matrix

04510

04512

04610

TC0100000858.mm.2 Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 1 89454810 NM_001037136, NM_178119, BC172673 NM_001037136, NM_178119, BC172673 NM_001037136, NM_178119, BC172673 29

nucleotide binding

GTPase activity

GTPase activator activity

GTP binding

phospholipid binding

nucleus

cytoplasm

cytosol

protein transport

metal ion binding

04144

TC0100002354.mm.2 Hspd1 heat shock protein 1 (chaperonin) 1 -55077833, -55077832 NM_010477, BC016400 NM_010477, BC016400 137

nucleotide binding

lipopolysaccharide binding

lipopolysaccharide binding

p53 binding

MyD88-dependent toll-like receptor signaling pathway

positive regulation of T cell mediated immune response to tumor cell

double-stranded RNA binding

ATP binding

extracellular space

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial matrix

mitochondrial matrix

early endosome

peroxisomal matrix

rough endoplasmic reticulum

Golgi apparatus

cytosol

plasma membrane

plasma membrane

clathrin-coated pit

protein folding

activation of cysteine-type endopeptidase activity involved in apoptotic process

response to unfolded protein

high-density lipoprotein particle binding

apoptotic mitochondrial changes

apoptotic mitochondrial changes

cell surface

membrane

isomerase activity

enzyme binding

mitochondrial crista

coated vesicle

secretory granule

secretory granule

ubiquitin protein ligase binding

Golgi cisterna

positive regulation of interferon-alpha production

positive regulation of interferon-alpha production

positive regulation of interferon-alpha production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

protein-containing complex

apolipoprotein binding

apolipoprotein A-I binding

mitochondrial unfolded protein response

protein refolding

B cell proliferation

T cell activation

T cell activation

T cell activation

T cell activation

B cell activation

zymogen granule

positive regulation of macrophage activation

positive regulation of apoptotic process

negative regulation of apoptotic process

myelin sheath

intracellular membrane-bounded organelle

negative regulation of neuron apoptotic process

protein-containing complex binding

protein import into mitochondrial intermembrane space

membrane raft

lipopolysaccharide receptor complex

isotype switching to IgG isotypes

positive regulation of inflammatory response

protein stabilization

positive regulation of T cell activation

positive regulation of T cell activation

positive regulation of T cell activation

chaperone binding

chaperone binding

biological process involved in interaction with symbiont

extracellular exosome

negative regulation of apoptotic process in bone marrow cell

cellular response to interleukin-7

modification-dependent protein binding

negative regulation of reactive oxygen species biosynthetic process

03018

04940

TC0500002240.mm.2 Nop14 NOP14 nucleolar protein 5 -34638535 NM_029278, BC024998, BC043043 NM_029278, BC024998, BC043043 NM_029278, BC024998, BC043043 21

nucleus

nucleoplasm

nucleolus

nucleolus

rRNA processing

enzyme binding

maturation of SSU-rRNA

Noc4p-Nop14p complex

small-subunit processome

ribosome biogenesis

 
TC1600000335.mm.2 St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 16 23226020, 23290469, 23224739 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 78

Golgi trans cisterna

Golgi membrane

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

extracellular region

endoplasmic reticulum

Golgi apparatus

Golgi medial cisterna

N-acetylneuraminate metabolic process

protein glycosylation

sialyltransferase activity

sialyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein N-linked glycosylation via asparagine

protein N-linked glycosylation via asparagine

positive regulation of mononuclear cell proliferation

protein homodimerization activity

negative regulation of chemotaxis

sialylation

regulation of substrate adhesion-dependent cell spreading

protein sialylation

negative regulation of macrophage apoptotic process

00510

00514

01100

TC0100001656.mm.2 Exo1 exonuclease 1 1 175880777 NM_012012, BC006671 NM_012012, BC006671 51

immune system process

humoral immune response mediated by circulating immunoglobulin

DNA binding

chromatin binding

catalytic activity

nuclease activity

endonuclease activity

exonuclease activity

nucleus

nucleus

nucleoplasm

plasma membrane

nucleobase-containing compound metabolic process

DNA repair

mismatch repair

mismatch repair

DNA recombination

DNA recombination

cellular response to DNA damage stimulus

5'-3' exonuclease activity

somatic hypermutation of immunoglobulin genes

nuclear body

hydrolase activity

hydrolase activity, acting on ester bonds

5'-flap endonuclease activity

5'-3' exodeoxyribonuclease activity

5'-3' exodeoxyribonuclease activity

single-stranded DNA 5'-3' exodeoxyribonuclease activity

isotype switching

metal ion binding

flap endonuclease activity

meiotic cell cycle

double-stranded DNA 5'-3' exodeoxyribonuclease activity

03430

TC0100000351.mm.2 Wdr75 WD repeat domain 75 1 45795165 NM_028599, BC117880, BC117881 NM_028599, BC117880, BC117881 NM_028599, BC117880, BC117881 23

nucleus

nucleolus

rRNA processing

ribosome biogenesis

positive regulation of transcription by RNA polymerase I

positive regulation of rRNA processing

03008

TC0500003219.mm.2 Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta 5 -122731169 NM_001199676, NM_145358, BC023103 NM_001199676, NM_145358, BC023103 NM_001199676, NM_145358, BC023103 67

nucleotide binding

positive regulation of protein phosphorylation

protein kinase activity

protein serine/threonine kinase activity

calmodulin-dependent protein kinase activity

calcium ion binding

protein binding

calmodulin binding

ATP binding

nucleus

cytoplasm

cytosol

protein phosphorylation

kinase activity

phosphorylation

transferase activity

activation of protein kinase activity

cell projection

protein autophosphorylation

CAMKK-AMPK signaling cascade

04920

TC0500002650.mm.2 Noa1 nitric oxide associated 1 5 -77294168 NM_019836, BC017154 NM_019836, BC017154 24

nucleotide binding

GTP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

apoptotic process

regulation of cell death

regulation of cell death

regulation of cell death

membrane

extrinsic component of mitochondrial inner membrane

mitochondrial translation

regulation of cellular respiration

regulation of cellular respiration

 
TC1100003780.mm.2 Kat2a K(lysine) acetyltransferase 2A 11 -100704745 NM_001038010, NM_020004, BC063752 NM_001038010, NM_020004, BC063752 NM_001038010, NM_020004, BC063752 93

histone acetyltransferase complex

histone acetyltransferase complex

chromatin

in utero embryonic development

somitogenesis

somitogenesis

cytokine production

neural tube closure

chromatin binding

chromatin binding

transcription coactivator activity

histone acetyltransferase activity

histone acetyltransferase activity

protein binding

nucleus

nucleus

Ada2/Gcn5/Ada3 transcription activator complex

Ada2/Gcn5/Ada3 transcription activator complex

chromosome

cytoplasm

centrosome

cytoskeleton

regulation of transcription, DNA-templated

nervous system development

long-term memory

N-acetyltransferase activity

transcription factor binding

transcription factor binding

cell population proliferation

H3 histone acetyltransferase activity

H3 histone acetyltransferase activity

acetyltransferase activity

histone acetylation

histone deubiquitination

transferase activity

transferase activity, transferring acyl groups

internal peptidyl-lysine acetylation

protein phosphatase binding

telencephalon development

metencephalon development

midbrain development

STAGA complex

STAGA complex

positive regulation of cell projection organization

regulation of protein stability

transcription factor TFTC complex

positive regulation of histone acetylation

multicellular organism growth

histone deacetylase binding

histone H3 acetylation

histone H3 acetylation

histone H4-K12 acetylation

histone acetyltransferase activity (H4-K12 specific)

histone H3-K14 acetylation

oxoglutarate dehydrogenase complex

regulation of regulatory T cell differentiation

positive regulation of gluconeogenesis

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of centriole replication

regulation of synaptic plasticity

intracellular distribution of mitochondria

regulation of T cell activation

regulation of cartilage development

peptide-lysine-N-acetyltransferase activity

alpha-tubulin acetylation

mitotic spindle

histone succinylation

histone succinyltransferase activity

peptidyl-lysine glutarylation

histone glutaryltransferase activity

regulation of bone development

regulation of stem cell population maintenance

positive regulation of cardiac muscle cell differentiation

04330

TSUnmapped00000020.mm.2 Snx29 sorting nexin 29 16 11322903, 11405647 NM_001290148 15

molecular_function

biological_process

phosphatidylinositol binding

 
TC0400002854.mm.2 Tle1 transducin-like enhancer of split 1 4 -72157579, -72109944 NM_001285529, NM_001285530, NM_001285531, NM_001285532, NM_011599, BC057573 NM_001285529, NM_001285530, NM_001285531, NM_001285532, NM_011599, BC057573 NM_001285529, NM_001285530, NM_001285531, NM_001285532, NM_011599, BC057573 NM_001285529, NM_001285530, NM_001285531, NM_001285532, NM_011599, BC057573 NM_001285529, NM_001285530, NM_001285531, NM_001285532, NM_011599, BC057573 NM_001285529, NM_001285530, NM_001285531, NM_001285532, NM_011599, BC057573 85

negative regulation of transcription by RNA polymerase II

chromatin binding

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

cytoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription factor binding

positive regulation of gene expression

Wnt signaling pathway

identical protein binding

negative regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of transcription, DNA-templated

repressing transcription factor binding

negative regulation of canonical Wnt signaling pathway

beta-catenin-TCF complex

negative regulation of anoikis

 
TC0700004201.mm.2 Cdr2 cerebellar degeneration-related 2 7 -120957039, -120957036 NM_007672, BC117530, BC118511 NM_007672, BC117530, BC118511 NM_007672, BC117530, BC118511 20

molecular_function

cytoplasm

biological_process

 
TC0200001757.mm.2 Knl1 kinetochore scaffold 1 2 119047118, 119047118 NM_029617, BC080815 NM_029617, BC080815 19

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

condensed chromosome kinetochore

acrosomal vesicle

molecular_function

nucleus

nucleus

nucleoplasm

chromosome

cell cycle

chromosome segregation

attachment of spindle microtubules to kinetochore

attachment of spindle microtubules to kinetochore

negative regulation of phosphatase activity

nuclear body

protein localization to kinetochore

protein localization to kinetochore

cell division

 
TC0900002007.mm.2 Dcps decapping enzyme, scavenger 9 -35124413 NM_027030, BC016273 NM_027030, BC016273 22

deadenylation-dependent decapping of nuclear-transcribed mRNA

RNA 7-methylguanosine cap binding

RNA 7-methylguanosine cap binding

P-body

nucleus

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

mRNA processing

RNA splicing

hydrolase activity

cellular response to menadione

identical protein binding

negative regulation of programmed cell death

mRNA cis splicing, via spliceosome

m7G(5')pppN diphosphatase activity

m7G(5')pppN diphosphatase activity

03018

TC0700000786.mm.2 Klk1b11 kallikrein 1-related peptidase b11 7 43995876 NM_010640, BC013660 NM_010640, BC013660 13

regulation of systemic arterial blood pressure

endopeptidase activity

serine-type endopeptidase activity

extracellular space

proteolysis

peptidase activity

serine-type peptidase activity

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

secretory granule

zymogen activation

protein-containing complex

 
TC1000002639.mm.2 Parpbp PARP1 binding protein 10 -88091397 NM_029249, BC070476 NM_029249, BC070476 21

chromatin

chromatin

DNA binding

protein binding

nucleus

nucleoplasm

cytoplasm

DNA repair

cellular response to DNA damage stimulus

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

 
TC0700001989.mm.2 Lrrc27 leucine rich repeat containing 27 7 139212987, 139213274 NM_001143755, NM_027164, BC050816 NM_001143755, NM_027164, BC050816 NM_001143755, NM_027164, BC050816 11

molecular_function

 
TC1500001742.mm.2 Top1mt DNA topoisomerase 1, mitochondrial 15 -75657032 NM_028404, BC138582, BC138583, BC145336 NM_028404, BC138582, BC138583, BC145336 NM_028404, BC138582, BC138583, BC145336 NM_028404, BC138582, BC138583, BC145336 21

DNA binding

DNA topoisomerase activity

DNA topoisomerase type I (single strand cut, ATP-independent) activity

nucleoplasm

chromosome

mitochondrion

mitochondrion

DNA replication

DNA topological change

isomerase activity

mitochondrial nucleoid

mitochondrial nucleoid

 
TC0400001006.mm.2 Alg6 asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase) 4 99715629 NM_001081264, BC050854 NM_001081264, BC050854 15

endoplasmic reticulum

endoplasmic reticulum membrane

protein N-linked glycosylation

protein N-linked glycosylation

dolichol-linked oligosaccharide biosynthetic process

oligosaccharide-lipid intermediate biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring hexosyl groups

dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

glucosyltransferase activity

00510

01100

TC0600003148.mm.2 Cd9 CD9 antigen 6 -125460265 NM_007657, BC070474, CD9 NM_007657, BC070474, CD9 NM_007657, BC070474, CD9 130

integrin binding

integrin binding

protein binding

extracellular region

plasma membrane

plasma membrane

integral component of plasma membrane

cell adhesion

single fertilization

fusion of sperm to egg plasma membrane involved in single fertilization

fusion of sperm to egg plasma membrane involved in single fertilization

negative regulation of cell population proliferation

glial cell migration

external side of plasma membrane

cell surface

myoblast fusion involved in skeletal muscle regeneration

membrane

integral component of membrane

apical plasma membrane

paranodal junction assembly

receptor internalization

protein-containing complex

sperm-egg recognition

negative regulation of cellular component movement

extracellular exosome

extracellular exosome

cellular response to low-density lipoprotein particle stimulus

negative regulation of platelet aggregation

regulation of macrophage migration

04640

TC1800001654.mm.2 Rbfa ribosome binding factor A 18 -80192263 NM_199197, BC064066 NM_199197, BC064066 17

molecular_function

cellular_component

mitochondrion

rRNA processing

 
TC0200002731.mm.2 Gm2026 predicted gene 2026 2 -175192004, -175419390, 175640390, 175737941, -176470368, -176619932 NM_001177543 9

cellular_component

 
TC0200001012.mm.2 Klhl23 kelch-like 23 2 69822369, 69821940, 69822840 NM_177784, BC072626 NM_177784, BC072626 15    
TC1000002043.mm.2         NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697  

in utero embryonic development

adenosylmethionine decarboxylase activity

adenosylmethionine decarboxylase activity

adenosylmethionine decarboxylase activity

protein binding

cytosol

cytosol

polyamine biosynthetic process

spermine biosynthetic process

spermine biosynthetic process

spermidine biosynthetic process

spermidine biosynthetic process

lyase activity

carboxy-lyase activity

putrescine binding

putrescine binding

identical protein binding

 
TC1300001631.mm.2 H4c6 H4 clustered histone 6 13 -23551285 NM_175655, BC156748 NM_175655, BC156748 5

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

protein domain specific binding

protein-containing complex

negative regulation of megakaryocyte differentiation

05322

TC1700001163.mm.2 Ttc27 tetratricopeptide repeat domain 27 17 74717749 NM_152817, BC021912 NM_152817, BC021912 18

molecular_function

cellular_component

biological_process

 
TC1200001834.mm.2 Mis18bp1 MIS18 binding protein 1 12 -65132734 NM_172578, BC052175 NM_172578, BC052175 24

chromosome, centromeric region

condensed nuclear chromosome kinetochore

DNA binding

protein binding

nucleus

chromosome

cell cycle

cell division

 
TC1700000657.mm.2 Lsm2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated 17 34982129, 34981853, 34982129, 34981853 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 32

spliceosomal tri-snRNP complex assembly

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

P-body

RNA binding

protein binding

nucleus

nucleoplasm

spliceosomal complex

U6 snRNP

cytoplasm

mRNA processing

mRNA catabolic process

RNA splicing

protein kinase binding

small GTPase binding

U4/U6 x U5 tri-snRNP complex

U4/U6 x U5 tri-snRNP complex

U2-type precatalytic spliceosome

precatalytic spliceosome

catalytic step 2 spliceosome

catalytic step 2 spliceosome

Lsm2-8 complex

Lsm1-7-Pat1 complex

03018

03040

TC1600000238.mm.2 Trmt2a TRM2 tRNA methyltransferase 2A 16 18248882 NM_001080999, NM_001081000, NM_001195205, BC027431, BC038486, BC046976 NM_001080999, NM_001081000, NM_001195205, BC027431, BC038486, BC046976 NM_001080999, NM_001081000, NM_001195205, BC027431, BC038486, BC046976 NM_001080999, NM_001081000, NM_001195205, BC027431, BC038486, BC046976 NM_001080999, NM_001081000, NM_001195205, BC027431, BC038486, BC046976 NM_001080999, NM_001081000, NM_001195205, BC027431, BC038486, BC046976 40

nucleic acid binding

RNA binding

RNA processing

methyltransferase activity

RNA methyltransferase activity

transferase activity

methylation

 
TC0200004537.mm.2 Atp8b4 ATPase, class I, type 8B, member 4 2 -126320972, -126320972 NM_001080944 12

Golgi apparatus

trans-Golgi network

plasma membrane

plasma membrane

Golgi organization

phospholipid translocation

ATPase-coupled intramembrane lipid transporter activity

 
TC0300000624.mm.2 4930579G24Rik RIKEN cDNA 4930579G24 gene 3 79629078 NM_029482 8

molecular_function

cellular_component

cytoplasm

biological_process

 
TC1900001622.mm.2 Calhm2 calcium homeostasis modulator family member 2 19 -47132231 NM_133746, BC019197 NM_133746, BC019197 13

cation channel activity

integral component of plasma membrane

ion transport

membrane

integral component of membrane

positive regulation of apoptotic process

 
TC1200001012.mm.2 Rin3 Ras and Rab interactor 3 12 102283073, 102283640 NM_001161365, NM_177620, BC137907 NM_001161365, NM_177620, BC137907 NM_001161365, NM_177620, BC137907 16

negative regulation of receptor internalization

guanyl-nucleotide exchange factor activity

GTPase activator activity

cytoplasm

endosome

early endosome

signal transduction

endocytic vesicle

axon

dendrite

small GTPase binding

cytoplasmic vesicle

vesicle

neuronal cell body

negative regulation of mast cell chemotaxis

regulation of vesicle size

 
TC0200004376.mm.2 Dph6 diphthamine biosynthesis 6 2 -114516417 NM_025675, BC022995 NM_025675, BC022995 17

nucleotide binding

ATP binding

nucleoplasm

nucleolus

ligase activity

diphthine-ammonia ligase activity

diphthine-ammonia ligase activity

peptidyl-diphthamide biosynthetic process from peptidyl-histidine

 
MG-1-neg-10339930_st                
TC1300001635.mm.2 H2bc7 H2B clustered histone 7 13 -23573759 NM_178195, BC160307 NM_178195, BC160307 6

innate immune response in mucosa

DNA binding

extracellular space

nucleoplasm

cytosol

nucleosome assembly

antibacterial humoral response

identical protein binding

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

05322

TC0200005271.mm.2 Aurka aurora kinase A 2 -172356189 NM_011497, BC005425, BC014711 NM_011497, BC005425, BC014711 NM_011497, BC005425, BC014711 115

nucleotide binding

meiotic spindle organization

microtubule cytoskeleton organization

mitotic cell cycle

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

centrosome

centrosome

microtubule organizing center

spindle

cytosol

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cilium

protein phosphorylation

protein phosphorylation

cell cycle

spindle organization

mitotic spindle organization

mitotic spindle organization

spindle assembly involved in female meiosis I

centrosome cycle

mitotic centrosome separation

mitotic centrosome separation

response to wounding

anterior/posterior axis specification

negative regulation of gene expression

microtubule cytoskeleton

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

protein kinase binding

cell projection organization

spindle pole centrosome

spindle pole centrosome

ubiquitin protein ligase binding

regulation of protein stability

negative regulation of protein binding

chromosome passenger complex

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cytokinesis

histone serine kinase activity

histone serine kinase activity

germinal vesicle

cell projection

negative regulation of apoptotic process

axon hillock

pronucleus

protein heterodimerization activity

perinuclear region of cytoplasm

spindle midzone

cell division

meiotic cell cycle

centrosome localization

protein localization to centrosome

mitotic spindle

meiotic spindle

negative regulation of spindle checkpoint

liver regeneration

mitotic spindle pole

positive regulation of oocyte maturation

neuron projection extension

04114

TC1500001823.mm.2 Foxred2 FAD-dependent oxidoreductase domain containing 2 15 -77940521 NM_001017983, NM_001168260, BC086662 NM_001017983, NM_001168260, BC086662 NM_001017983, NM_001168260, BC086662 12

endoplasmic reticulum

endoplasmic reticulum lumen

endoplasmic reticulum lumen

oxidoreductase activity

ubiquitin-dependent ERAD pathway

ubiquitin-dependent ERAD pathway

flavin adenine dinucleotide binding

 
TC1000002443.mm.2 Pwp2 PWP2 periodic tryptophan protein homolog (yeast) 10 -78170909 NM_029546, BC112325, BC128480 NM_029546, BC112325, BC128480 NM_029546, BC112325, BC128480 23

ribosomal small subunit assembly

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nucleus

small-subunit processome

Pwp2p-containing subcomplex of 90S preribosome

03008

TC1900001472.mm.2 Noc3l NOC3 like DNA replication regulator 19 -38788127 NM_021315, BC031132 NM_021315, BC031132 29

chromatin binding

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

mitochondrion

DNA replication initiation

nuclear speck

fat cell differentiation

 
TC0500002095.mm.2 Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 5 -24862734, -24862734, -24862734 NM_001170555, NM_001170556, NM_145401, BC015283 NM_001170555, NM_001170556, NM_145401, BC015283 NM_001170555, NM_001170556, NM_145401, BC015283 NM_001170555, NM_001170556, NM_145401, BC015283 37

nucleotide binding

AMP-activated protein kinase activity

AMP-activated protein kinase activity

cAMP-dependent protein kinase inhibitor activity

ATP binding

nucleus

nucleoplasm

cytoplasm

cytosol

glycogen metabolic process

regulation of glycolytic process

protein phosphorylation

negative regulation of protein kinase activity

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

cAMP-dependent protein kinase regulator activity

phosphorylase kinase regulator activity

positive regulation of peptidyl-threonine phosphorylation

AMP binding

AMP binding

regulation of fatty acid metabolic process

protein kinase regulator activity

protein kinase binding

protein kinase binding

protein kinase activator activity

nucleotide-activated protein kinase complex

nucleotide-activated protein kinase complex

adenyl ribonucleotide binding

intracellular signal transduction

cellular response to glucose starvation

ADP binding

positive regulation of protein kinase activity

regulation of catalytic activity

regulation of catalytic activity

regulation of protein serine/threonine kinase activity

04910

04920

05410

TC0300002352.mm.2 Cks1b CDC28 protein kinase 1b 3 -89415471 NM_016904, BC076579 NM_016904, BC076579 38

cyclin-dependent protein kinase holoenzyme complex

regulation of transcription, DNA-templated

cell cycle

regulation of mitotic cell cycle

cell population proliferation

embryo development

cyclin-dependent protein serine/threonine kinase regulator activity

SCF ubiquitin ligase complex

protein kinase binding

histone binding

ubiquitin binding

mitotic cell cycle phase transition

cell division

cyclin-dependent protein serine/threonine kinase activator activity

05200

05222

TC0100003477.mm.2                
TC1200000988.mm.2 Tdp1 tyrosyl-DNA phosphodiesterase 1 12 99884517, 99884517 NM_028354, BC019804, BC065162 NM_028354, BC019804, BC065162 NM_028354, BC019804, BC065162 35

single strand break repair

single strand break repair

single strand break repair

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

nuclease activity

exonuclease activity

nucleus

nucleus

nucleoplasm

plasma membrane

DNA repair

DNA repair

double-strand break repair

double-strand break repair

cellular response to DNA damage stimulus

phosphoric diester hydrolase activity

hydrolase activity

3'-tyrosyl-DNA phosphodiesterase activity

3'-tyrosyl-DNA phosphodiesterase activity

intracellular membrane-bounded organelle

 
TC0200001881.mm.2 Dut deoxyuridine triphosphatase 2 125247247, 125247514 NM_001159646, NM_023595, BC019979, BC053693 NM_001159646, NM_023595, BC019979, BC053693 NM_001159646, NM_023595, BC019979, BC053693 NM_001159646, NM_023595, BC019979, BC053693 32

magnesium ion binding

dUTP diphosphatase activity

dUTP diphosphatase activity

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

dUMP biosynthetic process

dUMP biosynthetic process

receptor inhibitor activity

pyrimidine deoxyribonucleotide binding

identical protein binding

peroxisome proliferator activated receptor binding

regulation of protein-containing complex assembly

dUTP catabolic process

dUTP catabolic process

00240

01100

TC0100003021.mm.2 Zranb3 zinc finger, RAN-binding domain containing 3 1 -127954178, -127954178, -127954178 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 20

nucleotide binding

nucleic acid binding

catalytic activity

helicase activity

nuclease activity

endonuclease activity

endodeoxyribonuclease activity

endodeoxyribonuclease activity

ATP binding

nucleus

nucleoplasm

chromosome

DNA repair

DNA repair

cellular response to DNA damage stimulus

metabolic process

response to UV

hydrolase activity

replication fork processing

replication fork processing

DNA rewinding

annealing helicase activity

nuclear replication fork

nuclear replication fork

negative regulation of DNA recombination

metal ion binding

replication fork protection

replication fork protection

K63-linked polyubiquitin modification-dependent protein binding

 
TC1700002795.mm.2         NM_001123367, NM_001123368, BC061136, BC131981, BC131983 NM_001123367, NM_001123368, BC061136, BC131981, BC131983 NM_001123367, NM_001123368, BC061136, BC131981, BC131983 NM_001123367, NM_001123368, BC061136, BC131981, BC131983 NM_001123367, NM_001123368, BC061136, BC131981, BC131983  

molecular_function

protein binding

cellular_component

cytosol

cytoplasmic dynein complex

microtubule-based movement

biological_process

extrinsic component of membrane

sperm flagellum

 
TC0X00001323.mm.2 Bex3 brain expressed X-linked 3 X 136270252 NM_001110233, NM_001110234, NM_009750, BC027815 NM_001110233, NM_001110234, NM_009750, BC027815 NM_001110233, NM_001110234, NM_009750, BC027815 NM_001110233, NM_001110234, NM_009750, BC027815 35

signaling receptor binding

death receptor binding

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

cytosol

apoptotic process

signal transduction

extrinsic apoptotic signaling pathway via death domain receptors

identical protein binding

metal ion binding

04722

TC0200005339.mm.2         NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

molecular_function

cellular_component

nucleus

regulation of transcription by RNA polymerase II

biological_process

 
TC0800002529.mm.2 Gab1 growth factor receptor bound protein 2-associated protein 1 8 -80764433, -80764430 NM_021356, BC007483, BC094659 NM_021356, BC007483, BC094659 NM_021356, BC007483, BC094659 95

activation of MAPK activity

angiogenesis

protein binding

cytoplasm

cytosol

cell-cell junction

response to oxidative stress

signal transduction

epidermal growth factor receptor signaling pathway

activation of JUN kinase activity

heart development

epidermis development

regulation of cell migration

actin cytoskeleton reorganization

response to hepatocyte growth factor

cellular response to vascular endothelial growth factor stimulus

vascular endothelial growth factor signaling pathway

positive regulation of cell migration by vascular endothelial growth factor signaling pathway

positive regulation of MAPK cascade

positive regulation of angiogenesis

platelet-derived growth factor receptor signaling pathway

labyrinthine layer development

interleukin-6-mediated signaling pathway

endothelial cell chemotaxis to vascular endothelial growth factor

04012

04722

05100

05211

TC0200001002.mm.2 Nostrin nitric oxide synthase trafficker 2 69135799 NM_181547, BC069942 NM_181547, BC069942 17

DNA binding

protein binding

nucleus

cytoplasm

cytoskeleton

plasma membrane

endocytosis

signal transduction

membrane

cytoplasmic vesicle

negative regulation of transcription, DNA-templated

 
TC0700001343.mm.2 Nars2 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) 7 96951526 NM_153591, BC030041 NM_153591, BC030041 18

nucleotide binding

nucleic acid binding

aminoacyl-tRNA ligase activity

asparagine-tRNA ligase activity

ATP binding

nucleoplasm

mitochondrion

mitochondrion

cytosol

translation

tRNA aminoacylation for protein translation

asparaginyl-tRNA aminoacylation

ligase activity

00970

TC0200005350.mm.2         NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

molecular_function

cellular_component

nucleus

regulation of transcription by RNA polymerase II

biological_process

 
TC1100004056.mm.2         XR_106365      
TC1200001908.mm.2 Dhrs7 dehydrogenase/reductase (SDR family) member 7 12 -72650352 NM_025522, BC016189 NM_025522, BC016189 18

biological_process

oxidoreductase activity

 
TC0800000371.mm.2 Fut10 fucosyltransferase 10 8 31187330, 31187330 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 17

Golgi membrane

nucleoplasm

endoplasmic reticulum

Golgi apparatus

protein glycosylation

fucosyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

cerebral cortex radially oriented cell migration

fucosylation

alpha-(1->3)-fucosyltransferase activity

alpha-(1->3)-fucosyltransferase activity

neuronal stem cell population maintenance

 
TC1100003941.mm.2 Kpna2 karyopherin (importin) alpha 2 11 -106988628 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 97

protein binding

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

cytosol

cytosol

protein import into nucleus

NLS-bearing protein import into nucleus

NLS-bearing protein import into nucleus

nuclear localization sequence binding

nuclear localization sequence binding

cytoplasmic stress granule

histone deacetylase binding

nuclear import signal receptor activity

nuclear import signal receptor activity

repressing transcription factor binding

entry of viral genome into host nucleus through nuclear pore complex via importin

entry of viral genome into host nucleus through nuclear pore complex via importin

extrinsic component of postsynaptic specialization membrane

glutamatergic synapse

postsynapse to nucleus signaling pathway

positive regulation of viral life cycle

positive regulation of viral life cycle

 
TC0800000912.mm.2 Rnf150 ring finger protein 150 8 82863355 NM_177378, BC160221 NM_177378, BC160221 10

cytoplasm

ubiquitin-dependent protein catabolic process

membrane

integral component of membrane

metal ion binding

ubiquitin protein ligase activity

 
TC1200001861.mm.2 Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 12 -69201778 NM_011133, BC063772 NM_011133, BC063772 23

DNA binding

DNA-directed DNA polymerase activity

nucleus

nucleoplasm

DNA replication

DNA-dependent DNA replication

epsilon DNA polymerase complex

epsilon DNA polymerase complex

nuclear body

error-prone translesion synthesis

intracellular membrane-bounded organelle

00230

00240

01100

03030

03410

03420

TC0400000567.mm.2 Smc2 structural maintenance of chromosomes 2 4 52439220 NM_008017, BC094380 NM_008017, BC094380 37

single strand break repair

nucleotide binding

nuclear chromosome

condensed chromosome

condensed chromosome

condensin complex

condensin complex

condensin complex

condensin complex

chromatin binding

single-stranded DNA binding

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

nucleolus

cytoplasm

cell cycle

mitotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

meiotic chromosome segregation

chromosome organization

cell division

kinetochore organization

 
TC0500003418.mm.2 Cux1 cut-like homeobox 1 5 -136248134, -136266409, -136266409, -136248134 NM_009986, NM_198602, BC090847 NM_009986, NM_198602, BC090847 NM_009986, NM_198602, BC090847 445

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

kidney development

DNA binding

chromatin binding

nucleus

nucleus

cytoplasm

Golgi apparatus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

intra-Golgi vesicle-mediated transport

multicellular organism development

membrane

integral component of membrane

integral component of Golgi membrane

lung development

inner ear auditory receptor cell differentiation

neuron projection

sequence-specific DNA binding

positive regulation of dendrite morphogenesis

 
TC0500002059.mm.2 Pus7 pseudouridylate synthase 7 5 -23740164, -23740164 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 18

pseudouridine synthesis

RNA binding

nucleus

nucleus

tRNA processing

RNA modification

pseudouridine synthase activity

pseudouridine synthase activity

isomerase activity

negative regulation of translation

enzyme binding

tRNA pseudouridine synthesis

regulation of hematopoietic stem cell differentiation

mRNA pseudouridine synthesis

regulation of mesoderm development

 
TC0700004188.mm.2 Thumpd1 THUMP domain containing 1 7 -119715093 NM_145585, BC004776 NM_145585, BC004776 21

RNA binding

cellular_component

tRNA modification

 
TC1000001601.mm.2         NM_172790, NR_105879, BC117907, BC117908 NM_172790, NR_105879, BC117907, BC117908 NM_172790, NR_105879, BC117907, BC117908 NM_172790, NR_105879, BC117907, BC117908  

molecular_function

cellular_component

biological_process

 
TC1800001368.mm.2 Marchf3 membrane associated ring-CH-type finger 3 18 -56761715, -56775146 NM_177115, BC107232, BC107233 NM_177115, BC107232, BC107233 NM_177115, BC107232, BC107233 15

ubiquitin-protein transferase activity

lysosome

endosome

endocytosis

zinc ion binding

membrane

integral component of membrane

protein ubiquitination

transferase activity

cytoplasmic vesicle

intracellular membrane-bounded organelle

metal ion binding

 
TC0300003226.mm.2 Gm5150 predicted gene 5150 3 -15948069 NM_001081687, BC156687 NM_001081687, BC156687 3

molecular_function

plasma membrane

positive regulation of phagocytosis

positive regulation of T cell activation

 
TC0700001442.mm.2 Anapc15 anaphase promoting complex C subunit 15 7 101881324, 101896330, 101885859 NM_027532, BC006736, BC080730 NM_027532, BC006736, BC080730 NM_027532, BC006736, BC080730 20

molecular_function

anaphase-promoting complex

cell cycle

cell division

regulation of mitotic cell cycle spindle assembly checkpoint

 
TC1500001300.mm.2 Otulinl OTU deubiquitinase with linear linkage specificity like 15 -27655070 NM_001242423, NM_001242424, NM_198301, BC052328 NM_001242423, NM_001242424, NM_198301, BC052328 NM_001242423, NM_001242424, NM_198301, BC052328 NM_001242423, NM_001242424, NM_198301, BC052328 15

molecular_function

nucleus

nuclear envelope

cytoplasm

endoplasmic reticulum

biological_process

membrane

extrinsic component of endoplasmic reticulum membrane

 
TC1600000464.mm.2 Osbpl11 oxysterol binding protein-like 11 16 33185070 NM_176840, BC035278 NM_176840, BC035278 25

nucleoplasm

endosome

Golgi apparatus

cytosol

lipid transport

lipid binding

positive regulation of sequestering of triglyceride

sterol transporter activity

membrane

sterol binding

intracellular membrane-bounded organelle

fat cell differentiation

 
TC1700002286.mm.2 Sgo1 shugoshin 1 17 -53674786 NM_028232, BC089014 NM_028232, BC089014 41

mitotic sister chromatid segregation

chromosome, centromeric region

chromosome, centromeric region

kinetochore

kinetochore

kinetochore

condensed chromosome, centromeric region

condensed chromosome, centromeric region

spindle pole

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

cytosol

cytoskeleton

cell cycle

chromosome segregation

attachment of spindle microtubules to kinetochore

centriole-centriole cohesion

centriole-centriole cohesion

kinase binding

meiotic chromosome segregation

homologous chromosome segregation

meiotic sister chromatid cohesion

cell division

mitotic sister chromatid cohesion, centromeric

04114

TC0200004665.mm.2 Rassf2 Ras association (RalGDS/AF-6) domain family member 2 2 -131992849, -131992849 NM_175445, BC057402 NM_175445, BC057402 22

chromosome, centromeric region

kinetochore

skeletal system development

ossification

protein kinase activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

cytosol

plasma membrane

cell cycle

signal transduction

positive regulation of protein autophosphorylation

protein-containing complex

negative regulation of peptidyl-serine phosphorylation

epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade

regulation of apoptotic process

positive regulation of apoptotic process

regulation of osteoblast differentiation

regulation of osteoclast differentiation

positive regulation of protein kinase activity

positive regulation of protein kinase activity

positive regulation of JNK cascade

positive regulation of JNK cascade

bone remodeling

homeostasis of number of cells

protein stabilization

regulation of NIK/NF-kappaB signaling

regulation of NIK/NF-kappaB signaling

negative regulation of NIK/NF-kappaB signaling

 
TC0100000399.mm.2 Mars2 methionine-tRNA synthetase 2 (mitochondrial) 1 55237176 NM_175439, BC099669, BC132343, BC137739 NM_175439, BC099669, BC132343, BC137739 NM_175439, BC099669, BC132343, BC137739 NM_175439, BC099669, BC132343, BC137739 20

nucleotide binding

aminoacyl-tRNA ligase activity

methionine-tRNA ligase activity

methionine-tRNA ligase activity

ATP binding

mitochondrion

mitochondrial matrix

translation

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

methionyl-tRNA aminoacylation

ligase activity

00450

00970

TC0400000501.mm.2 Ncbp1 nuclear cap binding protein subunit 1 4 46138510 NM_001033201, BC138898 NM_001033201, BC138898 29

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

spliceosomal complex assembly

RNA cap binding

RNA 7-methylguanosine cap binding

RNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

mRNA cap binding complex

mRNA cap binding complex

nuclear cap binding complex

nuclear cap binding complex

7-methylguanosine mRNA capping

mRNA processing

RNA catabolic process

mRNA export from nucleus

mRNA export from nucleus

regulation of translation

regulation of translational initiation

RNA splicing

RNA metabolic process

positive regulation of cell growth

gene silencing by RNA

positive regulation of mRNA 3'-end processing

RNA cap binding complex

mRNA cis splicing, via spliceosome

positive regulation of mRNA splicing, via spliceosome

regulation of mRNA processing

mRNA transport

pre-mRNA cleavage required for polyadenylation

positive regulation of RNA binding

ribonucleoprotein complex

03013

03015

03040

TC0500001853.mm.2 B3glct beta-3-glucosyltransferase 5 149678229 NM_001081204 19

cellular_component

endoplasmic reticulum

carbohydrate metabolic process

fucose metabolic process

biological_process

acetylglucosaminyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

00514

TC0900001005.mm.2 Fam214a family with sequence similarity 214, member A 9 74952879, 74976110, 74953052 NM_001113283, NM_153584, BC031353 NM_001113283, NM_153584, BC031353 NM_001113283, NM_153584, BC031353 15

molecular_function

cellular_component

biological_process

 
TC0100000471.mm.2 Abi2 abl interactor 2 1 60409618 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 33

cytoplasm

cytosol

cytoskeleton

actin filament

adherens junction

adherens junction

nervous system development

learning or memory

actin polymerization or depolymerization

positive regulation of lamellipodium assembly

dendrite development

cell migration

Rac protein signal transduction

SH3 domain binding

SH3 domain binding

peptidyl-tyrosine phosphorylation

lamellipodium

lamellipodium

cell junction

dendrite

SCAR complex

small GTPase binding

ubiquitin protein ligase binding

filopodium tip

signaling adaptor activity

identical protein binding

cell projection

camera-type eye development

dendritic spine

zonula adherens assembly

synapse

regulation of dendritic spine morphogenesis

proline-rich region binding

lens fiber cell morphogenesis

postsynaptic actin cytoskeleton

postsynaptic actin cytoskeleton

postsynaptic actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

glutamatergic synapse

glutamatergic synapse

positive regulation of Arp2/3 complex-mediated actin nucleation

04810

MG-1-neg-10338901_st                
TC1000000566.mm.2 Lrrc20 leucine rich repeat containing 20 10 61475832 NM_153542, BC036304 NM_153542, BC036304 15

molecular_function

cellular_component

biological_process

 
TC0200002668.mm.2 Cass4 Cas scaffolding protein family member 4 2 172393643 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 NM_001080820, NM_001276422, NM_001276423, BC117858, BC117859, BC129975, BC129976, NM_001033538 13

cytoplasm

cytoplasm

cytoskeleton

plasma membrane

focal adhesion

cell adhesion

transmembrane receptor protein tyrosine kinase signaling pathway

cell migration

cell junction

positive regulation of cell migration

positive regulation of protein kinase B signaling

positive regulation of protein tyrosine kinase activity

actin filament reorganization

positive regulation of substrate adhesion-dependent cell spreading

protein tyrosine kinase binding

 
TC1400001931.mm.2 Wdhd1 WD repeat and HMG-box DNA binding protein 1 14 -47240943 NM_172598, BC063740 NM_172598, BC063740 22

mitotic cell cycle

chromosome, centromeric region

DNA binding

chromatin binding

chromatin binding

RNA binding

protein binding

nucleus

nucleoplasm

DNA-dependent DNA replication

DNA repair

RNA processing

regulation of chromosome organization

nuclear replication fork

RNA polymerase binding

heterochromatin maintenance

 
TC1400000347.mm.2 Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 14 32513520 NM_001081221, BC167234 NM_001081221, BC167234 84

single strand break repair

DNA damage checkpoint

nucleotide binding

response to superoxide

positive regulation of defense response to virus by host

DNA binding

chromatin binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

nucleolus

DNA repair

DNA repair

DNA repair

transcription-coupled nucleotide-excision repair

transcription-coupled nucleotide-excision repair

transcription-coupled nucleotide-excision repair

base-excision repair

pyrimidine dimer repair

transcription elongation from RNA polymerase I promoter

cellular response to DNA damage stimulus

response to oxidative stress

response to oxidative stress

activation of JNKK activity

activation of JUN kinase activity

nervous system development

protein C-terminus binding

transcription elongation factor complex

DNA-dependent ATPase activity

DNA-dependent ATPase activity

intrinsic apoptotic signaling pathway in response to DNA damage

response to UV

response to UV

response to toxic substance

response to X-ray

response to UV-B

response to gamma radiation

positive regulation of gene expression

nuclear body

hydrolase activity

neurogenesis

neuron differentiation

protein tyrosine kinase activator activity

neuron projection development

regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of peptidyl-serine phosphorylation of STAT protein

multicellular organism growth

ATP-dependent chromatin remodeling

sequence-specific DNA binding

protein-containing complex binding

photoreceptor cell maintenance

positive regulation of DNA repair

protein N-terminus binding

positive regulation of transcription initiation from RNA polymerase II promoter

positive regulation of transcription initiation from RNA polymerase II promoter

RNA polymerase binding

site of DNA damage

double-strand break repair via classical nonhomologous end joining

positive regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via nonhomologous end joining

03420

TC1000000312.mm.2 Hdac2 histone deacetylase 2 10 36974543 NM_008229, BC138517 NM_008229, BC138517 299

histone deacetylase complex

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

chromatin

heterochromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II repressing transcription factor binding

RNA polymerase II transcription corepressor binding

chromatin binding

histone deacetylase activity

histone deacetylase activity

histone deacetylase activity

histone deacetylase activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

transcription regulator complex

cytoplasm

cytoplasm

chromatin organization

protein deacetylation

transcription factor binding

transcription factor binding

positive regulation of cell population proliferation

positive regulation of cell population proliferation

epidermal cell differentiation

positive regulation of epithelial to mesenchymal transition

negative regulation of neuron projection development

negative regulation of neuron projection development

dendrite development

histone deacetylation

histone deacetylation

Sin3 complex

NuRD complex

hydrolase activity

transcription repressor complex

deacetylase activity

deacetylase activity

enzyme binding

enzyme binding

hippocampus development

neuron differentiation

heat shock protein binding

chromatin DNA binding

NAD-dependent histone deacetylase activity (H3-K14 specific)

positive regulation of interleukin-1 production

positive regulation of tumor necrosis factor production

circadian regulation of gene expression

protein-containing complex

protein deacetylase activity

protein deacetylase activity

histone deacetylase activity (H4-K16 specific)

ESC/E(Z) complex

Krueppel-associated box domain binding

cellular response to trichostatin A

odontogenesis of dentin-containing tooth

positive regulation of tyrosine phosphorylation of STAT protein

embryonic digit morphogenesis

histone deacetylase binding

negative regulation of apoptotic process

negative regulation of DNA binding

negative regulation of DNA-binding transcription factor activity

sequence-specific DNA binding

positive regulation of proteolysis

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

rhythmic process

positive regulation of oligodendrocyte differentiation

positive regulation of oligodendrocyte differentiation

NF-kappaB binding

positive regulation of DNA-binding transcription factor activity

regulation of protein kinase B signaling

cardiac muscle cell development

negative regulation of cardiac muscle cell proliferation

regulation of sarcomere organization

hair follicle placode formation

negative regulation of dendritic spine development

eyelid development in camera-type eye

fungiform papilla formation

cellular response to hydrogen peroxide

histone H3-K27 methylation

heterochromatin maintenance

histone H3 deacetylation

histone H3 deacetylation

histone H3 deacetylation

histone H4 deacetylation

histone H4 deacetylation

negative regulation of canonical Wnt signaling pathway

regulation of protein deacetylation

RNA polymerase II transcription repressor complex

positive regulation of male mating behavior

negative regulation of pri-miRNA transcription by RNA polymerase II

negative regulation of pri-miRNA transcription by RNA polymerase II

promoter-specific chromatin binding

positive regulation of signaling receptor activity

negative regulation of peptidyl-lysine acetylation

negative regulation of intrinsic apoptotic signaling pathway

04110

04330

05016

05200

05220

TC1300000626.mm.2 Simc1 SUMO-interacting motifs containing 1 13 54503804 NM_176987, BC167252 NM_176987, BC167252 12

cytoplasm

biological_process

sarcomere

peptidase inhibitor activity

SUMO polymer binding

SUMO polymer binding

 
TC0700003075.mm.2 E2f8 E2F transcription factor 8 7 -48866428, -48866428 NM_001013368, BC086675, E2F NM_001013368, BC086675, E2F NM_001013368, BC086675, E2F 43

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity

DNA-binding transcription repressor activity, RNA polymerase II-specific

placenta development

sprouting angiogenesis

sprouting angiogenesis

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

nucleus

nucleoplasm

transcription regulator complex

nucleolus

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cell cycle

cell population proliferation

negative regulation of cytokinesis

positive regulation of DNA endoreduplication

cell cycle comprising mitosis without cytokinesis

identical protein binding

positive regulation of transcription by RNA polymerase II

trophoblast giant cell differentiation

chorionic trophoblast cell differentiation

hepatocyte differentiation

RNA polymerase II transcription regulator complex

sequence-specific double-stranded DNA binding

 
TC1100000021.mm.2 Morc2a microrchidia 2A 11 3649436, 3658671 NM_001159288, NM_198162, BC059243 NM_001159288, NM_198162, BC059243 NM_001159288, NM_198162, BC059243 25

nucleotide binding

magnesium ion binding

heterochromatin

chromatin binding

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

chromatin remodeling

cellular response to DNA damage stimulus

zinc ion binding

nuclear matrix

hydrolase activity

ATPase activity

histone binding

protein homodimerization activity

negative regulation of gene expression, epigenetic

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

metal ion binding

positive regulation of DNA methylation-dependent heterochromatin assembly

positive regulation of DNA methylation-dependent heterochromatin assembly

 
TC1200000348.mm.2 Etv1 ets variant 1 12 38783710, 38780081 NM_001163154, NM_007960, BC005645 NM_001163154, NM_007960, BC005645 NM_001163154, NM_007960, BC005645 289

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

axon guidance

muscle organ development

mechanosensory behavior

cell differentiation

sequence-specific DNA binding

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

peripheral nervous system neuron development

sequence-specific double-stranded DNA binding

 
TC0700001906.mm.2 Tacc2 transforming, acidic coiled-coil containing protein 2 7 130577437, 130692617 NM_001004468, NM_021314, NM_206856 NM_001004468, NM_021314, NM_206856 NM_001004468, NM_021314, NM_206856 33

microtubule cytoskeleton organization

microtubule cytoskeleton organization

nucleus

nucleoplasm

cytoplasm

cytosol

cytoskeleton

plasma membrane

mitotic spindle organization

cell population proliferation

cell population proliferation

protein domain specific binding

cerebral cortex development

cerebral cortex development

neurogenesis

interkinetic nuclear migration

astral microtubule organization

regulation of microtubule-based process

nuclear hormone receptor binding

 
TC1000000191.mm.2 Slc18b1 solute carrier family 18, subfamily B, member 1 10 23796985 NM_183116 17

membrane

integral component of membrane

transmembrane transporter activity

 
TC0100002963.mm.2 Tmem37 transmembrane protein 37 1 -120067376 NM_019432, BC024613 NM_019432, BC024613 20

voltage-gated ion channel activity

calcium channel activity

ion transport

calcium ion transport

membrane

integral component of membrane

regulation of ion transmembrane transport

calcium ion transmembrane transport

 
TC0900003168.mm.2 Crtap cartilage associated protein 9 -114375130 NM_019922, BC049890 NM_019922, BC049890 28

collagen binding

extracellular region

extracellular space

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

spermatogenesis

peptidyl-proline hydroxylation to 3-hydroxy-L-proline

peptidyl-proline hydroxylation to 3-hydroxy-L-proline

collagen fibril organization

protein stabilization

negative regulation of post-translational protein modification

 
TC0600000127.mm.2 Cav2 caveolin 2 6 17281184, 17281184 NM_001277756, NM_016900, BC023095 NM_001277756, NM_016900, BC023095 NM_001277756, NM_016900, BC023095 68

SNARE binding

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

acrosomal membrane

caveolar macromolecular signaling complex

protein binding

nucleus

nuclear envelope

nuclear inner membrane

cytoplasm

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

lipid droplet

cytosol

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

caveola

caveola

caveola

focal adhesion

focal adhesion

focal adhesion

endocytosis

vesicle fusion

vesicle fusion

mitochondrion organization

endoplasmic reticulum organization

chemical synaptic transmission

negative regulation of cell population proliferation

insulin receptor signaling pathway

insulin receptor signaling pathway

cell surface

membrane

membrane

vesicle organization

receptor-mediated endocytosis of virus by host cell

protein kinase binding

protein kinase binding

protein kinase binding

syntaxin binding

transport vesicle

cell differentiation

negative regulation of transforming growth factor beta receptor signaling pathway

protein-macromolecule adaptor activity

extrinsic component of cytoplasmic side of plasma membrane

extrinsic component of cytoplasmic side of plasma membrane

cytoplasmic vesicle

cytoplasmic vesicle

mitogen-activated protein kinase kinase kinase binding

D1 dopamine receptor binding

D1 dopamine receptor binding

protein-containing complex

protein-containing complex

sarcolemma

protein homodimerization activity

positive regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of GTPase activity

positive regulation by host of viral release from host cell

positive regulation by host of viral process

membrane raft

protein heterodimerization activity

vesicle docking

vesicle docking

perinuclear region of cytoplasm

perinuclear region of cytoplasm

perinuclear region of cytoplasm

skeletal muscle fiber development

positive regulation of peptidyl-tyrosine phosphorylation

phosphoprotein binding

regulation of cytosolic calcium ion concentration

molecular adaptor activity

molecular adaptor activity

positive regulation of dopamine receptor signaling pathway

positive regulation of dopamine receptor signaling pathway

caveola assembly

caveola assembly

caveola assembly

basement membrane organization

scaffold protein binding

positive regulation of protein localization to nucleus

04144

04510

05100

TC0X00001674.mm.2 Fancb Fanconi anemia, complementation group B X 164980591 NM_001146081, NM_175027, BC083151 NM_001146081, NM_175027, BC083151 NM_001146081, NM_175027, BC083151 17

molecular_function

nucleus

DNA repair

cellular response to DNA damage stimulus

cellular response to drug

cellular response to drug

interstrand cross-link repair

Fanconi anaemia nuclear complex

Fanconi anaemia nuclear complex

cellular response to camptothecin

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair via homologous recombination

replication-born double-strand break repair via sister chromatid exchange

replication-born double-strand break repair via sister chromatid exchange

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

 
TC1600000440.mm.2 Tm4sf19 transmembrane 4 L six family member 19 16 32400505 NM_001160402, BC147727, BC147729 NM_001160402, BC147727, BC147729 NM_001160402, BC147727, BC147729 4

molecular_function

biological_process

integral component of membrane

 
TC0600001027.mm.2 Rpn1 ribophorin I 6 88084472 NM_133933, BC016080 NM_133933, BC016080 35

dolichyl-diphosphooligosaccharide-protein glycotransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

rough endoplasmic reticulum

rough endoplasmic reticulum

cytosol

protein glycosylation

protein N-linked glycosylation

oligosaccharyltransferase complex

oligosaccharyltransferase complex

membrane

integral component of membrane

protein N-linked glycosylation via asparagine

protein N-linked glycosylation via asparagine

00510

01100

04141

TC1400002387.mm.2                
TC0900002367.mm.2 1700017B05Rik RIKEN cDNA 1700017B05 gene 9 -57252321 NM_028820, BC118527, BC150963, BC150965 NM_028820, BC118527, BC150963, BC150965 NM_028820, BC118527, BC150963, BC150965 NM_028820, BC118527, BC150963, BC150965 16

molecular_function

cytosol

biological_process

 
TC0300001478.mm.2 Znhit6 zinc finger, HIT type 6 3 145576215, 145576207 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 13

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

box C/D snoRNP assembly

box C/D snoRNP assembly

TFIID-class transcription factor complex binding

nucleus

enzyme binding

ribosome biogenesis

identical protein binding

metal ion binding

snoRNA localization

snoRNA localization

ATPase binding

protein complex oligomerization

pre-snoRNP complex

pre-snoRNP complex

 
TC0900002047.mm.2 Ccdc15 coiled-coil domain containing 15 9 -37267463 NM_001081429 12

molecular_function

centrosome

centrosome

biological_process

 
TC1200002092.mm.2 Acyp1 acylphosphatase 1, erythrocyte (common) type 12 -85272397, -85278893, -85272397 NM_025421, BC061088, BC116781, BC116783 NM_025421, BC061088, BC116781, BC116783 NM_025421, BC061088, BC116781, BC116783 NM_025421, BC061088, BC116781, BC116783 13

acylphosphatase activity

biological_process

hydrolase activity

00620

MG-1-neg-10341270_st                
TC0900002489.mm.2 Zwilch zwilch kinetochore protein 9 -64137143 NM_026507, BC027435 NM_026507, BC027435 18

chromosome, centromeric region

kinetochore

molecular_function

chromosome

cell cycle

mitotic cell cycle checkpoint

protein localization to kinetochore

cell division

signal transduction involved in mitotic cell cycle checkpoint

RZZ complex

 
TC1300002766.mm.2 Nsun2 NOL1/NOP2/Sun domain family member 2 13 69612015 NM_145354, BC013625 NM_145354, BC013625 49

tRNA binding

RNA methylation

in utero embryonic development

RNA binding

extracellular region

nucleus

nucleolus

cytoplasm

cytoplasm

mitochondrion

cytoskeleton

cell cycle

spermatogenesis

spermatid development

tRNA processing

methyltransferase activity

regulation of mRNA export from nucleus

tRNA (cytosine-5-)-methyltransferase activity

tRNA (cytosine-5-)-methyltransferase activity

tRNA (cytosine-5-)-methyltransferase activity

tRNA (cytosine-5-)-methyltransferase activity

transferase activity

cell differentiation

tRNA methylation

tRNA methylation

tRNA methylation

tRNA methylation

methylation

meiotic cell cycle checkpoint

chromatoid body

tRNA stabilization

hair follicle maturation

cell division

mRNA (cytidine-5-)-methyltransferase activity

mRNA (cytidine-5-)-methyltransferase activity

extracellular exosome

mRNA methylation

mRNA methylation

regulation of stem cell differentiation

 
TC0200001546.mm.2 Lmo2 LIM domain only 2 2 103969556, 103970286, 103957994 NM_001142335, NM_001142336, NM_001142337, NM_008505, BC057880 NM_001142335, NM_001142336, NM_001142337, NM_008505, BC057880 NM_001142335, NM_001142336, NM_001142337, NM_008505, BC057880 NM_001142335, NM_001142336, NM_001142337, NM_008505, BC057880 NM_001142335, NM_001142336, NM_001142337, NM_008505, BC057880 110

RNA polymerase II activating transcription factor binding

transcription coregulator binding

DNA binding

chromatin binding

transcription coactivator activity

protein binding

nucleus

transcription regulator complex

transcription factor binding

protein-containing complex

embryonic hemopoiesis

identical protein binding

bHLH transcription factor binding

negative regulation of erythrocyte differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

cellular response to thyroid hormone stimulus

 
MG-1-pos-10338865_st                
TC1500001653.mm.2 Tmem71 transmembrane protein 71 15 -66526211 NM_172514, BC117823, BC117824 NM_172514, BC117823, BC117824 NM_172514, BC117823, BC117824 13

molecular_function

mitochondrion

biological_process

membrane

integral component of membrane

 
TC1900001619.mm.2 Pcgf6 polycomb group ring finger 6 19 -47033616 NM_027654, BC016195, BC089460 NM_027654, BC016195, BC089460 NM_027654, BC016195, BC089460 35

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

protein binding

nucleus

nucleus

regulation of transcription by RNA polymerase II

protein domain specific binding

PcG protein complex

PcG protein complex

PRC1 complex

PRC1 complex

histone H2A-K119 monoubiquitination

histone H2A-K119 monoubiquitination

negative regulation of transcription, DNA-templated

metal ion binding

 
TC1400002260.mm.2 Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 14 -65819026 NM_028039, BC033303, BC071275 NM_028039, BC033303, BC071275 NM_028039, BC033303, BC071275 35

chromatin

XY body

hematopoietic progenitor cell differentiation

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

nucleus

nucleoplasm

chromosome

pericentric heterochromatin

Golgi apparatus

regulation of DNA replication

regulation of DNA replication

double-strand break repair

cell cycle

chromosome segregation

sister chromatid cohesion

chromocenter

acetyltransferase activity

transferase activity

transferase activity, transferring acyl groups

cell junction

post-translational protein acetylation

post-translational protein acetylation

site of double-strand break

metal ion binding

protein localization to chromatin

 
TC1400000862.mm.2 Arl11 ADP-ribosylation factor-like 11 14 61309752 NM_177337, BC064093 NM_177337, BC064093 13

nucleotide binding

hematopoietic progenitor cell differentiation

GTP binding

cytoplasm

plasma membrane

intracellular protein transport

vesicle-mediated transport

 
TC1100002740.mm.2 Rad50 RAD50 double strand break repair protein 11 -53649518 NM_009012, BC168398 NM_009012, BC168398 68

single-stranded DNA endodeoxyribonuclease activity

regulation of mitotic recombination

nucleotide binding

telomere maintenance via recombination

telomere maintenance

chromosome, telomeric region

chromatin

condensed nuclear chromosome

condensed nuclear chromosome

DNA binding

DNA helicase activity

double-stranded DNA binding

double-stranded telomeric DNA binding

ATP binding

nucleus

nucleoplasm

chromosome

DNA repair

double-strand break repair

double-strand break repair

DNA recombination

cellular response to DNA damage stimulus

telomere maintenance via telomerase

telomere maintenance via telomerase

cell cycle

regulation of mitotic cell cycle

3'-5' exonuclease activity

inclusion body

hydrolase activity

ATPase activity

protein-macromolecule adaptor activity

Mre11 complex

Mre11 complex

telomeric 3' overhang formation

positive regulation of protein autophosphorylation

positive regulation of telomere maintenance

DNA duplex unwinding

DNA duplex unwinding

positive regulation of kinase activity

site of double-strand break

identical protein binding

single-stranded telomeric DNA binding

protein-containing complex binding

pronucleus

negative regulation of viral entry into host cell

metal ion binding

perinuclear region of cytoplasm

chromosome organization

meiotic cell cycle

G-quadruplex DNA binding

chromosome organization involved in meiotic cell cycle

chromosome organization involved in meiotic cell cycle

nucleic acid phosphodiester bond hydrolysis

negative regulation of telomere capping

03440

03450

TC0100001853.mm.2 Ints7 integrator complex subunit 7 1 191575635 NM_178632, BC054120 NM_178632, BC054120 25

DNA damage checkpoint

molecular_function

nucleus

chromosome

cytoplasm

cellular response to DNA damage stimulus

snRNA processing

nuclear body

integrator complex

integrator complex

snRNA 3'-end processing

cellular response to ionizing radiation

 
TC0700003608.mm.2 Cpeb1 cytoplasmic polyadenylation element binding protein 1 7 -81347025, -81347025 NM_001252525, NM_001252526, NM_007755, BC125476 NM_001252525, NM_001252526, NM_007755, BC125476 NM_001252525, NM_001252526, NM_007755, BC125476 NM_001252525, NM_001252526, NM_007755, BC125476 64

translation repressor activity, mRNA regulatory element binding

translation repressor activity, mRNA regulatory element binding

nucleic acid binding

RNA binding

mRNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

centrosome

cytosol

mRNA processing

regulation of translation

synaptonemal complex assembly

translation factor activity, RNA binding

negative regulation of cell population proliferation

positive regulation of neuron projection development

postsynaptic density

membrane

negative regulation of translation

cell junction

positive regulation of cell migration

growth cone

cellular response to insulin stimulus

mRNA 3'-UTR AU-rich region binding

neuron projection

ribosome binding

neuronal cell body

translation regulator activity

synapse

positive regulation of translation

metal ion binding

regulation of neuronal synaptic plasticity

perinuclear region of cytoplasm

mRNA transport

positive regulation of nitric-oxide synthase biosynthetic process

cellular response to amino acid stimulus

cellular response to hypoxia

cellular response to hypoxia

meiotic spindle

positive regulation of mRNA polyadenylation

messenger ribonucleoprotein complex

negative regulation of cytoplasmic translation

negative regulation of cytoplasmic translation

negative regulation of cytoplasmic translation

04114

04320

04914

TC0500000050.mm.2 Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A 5 8567090 NM_011076 275

G2/M transition of mitotic cell cycle

nucleotide binding

ATP binding

nucleoplasm

plasma membrane

plasma membrane

plasma membrane

ABC-type xenobiotic transporter activity

ABC-type xenobiotic transporter activity

hormone transport

cell surface

efflux transmembrane transporter activity

efflux transmembrane transporter activity

membrane

integral component of membrane

apical plasma membrane

apical plasma membrane

ATPase activity

ATPase activity

transmembrane transporter activity

brush border membrane

ubiquitin protein ligase binding

carbohydrate export

maintenance of blood-brain barrier

ATPase-coupled transmembrane transporter activity

xenobiotic transmembrane transporter activity

xenobiotic transmembrane transporter activity

xenobiotic transmembrane transporter activity

daunorubicin transport

apical part of cell

phospholipid translocation

phospholipid translocation

phospholipid translocation

intercellular canaliculus

terpenoid transport

carboxylic acid transmembrane transporter activity

regulation of response to osmotic stress

intestinal absorption

transmembrane transport

negative regulation of cell death

establishment of blood-brain barrier

transepithelial transport

stem cell proliferation

phosphatidylcholine floppase activity

phosphatidylcholine floppase activity

phosphatidylcholine floppase activity

phosphatidylethanolamine flippase activity

phosphatidylethanolamine flippase activity

phosphatidylethanolamine flippase activity

ceramide floppase activity

ceramide floppase activity

ceramide floppase activity

ceramide translocation

ceramide translocation

ceramide translocation

export across plasma membrane

export across plasma membrane

floppase activity

floppase activity

positive regulation of anion channel activity

protein localization to bicellular tight junction

positive regulation of establishment of Sertoli cell barrier

regulation of intestinal absorption

carboxylic acid transmembrane transport

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

establishment of blood-retinal barrier

positive regulation of response to drug

regulation of chloride transport

02010

04976

TC0200002043.mm.2 Mcm8 minichromosome maintenance 8 homologous recombination repair factor 2 132816140 NM_025676, BC046780, BC052070 NM_025676, BC046780, BC052070 NM_025676, BC046780, BC052070 19

nucleotide binding

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

DNA binding

chromatin binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

cytosol

DNA replication

DNA replication initiation

DNA repair

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

cell cycle

female gamete generation

hydrolase activity

enzyme binding

MutLbeta complex binding

MutSalpha complex binding

MutSbeta complex binding

recombinational interstrand cross-link repair

MCM complex

male gamete generation

protein stabilization

protein localization to chromatin

MCM8-MCM9 complex

MCM8-MCM9 complex

 
TC0300002580.mm.2 Wdr3 WD repeat domain 3 3 -100138179 NM_175552, BC063100 NM_175552, BC063100 20

nucleus

nucleoplasm

nucleolus

maturation of SSU-rRNA

snoRNA binding

nuclear membrane

small-subunit processome

Pwp2p-containing subcomplex of 90S preribosome

03008

TC1300001374.mm.2 Net1 neuroepithelial cell transforming gene 1 13 -3882017, -3882017 NM_001047159, NM_019671, BC004699 NM_001047159, NM_019671, BC004699 NM_001047159, NM_019671, BC004699 33

guanyl-nucleotide exchange factor activity

protein binding

nucleus

cytoplasm

plasma membrane

small GTPase binding

regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

intracellular signal transduction

positive regulation of apoptotic process

positive regulation of GTPase activity

myoblast migration

cellular response to hydrogen peroxide

cellular response to ionizing radiation

positive regulation of substrate adhesion-dependent cell spreading

 
TC1300000781.mm.2 Cdk20 cyclin-dependent kinase 20 13 64432552 NM_053180, BC031907 NM_053180, BC031907 24

nucleotide binding

neural tube closure

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

cytoplasm

cilium

protein phosphorylation

cell cycle

multicellular organism development

kinase activity

phosphorylation

transferase activity

floor plate formation

embryonic camera-type eye development

cell projection

embryonic skeletal system development

cell division

roof of mouth development

positive regulation of cardiac muscle cell proliferation

protein localization to cilium

protein threonine kinase activity

regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of protein maturation

embryonic brain development

 
TC1700001357.mm.2 Tfb1m transcription factor B1, mitochondrial 17 -3519250 NM_146074, BC032930 NM_146074, BC032930 26

rRNA modification

rRNA (adenine-N6,N6-)-dimethyltransferase activity

rRNA (adenine-N6,N6-)-dimethyltransferase activity

DNA binding

RNA binding

mitochondrion

mitochondrial matrix

rRNA processing

transcription initiation from mitochondrial promoter

methyltransferase activity

rRNA methyltransferase activity

transferase activity

rRNA methylation

methylation

mitochondrial transcription factor activity

mitochondrial nucleoid

 
TC0100003877.mm.2 Poglut2 protein O-glucosyltransferase 2 1 -44106545 NM_023645, BC023141 NM_023645, BC023141 23

nucleoplasm

endoplasmic reticulum

endoplasmic reticulum lumen

cytosol

endomembrane system

transferase activity

transferase activity, transferring glycosyl groups

protein O-linked glycosylation via serine

UDP-glucosyltransferase activity

UDP-xylosyltransferase activity

glucosyltransferase activity

 
TC1200000255.mm.2 Tmem18 transmembrane protein 18 12 30584442 NM_172049, BC024093 NM_172049, BC024093 14

molecular_function

DNA binding

nucleus

cytoplasm

membrane

integral component of membrane

cell migration

 
TC0200002442.mm.2 Fam83d family with sequence similarity 83, member D 2 158768098 NM_027975, BC068129 NM_027975, BC068129 16

epithelial to mesenchymal transition

cytoplasm

spindle

cytosol

cytosol

cytoskeleton

cell cycle

signal transduction

microtubule binding

cell population proliferation

microtubule cytoskeleton

cell migration

kinesin binding

protein kinase binding

protein kinase binding

regulation of TOR signaling

regulation of TOR signaling

regulation of protein catabolic process

intercellular bridge

cell division

metaphase plate congression

regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade

mitotic spindle

mitotic spindle pole

mitotic spindle pole

protein localization to mitotic spindle

protein localization to mitotic spindle

positive regulation of cell cycle G1/S phase transition

positive regulation of cell cycle G1/S phase transition

 
TC1200000825.mm.2 Ylpm1 YLP motif containing 1 12 84996320 NM_178363 25

negative regulation of transcription by RNA polymerase II

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleus

nucleus

nucleus

nucleoplasm

cytosol

nuclear speck

regulation of telomere maintenance

regulation of telomere maintenance

 
TC0400004151.mm.2 Atad3a ATPase family, AAA domain containing 3A 4 -155740639 NM_179203, BC023301, BC058373, BC060036 NM_179203, BC023301, BC058373, BC060036 NM_179203, BC023301, BC058373, BC060036 NM_179203, BC023301, BC058373, BC060036 43

nucleotide binding

regulation of cell growth

protein binding

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrion organization

zinc ion binding

membrane

integral component of membrane

mitochondrial nucleoid

identical protein binding

negative regulation of apoptotic process

antiviral innate immune response

 
TC1400000501.mm.2 Cdkn3 cyclin-dependent kinase inhibitor 3 14 46760540 NM_028222, BC049694 NM_028222, BC049694 17

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

protein binding

cytoplasm

cytosol

cellular response to DNA damage stimulus

cell cycle

cell cycle arrest

cell cycle arrest

dephosphorylation

hydrolase activity

phosphatase activity

perinuclear region of cytoplasm

 
TC0300002906.mm.2 Larp7 La ribonucleoprotein domain family, member 7 3 -127536713 NM_138593, BC153029 NM_138593, BC153029 33

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

box C/D RNA 3'-end processing

box C/D RNA 3'-end processing

nucleic acid binding

RNA binding

nucleus

nucleus

nucleoplasm

cytosol

RNA processing

mRNA processing

spermatogenesis

RNA splicing

U6 snRNA binding

U6 snRNA binding

cell differentiation

negative regulation of viral transcription

negative regulation of chromatin binding

germ cell proliferation

regulation of mRNA splicing, via spliceosome

regulation of mRNA splicing, via spliceosome

7SK snRNA binding

7SK snRNP

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of protein localization to Cajal body

positive regulation of snRNA transcription by RNA polymerase II

U6 2'-O-snRNA methylation

U6 2'-O-snRNA methylation

ribonucleoprotein complex

 
TC0500001066.mm.2 Cdc7 cell division cycle 7 (S. cerevisiae) 5 106964321, 106964560 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 32

nucleotide binding

double-strand break repair via break-induced replication

protein kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

protein phosphorylation

cell cycle

positive regulation of cell population proliferation

positive regulation of nuclear cell cycle DNA replication

positive regulation of G2/M transition of mitotic cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

cell cycle phase transition

intercellular bridge

metal ion binding

cell division

mitotic spindle

04110

TC0300000807.mm.2 S100a4 S100 calcium binding protein A4 3 90603769 NM_011311, BC051214, BC094635, S100 NM_011311, BC051214, BC094635, S100 NM_011311, BC051214, BC094635, S100 NM_011311, BC051214, BC094635, S100 169

actin binding

calcium ion binding

calcium ion binding

calcium ion binding

protein binding

nucleus

nucleus

identical protein binding

identical protein binding

neuron projection

positive regulation of I-kappaB kinase/NF-kappaB signaling

positive regulation of I-kappaB kinase/NF-kappaB signaling

metal ion binding

transition metal ion binding

calcium-dependent protein binding

calcium-dependent protein binding

perinuclear region of cytoplasm

perinuclear region of cytoplasm

RAGE receptor binding

RAGE receptor binding

 
TC1700001805.mm.2 Glo1 glyoxalase 1 17 -30592861 NM_001113560, NM_025374, BC024663, BC081432 NM_001113560, NM_025374, BC024663, BC081432 NM_001113560, NM_025374, BC024663, BC081432 NM_001113560, NM_025374, BC024663, BC081432 99

lactoylglutathione lyase activity

lactoylglutathione lyase activity

nucleoplasm

cytosol

plasma membrane

carbohydrate metabolic process

regulation of transcription by RNA polymerase II

glutathione metabolic process

zinc ion binding

zinc ion binding

methylglyoxal metabolic process

lyase activity

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

osteoclast differentiation

negative regulation of apoptotic process

metal ion binding

00620

TC0500000852.mm.2 Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 5 90931195 NM_026788 17

histidine biosynthetic process

catalytic activity

methenyltetrahydrofolate cyclohydrolase activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

purine nucleotide biosynthetic process

one-carbon metabolic process

metabolic process

cellular amino acid biosynthetic process

methionine biosynthetic process

10-formyltetrahydrofolate metabolic process

membrane

oxidoreductase activity

hydrolase activity

tetrahydrofolate interconversion

tetrahydrofolate interconversion

00670

01100

TC0100001548.mm.2 Tmco1 transmembrane and coiled-coil domains 1 1 167308669 NM_001039483, BC011457, BC019761, BC020098 NM_001039483, BC011457, BC019761, BC020098 NM_001039483, BC011457, BC019761, BC020098 NM_001039483, BC011457, BC019761, BC020098 31

calcium channel activity

calcium channel activity

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

ion transport

calcium ion transport

cellular calcium ion homeostasis

ER overload response

membrane

integral component of membrane

integral component of endoplasmic reticulum membrane

endoplasmic reticulum calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

calcium ion transmembrane transport

calcium ion transmembrane transport

 
TC0200002579.mm.2 Ddx27 DEAD box helicase 27 2 167015312 NM_153065, BC011321 NM_153065, BC011321 30

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

nucleus

chromosome

nucleolus

nucleolus

rRNA processing

hydrolase activity

ribosome biogenesis

 
TC1900000763.mm.2 Pdcd4 programmed cell death 4 19 53903350, 53892230 NM_001168491, NM_001168492, NM_011050, BC055739 NM_001168491, NM_001168492, NM_011050, BC055739 NM_001168491, NM_001168492, NM_011050, BC055739 NM_001168491, NM_001168492, NM_011050, BC055739 88

RNA binding

protein binding

nucleus

nucleus

cytoplasm

cytosol

cytosol

apoptotic process

cell aging

BMP signaling pathway

positive regulation of smooth muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of transcription, DNA-templated

positive regulation of inflammatory response

regulation of protein metabolic process

epithelial to mesenchymal transition involved in cardiac fibroblast development

cellular response to lipopolysaccharide

negative regulation of cytokine production involved in inflammatory response

positive regulation of NIK/NF-kappaB signaling

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of myofibroblast differentiation

negative regulation of vascular associated smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of endothelial cell apoptotic process

 
TC1000000744.mm.2 Lss lanosterol synthase 10 76531604 NM_146006, BC029082 NM_146006, BC029082 36

lanosterol synthase activity

lanosterol synthase activity

endoplasmic reticulum

endoplasmic reticulum membrane

lipid droplet

lipid droplet

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

membrane

sterol metabolic process

isomerase activity

intramolecular transferase activity

regulation of protein stability

intracellular membrane-bounded organelle

00100

01100

TC0600002656.mm.2 Arhgap25 Rho GTPase activating protein 25 6 -87458544, -87458544 NM_001037727, NM_001286610, NM_175476, NR_104483, BC138751, BC138752 NM_001037727, NM_001286610, NM_175476, NR_104483, BC138751, BC138752 NM_001037727, NM_001286610, NM_175476, NR_104483, BC138751, BC138752 NM_001037727, NM_001286610, NM_175476, NR_104483, BC138751, BC138752 NM_001037727, NM_001286610, NM_175476, NR_104483, BC138751, BC138752 NM_001037727, NM_001286610, NM_175476, NR_104483, BC138751, BC138752 21

phagocytic cup

phagocytic cup

GTPase activator activity

phagocytosis, engulfment

phagocytosis, engulfment

actin filament organization

actin filament organization

signal transduction

negative regulation of small GTPase mediated signal transduction

negative regulation of small GTPase mediated signal transduction

activation of GTPase activity

 
TC1700002771.mm.2 Nme3 NME/NM23 nucleoside diphosphate kinase 3 17 24896499 NM_019730, BC028503, NME/NM23 NM_019730, BC028503, NME/NM23 NM_019730, BC028503, NME/NM23 24

nucleotide binding

nucleoside diphosphate kinase activity

ATP binding

mitochondrion

GTP biosynthetic process

UTP biosynthetic process

CTP biosynthetic process

nucleotide metabolic process

kinase activity

phosphorylation

transferase activity

metal ion binding

00230

00240

01100

TC1900001510.mm.2 Arhgap19 Rho GTPase activating protein 19 19 -41766587 NM_001163495, NM_027667, BC086680, BC139195 NM_001163495, NM_027667, BC086680, BC139195 NM_001163495, NM_027667, BC086680, BC139195 NM_001163495, NM_027667, BC086680, BC139195 22

GTPase activator activity

cytoplasm

plasma membrane

signal transduction

intracellular membrane-bounded organelle

regulation of small GTPase mediated signal transduction

 
TC0X00000652.mm.2 Hmgb3 high mobility group box 3 X 71555916 NM_008253, BC011276, BC083352, BC158037 NM_008253, BC011276, BC083352, BC158037 NM_008253, BC011276, BC083352, BC158037 NM_008253, BC011276, BC083352, BC158037 39

immune system process

DNA binding

RNA binding

nucleus

chromosome

cytoplasm

regulation of transcription by RNA polymerase II

DNA binding, bending

innate immune response

negative regulation of B cell differentiation

negative regulation of myeloid cell differentiation

 
MG-1-neg-10339902_st                
TC0500002458.mm.2 Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 5 -62602445 NM_178407 18

GTPase activator activity

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

signal transduction

positive regulation of GTPase activity

metal ion binding

04144

TC0200005331.mm.2         XR_140551      
TC1800000344.mm.2 Wdr55 WD repeat domain 55 18 36760221 NM_026464, BC131932, BC131934 NM_026464, BC131932, BC131934 NM_026464, BC131932, BC131934 17

molecular_function

nucleus

nucleoplasm

nucleolus

nucleolus

cytoplasm

rRNA processing

rRNA processing

 
TC0100000267.mm.2 Lipt1 lipoyltransferase 1 1 37872218, 37872349, 37871737 NM_001037918, BC019519 NM_001037918, BC019519 16

cytoplasm

mitochondrion

mitochondrion

cellular protein modification process

protein lipoylation

transferase activity

transferase activity, transferring acyl groups

lipoyltransferase activity

00785

01100

TC0800000968.mm.2 Syce2 synaptonemal complex central element protein 2 8 84872110, 84872257 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 31

synaptonemal complex

central element

central element

protein binding

nucleus

nucleoplasm

nucleoplasm

chromosome

cell cycle

synaptonemal complex assembly

cell division

meiotic cell cycle

 
TC1200001832.mm.2 Fkbp3 FK506 binding protein 3 12 -65062431 NM_013902, BC002122, FK506 NM_013902, BC002122, FK506 NM_013902, BC002122, FK506 31

peptidyl-prolyl cis-trans isomerase activity

protein binding

nucleus

isomerase activity

 
TC0700004326.mm.2 Zfp764 zinc finger protein 764 7 -127403667 NM_001167832, NM_146203, BC026397 NM_001167832, NM_146203, BC026397 NM_001167832, NM_146203, BC026397 16

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
TC1100002297.mm.2 Cep68 centrosomal protein 68 11 -20227036 NM_172260, BC027174 NM_172260, BC027174 20

nucleoplasm

cytoplasm

centrosome

cytosol

cytoskeleton

centrosome cycle

centriole-centriole cohesion

protein kinase binding

protein domain specific binding

cell junction

protein localization to organelle

centriolar satellite

 
TC0100000829.mm.2 Dgkd diacylglycerol kinase, delta 1 87853286 NM_177646 35

nucleotide binding

NAD+ kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

ATP binding

cytoplasm

cytosol

plasma membrane

clathrin-coated pit

phosphatidic acid biosynthetic process

endocytosis

signal transduction

protein kinase C-activating G protein-coupled receptor signaling pathway

response to organic substance

protein transport

membrane

kinase activity

phosphorylation

transferase activity

kinase binding

cytoplasmic vesicle

intracellular signal transduction

identical protein binding

protein homodimerization activity

positive regulation of epidermal growth factor receptor signaling pathway

diacylglycerol metabolic process

diacylglycerol metabolic process

diacylglycerol metabolic process

lipid phosphorylation

lipid phosphorylation

lipid phosphorylation

metal ion binding

protein heterodimerization activity

negative regulation of protein kinase C signaling

positive regulation of clathrin-dependent endocytosis

00561

00564

01100

04070

TC0400002613.mm.2 Alg2 asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase) 4 -47469832 NM_019998, BC051951, BC052411 NM_019998, BC051951, BC052411 NM_019998, BC051951, BC052411 22

alpha-1,3-mannosyltransferase activity

alpha-1,3-mannosyltransferase activity

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity

nucleus

cytoplasm

cytosol

protein glycosylation

dolichol-linked oligosaccharide biosynthetic process

oligosaccharide-lipid intermediate biosynthetic process

actin cytoskeleton

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein glycosylation in endoplasmic reticulum

protein glycosylation in endoplasmic reticulum

protein heterodimerization activity

protein N-terminus binding

calcium-dependent protein binding

perinuclear region of cytoplasm

response to calcium ion

GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity

00510

01100

TC1600000138.mm.2 Snx29 sorting nexin 29 16 11322903, 11405647 NM_028964 15

molecular_function

biological_process

phosphatidylinositol binding

 
TC1300001642.mm.2 H3c3 H3 clustered histone 3 13 -23745041 NM_175653, BC120800, BC120802 NM_175653, BC120800, BC120802 NM_175653, BC120800, BC120802 7

nucleosome

nucleus

nucleoplasm

nucleosome assembly

05322

TC1400000910.mm.2 Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 14 63860311 NM_028228, BC115636 NM_028228, BC115636 17

nuclear chromosome

chromosome, centromeric region

kinetochore

chromosome, telomeric region

nucleic acid binding

nucleus

nucleoplasm

chromosome

nucleolus

mitochondrion

spindle

telomere maintenance via telomerase

mitotic metaphase plate congression

telomerase inhibitor activity

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of protein ubiquitination

regulation of protein stability

negative regulation of telomere maintenance via telomerase

protein-containing complex binding

negative regulation of telomerase activity

telomerase RNA binding

protein localization to chromosome, telomeric region

protein localization to nucleolus

positive regulation of telomeric DNA binding

positive regulation of protein localization to nucleolus

 
TC1100003410.mm.2 Aatf apoptosis antagonizing transcription factor 11 -84422855 NM_019816, BC025080 NM_019816, BC025080 42

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

Golgi apparatus

cytosol

regulation of transcription by RNA polymerase II

cell adhesion

regulation of mitotic cell cycle

protein kinase binding

negative regulation of superoxide anion generation

embryonic cleavage

ribosome biogenesis

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of apoptotic process

leucine zipper domain binding

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

tau protein binding

negative regulation of reactive oxygen species metabolic process

negative regulation of apoptotic signaling pathway

 
MG-1-pos-10338128_st                
TC0100002899.mm.2 Kdsr 3-ketodihydrosphingosine reductase 1 -106720409, -106731201 NM_027534, BC023820 NM_027534, BC023820 23

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

sphingolipid metabolic process

3-keto-sphinganine metabolic process

3-keto-sphinganine metabolic process

membrane

integral component of membrane

oxidoreductase activity

sphingolipid biosynthetic process

sphingolipid biosynthetic process

3-dehydrosphinganine reductase activity

3-dehydrosphinganine reductase activity

00600

01100

TC0700002924.mm.2         XR_105097      
TC0600002917.mm.2 Camk1 calcium/calmodulin-dependent protein kinase I 6 -113334123 NM_133926, BC014825 NM_133926, BC014825 49

nucleotide binding

catalytic activity

protein kinase activity

protein serine/threonine kinase activity

calmodulin-dependent protein kinase activity

calmodulin-dependent protein kinase activity

protein binding

calmodulin binding

ATP binding

intracellular anatomical structure

nucleus

cytoplasm

protein phosphorylation

protein phosphorylation

protein phosphorylation

nucleocytoplasmic transport

nucleocytoplasmic transport

cell cycle

signal transduction

multicellular organism development

nervous system development

metabolic process

positive regulation of neuron projection development

postsynaptic density

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

cell differentiation

negative regulation of protein binding

regulation of protein localization

positive regulation of peptidyl-serine phosphorylation

regulation of protein binding

positive regulation of transcription by RNA polymerase II

positive regulation of protein export from nucleus

positive regulation of protein export from nucleus

regulation of synapse organization

regulation of muscle cell differentiation

positive regulation of muscle cell differentiation

positive regulation of synapse structural plasticity

positive regulation of syncytium formation by plasma membrane fusion

positive regulation of dendritic spine development

positive regulation of protein serine/threonine kinase activity

glutamatergic synapse

positive regulation of protein acetylation

 
TC1600001050.mm.2 Chaf1b chromatin assembly factor 1, subunit B (p60) 16 93883900 NM_028083, BC013532 NM_028083, BC013532 29

chromatin

protein binding

nucleus

nucleoplasm

cytoplasm

DNA replication

DNA repair

nucleosome assembly

DNA replication-dependent nucleosome assembly

cellular response to DNA damage stimulus

cell cycle

chromatin assembly

protein-containing complex

CAF-1 complex

CAF-1 complex

 
TC0X00002648.mm.2 Maged1 MAGE family member D1 X -94535473 NM_019791, BC016438, BC031461 NM_019791, BC016438, BC031461 NM_019791, BC016438, BC031461 69

chromatin

transcription coactivator activity

protein binding

nucleus

cytoplasm

cytosol

plasma membrane

regulation of transcription by RNA polymerase II

membrane

circadian regulation of gene expression

protein-containing complex

regulation of circadian rhythm

identical protein binding

regulation of apoptotic process

positive regulation of MAP kinase activity

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

rhythmic process

negative regulation of epithelial cell proliferation

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of apoptotic signaling pathway

positive regulation of apoptotic signaling pathway

04722

TC0200002157.mm.2 Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2 145242610, 145167774 NM_053195, BC017615 NM_053195, BC017615 13

calcium channel activity

plasma membrane

plasma membrane

integral component of plasma membrane

ion transport

cation transport

potassium ion transport

sodium ion transport

calcium ion transport

cellular calcium ion homeostasis

cellular calcium ion homeostasis

cellular calcium ion homeostasis

cellular calcium ion homeostasis

calcium, potassium:sodium antiporter activity

calcium, potassium:sodium antiporter activity

calcium, potassium:sodium antiporter activity

calcium, potassium:sodium antiporter activity

positive regulation of gene expression

negative regulation of gene expression

symporter activity

antiporter activity

membrane

integral component of membrane

bone mineralization

sodium ion transmembrane transport

transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane transport

potassium ion transmembrane transport

cell periphery

cell periphery

 
TC1200002002.mm.2 Erh ERH mRNA splicing and mitosis factor 12 -80634020 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 34

osteoblast differentiation

nucleus

methyl-CpG binding

membrane

midbody

methylosome

 
MG-1-neg-10343507_st                
TC0400002709.mm.2 Tmem245 transmembrane protein 245 4 -56876013, -56876012 NM_175518 16

membrane

integral component of membrane

 
TC1400001152.mm.2 Bora bora, aurora kinase A activator 14 99046376 NM_175265, BC052183 NM_175265, BC052183 19

nucleus

cytoplasm

cell cycle

regulation of mitotic nuclear division

regulation of mitotic nuclear division

protein kinase binding

protein kinase binding

activation of protein kinase activity

regulation of protein localization

cell division

regulation of mitotic spindle organization

regulation of mitotic spindle organization

meiotic spindle

 
TC0400001477.mm.2 Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 4 127021300, 127021300 NM_023603, NR_045010, BC089305 NM_023603, NR_045010, BC089305 NM_023603, NR_045010, BC089305 84

negative regulation of transcription by RNA polymerase II

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

double-strand break repair via homologous recombination

chromatin

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

activation of innate immune response

immune system process

nucleic acid binding

DNA binding

chromatin binding

RNA binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

DNA repair

regulation of transcription, DNA-templated

mRNA processing

cellular response to DNA damage stimulus

RNA splicing

nuclear matrix

paraspeckles

paraspeckles

regulation of circadian rhythm

negative regulation of circadian rhythm

protein homodimerization activity

histone deacetylase binding

innate immune response

positive regulation of sister chromatid cohesion

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

rhythmic process

chromosome organization

regulation of cell cycle

histone H3 deacetylation

RNA polymerase II transcription regulator complex

dendritic transport of messenger ribonucleoprotein complex

dendritic transport of messenger ribonucleoprotein complex

dendritic transport of messenger ribonucleoprotein complex

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

 
TC0200000391.mm.2 Zmynd19 zinc finger, MYND domain containing 19 2 24949776, 24950157 NM_026021, BC027321 NM_026021, BC027321 26

molecular_function

cytoplasm

plasma membrane

biological_process

membrane

synapse

metal ion binding

 
TC1100004000.mm.2 Abca9 ATP-binding cassette, sub-family A (ABC1), member 9 11 -110100821 NM_147220 15

nucleotide binding

lipid transporter activity

ATP binding

mitochondrion

lipid transport

membrane

integral component of membrane

ATPase activity

ATPase-coupled transmembrane transporter activity

intracellular membrane-bounded organelle

02010

TC0X00002269.mm.2 Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 X -57231484, -57231484 NM_152801, BC156697 NM_152801, BC156697 35

guanyl-nucleotide exchange factor activity

protein binding

cell-cell junction

lamellipodium

lamellipodium assembly

regulation of Rho protein signal transduction

intracellular signal transduction

cell projection

04810

05212

TC1900000814.mm.2 Trub1 TruB pseudouridine (psi) synthase family member 1 19 57452905, 57452905 NM_028115, NM_029839, BC089592 NM_028115, NM_029839, BC089592 NM_028115, NM_029839, BC089592 18

pseudouridine synthesis

RNA binding

nucleus

cytoplasm

mitochondrion

cytosol

RNA processing

tRNA modification

RNA modification

pseudouridine synthase activity

pseudouridine synthase activity

isomerase activity

mRNA pseudouridine synthesis

mRNA pseudouridine synthesis

 
TC0200001741.mm.2 Bub1b BUB1B, mitotic checkpoint serine/threonine kinase 2 118598210 NM_009773, BC031577 NM_009773, BC031577 96

nucleotide binding

chromosome, centromeric region

kinetochore

kinetochore

kinetochore

condensed chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed chromosome outer kinetochore

condensed chromosome outer kinetochore

protein kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

chromosome

cytoplasm

spindle

cytosol

protein phosphorylation

apoptotic process

cell cycle

metaphase/anaphase transition of mitotic cell cycle

mitotic spindle assembly checkpoint

kinase activity

phosphorylation

transferase activity

perinuclear region of cytoplasm

cell division

meiotic sister chromatid cohesion, centromeric

protein localization to chromosome, centromeric region

04110

TC0200004725.mm.2 Tasp1 taspase, threonine aspartase 1 2 -139833478, -139976218 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 25

threonine-type endopeptidase activity

threonine-type endopeptidase activity

cytoplasm

proteolysis

peptidase activity

hydrolase activity

identical protein binding

positive regulation of transcription, DNA-templated

protein maturation

 
TC1100004301.mm.2 Trim47 tripartite motif-containing 47 11 -116105749 NM_001205081, NM_172570, BC132148, BC137953, BC145059 NM_001205081, NM_172570, BC132148, BC137953, BC145059 NM_001205081, NM_172570, BC132148, BC137953, BC145059 NM_001205081, NM_172570, BC132148, BC137953, BC145059 NM_001205081, NM_172570, BC132148, BC137953, BC145059 23

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

nucleus

cytoplasm

cytosol

zinc ion binding

protein ubiquitination

protein ubiquitination

transferase activity

metal ion binding

 
TC0600003003.mm.2 Ankrd26 ankyrin repeat domain 26 6 -118501299 NM_001081112 22

protein binding

cytoplasm

centrosome

actin cytoskeleton

regulation of lipid metabolic process

regulation of fatty acid metabolic process

negative regulation of multicellular organism growth

glucose homeostasis

negative regulation of fat cell differentiation

negative regulation of organ growth

negative regulation of insulin receptor signaling pathway

regulation of feeding behavior

negative regulation of ERK1 and ERK2 cascade

 
TC0X00002689.mm.2 Ophn1 oligophrenin 1 X -98554279, -98873725 NM_052976, BC004845 NM_052976, BC004845 39

actin binding

GTPase activator activity

GTPase activator activity

protein binding

phospholipid binding

cytoplasm

cytoplasm

endocytosis

signal transduction

nervous system development

actin cytoskeleton

actin cytoskeleton

cerebellar granule cell differentiation

cerebral cortex neuron differentiation

actin cytoskeleton organization

actin cytoskeleton organization

cell junction

regulation of endocytosis

regulation of endocytosis

neuron differentiation

dendrite

neuron projection development

cell junction assembly

regulation of Rho protein signal transduction

ionotropic glutamate receptor binding

cell projection

terminal bouton

terminal bouton

dendritic spine

dendritic spine

establishment of epithelial cell apical/basal polarity

synapse

synaptic vesicle endocytosis

synaptic vesicle endocytosis

synaptic vesicle endocytosis

cell morphogenesis involved in neuron differentiation

regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic

maintenance of postsynaptic specialization structure

glutamatergic synapse

regulation of postsynaptic neurotransmitter receptor internalization

negative regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process

 
TC1800000019.mm.2 Svil supervillin 18 5046588, 5046588 NM_153153 32

actin binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

nucleus

cytoplasm

cytoplasm

cytosol

cytoskeleton

plasma membrane

cytoskeleton organization

skeletal muscle tissue development

actin polymerization or depolymerization

actin cytoskeleton

actin cytoskeleton

membrane

cell junction

cell projection

costamere

actin filament severing

actin filament binding

actin filament binding

barbed-end actin filament capping

 
TC0100001303.mm.2 Aspm abnormal spindle microtubule assembly 1 139454772 NM_009791 49

spindle pole

neuron migration

neuron migration

positive regulation of neuroblast proliferation

positive regulation of neuroblast proliferation

calmodulin binding

nucleus

cytoplasm

centrosome

cytoskeleton

microtubule

cell cycle

spindle organization

spermatogenesis

brain development

male gonad development

apical plasma membrane

forebrain neuroblast division

cerebral cortex development

midbody

midbody

microtubule minus-end

negative regulation of neuron differentiation

negative regulation of asymmetric cell division

oogenesis

developmental growth

cell division

regulation of meiotic cell cycle

spindle localization

maintenance of centrosome location

meiotic spindle

positive regulation of canonical Wnt signaling pathway

spindle assembly involved in meiosis

neuronal stem cell population maintenance

mitotic spindle pole

mitotic spindle pole

 
TC0200003401.mm.2 Strbp spermatid perinuclear RNA binding protein 2 -37569867, -37569867, -37569867, -37569867 NM_009261, BC014710 NM_009261, BC014710 32

manchette

RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

nucleus

cytoplasm

cytoskeleton

movement of cell or subcellular component

multicellular organism development

spermatogenesis

spermatid development

mechanosensory behavior

microtubule binding

microtubule cytoskeleton

tubulin binding

cell differentiation

 
TC1300001205.mm.2 Depdc1b DEP domain containing 1B 13 108316336 NM_178683, BC152330, BC152331 NM_178683, BC152330, BC152331 NM_178683, BC152330, BC152331 16

molecular_function

GTPase activator activity

signal transduction

cell migration

positive regulation of Wnt signaling pathway

positive regulation of Wnt signaling pathway

intracellular signal transduction

 
TC0500000307.mm.2         NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788  

nucleotide binding

UTP binding

catalytic activity

aspartate carbamoyltransferase activity

aspartate carbamoyltransferase activity

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

dihydroorotase activity

dihydroorotase activity

protein kinase activity

ATP binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

'de novo' pyrimidine nucleobase biosynthetic process

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine nucleotide biosynthetic process

UTP biosynthetic process

UTP biosynthetic process

cellular amino acid metabolic process

glutamine metabolic process

glutamine metabolic process

nitrogen compound metabolic process

metabolic process

zinc ion binding

nuclear matrix

amino acid binding

transferase activity

carboxyl- or carbamoyltransferase activity

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

ligase activity

drug metabolic process

peptidyl-threonine phosphorylation

citrulline biosynthetic process

citrulline biosynthetic process

enzyme binding

response to insulin

protein-containing complex

response to starvation

identical protein binding

cell projection

neuronal cell body

terminal bouton

protein autophosphorylation

metal ion binding

 
TC1200000675.mm.2 Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase 12 76255231 NM_138745, BC008523 NM_138745, BC008523 53

histidine biosynthetic process

nucleotide binding

neutrophil homeostasis

neural tube closure

catalytic activity

formate-tetrahydrofolate ligase activity

formate-tetrahydrofolate ligase activity

methenyltetrahydrofolate cyclohydrolase activity

methenyltetrahydrofolate cyclohydrolase activity

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

ATP binding

cytoplasm

mitochondrion

cytosol

cytosol

purine nucleotide biosynthetic process

methionine metabolic process

one-carbon metabolic process

heart development

metabolic process

cellular amino acid biosynthetic process

serine family amino acid metabolic process

serine family amino acid biosynthetic process

methionine biosynthetic process

10-formyltetrahydrofolate biosynthetic process

10-formyltetrahydrofolate biosynthetic process

oxidoreductase activity

hydrolase activity

ligase activity

transsulfuration

tetrahydrofolate interconversion

tetrahydrofolate interconversion

tetrahydrofolate interconversion

somite development

00670

01100

TC1300001419.mm.2 Gtpbp4 GTP binding protein 4 13 -8972477 NM_027000, BC025431 NM_027000, BC025431 30

regulation of cyclin-dependent protein serine/threonine kinase activity

nucleotide binding

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GTPase activity

GTP binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

negative regulation of DNA replication

negative regulation of cell population proliferation

negative regulation of cell-cell adhesion

negative regulation of cell migration

negative regulation of protein ubiquitination

nuclear membrane

negative regulation of collagen binding

ribosome biogenesis

perinuclear region of cytoplasm

protein stabilization

03008

TC1100003345.mm.2 Myo1d myosin ID 11 -80482126 NM_177390, BC150765 NM_177390, BC150765 34

microfilament motor activity

microfilament motor activity

nucleotide binding

motor activity

actin binding

protein binding

calmodulin binding

ATP binding

cytoplasm

endosome

smooth endoplasmic reticulum

plasma membrane

microvillus

brush border

brush border

actin filament organization

negative regulation of phosphatase activity

protein transport

actin cytoskeleton

membrane

basolateral plasma membrane

myosin complex

protein domain specific binding

vesicle transport along actin filament

axon

axolemma

actin-dependent ATPase activity

actin-dependent ATPase activity

cytoplasmic vesicle

vesicle

cell projection

neuron projection

neuronal cell body

neuronal cell body

myelin sheath

myelin sheath

myelin sheath

plasma membrane raft

calcium-dependent protein binding

actin filament binding

actin filament binding

cellular localization

apical dendrite

 
TC1400002863.mm.2 Ipo4 importin 4 14 -55625399 NM_024267, BC003469, BC085150 NM_024267, BC003469, BC085150 NM_024267, BC003469, BC085150 25

chromatin

protein binding

nucleus

cytoplasm

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

protein import into nucleus

protein import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transport

small GTPase binding

protein-containing complex

ribosome biogenesis

nuclear import signal receptor activity

 
TC0900000581.mm.2 Nxpe4 neurexophilin and PC-esterase domain family, member 4 9 48362040 NM_172921, BC085195, BC094249 NM_172921, BC085195, BC094249 NM_172921, BC085195, BC094249 13

molecular_function

extracellular region

biological_process

 
TC0400001215.mm.2 Stil Scl/Tal1 interrupting locus 4 115000117 NM_009185, BC141175, BC145493 NM_009185, BC141175, BC145493 NM_009185, BC141175, BC145493 29

embryonic axis specification

in utero embryonic development

neural tube closure

heart looping

protein binding

cytoplasm

centrosome

centrosome

centriole

centriole

cytoskeleton

mitotic spindle organization

mitotic spindle organization

smoothened signaling pathway

smoothened signaling pathway

multicellular organism development

determination of left/right symmetry

neural tube development

forebrain development

notochord development

floor plate development

multicellular organism growth

identical protein binding

negative regulation of apoptotic process

positive regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of centriole replication

centrosome duplication

centrosome duplication

centrosome duplication

mitotic spindle checkpoint

protein localization to centrosome

protein localization to centrosome

non-motile cilium assembly

 
TC0300000354.mm.2 Noct nocturnin 3 51224446 NM_009834, BC139369, BC139370 NM_009834, BC139369, BC139370 NM_009834, BC139369, BC139370 48

3'-5'-exoribonuclease activity

deadenylation-dependent decapping of nuclear-transcribed mRNA

P-body

RNA binding

mRNA binding

poly(A)-specific ribonuclease activity

poly(A)-specific ribonuclease activity

protein binding

nucleus

cytoplasm

mitochondrion

NADP metabolic process

circadian rhythm

circadian rhythm

response to extracellular stimulus

negative regulation of gene expression

hydrolase activity

NADP phosphatase activity

response to lipopolysaccharide

circadian regulation of gene expression

P-body assembly

regulation of circadian rhythm

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

regulation of embryonic development

metal ion binding

mRNA stabilization

perinuclear region of cytoplasm

rhythmic process

NADPH phosphatase activity

 
TC0100001699.mm.2 Sccpdh saccharopine dehydrogenase (putative) 1 179668230 NM_178653, BC025803 NM_178653, BC025803 18

molecular_function

mitochondrion

mitochondrion

lipid droplet

lipid droplet

plasma membrane

glycolipid biosynthetic process

oxidoreductase activity

midbody

 
MG-1-pos-10341135_st                
TC0800001533.mm.2 Rab4a RAB4A, member RAS oncogene family 8 123805995 NM_009003, BC138508 NM_009003, BC138508 35

nucleotide binding

ATPase activator activity

GTPase activity

protein binding

GTP binding

cytoplasm

endosome

endosome

cytosol

plasma membrane

small GTPase mediated signal transduction

protein transport

membrane

GDP binding

antigen processing and presentation

syntaxin binding

regulation of endocytosis

regulation of endocytosis

cytoplasmic vesicle membrane

vesicle

Rab protein signal transduction

insulin-responsive compartment

insulin-responsive compartment

ionotropic glutamate receptor binding

intracellular membrane-bounded organelle

perinuclear region of cytoplasm

ATPase binding

recycling endosome

extracellular exosome

postsynaptic recycling endosome

postsynaptic recycling endosome

anchored component of synaptic vesicle membrane

04144

TC0400000133.mm.2 Tmem64 transmembrane protein 64 4 15265819 NM_181401, BC030341 NM_181401, BC030341 20

protein binding

endoplasmic reticulum

membrane

integral component of membrane

regulation of ATPase activity

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

positive regulation of osteoclast differentiation

positive regulation of bone resorption

regulation of cytosolic calcium ion concentration

negative regulation of canonical Wnt signaling pathway

 
TC0400001743.mm.2 Akr7a5 aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) 4 139310743 NM_025337, BC031857 NM_025337, BC031857 25

alditol:NADP+ 1-oxidoreductase activity

nuclear envelope

cytoplasm

mitochondrion

Golgi apparatus

cytosol

oxidoreductase activity

phenanthrene-9,10-epoxide hydrolase activity

daunorubicin metabolic process

doxorubicin metabolic process

 
TC1000003023.mm.2 Hmga2 high mobility group AT-hook 2 10 -120361267 NM_010441, BC052158, BC069985, BC085085 NM_010441, BC052158, BC069985, BC085085 NM_010441, BC052158, BC069985, BC085085 NM_010441, BC052158, BC069985, BC085085 139

negative regulation of transcription by RNA polymerase II

nuclear chromosome

chromatin

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

minor groove of adenine-thymine-rich DNA binding

transcription coregulator activity

protein binding

nucleus

nucleus

nucleus

regulation of transcription, DNA-templated

cell cycle

signal transduction

spermatogenesis

positive regulation of cell population proliferation

male gonad development

regulation of cell cycle process

positive regulation of gene expression

enzyme binding

cell proliferation in forebrain

pituitary gland development

negative regulation of Wnt signaling pathway

chromosome condensation

adrenal gland development

negative regulation of intracellular steroid hormone receptor signaling pathway

somatic stem cell population maintenance

somatic stem cell population maintenance

regulation of growth

positive regulation of multicellular organism growth

positive regulation of angiogenesis

positive regulation of transcription by RNA polymerase II

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of astrocyte differentiation

positive regulation of DNA-binding transcription factor activity

cell division

meiotic cell cycle

regulation of growth hormone secretion

lung epithelium development

epithelial tube branching involved in lung morphogenesis

positive regulation of epithelial cell proliferation involved in lung morphogenesis

adipose tissue development

fat pad development

positive regulation of cell proliferation in bone marrow

regulation of peptide hormone secretion

positive regulation of stem cell proliferation

negative regulation of cellular senescence

 
TC1400002341.mm.2 Polr3d polymerase (RNA) III (DNA directed) polypeptide D 14 -70438747, -70438747 NM_001164082, NM_025945, BC016102 NM_001164082, NM_025945, BC016102 NM_001164082, NM_025945, BC016102 19

immune system process

DNA binding

chromatin binding

chromatin binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase III complex

RNA polymerase III complex

cytosol

transcription by RNA polymerase III

positive regulation of interferon-beta production

innate immune response

positive regulation of innate immune response

defense response to virus

00230

00240

01100

03020

04623

TC1500001347.mm.2 Rida reactive intermediate imine deaminase A homolog 15 -34484021 NM_008287, BC092375, BC125590, BC125592 NM_008287, BC092375, BC125590, BC125592 NM_008287, BC092375, BC125590, BC125592 NM_008287, BC092375, BC125590, BC125592 17

RNA binding

mRNA binding

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrial matrix

peroxisome

cytosol

cytosol

mRNA catabolic process

hydrolase activity

endoribonuclease activity, producing 3'-phosphomonoesters

negative regulation of translation

deaminase activity

deaminase activity

long-chain fatty acid binding

identical protein binding

ion binding

transition metal ion binding

negative regulation of epithelial cell proliferation

mRNA destabilization

organonitrogen compound catabolic process

organonitrogen compound catabolic process

 
TC1300000045.mm.2 Idi1 isopentenyl-diphosphate delta isomerase 13 8885605 NM_145360, BC004801, BC110313 NM_145360, BC004801, BC110313 NM_145360, BC004801, BC110313 26

magnesium ion binding

isopentenyl-diphosphate delta-isomerase activity

isopentenyl-diphosphate delta-isomerase activity

cytoplasm

mitochondrion

peroxisome

isoprenoid biosynthetic process

isopentenyl diphosphate biosynthetic process

manganese ion binding

response to stilbenoid

00900

01100

TC0100001271.mm.2 Kif14 kinesin family member 14 1 136467847 NM_001287179, BC158132, NM_001081258 NM_001287179, BC158132, NM_001081258 NM_001287179, BC158132, NM_001081258 25

nucleotide binding

regulation of cell growth

microtubule motor activity

ATP binding

nucleus

cytoplasm

cytosol

cytoskeleton

kinesin complex

microtubule

microtubule

plasma membrane

microtubule-based movement

mitotic metaphase plate congression

microtubule binding

microtubule binding

positive regulation of cell population proliferation

ATP-dependent microtubule motor activity, plus-end-directed

regulation of G2/M transition of mitotic cell cycle

tubulin binding

ATPase activity

ATPase activity

protein kinase binding

cerebellar granular layer structural organization

cerebellar Purkinje cell layer structural organization

cerebellar cortex development

hippocampus development

olfactory bulb development

cell proliferation in forebrain

cerebral cortex development

regulation of cell adhesion

PDZ domain binding

regulation of cell migration

midbody

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

regulation of myelination

activation of protein kinase activity

positive regulation of cytokinesis

regulation of Rap protein signal transduction

negative regulation of integrin activation

substrate adhesion-dependent cell spreading

negative regulation of apoptotic process

proteasome-mediated ubiquitin-dependent protein catabolic process

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

establishment of protein localization

spindle midzone

cell division

Flemming body

regulation of cell maturation

regulation of G1/S transition of mitotic cell cycle

 
TC0900000639.mm.2 Poglut3 protein O-glucosyltransferase 3 9 53384022 NM_212445 16

endoplasmic reticulum

endomembrane system

transferase activity

transferase activity, transferring glycosyl groups

protein O-linked glycosylation via serine

UDP-glucosyltransferase activity

UDP-xylosyltransferase activity

glucosyltransferase activity

 
TC1200001306.mm.2 Ncapg2 non-SMC condensin II complex, subunit G2 12 116405435 NM_133762, BC076631 NM_133762, BC076631 27

mitotic sister chromatid segregation

condensin complex

condensin complex

condensin complex

inner cell mass cell proliferation

protein binding

nucleus

nucleus

nucleoplasm

transcription by RNA polymerase II

transcription by RNA polymerase II

cell cycle

nuclear speck

erythrocyte differentiation

erythrocyte differentiation

chromosome condensation

methylated histone binding

bHLH transcription factor binding

cell division

transcription regulator inhibitor activity

 
TC0100002413.mm.2 Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 1 -60483184 NM_001045513 23

protein binding

cytosol

cytosol

plasma membrane

plasma membrane

nuclear body

cell leading edge

axon extension

 
TC0100000526.mm.2 Fastkd2 FAST kinase domains 2 1 63730624 NM_172422, BC008271, BC057208, BC080813 NM_172422, BC008271, BC057208, BC080813 NM_172422, BC008271, BC057208, BC080813 NM_172422, BC008271, BC057208, BC080813 19

RNA binding

protein kinase activity

mitochondrion

mitochondrion

mitochondrial inner membrane

rRNA binding

ribonucleoprotein granule

ribosome biogenesis

mitochondrial nucleoid

positive regulation of mitochondrial translation

apoptotic process in response to mitochondrial fragmentation

mitochondrial large ribosomal subunit assembly

 
TC1100000544.mm.2 Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 11 50377677, 50378290, 50377796, 50378235, 50376989 NM_021510, BC042187, BC056224 NM_021510, BC042187, BC056224 NM_021510, BC042187, BC056224 52

nucleic acid binding

RNA binding

RNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

spliceosomal complex

cytosol

mRNA processing

RNA splicing

identical protein binding

regulation of RNA splicing

regulation of RNA splicing

catalytic step 2 spliceosome

cellular response to interleukin-7

ribonucleoprotein complex

 
TC1300001560.mm.2 H1f5 H1.5 linker histone, cluster member 13 -21779831 NM_020034, BC146469 NM_020034, BC146469 34

nucleosome

DNA binding

double-stranded DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

muscle organ development

nucleosome positioning

chromosome condensation

nucleosomal DNA binding

negative regulation of chromatin silencing

negative regulation of DNA recombination

 
TC1600001124.mm.2 Adcy9 adenylate cyclase 9 16 -4284885 NM_009624, BC166017 NM_009624, BC166017 44

nucleotide binding

in utero embryonic development

adenylate cyclase activity

adenylate cyclase activity

adenylate cyclase activity

ATP binding

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

cAMP biosynthetic process

cAMP biosynthetic process

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cyclic nucleotide biosynthetic process

membrane

integral component of membrane

lyase activity

phosphorus-oxygen lyase activity

axon

dendrite

intracellular signal transduction

metal ion binding

adenylate cyclase-activating adrenergic receptor signaling pathway

00230

04020

04062

04114

04270

04540

04912

04914

04916

04962

04970

04971

04972

04976

05414

TC0X00000454.mm.2 Stk26 serine/threonine kinase 26 X 50841370 NM_133729, BC005708, BC132438, BC138193 NM_133729, BC005708, BC132438, BC138193 NM_133729, BC005708, BC132438, BC138193 NM_133729, BC005708, BC132438, BC138193 20

Golgi membrane

nucleotide binding

magnesium ion binding

protein kinase activity

protein serine/threonine kinase activity

ATP binding

cytoplasm

Golgi apparatus

Golgi-associated vesicle

cytosol

protein phosphorylation

apoptotic process

cellular response to starvation

membrane

kinase activity

phosphorylation

apical plasma membrane

transferase activity

microvillus assembly

negative regulation of cell migration

response to hydrogen peroxide

identical protein binding

protein homodimerization activity

regulation of apoptotic process

protein autophosphorylation

metal ion binding

perinuclear region of cytoplasm

cell periphery

regulation of hydrogen peroxide-induced cell death

 
TC0200000354.mm.2 Pdss1 prenyl (solanesyl) diphosphate synthase, subunit 1 2 22895521, 22895521 NM_019501, BC026820 NM_019501, BC026820 18

trans-hexaprenyltranstransferase activity

trans-hexaprenyltranstransferase activity

prenyltransferase activity

protein binding

mitochondrion

ubiquinone biosynthetic process

ubiquinone biosynthetic process

ubiquinone biosynthetic process

isoprenoid biosynthetic process

isoprenoid biosynthetic process

isoprenoid biosynthetic process

transferase activity

metal ion binding

protein heterodimerization activity

trans-octaprenyltranstransferase activity

all-trans-decaprenyl-diphosphate synthase activity

transferase complex

transferase complex

transferase complex

00900

TC1900000758.mm.2 Smc3 structural maintenance of chromosomes 3 19 53600395 NM_007790, BC057345, BC062935 NM_007790, BC057345, BC062935 NM_007790, BC057345, BC062935 75

nucleotide binding

chromosome, centromeric region

chromatin

lateral element

chromatin binding

protein binding

ATP binding

basement membrane

nucleus

nucleoplasm

nucleoplasm

chromosome

regulation of DNA replication

DNA repair

cellular response to DNA damage stimulus

cell cycle

sister chromatid cohesion

cohesin complex

cohesin complex

nuclear matrix

stem cell population maintenance

meiotic cohesin complex

meiotic cohesin complex

nuclear meiotic cohesin complex

mediator complex binding

protein heterodimerization activity

beta-tubulin binding

chromosome organization

cell division

meiotic cell cycle

meiotic cell cycle

dynein complex binding

mitotic spindle assembly

mitotic spindle pole

04110

04114

TC1500002037.mm.2 Hdac10 histone deacetylase 10 15 -89123302 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 24

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

histone deacetylase activity

nucleus

nucleoplasm

cytoplasm

DNA repair

DNA recombination

regulation of transcription, DNA-templated

autophagy

cellular response to DNA damage stimulus

macroautophagy

histone deacetylation

hydrolase activity

deacetylase activity

enzyme binding

positive regulation of mismatch repair

peptidyl-lysine deacetylation

homologous recombination

histone deacetylase binding

negative regulation of transcription, DNA-templated

metal ion binding

acetylputrescine deacetylase activity

acetylspermidine deacetylase activity

polyamine deacetylation

spermidine deacetylation

 
TC0200004440.mm.2 Oip5 Opa interacting protein 5 2 -119609531 NM_001042653, BC115883, BC116660 NM_001042653, BC115883, BC116660 NM_001042653, BC115883, BC116660 14

chromosome, centromeric region

chromatin

chromatin

nucleus

nucleus

nucleus

chromosome

cell cycle

chromosome segregation

chromocenter

Cajal body

nuclear speck

CENP-A containing nucleosome assembly

identical protein binding

intracellular membrane-bounded organelle

metal ion binding

cell division

 
TC0X00003175.mm.2 Tsr2 TSR2 20S rRNA accumulation X -151087093 NM_001164578, NM_175146, NR_028392, BC049668 NM_001164578, NM_175146, NR_028392, BC049668 NM_001164578, NM_175146, NR_028392, BC049668 NM_001164578, NM_175146, NR_028392, BC049668 16

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

molecular_function

rRNA processing

 
TC0800002236.mm.2 Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 8 -54520432 NM_029701, BC054817 NM_029701, BC054817 18

endoplasmic reticulum

signal peptidase complex

signal peptide processing

proteolysis

peptidase activity

membrane

integral component of membrane

hydrolase activity

viral protein processing

intracellular membrane-bounded organelle

protein targeting to ER

03060

TC0500000434.mm.2 Lyar Ly1 antibody reactive clone 5 38220481 NM_025281, BC116923, BC116927 NM_025281, BC116923, BC116927 NM_025281, BC116923, BC116927 30

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

photoreceptor outer segment

immune system process

DNA binding

DNA binding

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

rRNA processing

rRNA processing

activating transcription factor binding

identical protein binding

cell projection

innate immune response

negative regulation of innate immune response

positive regulation of transcription by RNA polymerase I

metal ion binding

erythrocyte development

positive regulation of phagocytosis

transcription regulator inhibitor activity

 
TC0700002057.mm.2 Ap2a2 adaptor-related protein complex 2, alpha 2 subunit 7 141562179 NM_007459, BC058099 NM_007459, BC058099 78

protein binding

plasma membrane

clathrin-coated pit

intracellular protein transport

endocytosis

receptor-mediated endocytosis

synaptic vesicle

lipid binding

protein transport

membrane

vesicle-mediated transport

kinase binding

protein kinase binding

protein domain specific binding

membrane coat

AP-2 adaptor complex

AP-2 adaptor complex

AP-2 adaptor complex

clathrin adaptor complex

secretory granule

cytoplasmic vesicle

phosphatidylinositol binding

clathrin adaptor activity

protein-containing complex binding

clathrin-dependent endocytosis

clathrin-dependent endocytosis

clathrin-dependent endocytosis

disordered domain specific binding

cargo adaptor activity

regulation of hematopoietic stem cell differentiation

04144

05016

TC0200003697.mm.2 Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 2 -69193894 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 23

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

condensed chromosome kinetochore

molecular_function

nucleus

chromosome

cytosol

cell cycle

mitotic spindle organization

chromosome segregation

chromosome segregation

Ndc80 complex

Ndc80 complex

cell division

 
TC1500000392.mm.2 Deptor DEP domain containing MTOR-interacting protein 15 55112316, 55133435 NM_001037937, NM_145470, BC156690 NM_001037937, NM_145470, BC156690 NM_001037937, NM_145470, BC156690 42

negative regulation of protein kinase activity

negative regulation of TOR signaling

intracellular signal transduction

negative regulation of cell size

regulation of extrinsic apoptotic signaling pathway

 
TC0600000962.mm.2 Smyd5 SET and MYND domain containing 5 6 85431975 NM_144918, BC016525 NM_144918, BC016525 22

molecular_function

cellular_component

biological_process

methyltransferase activity

transferase activity

methylation

metal ion binding

 
TC0900001461.mm.2 Ngp neutrophilic granule protein 9 110419807 NM_008694, BC119403, BC119405 NM_008694, BC119403, BC119405 NM_008694, BC119403, BC119405 22

cysteine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular region

extracellular space

extracellular space

defense response

negative regulation of peptidase activity

negative regulation of angiogenesis

peptidase inhibitor activity

cytoplasmic vesicle

negative regulation of lymphangiogenesis

 
TC0500001251.mm.2 Pop5 processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) 5 115235850 NM_026398, BC022670 NM_026398, BC022670 19

ribonuclease MRP activity

ribonuclease MRP complex

ribonuclease MRP complex

ribonuclease MRP complex

tRNA 5'-leader removal

ribonuclease P activity

ribonuclease P activity

ribonuclease P activity

ribonuclease activity

nucleus

nucleolar ribonuclease P complex

nucleolar ribonuclease P complex

nucleolus

rRNA processing

rRNA processing

tRNA processing

tRNA processing

RNA metabolic process

hydrolase activity

multimeric ribonuclease P complex

ribonuclease P RNA binding

03008

03013

TC1100003318.mm.2 Wsb1 WD repeat and SOCS box-containing 1 11 -79239381, -79239382 NM_001042565, NM_019653, BC053391 NM_001042565, NM_019653, BC053391 NM_001042565, NM_019653, BC053391 31

biological_process

intracellular signal transduction

 
TC0600001998.mm.2 Tmem209 transmembrane protein 209 6 -30481232, -30481038 NM_178625, BC052187, BC057109 NM_178625, BC052187, BC057109 NM_178625, BC052187, BC057109 15

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC1700001138.mm.2 Wdr43 WD repeat domain 43 17 71616214 NM_175639 22

chromatin

RNA polymerase II complex binding

fibrillar center

transcription elongation regulator activity

RNA binding

protein binding

nucleus

nucleoplasm

nucleolus

nucleolus

rRNA processing

regulation of transcription elongation from RNA polymerase II promoter

ribosome biogenesis

positive regulation of transcription by RNA polymerase I

regulation of stem cell population maintenance

positive regulation of rRNA processing

03008

TC1600001378.mm.2 Tra2b transformer 2 beta 16 -22244551 NM_009186, BC061177, BC086795 NM_009186, BC061177, BC086795 NM_009186, BC061177, BC086795 54

regulation of alternative mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

mRNA binding

protein binding

nucleus

nucleus

nuclear inner membrane

nucleoplasm

spliceosomal complex

spliceosomal complex

mRNA processing

RNA splicing

protein domain specific binding

cerebral cortex regionalization

protein-containing complex

pre-mRNA binding

pre-mRNA binding

identical protein binding

regulation of RNA splicing

negative regulation of mRNA splicing, via spliceosome

positive regulation of mRNA splicing, via spliceosome

positive regulation of mRNA splicing, via spliceosome

positive regulation of mRNA splicing, via spliceosome

positive regulation of mRNA splicing, via spliceosome

perinuclear region of cytoplasm

poly-purine tract binding

cellular response to glucose stimulus

embryonic brain development

03040

TC0400002527.mm.2 Arhgef39 Rho guanine nucleotide exchange factor (GEF) 39 4 -43496143 NM_001013377, BC080700 NM_001013377, BC080700 13

guanyl-nucleotide exchange factor activity

plasma membrane

plasma membrane

membrane

positive regulation of cell migration

positive regulation of cell migration

regulation of Rho protein signal transduction

 
TC0600001254.mm.2 Fancd2 Fanconi anemia, complementation group D2 6 113531681, 113531681 NM_001033244, BC139004 NM_001033244, BC139004 85

condensed chromosome

condensed chromosome

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytosol

DNA repair

cellular response to DNA damage stimulus

cell cycle

homologous chromosome pairing at meiosis

homologous chromosome pairing at meiosis

multicellular organism development

gamete generation

response to gamma radiation

nuclear body

intra-S DNA damage checkpoint

cellular response to oxidative stress

interstrand cross-link repair

regulation of regulatory T cell differentiation

brain morphogenesis

regulation of inflammatory response

regulation of DNA-binding transcription factor activity

DNA polymerase binding

DNA polymerase binding

neuronal stem cell population maintenance

double-strand break repair involved in meiotic recombination

regulation of CD40 signaling pathway

 
TC0400004186.mm.2 Nfia nuclear factor I/A 4 97581942, 97777625 NM_001122953, NM_010905, BC075702, BC122878 NM_001122953, NM_010905, BC075702, BC122878 NM_001122953, NM_010905, BC075702, BC122878 NM_001122953, NM_010905, BC075702, BC122878 121

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

intracellular anatomical structure

nucleus

nucleus

nucleus

nucleoplasm

DNA replication

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription factor binding

cell junction

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

synapse maturation

ureter development

 
TC1700000819.mm.2 Mmut methylmalonyl-Coenzyme A mutase 17 40934684 NM_008650, BC019175 NM_008650, BC019175 42

catalytic activity

GTPase activity

methylmalonyl-CoA mutase activity

methylmalonyl-CoA mutase activity

methylmalonyl-CoA mutase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

post-embryonic development

isomerase activity

intramolecular transferase activity

cobalamin binding

identical protein binding

protein homodimerization activity

positive regulation of GTPase activity

metal ion binding

homocysteine metabolic process

modified amino acid binding

00280

00630

00640

01100

TC0X00001371.mm.2 Rnf128 ring finger protein 128 X 139610619, 139563339 NM_001254761, NM_023270, BC010477 NM_001254761, NM_023270, BC010477 NM_001254761, NM_023270, BC010477 49

negative regulation of cytokine production

cytoplasm

late endosome

late endosome

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cytoskeleton

ubiquitin-dependent protein catabolic process

membrane

integral component of membrane

transferase activity

regulation of protein stability

metal ion binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

 
TC1000001282.mm.2 E2f7 E2F transcription factor 7 10 110745438 NM_178609, BC145429, BC150772, E2F NM_178609, BC145429, BC150772, E2F NM_178609, BC145429, BC150772, E2F NM_178609, BC145429, BC150772, E2F 39

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity

DNA-binding transcription repressor activity

DNA-binding transcription repressor activity, RNA polymerase II-specific

placenta development

sprouting angiogenesis

sprouting angiogenesis

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

cell cycle

negative regulation of cell population proliferation

negative regulation of cell population proliferation

nuclear speck

DNA damage response, signal transduction by p53 class mediator

negative regulation of cytokinesis

positive regulation of DNA endoreduplication

identical protein binding

positive regulation of transcription by RNA polymerase II

trophoblast giant cell differentiation

chorionic trophoblast cell differentiation

hepatocyte differentiation

negative regulation of transcription involved in G1/S transition of mitotic cell cycle

RNA polymerase II transcription regulator complex

sequence-specific double-stranded DNA binding

negative regulation of G1/S transition of mitotic cell cycle

 
TC0400000530.mm.2 Stx17 syntaxin 17 4 48124918 NM_026343, BC028639 NM_026343, BC028639 23

SNARE binding

SNARE binding

autophagosome membrane

autophagosome membrane

SNAP receptor activity

SNAP receptor activity

cytoplasm

autophagosome

autophagosome

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum-Golgi intermediate compartment

cytosol

plasma membrane

intracellular protein transport

exocytosis

endoplasmic reticulum to Golgi vesicle-mediated transport

vesicle fusion

autophagy

Golgi organization

endomembrane system

membrane

integral component of membrane

vesicle-mediated transport

autophagosome membrane docking

protein kinase binding

protein phosphatase binding

COPII-coated ER to Golgi transport vesicle

smooth endoplasmic reticulum membrane

HOPS complex

SNARE complex

SNARE complex

cytoplasmic vesicle

protein localization to phagophore assembly site

mitochondria-associated endoplasmic reticulum membrane

vesicle docking

endoplasmic reticulum-Golgi intermediate compartment organization

autophagosome maturation

04130

TC0600003000.mm.2 Bms1 BMS1, ribosome biogenesis factor 6 -118383380 NM_194339, BC057054 NM_194339, BC057054 17

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GTPase activity

GTP binding

nucleoplasm

chromosome

nucleolus

90S preribosome

U3 snoRNA binding

03008

TC0200005489.mm.2 Zfp965 zinc finger protein 965 2 175470024 NM_001242944 1

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleoplasm

regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
TC0800001245.mm.2 Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 8 106168853, 106168920 NM_178798, BC038404 NM_178798, BC038404 20

amino acid transmembrane transport

plasma membrane

amino acid transport

basic amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

antiporter activity

ornithine transport

membrane

integral component of membrane

transmembrane transporter activity

intracellular membrane-bounded organelle

transmembrane transport

basic amino acid transmembrane transport

 
TC1500001698.mm.2 Slc45a4 solute carrier family 45, member 4 15 -73577423, -73577423, -73577423 NM_001033219, NM_001168255, BC056501 NM_001033219, NM_001168255, BC056501 NM_001033219, NM_001168255, BC056501 24

sucrose:proton symporter activity

sucrose:proton symporter activity

sucrose transport

membrane

integral component of membrane

 
MG-1-pos-10340825_st                
TC0700001131.mm.2 Ticrr TOPBP1-interacting checkpoint and replication regulator 7 79660195 NM_029835, BC158103 NM_029835, BC158103 18

chromatin binding

chromatin binding

nucleus

nucleus

nucleoplasm

cytosol

DNA replication

DNA repair

cellular response to DNA damage stimulus

cell cycle

mitotic G2 DNA damage checkpoint

response to ionizing radiation

regulation of DNA-dependent DNA replication initiation

regulation of DNA-dependent DNA replication initiation

mitotic DNA replication checkpoint

intracellular membrane-bounded organelle

 
TC0800001639.mm.2 Shcbp1 Shc SH2-domain binding protein 1 8 -4735975 NM_011369, BC070455 NM_011369, BC070455 24

protein binding

cellular_component

cytoplasm

cytoskeleton

fibroblast growth factor receptor signaling pathway

fibroblast growth factor receptor signaling pathway

SH2 domain binding

regulation of neural precursor cell proliferation

 
MG-1-pos-10342215_st                
TC1100001899.mm.2 Nup85 nucleoporin 85 11 115564443 NM_001002929, BC079856 NM_001002929, BC079856 21

chromosome, centromeric region

kinetochore

nucleus

nuclear pore

nucleoplasm

chromosome

cytoplasm

cytosol

cytoskeleton

plasma membrane

mRNA export from nucleus

protein import into nucleus

chemotaxis

protein transport

membrane

structural constituent of nuclear pore

cytokine-mediated signaling pathway

lamellipodium assembly

nuclear pore outer ring

nuclear pore outer ring

CCR2 chemokine receptor binding

positive regulation of transcription, DNA-templated

macrophage chemotaxis

mRNA transport

nephron development

03013

TC0900001441.mm.2 Nme6 NME/NM23 nucleoside diphosphate kinase 6 9 109832793 NM_018757, BC002007, NME/NM23 NM_018757, BC002007, NME/NM23 NM_018757, BC002007, NME/NM23 23

nucleotide binding

nucleoside diphosphate kinase activity

nucleoside diphosphate kinase activity

ATP binding

mitochondrion

mitochondrion

mitochondrion

nucleoside diphosphate phosphorylation

GTP biosynthetic process

UTP biosynthetic process

CTP biosynthetic process

nucleotide metabolic process

kinase activity

phosphorylation

transferase activity

negative regulation of cell growth

negative regulation of cell growth

negative regulation of mitotic nuclear division

negative regulation of mitotic nuclear division

metal ion binding

00230

00240

01100

TC1600002056.mm.2 Urb1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 16 -90751526 NM_029497 16

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

fibrillar center

nucleus

nucleolus

nucleolus

 
TC1400000858.mm.2 Sacs sacsin 14 61138456, 61138456 NM_172809, BC138482, BC138483, BC171956 NM_172809, BC138482, BC138483, BC171956 NM_172809, BC138482, BC138483, BC171956 NM_172809, BC138482, BC138483, BC171956 26

cytoplasm

Hsp70 protein binding

low-density lipoprotein particle receptor binding

chaperone binding

 
TC0700002744.mm.2 Zfp146 zinc finger protein 146 7 -30160486 NM_011980, BC127038, BC127039 NM_011980, BC127038, BC127039 NM_011980, BC127038, BC127039 22

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

nucleus

nucleolus

cytosol

regulation of transcription by RNA polymerase II

metal ion binding

 
TC0200004589.mm.2                
TC0200000352.mm.2 Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2 22774326 NM_019456, BC023110 NM_019456, BC023110 28

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

protein binding

cytoplasm

cytosol

cytosol

cytosol

cytoskeleton

plasma membrane

plasma membrane

plasma membrane

signal transduction

membrane

cell junction

T cell receptor complex

cell projection

positive regulation of cell adhesion

 
TC0900002613.mm.2 Tcf12 transcription factor 12 9 -71844251, -71844251, -71844251 NM_001253862, NM_001253863, NM_001253864, NM_001253865, NM_011544, BC037097 NM_001253862, NM_001253863, NM_001253864, NM_001253865, NM_011544, BC037097 NM_001253862, NM_001253863, NM_001253864, NM_001253865, NM_011544, BC037097 NM_001253862, NM_001253863, NM_001253864, NM_001253865, NM_011544, BC037097 NM_001253862, NM_001253863, NM_001253864, NM_001253865, NM_011544, BC037097 NM_001253862, NM_001253863, NM_001253864, NM_001253865, NM_011544, BC037097 124

chromatin

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

cytoplasm

regulation of transcription by RNA polymerase II

multicellular organism development

nervous system development

transcription factor binding

positive regulation of gene expression

nuclear speck

cell differentiation

cAMP response element binding

intracellular membrane-bounded organelle

bHLH transcription factor binding

positive regulation of neuron differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

SMAD binding

protein heterodimerization activity

protein dimerization activity

E-box binding

HMG box domain binding

RNA polymerase II transcription regulator complex

sequence-specific double-stranded DNA binding

 
TC0800001204.mm.2 Cbfb core binding factor beta 8 105170673 NM_001161456, NM_001161457, NM_001161458, NM_022309, BC006763, BC026749, BC040752 NM_001161456, NM_001161457, NM_001161458, NM_022309, BC006763, BC026749, BC040752 NM_001161456, NM_001161457, NM_001161458, NM_022309, BC006763, BC026749, BC040752 NM_001161456, NM_001161457, NM_001161458, NM_022309, BC006763, BC026749, BC040752 NM_001161456, NM_001161457, NM_001161458, NM_022309, BC006763, BC026749, BC040752 NM_001161456, NM_001161457, NM_001161458, NM_022309, BC006763, BC026749, BC040752 NM_001161456, NM_001161457, NM_001161458, NM_022309, BC006763, BC026749, BC040752 145

negative regulation of transcription by RNA polymerase II

protein polyubiquitination

ossification

osteoblast differentiation

DNA binding

transcription coactivator activity

protein binding

nucleus

nucleoplasm

regulation of transcription by RNA polymerase II

core-binding factor complex

core-binding factor complex

lymphocyte differentiation

myeloid cell differentiation

protein-containing complex

negative regulation of CD4-positive, alpha-beta T cell differentiation

positive regulation of CD8-positive, alpha-beta T cell differentiation

sequence-specific DNA binding

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

cell maturation

definitive hemopoiesis

 
TC1000001868.mm.2 Eya4 EYA transcriptional coactivator and phosphatase 4 10 -23102961, -23102961 NM_010167, BC120898, BC120899 NM_010167, BC120898, BC120899 NM_010167, BC120898, BC120899 28

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

nucleus

cytoplasm

DNA repair

chromatin organization

cellular response to DNA damage stimulus

multicellular organism development

sensory perception of sound

transcription factor binding

histone dephosphorylation

hydrolase activity

cell differentiation

middle ear morphogenesis

positive regulation of DNA repair

metal ion binding

anatomical structure development

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

 
MG-1-neg-10339405_st                
MG-1-pos-10343496_st                
TC0800002618.mm.2 Neto2 neuropilin (NRP) and tolloid (TLL)-like 2 8 -85636717, -85636717 NM_001081324, BC151050, BC157941, BC172104, BC172139 NM_001081324, BC151050, BC157941, BC172104, BC172139 NM_001081324, BC151050, BC157941, BC172104, BC172139 NM_001081324, BC151050, BC157941, BC172104, BC172139 NM_001081324, BC151050, BC157941, BC172104, BC172139 35

plasma membrane

postsynaptic density

membrane

integral component of membrane

ionotropic glutamate receptor binding

synapse

regulation of kainate selective glutamate receptor activity

 
MG-1-neg-10338964_st                
TC1100000407.mm.2 Nudcd2 NudC domain containing 2 11 40733660 NM_026023, BC005646 NM_026023, BC005646 19

chromosome, centromeric region

kinetochore

chromosome

cytoplasm

cytosol

cytoskeleton

protein folding

microtubule cytoskeleton

intercellular bridge

unfolded protein binding

mitotic spindle

 
MG-1-neg-10344006_st                
TC0100003887.mm.2 Nos1ap nitric oxide synthase 1 (neuronal) adaptor protein 1 -170315466, -170315466 NM_001109985, NM_027528, BC160272 NM_001109985, NM_027528, BC160272 NM_001109985, NM_027528, BC160272 28

protease binding

nucleus

cytoplasm

mitochondrion

cytosol

caveola

biological_process

Z disc

PDZ domain binding

T-tubule

nuclear membrane

sarcoplasmic reticulum membrane

nitric-oxide synthase binding

nitric-oxide synthase binding

nitric-oxide synthase binding

presynapse

postsynapse

glutamatergic synapse

negative regulation of neuron death

regulation of high voltage-gated calcium channel activity

inward rectifier potassium channel complex

L-type voltage-gated calcium channel complex

positive regulation of peptidyl-cysteine S-nitrosylation

 
TC0100001595.mm.2 Cd244a CD244 molecule A 1 171559192 NM_018729, BC145067, BC150692, BC160247, CD244 NM_018729, BC145067, BC150692, BC160247, CD244 NM_018729, BC145067, BC150692, BC160247, CD244 NM_018729, BC145067, BC150692, BC160247, CD244 NM_018729, BC145067, BC150692, BC160247, CD244 80

myeloid dendritic cell activation

adaptive immune response

natural killer cell activation involved in immune response

natural killer cell activation involved in immune response

immune system process

protein binding

plasma membrane

immune response

external side of plasma membrane

external side of plasma membrane

membrane

integral component of membrane

positive regulation of interferon-gamma production

positive regulation of interleukin-8 production

positive regulation of natural killer cell proliferation

signaling receptor activity

MHC class I protein binding

innate immune response

positive regulation of inositol phosphate biosynthetic process

positive regulation of granzyme B production

positive regulation of CD8-positive, alpha-beta T cell proliferation

04650

TC0200000274.mm.2 Plxdc2 plexin domain containing 2 2 16356303 NM_026162, BC057881 NM_026162, BC057881 29

plasma membrane

membrane

integral component of membrane

collagen-containing extracellular matrix

 
TC1100004268.mm.2 Fbxw10 F-box and WD-40 domain protein 10 11 62847122 NM_001033669, BC141212, BC172760 NM_001033669, BC141212, BC172760 NM_001033669, BC141212, BC172760 13

cellular_component

biological_process

 
TC0200002844.mm.2 Rpp38 ribonuclease P/MRP 38 subunit 2 -3328948 NM_001013376, BC051448 NM_001013376, BC051448 15

fibrillar center

fibrillar center

tRNA 5'-leader removal

tRNA 5'-leader removal

ribonuclease P activity

ribonuclease P activity

nucleus

nucleolus

rRNA processing

tRNA processing

hydrolase activity

multimeric ribonuclease P complex

multimeric ribonuclease P complex

ribonuclease P RNA binding

ribonuclease P RNA binding

03008

03013

TC1100000164.mm.2 Fbxo48 F-box protein 48 11 16951409, 16951374 NM_176982, BC125589, BC125591 NM_176982, BC125589, BC125591 NM_176982, BC125589, BC125591 10

molecular_function

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

 
TC1100002486.mm.2 Npm1 nucleophosmin 1 11 -33152497, -33154924 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 155

ribosomal large subunit export from nucleus

ribosomal large subunit export from nucleus

ribosomal small subunit export from nucleus

ribosomal small subunit export from nucleus

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

core promoter sequence-specific DNA binding

regulation of cell growth

granular component

p53 binding

nucleic acid binding

DNA binding

chromatin binding

transcription coactivator activity

RNA binding

RNA binding

RNA binding

protein kinase inhibitor activity

protein binding

ATP binding

phosphatidylinositol-3,4,5-trisphosphate binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

cytoplasm

centrosome

centrosome

centrosome

cytosol

cytoskeleton

DNA repair

nucleosome assembly

chromatin remodeling

rRNA export from nucleus

rRNA export from nucleus

rRNA export from nucleus

cell volume homeostasis

cell volume homeostasis

nucleocytoplasmic transport

nucleocytoplasmic transport

centrosome cycle

cell aging

protein localization

protein localization

transcription factor binding

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

rRNA transcription

posttranscriptional regulation of gene expression

negative regulation of gene expression

negative regulation of cardiac muscle cell apoptotic process

regulation of centrosome duplication

regulation of centrosome duplication

positive regulation of centrosome duplication

negative regulation of centrosome duplication

large ribosomal subunit

small ribosomal subunit

nuclear matrix

nuclear speck

rRNA binding

enzyme binding

protein kinase binding

Tat protein binding

positive regulation of cellular biosynthetic process

positive regulation of cellular biosynthetic process

positive regulation of protein ubiquitination

spindle pole centrosome

regulation of protein stability

protein destabilization

regulation of endodeoxyribonuclease activity

protein-containing complex

protein-DNA complex

activating transcription factor binding

cellular response to UV

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

ribosomal small subunit biogenesis

ribosomal small subunit biogenesis

ribosomal small subunit biogenesis

histone binding

histone binding

identical protein binding

identical protein binding

protein homodimerization activity

ribosomal large subunit binding

ribosomal small subunit binding

negative regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of catalytic activity

protein kinase B binding

regulation of DNA damage response, signal transduction by p53 class mediator

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of protein kinase activity by regulation of protein phosphorylation

positive regulation of translation

positive regulation of DNA replication

positive regulation of protein kinase activity

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of centriole replication

protein N-terminus binding

negative regulation of mRNA splicing, via spliceosome

negative regulation of epithelial cell proliferation

protein stabilization

protein stabilization

positive regulation of DNA metabolic process

NF-kappaB binding

unfolded protein binding

positive regulation of NF-kappaB transcription factor activity

regulation of cell cycle

regulation of endoribonuclease activity

regulation of eIF2 alpha phosphorylation by dsRNA

positive regulation of DNA-directed DNA polymerase activity

regulation of mRNA stability involved in cellular response to UV

positive regulation of cell cycle G2/M phase transition

positive regulation of protein localization to nucleolus

ribonucleoprotein complex

ribonucleoprotein complex

 
TC0400000484.mm.2 Polr1e polymerase (RNA) I polypeptide E 4 45018608 NM_001285800, NM_022811, BC034783 NM_001285800, NM_022811, BC034783 NM_001285800, NM_022811, BC034783 30

RNA polymerase I general transcription initiation factor binding

RNA polymerase I preinitiation complex assembly

RNA polymerase I preinitiation complex assembly

fibrillar center

DNA binding

DNA-directed 5'-3' RNA polymerase activity

protein binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

RNA polymerase I complex

RNA polymerase I complex

transcription, DNA-templated

transcription elongation from RNA polymerase I promoter

nucleolar large rRNA transcription by RNA polymerase I

nucleolar large rRNA transcription by RNA polymerase I

00230

00240

01100

03020

TC0300001587.mm.2 Depdc1a DEP domain containing 1a 3 159495432 NM_001172092, NM_001172093, NM_029523, BC023934 NM_001172092, NM_001172093, NM_029523, BC023934 NM_001172092, NM_001172093, NM_029523, BC023934 NM_001172092, NM_001172093, NM_029523, BC023934 12

GTPase activator activity

nucleus

nucleus

signal transduction

transcription repressor complex

transcription repressor complex

intracellular signal transduction

negative regulation of transcription, DNA-templated

 
TC0200002720.mm.2         NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

cellular_component

regulation of transcription by RNA polymerase II

 
TC0200002738.mm.2         NM_001177405, NM_001177406, NM_001177404, NM_001177407 NM_001177405, NM_001177406, NM_001177404, NM_001177407 NM_001177405, NM_001177406, NM_001177404, NM_001177407 NM_001177405, NM_001177406, NM_001177404, NM_001177407  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

cellular_component

regulation of transcription by RNA polymerase II

 
TC0200005341.mm.2         NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

cellular_component

regulation of transcription by RNA polymerase II

 
TC1500001202.mm.2 Brix1 BRX1, biogenesis of ribosomes 15 -10474778 NM_026396, BC014832 NM_026396, BC014832 23

ribosomal large subunit assembly

RNA binding

nucleus

chromosome

nucleolus

nucleolus

ribosome biogenesis

 
TC0200000473.mm.2 Wdr5 WD repeat domain 5 2 27515146 NM_080848, BC016103, BC025801 NM_080848, BC016103, BC025801 NM_080848, BC016103, BC025801 64

histone acetyltransferase complex

skeletal system development

protein binding

intracellular anatomical structure

nucleus

nucleus

nucleoplasm

nucleoplasm

Ada2/Gcn5/Ada3 transcription activator complex

Ada2/Gcn5/Ada3 transcription activator complex

chromatin organization

neuron projection development

methylated histone binding

histone methyltransferase complex

histone binding

histone methyltransferase activity (H3-K4 specific)

histone H3 acetylation

histone H4-K5 acetylation

histone H4-K8 acetylation

histone H4-K16 acetylation

MLL3/4 complex

positive regulation of gluconeogenesis

Set1C/COMPASS complex

Set1C/COMPASS complex

histone H3-K4 methylation

histone H3-K4 methylation

histone H3-K4 methylation

positive regulation of histone H3-K4 methylation

negative regulation of histone H3-K4 methylation

MLL1 complex

 
TC1700001439.mm.2 Pacrg PARK2 co-regulated 17 -10403011 NM_027032, BC120740 NM_027032, BC120740 35

G protein-coupled receptor binding

manchette

actin binding

protein binding

mitochondrion

cytosol

cytosol

cytosol

cilium

spermatid development

Hsp70 protein binding

Hsp70 protein binding

heat shock protein binding

ubiquitin protein ligase binding

ubiquitin protein ligase binding

vesicle

vesicle

vesicle

cellular protein localization

cellular response to unfolded protein

neuron projection

neuron projection

neuron projection

alpha-tubulin binding

cell body

beta-tubulin binding

chaperone binding

chaperone binding

Hsp90 protein binding

Hsp90 protein binding

negative regulation of cell death

negative regulation of cell death

negative regulation of cell death

sperm midpiece

 
TC0X00000958.mm.2 Kif4 kinesin family member 4 X 100626064 NM_008446, BC050946 NM_008446, BC050946 43

nucleotide binding

mitotic cytokinesis

DNA binding

microtubule motor activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

cytoskeleton

microtubule

microtubule-based movement

mitotic spindle organization

microtubule binding

midbody

metal ion binding

mitotic spindle midzone assembly

iron-sulfur cluster binding

 
TC0100001240.mm.2 Ube2t ubiquitin-conjugating enzyme E2T 1 134962564 NM_001278115, NM_026024, BC029213 NM_001278115, NM_026024, BC029213 NM_001278115, NM_026024, BC029213 19

nucleotide binding

protein polyubiquitination

chromatin binding

ubiquitin-protein transferase activity

ATP binding

nucleus

nucleoplasm

nucleolus

DNA repair

protein monoubiquitination

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

transferase activity

ubiquitin protein ligase binding

protein K29-linked ubiquitination

protein K27-linked ubiquitination

protein autoubiquitination

ubiquitin conjugating enzyme activity

ubiquitin conjugating enzyme activity

protein K63-linked ubiquitination

protein K48-linked ubiquitination

protein K11-linked ubiquitination

protein K6-linked ubiquitination

 
TC0900000819.mm.2 Tipin timeless interacting protein 9 64281584 NM_025372, BC016211 NM_025372, BC016211 25

DNA replication checkpoint

DNA replication checkpoint

DNA damage checkpoint

chromatin

DNA binding

protein binding

nucleus

nucleus

cytoplasm

cellular response to DNA damage stimulus

cell cycle

positive regulation of cell population proliferation

response to UV

replication fork protection complex

intra-S DNA damage checkpoint

replication fork arrest

cell cycle phase transition

replication fork protection

cell division

 
TC0X00000429.mm.2 Utp14a UTP14A small subunit processome component X 48256933 NM_028276, BC082590 NM_028276, BC082590 22

nucleus

nucleolus

nucleolus

cytosol

rRNA processing

small-subunit processome

ribosome biogenesis

03008

TC1900001089.mm.2 Incenp inner centromere protein 19 -9872294 NM_016692, BC052414 NM_016692, BC052414 37

mitotic sister chromatid segregation

mitotic cytokinesis

mitotic cytokinesis

chromosome, centromeric region

chromosome, centromeric region

kinetochore

kinetochore

condensed chromosome

synaptonemal complex

lateral element

central element

nucleus

nucleoplasm

chromosome

pericentric heterochromatin

cytoplasm

spindle

cytosol

cytoskeleton

microtubule

cell cycle

chromosome segregation

meiotic chromosome condensation

chromocenter

histone phosphorylation

nuclear body

midbody

midbody

midbody

chromosome passenger complex

protein-containing complex

protein serine/threonine kinase activator activity

meiotic spindle midzone assembly

cell division

metaphase plate congression

positive regulation of protein serine/threonine kinase activity

regulation of mitotic cytokinesis

meiotic spindle midzone

 
TC0400000309.mm.2 Rars2 arginyl-tRNA synthetase 2, mitochondrial 4 34614956 NM_181406, BC024878 NM_181406, BC024878 23

nucleotide binding

aminoacyl-tRNA ligase activity

arginine-tRNA ligase activity

ATP binding

cytoplasm

mitochondrion

mitochondrion

translation

tRNA aminoacylation for protein translation

arginyl-tRNA aminoacylation

ligase activity

mitochondrial translation

00970

TC1600000376.mm.2 Il1rap interleukin 1 receptor accessory protein 16 26581704, 26581704, 26581704, 26581704 NM_001159317, NM_001159318, NM_008364, NM_134103, BC021159 NM_001159317, NM_001159318, NM_008364, NM_134103, BC021159 NM_001159317, NM_001159318, NM_008364, NM_134103, BC021159 NM_001159317, NM_001159318, NM_008364, NM_134103, BC021159 NM_001159317, NM_001159318, NM_008364, NM_134103, BC021159 51

interleukin-33 receptor activity

immune system process

interleukin-1 receptor activity

interleukin-1 receptor activity

interleukin-1 receptor binding

interleukin-1 receptor binding

protein binding

extracellular region

cytoplasm

plasma membrane

inflammatory response

signal transduction

membrane

integral component of membrane

hydrolase activity

cytokine-mediated signaling pathway

interleukin-2 production

interleukin-4 production

positive regulation of interleukin-13 production

positive regulation of interleukin-5 production

positive regulation of interleukin-6 production

protein-containing complex

interleukin-33-mediated signaling pathway

innate immune response

NAD(P)+ nucleosidase activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of synapse assembly

NAD+ nucleotidase, cyclic ADP-ribose generating

glutamatergic synapse

glutamatergic synapse

regulation of postsynaptic density assembly

regulation of postsynaptic density assembly

trans-synaptic signaling by trans-synaptic complex

trans-synaptic signaling by trans-synaptic complex

synaptic membrane adhesion

synaptic membrane adhesion

positive regulation of dendrite development

regulation of presynapse assembly

regulation of presynapse assembly

protein tyrosine kinase binding

04060

04210

TC0400001736.mm.2 Pla2g2e phospholipase A2, group IIE 4 138877941 NM_012044, BC027524 NM_012044, BC027524 28

phospholipase A2 activity

calcium ion binding

calcium ion binding

phospholipid binding

extracellular region

cytoplasm

lipid metabolic process

phospholipid metabolic process

inflammatory response

lipid catabolic process

hydrolase activity

low-density lipoprotein particle remodeling

phosphatidylcholine metabolic process

phosphatidylglycerol metabolic process

metal ion binding

calcium-dependent phospholipase A2 activity

calcium-dependent phospholipase A2 activity

calcium-dependent phospholipase A2 activity

arachidonic acid secretion

00564

00565

00590

00591

00592

01100

04010

04270

04370

04664

04730

04912

04972

04975

05145

TC1800001156.mm.2 Cdc25c cell division cycle 25C 18 -34732994 NM_009860, BC004669 NM_009860, BC004669 51

G2/M transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein binding

intracellular anatomical structure

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

mitochondrial intermembrane space

protein dephosphorylation

cell cycle

positive regulation of G2/M transition of mitotic cell cycle

nuclear speck

hydrolase activity

protein kinase binding

perinuclear region of cytoplasm

WW domain binding

cell division

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition

04110

04114

04914

TC0800003008.mm.2 Gcsh glycine cleavage system protein H (aminomethyl carrier) 8 -116981966 NM_026572, BC014745 NM_026572, BC014745 19

aminomethyltransferase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

glycine cleavage complex

protein lipoylation

protein lipoylation

glycine decarboxylation via glycine cleavage system

glycine decarboxylation via glycine cleavage system

enzyme binding

 
TC1400000177.mm.2 Vcl vinculin 14 20929397 NM_009502, BC008520 NM_009502, BC008520 214

stress fiber

morphogenesis of an epithelium

podosome

dystroglycan binding

actin binding

structural molecule activity

protein binding

cytoplasm

cytoskeleton

actin filament

plasma membrane

cell-cell junction

cell-cell junction

adherens junction

adherens junction

fascia adherens

focal adhesion

focal adhesion

cell adhesion

intercalated disc

actin cytoskeleton

membrane

Z disc

lamellipodium assembly

cell junction

regulation of cell migration

small GTPase binding

ubiquitin protein ligase binding

protein-containing complex

adherens junction assembly

protein localization to cell surface

sarcolemma

sarcolemma

costamere

costamere

apical junction assembly

cell-cell contact zone

membrane raft

alpha-catenin binding

axon extension

actin filament binding

regulation of focal adhesion assembly

epithelial cell-cell adhesion

regulation of establishment of endothelial barrier

regulation of protein localization to adherens junction

04510

04520

04670

04810

05100

05146

MG-1-pos-10343924_st                
TC0500000048.mm.2 Slc25a40 solute carrier family 25, member 40 5 8422837 NM_001289595, NM_001289596, NM_178766, BC083103 NM_001289595, NM_001289596, NM_178766, BC083103 NM_001289595, NM_001289596, NM_178766, BC083103 NM_001289595, NM_001289596, NM_178766, BC083103 15

mitochondrion

mitochondrial inner membrane

membrane

integral component of membrane

transmembrane transporter activity

transmembrane transport

 
TC0200001756.mm.2 Rpusd2 RNA pseudouridylate synthase domain containing 2 2 119034789 NM_173450, BC117827, BC117828 NM_173450, BC117827, BC117828 NM_173450, BC117827, BC117828 13

enzyme-directed rRNA pseudouridine synthesis

pseudouridine synthesis

RNA binding

RNA modification

pseudouridine synthase activity

 
TC0500003096.mm.2 Gatc glutamyl-tRNA(Gln) amidotransferase, subunit C 5 -115333241 NM_029645, BC021775 NM_029645, BC021775 14

nucleotide binding

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

translation

regulation of translational fidelity

ligase activity

glutamyl-tRNA(Gln) amidotransferase complex

glutamyl-tRNA(Gln) amidotransferase complex

mitochondrial translation

mitochondrial translation

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

glutaminyl-tRNAGln biosynthesis via transamidation

glutaminyl-tRNAGln biosynthesis via transamidation

 
TC0400003437.mm.2 Ctps cytidine 5'-triphosphate synthase 4 -120539867, -120539867 NM_016748, BC006698 NM_016748, BC006698 30

nucleotide binding

immune system process

CTP synthase activity

CTP synthase activity

ATP binding

cytoplasm

pyrimidine nucleotide biosynthetic process

CTP biosynthetic process

CTP biosynthetic process

glutamine metabolic process

ligase activity

pyrimidine nucleobase biosynthetic process

T cell proliferation

B cell proliferation

identical protein binding

identical protein binding

cytoophidium

cytoophidium

00240

01100

TC1100001329.mm.2 Ska2 spindle and kinetochore associated complex subunit 2 11 87109260 NM_025377, BC117001, BC119167 NM_025377, BC117001, BC119167 NM_025377, BC117001, BC119167 23

mitotic cell cycle

mitotic cell cycle

chromosome, centromeric region

kinetochore

condensed chromosome outer kinetochore

condensed chromosome outer kinetochore

chromosome

cytoplasm

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cell cycle

chromosome segregation

chromosome segregation

microtubule binding

microtubule binding

regulation of microtubule polymerization or depolymerization

cell division

 
TC0200003202.mm.2 Surf6 surfeit gene 6 2 -26890417 NM_009298, BC037634 NM_009298, BC037634 30

granular component

DNA binding

DNA binding

RNA binding

RNA binding

nucleus

nucleoplasm

nucleoplasm

chromosome

nucleolus

nucleolus

nucleolus

ribosome biogenesis

ribosome assembly

ribosomal large subunit biogenesis

ribosomal small subunit biogenesis

 
TC1500001534.mm.2 Dscc1 DNA replication and sister chromatid cohesion 1 15 -55076100 NM_183089, BC116833, BC116835 NM_183089, BC116833, BC116835 NM_183089, BC116833, BC116835 16

chromosome, centromeric region

chromosome, centromeric region

chromatin

chromatin

DNA binding

DNA clamp loader activity

DNA clamp loader activity

nucleus

nucleoplasm

DNA replication

regulation of DNA replication

regulation of DNA replication

cell cycle

mitotic sister chromatid cohesion

single-stranded DNA helicase activity

Ctf18 RFC-like complex

Ctf18 RFC-like complex

maintenance of mitotic sister chromatid cohesion

maintenance of mitotic sister chromatid cohesion

post-translational protein acetylation

positive regulation of DNA-directed DNA polymerase activity

 
TC0600003342.mm.2 Eps8 epidermal growth factor receptor pathway substrate 8 6 -137477244, -137477244, -137477244 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 73

actin binding

actin binding

protein binding

cytoplasm

plasma membrane

brush border

cell cortex

Rho protein signal transduction

adult locomotory behavior

regulation of cell shape

exit from mitosis

postsynaptic density

postsynaptic density

membrane

Rac protein signal transduction

NMDA selective glutamate receptor complex

cell junction

regulation of actin filament length

small GTPase binding

actin cytoskeleton reorganization

stereocilium

stereocilium bundle

stereocilium tip

ruffle membrane

ruffle membrane

regulation of Rho protein signal transduction

signaling adaptor activity

dendritic cell migration

cell projection

neuron projection

synapse

behavioral response to ethanol

barbed-end actin filament capping

barbed-end actin filament capping

actin filament bundle assembly

actin filament bundle assembly

actin filament bundle assembly

actin crosslink formation

actin crosslink formation

actin polymerization-dependent cell motility

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

regulation of postsynaptic membrane neurotransmitter receptor levels

regulation of postsynaptic membrane neurotransmitter receptor levels

regulation of postsynaptic membrane neurotransmitter receptor levels

positive regulation of ruffle assembly

cellular response to leukemia inhibitory factor

 
TC1100003569.mm.2 Eme1 essential meiotic structure-specific endonuclease 1 11 -94644972, -94644995 NM_177752, BC089459 NM_177752, BC089459 26

resolution of meiotic recombination intermediates

chromatin

heterochromatin

DNA binding

nuclease activity

endonuclease activity

protein binding

nucleus

DNA repair

double-strand break repair

DNA recombination

cellular response to DNA damage stimulus

hydrolase activity

replication fork processing

intra-S DNA damage checkpoint

metal ion binding

Holliday junction resolvase complex

response to intra-S DNA damage checkpoint signaling

03440

TC1700002561.mm.2 Cebpz CCAAT/enhancer binding protein zeta 17 -78919002 NM_001024806, BC160197 NM_001024806, BC160197 24

transcription coactivator activity

nucleus

nucleus

ribosome biogenesis

positive regulation of transcription by RNA polymerase II

 
TC1900001428.mm.2 Pank1 pantothenate kinase 1 19 -34806935, -34806935 NM_001114339, NM_023792, BC023496 NM_001114339, NM_023792, BC023496 NM_001114339, NM_023792, BC023496 33

nucleotide binding

pantothenate kinase activity

pantothenate kinase activity

pantothenate kinase activity

ATP binding

nucleus

nucleus

nucleus

cytosol

cytosol

cytosol

coenzyme A biosynthetic process

coenzyme A biosynthetic process

coenzyme A biosynthetic process

coenzyme A biosynthetic process

kinase activity

phosphorylation

transferase activity

clathrin coat

protein homodimerization activity

recycling endosome

cell periphery

acetyl-CoA binding

00770

01100

TC0100001178.mm.2 Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 1 131910457 NM_001145804, NM_175294, BC039951 NM_001145804, NM_175294, BC039951 NM_001145804, NM_175294, BC039951 32

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

chromatin

chromatin

cellular glucose homeostasis

chromatin binding

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

transcription coactivator activity

nucleus

nucleus

nucleoplasm

chromosome

nucleolus

cytoplasm

cytoplasm

cytoplasm

regulation of DNA replication

DNA repair

chromatin organization

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

transcription factor binding

release from viral latency

replication fork processing

interstrand cross-link repair

interstrand cross-link repair

glucose homeostasis

positive regulation by host of viral transcription

positive regulation by host of viral genome replication

positive regulation of transcription by RNA polymerase II

regulation of insulin receptor signaling pathway

positive regulation of insulin receptor signaling pathway

regulation of DNA strand elongation

cellular response to X-ray

modulation by host of RNA binding by virus

modulation by host of viral RNA-binding transcription factor activity

 
TC1800000535.mm.2 Snx24 sorting nexing 24 18 53245624 NM_029394, BC051168 NM_029394, BC051168 15

cellular_component

biological_process

lipid binding

phosphatidylinositol-5-phosphate binding

protein transport

membrane

cytoplasmic vesicle

phosphatidylinositol-3-phosphate binding

phosphatidylinositol binding

phosphatidylinositol-4-phosphate binding

phosphatidylinositol phosphate binding

 
TC1600000952.mm.2 N6amt1 N-6 adenine-specific DNA methyltransferase 1 (putative) 16 87354184 NM_001159331, NM_026366, BC098330, BC116393, BC116394 NM_001159331, NM_026366, BC098330, BC116393, BC116394 NM_001159331, NM_026366, BC098330, BC116393, BC116394 NM_001159331, NM_026366, BC098330, BC116393, BC116394 NM_001159331, NM_026366, BC098330, BC116393, BC116394 20

nucleic acid binding

protein binding

nucleus

chromatin organization

methyltransferase activity

protein methyltransferase activity

protein methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

toxin metabolic process

transferase activity

histone-lysine N-methyltransferase activity

peptidyl-glutamine methylation

peptidyl-glutamine methylation

arsonoacetate metabolic process

positive regulation of cell growth

methylarsonite methyltransferase activity

methylation

protein-containing complex

histone lysine methylation

eRF1 methyltransferase complex

protein-glutamine N-methyltransferase activity

protein-glutamine N-methyltransferase activity

S-adenosyl-L-methionine binding

 
TC0200000312.mm.2 Msrb2 methionine sulfoxide reductase B2 2 19371635 NM_029619, BC021619 NM_029619, BC021619 30

actin binding

cytoplasm

mitochondrion

mitochondrion

response to oxidative stress

zinc ion binding

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

actin filament polymerization

protein repair

peptide-methionine (R)-S-oxide reductase activity

peptide-methionine (R)-S-oxide reductase activity

L-methionine-(R)-S-oxide reductase activity

metal ion binding

 
TC0300000880.mm.2 Selenbp1 selenium binding protein 1 3 94933082 NM_009150, BC011202 NM_009150, BC011202 31

fibrillar center

nucleus

nucleolus

cytoplasm

selenium binding

protein transport

membrane

oxidoreductase activity

methanethiol oxidase activity

brown fat cell differentiation

 
TC1100003300.mm.2 Tmem97 transmembrane protein 97 11 -78541816 NM_133706, BC018156, BC093511 NM_133706, BC018156, BC093511 NM_133706, BC018156, BC093511 23

molecular_function

nucleus

lysosome

endoplasmic reticulum

endoplasmic reticulum

rough endoplasmic reticulum

plasma membrane

membrane

integral component of membrane

nuclear membrane

cholesterol homeostasis

 
TC1800000908.mm.2         NM_175542, NR_105777 NM_175542, NR_105777  

molecular_function

cytoplasm

centrosome

centriole

cytoskeleton

cilium

centriole replication

multicellular organism development

determination of left/right symmetry

centriole-centriole cohesion

integral component of membrane

ciliary basal body organization

ciliary basal body

ciliary basal body

cell projection

cilium organization

 
TC0700003599.mm.2 Wdr73 WD repeat domain 73 7 -80890722 NM_028026, NR_027976, BC028870, BC087940 NM_028026, NR_027976, BC028870, BC087940 NM_028026, NR_027976, BC028870, BC087940 NM_028026, NR_027976, BC028870, BC087940 20

spindle pole

spindle pole

molecular_function

cytoplasm

cytosol

cytosol

cytoskeleton

nucleus organization

cytoplasmic microtubule organization

cytoplasmic microtubule organization

cleavage furrow

negative regulation of apoptotic process

 
TC0400000091.mm.2         NM_001039556, NM_001256142, NM_001256145, BC057604 NM_001039556, NM_001256142, NM_001256145, BC057604 NM_001039556, NM_001256142, NM_001256145, BC057604 NM_001039556, NM_001256142, NM_001256145, BC057604  

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

nucleus

nucleus

nucleoplasm

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

reciprocal meiotic recombination

biological_process

determination of adult lifespan

response to ionizing radiation

response to ionizing radiation

DNA translocase activity

DNA translocase activity

response to drug

identical protein binding

 
TC0800000646.mm.2 Mfap3l microfibrillar-associated protein 3-like 8 60632824, 60655103, 60655556 NM_001177881, NM_001177882, NM_027756, BC095950 NM_001177881, NM_001177882, NM_027756, BC095950 NM_001177881, NM_001177882, NM_027756, BC095950 NM_001177881, NM_001177882, NM_027756, BC095950 14

molecular_function

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

plasma membrane

plasma membrane

biological_process

membrane

integral component of membrane

cell junction

 
TC1100003505.mm.2 Akap1 A kinase (PRKA) anchor protein 1 11 -88830791, -88830791, -88830791 NM_001042541, NM_009648, NR_104310 NM_001042541, NM_009648, NR_104310 NM_001042541, NM_009648, NR_104310 58

nucleic acid binding

RNA binding

protein binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

lipid droplet

apoptotic process

microtubule binding

negative regulation of cardiac muscle hypertrophy

regulation of protein kinase A signaling

membrane

integral component of membrane

protein kinase binding

protein phosphatase binding

mitochondrial crista

protein phosphatase 2B binding

neuromuscular junction

protein kinase A regulatory subunit binding

negative regulation of protein dephosphorylation

negative regulation of protein import into nucleus

postsynaptic membrane

beta-tubulin binding

molecular adaptor activity

antiviral innate immune response

 
MG-1-pos-10343025_st                
TC0200000459.mm.2 Surf2 surfeit gene 2 2 26916407 NM_013678, BC096401 NM_013678, BC096401 21

molecular_function

nucleoplasm

nucleolus

plasma membrane

biological_process

nuclear speck

 
MG-1-neg-10340688_st                
TC1300002617.mm.2 Ipo11 importin 11 13 -106794438 NM_029665, BC029746, BC031900, XM_003084943 NM_029665, BC029746, BC031900, XM_003084943 NM_029665, BC029746, BC031900, XM_003084943 NM_029665, BC029746, BC031900, XM_003084943 23

protein binding

nucleus

nuclear envelope

nucleoplasm

cytoplasm

cytosol

cytosol

protein import into nucleus

ribosomal protein import into nucleus

intracellular protein transport

protein transport

small GTPase binding

nuclear import signal receptor activity

 
TC0600001744.mm.2 Klhl42 kelch-like 42 6 147091074 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 16

protein polyubiquitination

protein polyubiquitination

ubiquitin-protein transferase activity

cytoplasm

cytoskeleton

cell cycle

Cul3-RING ubiquitin ligase complex

regulation of microtubule-based process

regulation of microtubule-based process

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

cell division

 
TC1700000705.mm.2 Mdc1 mediator of DNA damage checkpoint 1 17 35841497 NM_001010833 55

nucleus

nucleoplasm

chromosome

focal adhesion

DNA repair

cellular response to DNA damage stimulus

cell cycle

protein C-terminus binding

nuclear body

identical protein binding

FHA domain binding

 
TC0X00002631.mm.2 Pola1 polymerase (DNA directed), alpha 1 X -93304765 NM_008892, BC138047 NM_008892, BC138047 36

nucleotide binding

DNA synthesis involved in DNA repair

chromatin

nucleoside binding

nucleic acid binding

DNA binding

chromatin binding

chromatin binding

DNA replication origin binding

double-stranded DNA binding

single-stranded DNA binding

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

protein binding

nucleus

nucleus

nuclear envelope

nucleoplasm

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

nucleolus

cytoplasm

cytosol

DNA replication

DNA replication

DNA replication

DNA replication, synthesis of RNA primer

DNA replication, synthesis of RNA primer

DNA replication initiation

DNA strand elongation involved in DNA replication

leading strand elongation

leading strand elongation

lagging strand elongation

lagging strand elongation

double-strand break repair via nonhomologous end joining

nuclear matrix

transferase activity

nucleotidyltransferase activity

purine nucleotide binding

purine nucleotide binding

pyrimidine nucleotide binding

pyrimidine nucleotide binding

protein kinase binding

regulation of type I interferon production

metal ion binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

DNA biosynthetic process

mitotic DNA replication initiation

00230

00240

01100

03030

TC1600000176.mm.2 Nde1 nudE neurodevelopment protein 1 16 14163274 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 49

establishment of mitotic spindle orientation

establishment of mitotic spindle orientation

chromosome, centromeric region

kinetochore

kinetochore

neuron migration

protein binding

chromosome

cytoplasm

centrosome

centrosome

centrosome

microtubule organizing center

spindle

cytoskeleton

kinesin complex

microtubule

microtubule nucleation

microtubule nucleation

cell cycle

chromosome segregation

mitotic centrosome separation

multicellular organism development

nervous system development

neuroblast proliferation

microtubule binding

microtubule binding

cell migration

protein domain specific binding

cerebral cortex development

cerebral cortex development

cell differentiation

forebrain development

microtubule organizing center organization

spindle pole centrosome

identical protein binding

identical protein binding

synapse

vesicle transport along microtubule

vesicle transport along microtubule

centrosome duplication

cell division

establishment of chromosome localization

establishment of chromosome localization

centrosome localization

regulation of microtubule motor activity

 
TC0200000055.mm.2 Nudt5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 2 5845033 NM_016918, BC004571, BC049595 NM_016918, BC004571, BC049595 NM_016918, BC004571, BC049595 28

magnesium ion binding

RNA binding

nucleus

nucleus

nucleobase-containing compound metabolic process

chromatin remodeling

nucleoside phosphate metabolic process

ribonucleoside diphosphate catabolic process

transferase activity

nucleotidyltransferase activity

hydrolase activity

nucleoside-diphosphatase activity

ADP-sugar diphosphatase activity

D-ribose catabolic process

ribose phosphate metabolic process

snoRNA binding

identical protein binding

protein homodimerization activity

8-oxo-dGDP phosphatase activity

metal ion binding

ADP-ribose diphosphatase activity

ADP-ribose diphosphatase activity

ATP generation from poly-ADP-D-ribose

00230

TC0100003866.mm.2 Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 1 107511509, 107511422 NM_001174170, NM_011111, BC138815, BC138817 NM_001174170, NM_011111, BC138815, BC138817 NM_001174170, NM_011111, BC138815, BC138817 NM_001174170, NM_011111, BC138815, BC138817 55

serine-type endopeptidase inhibitor activity

extracellular region

extracellular space

cytoplasm

negative regulation of peptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

wound healing

negative regulation of apoptotic process

05146

TC1200001420.mm.2 Gen1 GEN1, Holliday junction 5' flap endonuclease 12 -11238937 NM_177331, BC090653, BC138157, BC138158 NM_177331, BC090653, BC138157, BC138158 NM_177331, BC090653, BC138157, BC138158 NM_177331, BC090653, BC138157, BC138158 21

magnesium ion binding

four-way junction DNA binding

four-way junction DNA binding

double-strand break repair via homologous recombination

DNA binding

catalytic activity

nuclease activity

endonuclease activity

nucleus

centrosome

DNA repair

cellular response to DNA damage stimulus

crossover junction endodeoxyribonuclease activity

regulation of centrosome duplication

hydrolase activity

5'-flap endonuclease activity

5'-flap endonuclease activity

replication fork processing

protein homodimerization activity

metal ion binding

resolution of recombination intermediates

resolution of mitotic recombination intermediates

positive regulation of mitotic cell cycle spindle assembly checkpoint

 
TC0600003136.mm.2 Ncapd2 non-SMC condensin I complex, subunit D2 6 -125168006 NM_146171, BC026982, BC029133 NM_146171, BC026982, BC029133 NM_146171, BC026982, BC029133 32

nuclear chromosome

mitotic cell cycle

condensed chromosome, centromeric region

condensed chromosome

condensed chromosome

condensin complex

condensin complex

condensin complex

chromatin binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

histone binding

histone binding

pronucleus

cell division

 
MG-1-neg-10341224_st                
MG-1-neg-10342714_st                
MG-1-neg-10342165_st                
TC0900001623.mm.2 Ss18l2 SS18, nBAF chromatin remodeling complex subunit like 2 9 121710388 NM_026794, BC027548 NM_026794, BC027548 17

molecular_function

transcription coactivator activity

nucleus

positive regulation of transcription by RNA polymerase II

positive regulation of dendrite morphogenesis

 
TC1100002593.mm.2 Thg1l tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 11 -45945305, -45945305 NM_001080969, BC092541, BC115560, BC115561 NM_001080969, BC092541, BC115560, BC115561 NM_001080969, BC092541, BC115560, BC115561 NM_001080969, BC092541, BC115560, BC115561 16

nucleotide binding

magnesium ion binding

guanyl-nucleotide exchange factor activity

ATP binding

GTP binding

cytoplasm

mitochondrion

tRNA modification

response to oxidative stress

tRNA processing

tRNA processing

mitochondrial fusion

tRNA guanylyltransferase activity

tRNA guanylyltransferase activity

transferase activity

nucleotidyltransferase activity

identical protein binding

metal ion binding

protein homotetramerization

stress-induced mitochondrial fusion

transferase complex

 
TC1300000273.mm.2 Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylase 13 24327403, 24415121 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 51

cytoplasm

endoplasmic reticulum

oxidoreductase activity

CMP-N-acetylneuraminate monooxygenase activity

CMP-N-acetylneuraminate monooxygenase activity

CMP-N-acetylneuraminate metabolic process

metal ion binding

iron-sulfur cluster binding

2 iron, 2 sulfur cluster binding

00520

TC0200001874.mm.2 Slc24a5 solute carrier family 24, member 5 2 125068126 NM_175034, BC094232, BC144866, BC145643 NM_175034, BC094232, BC144866, BC145643 NM_175034, BC094232, BC144866, BC145643 NM_175034, BC094232, BC144866, BC145643 17

calcium channel activity

Golgi apparatus

trans-Golgi network

trans-Golgi network

ion transport

potassium ion transport

sodium ion transport

calcium ion transport

cellular calcium ion homeostasis

calcium, potassium:sodium antiporter activity

calcium, potassium:sodium antiporter activity

symporter activity

antiporter activity

membrane

integral component of membrane

melanocyte differentiation

ion transmembrane transport

regulation of melanin biosynthetic process

negative regulation of melanin biosynthetic process

response to stimulus

transmembrane transport

calcium ion transmembrane transport

 
TC0800002523.mm.2 Abce1 ATP-binding cassette, sub-family E (OABP), member 1 8 -79683441 NM_015751, BC005422 NM_015751, BC005422 31

ribosomal subunit export from nucleus

nucleotide binding

iron ion binding

ATP binding

cytoplasm

mitochondrion

cytosol

eukaryotic translation initiation factor 3 complex

translational initiation

translational termination

ATPase activity

ribosomal small subunit binding

endoribonuclease inhibitor activity

negative regulation of endoribonuclease activity

 
TC1300001922.mm.2 Kif13a kinesin family member 13A 13 -46749087 NM_010617 23

nucleotide binding

microtubule motor activity

microtubule motor activity

protein binding

ATP binding

cytoplasm

endosome

Golgi apparatus

centrosome

cytoskeleton

kinesin complex

microtubule

intracellular protein transport

intracellular protein transport

microtubule-based movement

cell cycle

microtubule binding

endosome to lysosome transport

endosome membrane

protein transport

membrane

ATPase activity

midbody

melanosome organization

regulation of cytokinesis

trans-Golgi network membrane

vesicle cargo loading

Golgi to plasma membrane protein transport

cell division

plus-end-directed vesicle transport along microtubule

 
TC1300000715.mm.2 Rmi1 RecQ mediated genome instability 1 13 58402247, 58402596 NM_001168248, NM_028904, NR_031761, BC037694 NM_001168248, NM_028904, NR_031761, BC037694 NM_001168248, NM_028904, NR_031761, BC037694 NM_001168248, NM_028904, NR_031761, BC037694 24

nucleotide binding

resolution of meiotic recombination intermediates

double-strand break repair via homologous recombination

response to dietary excess

reduction of food intake in response to dietary excess

molecular_function

nucleus

nucleoplasm

DNA replication

response to glucose

nuclear body

nuclear body

RecQ family helicase-topoisomerase III complex

multicellular organism growth

glucose homeostasis

 
TC1700000896.mm.2 Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 17 46496788 NM_207161, BC048355 NM_207161, BC048355 17

nucleus

nucleus

cytoplasm

metabolic process

nucleotide metabolic process

deoxyribonucleoside monophosphate catabolic process

deoxyribonucleoside monophosphate catabolic process

hydrolase activity

hydrolase activity, acting on glycosyl bonds

positive regulation of cell growth

identical protein binding

protein homodimerization activity

deoxyribonucleoside 5'-monophosphate N-glycosidase activity

deoxyribonucleoside 5'-monophosphate N-glycosidase activity

 
TC0100001756.mm.2 Taf1a TATA-box binding protein associated factor, RNA polymerase I, A 1 183388984, 183388884 NM_001277957, NM_001277958, NM_001277959, NM_021466, BC061106, BC138425 NM_001277957, NM_001277958, NM_001277959, NM_021466, BC061106, BC138425 NM_001277957, NM_001277958, NM_001277959, NM_021466, BC061106, BC138425 NM_001277957, NM_001277958, NM_001277959, NM_021466, BC061106, BC138425 NM_001277957, NM_001277958, NM_001277959, NM_021466, BC061106, BC138425 NM_001277957, NM_001277958, NM_001277959, NM_021466, BC061106, BC138425 19

RNA polymerase I transcription regulator complex

DNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

transcription by RNA polymerase I

microtubule cytoskeleton

 
TC0X00001084.mm.2 P2ry10b purinergic receptor P2Y, G-protein coupled 10B X 107148926, 107149453, 107149614 NM_001122595, NM_001122596, NM_175442 NM_001122595, NM_001122596, NM_175442 NM_001122595, NM_001122596, NM_175442 11

G protein-coupled receptor activity

integral component of plasma membrane

positive regulation of Rho protein signal transduction

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

 
TC1500002075.mm.2 Abcd2 ATP-binding cassette, sub-family D (ALD), member 2 15 -91145870 NM_011994, BC019187 NM_011994, BC019187 52

very long-chain fatty acid metabolic process

nucleotide binding

long-chain fatty acid transporter activity

protein binding

ATP binding

mitochondrion

peroxisome

peroxisomal membrane

peroxisomal membrane

fatty acid beta-oxidation

fatty acid beta-oxidation

fatty acid beta-oxidation

peroxisome organization

response to bacterium

long-chain fatty acid import into peroxisome

membrane

integral component of membrane

ATPase activity

positive regulation of fatty acid beta-oxidation

positive regulation of fatty acid beta-oxidation

ATPase-coupled transmembrane transporter activity

very long-chain fatty acid catabolic process

very long-chain fatty acid catabolic process

very long-chain fatty acid catabolic process

protein homodimerization activity

myelin maintenance

transmembrane transport

negative regulation of cytokine production involved in inflammatory response

negative regulation of reactive oxygen species biosynthetic process

neuron projection maintenance

positive regulation of unsaturated fatty acid biosynthetic process

02010

04146

TC1100000383.mm.2 Pank3 pantothenate kinase 3 11 35769494 NM_145962, BC027089 NM_145962, BC027089 27

nucleotide binding

pantothenate kinase activity

pantothenate kinase activity

pantothenate kinase activity

ATP binding

nucleus

cytoplasm

cytosol

cytosol

coenzyme A biosynthetic process

coenzyme A biosynthetic process

coenzyme A biosynthetic process

kinase activity

phosphorylation

transferase activity

vitamin binding

protein homodimerization activity

acetyl-CoA binding

00770

01100

TC1300002380.mm.2 Rasa1 RAS p21 protein activator 1 13 -85214698 NM_145452, BC013637 NM_145452, BC013637 91

ruffle

phosphotyrosine residue binding

positive regulation of protein phosphorylation

negative regulation of cell-matrix adhesion

GTPase activator activity

signaling receptor binding

platelet-derived growth factor receptor binding

protein binding

cytosol

cytosol

plasma membrane

plasma membrane

negative regulation of cell adhesion

signal transduction

transcription factor binding

membrane

kinase binding

regulation of actin filament polymerization

receptor tyrosine kinase binding

nuclear membrane

cellular response to platelet-derived growth factor stimulus

response to drug

negative regulation of apoptotic process

protein kinase B binding

positive regulation of GTPase activity

ion channel binding

protein-containing complex binding

positive regulation of glucose import

positive regulation of fibroblast proliferation

blood vessel morphogenesis

positive regulation of peptidyl-tyrosine phosphorylation

GTPase binding

cellular response to epidermal growth factor stimulus

activation of GTPase activity

protein tyrosine kinase binding

04010

04360

TC1300002119.mm.2 Golm1 golgi membrane protein 1 13 -59634995 NM_001035122, NM_027307, BC011152, BC098486 NM_001035122, NM_027307, BC011152, BC098486 NM_001035122, NM_027307, BC011152, BC098486 NM_001035122, NM_027307, BC011152, BC098486 24

molecular_function

Golgi apparatus

Golgi apparatus

nucleus organization

membrane

integral component of membrane

regulation of lipid metabolic process

 

1021 Genes